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2 "Acetylation"
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Original Articles
Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Soo Kee Min, Young Ho Koh, Yunwoong Park, Hyo Jung Kim, Jinwon Seo, Hye-Rim Park, Seong Jin Cho, In Sun Kim
Korean J Pathol. 2012;46(2):142-150.   Published online April 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.142
  • 6,766 View
  • 65 Download
  • 25 Crossref
AbstractAbstract PDF
Background

It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.

Methods

We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.

Results

The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05).

Conclusions

HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.

Citations

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  • Chidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway
    Chunyan Wu, Shilv Chen, Zhimin Wu, Jiao Xue, Wen Zhang, Shan Wang, Xindong Zhao, Shaoling Wu
    Journal of Cancer Research and Clinical Oncology.2024;[Epub]     CrossRef
  • Targeting HDACs for diffuse large B-cell lymphoma therapy
    Chunyan Wu, Qiao Song, Sophie Gao, Shaoling Wu
    Scientific Reports.2024;[Epub]     CrossRef
  • Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
    Ailin Zhao, Hui Zhou, Jinrong Yang, Meng Li, Ting Niu
    Signal Transduction and Targeted Therapy.2023;[Epub]     CrossRef
  • Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease
    Miguel A. Ortega, Diego De Leon-Oliva, Cielo Garcia-Montero, Oscar Fraile-Martinez, Diego Liviu Boaru, María del Val Toledo Lobo, Ignacio García-Tuñón, Mar Royuela, Natalio García-Honduvilla, Julia Bujan, Luis G. Guijarro, Melchor Alvarez-Mon, Miguel Ánge
    Genes.2023; 14(4): 915.     CrossRef
  • HAT1: Landscape of Biological Function and Role in Cancer
    Vincenza Capone, Laura Della Torre, Daniela Carannante, Mehrad Babaei, Lucia Altucci, Rosaria Benedetti, Vincenzo Carafa
    Cells.2023; 12(7): 1075.     CrossRef
  • Recent advancement of HDAC inhibitors against breast cancer
    Syed Abdulla Mehmood, Kantrol Kumar Sahu, Sounok Sengupta, Sangh Partap, Rajshekhar Karpoormath, Brajesh Kumar, Deepak Kumar
    Medical Oncology.2023;[Epub]     CrossRef
  • Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis
    LaShanale Wallace, Esther A. Obeng
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Potential Therapeutic Use of Aptamers against HAT1 in Lung Cancer
    José Ignacio Klett-Mingo, Celia Pinto-Díez, Julio Cambronero-Plaza, Rebeca Carrión-Marchante, Miriam Barragán-Usero, María Isabel Pérez-Morgado, Eulalia Rodríguez-Martín, Mª Val Toledo-Lobo, Víctor M González, M. Elena Martín
    Cancers.2022; 15(1): 227.     CrossRef
  • Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment
    Bárbara Matos, John Howl, Carmen Jerónimo, Margarida Fardilha
    Drug Discovery Today.2021; 26(11): 2680.     CrossRef
  • Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer
    Yan Sun, Dianyun Ren, Yingke Zhou, Jian Shen, Heshui Wu, Xin Jin
    Cell Death & Disease.2021;[Epub]     CrossRef
  • Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach
    Sina Abdollahi, Seyedeh Zahra Dehghanian, Liang-Yi Hung, Shiang-Jie Yang, Dao-Peng Chen, L. Jeffrey Medeiros, Jung-Hsien Chiang, Kung-Chao Chang
    Biomarker Research.2021;[Epub]     CrossRef
  • The contributory roles of histone deacetylases (HDACs) in hematopoiesis regulation and possibilities for pharmacologic interventions in hematologic malignancies
    Mahdieh Mehrpouri, Atieh Pourbagheri-Sigaroodi, Davood Bashash
    International Immunopharmacology.2021; 100: 108114.     CrossRef
  • Emerging role of histone deacetylase inhibitors in the treatment of diffuse large B-cell lymphoma
    Mingyang Wang, Xiaosheng Fang, Xin Wang
    Leukemia & Lymphoma.2020; 61(4): 763.     CrossRef
  • Effective Treatment with PD-1 Antibody, Chidamide, Etoposide, and Thalidomide (PCET) for Relapsed/Refractory Natural Killer/T-Cell Lymphoma: A Report of Three Cases


    Lijun Du, Lei Zhang, Ling Li, Xin Li, Jiaqin Yan, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Zhaoming Li, Jingjing Wu, Hui Yu, Yu Chang, Zhiyuan Zhou, Feifei Nan, Xiaolong Wu, Li Tian, Mingzhi Zhang
    OncoTargets and Therapy.2020; Volume 13: 7189.     CrossRef
  • Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer
    Ping Fan, Jingyuan Zhao, Zibo Meng, Heyu Wu, Bo Wang, Heshui Wu, Xin Jin
    Journal of Experimental & Clinical Cancer Research.2019;[Epub]     CrossRef
  • Histone modifications: A review about the presence of this epigenetic phenomenon in carcinogenesis
    Emanuely Silva Chrun, Filipe Modolo, Filipe Ivan Daniel
    Pathology - Research and Practice.2017; 213(11): 1329.     CrossRef
  • Histone Acetyltransferase 1 Promotes Cell Proliferation and Induces Cisplatin Resistance in Hepatocellular Carcinoma
    Xin Jin, Shenghua Tian, Pingping Li
    Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics.2017; 25(6): 939.     CrossRef
  • HDACs and HDAC Inhibitors in Cancer Development and Therapy
    Yixuan Li, Edward Seto
    Cold Spring Harbor Perspectives in Medicine.2016; 6(10): a026831.     CrossRef
  • Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies
    Diana Markozashvili, Vincent Ribrag, Yegor S. Vassetzky
    Investigational New Drugs.2015; 33(6): 1280.     CrossRef
  • Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
    Hervé Ghesquieres, Susan L. Slager, Fabrice Jardin, Amelie S. Veron, Yan W. Asmann, Matthew J. Maurer, Thierry Fest, Thomas M. Habermann, Marie C. Bene, Anne J. Novak, Sylvain Mareschal, Corinne Haioun, Thierry Lamy, Stephen M. Ansell, Herve Tilly, Thomas
    Journal of Clinical Oncology.2015; 33(33): 3930.     CrossRef
  • Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
    Tobias Wagner, Peter Brand, Thorsten Heinzel, Oliver H. Krämer
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2014; 1846(2): 524.     CrossRef
  • Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis
    Alan Fu, Aaron E Hoffman, Ran Liu, Daniel I Jacobs, Tongzhang Zheng, Yong Zhu
    Epigenetics.2014; 9(5): 730.     CrossRef
  • Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
    Jinwon Seo, Soo Kee Min, Hye-Rim Park, Dong Hoon Kim, Mi Jung Kwon, Lee Su Kim, Young-Su Ju
    Journal of Breast Cancer.2014; 17(4): 323.     CrossRef
  • Diffuse large B-cell lymphoma
    Maurizio Martelli, Andrés J.M. Ferreri, Claudio Agostinelli, Alice Di Rocco, Michael Pfreundschuh, Stefano A. Pileri
    Critical Reviews in Oncology/Hematology.2013; 87(2): 146.     CrossRef
  • Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B‐cell lymphoma
    Kelly A. Cycon, Kathleen Mulvaney, Lisa M. Rimsza, Daniel Persky, Shawn P. Murphy
    Immunology.2013; 140(2): 259.     CrossRef
The Histone Acetyltransferase hMOF is Overexpressed in Non-small Cell Lung Carcinoma.
Joon Seon Song, Sung Min Chun, Ji Young Lee, Dong Kwan Kim, Yong Hee Kim, Se Jin Jang
Korean J Pathol. 2011;45(4):386-396.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.386
  • 4,478 View
  • 54 Download
  • 13 Crossref
AbstractAbstract PDF
BACKGROUND
One of the histone acetyltransferases (HATs) family of proteins, human MOF (hMOF, MYST1), is involved in histone H4 acetylation, particularly at lysine 16 (H4K16Ac), an epigenetic mark of active genes. Dysregulation of the epigenetic mark influences cellular biology and possibly leads to oncogenesis. We examined the involvement of hMOF and H4K16Ac in primary non-small cell lung cancer (NSCLC).
METHODS
Reverse transcription polymerase chain reaction using fresh-frozen lung cancer tissues and lung cancer cell lines and immunohistochemistry for hMOF and H4K16Ac via tissue microarray of 551 formalin-fixed paraffin-embedded NSCLC tissue blocks were conducted.
RESULTS
hMOF mRNA was frequently overexpressed in lung cancer tissues, compared with normal lung tissues (10/20, 50%). NSCLC tissues were positive for hMOF in 37.6% (184/489) and H4K16Ac in 24.7% (122/493) of cases. hMOF protein expression was tightly correlated with the H4K16Ac level in tumors (p<0.001). Knockdown of hMOF mRNA with siRNA led to a significant inhibition of growth in the Calu-6 cell line.
CONCLUSIONS
hMOF was frequently expressed in NSCLC and was correlated with H4K16Ac. To our knowledge, this is the first study that has focused on the expression status of HATs and hMOF in NSCLC. Our results clearly suggest a potential oncogenic role of the gene and support its utility as a potential therapeutic target.

Citations

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  • Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling
    Peichao Li, Lingxiao Yang, Sun Young Park, Fanrong Liu, Alex H. Li, Yilin Zhu, Huacong Sui, Fengyuan Gao, Lingbing Li, Lan Ye, Yongxin Zou, Zhongxian Tian, Yunpeng Zhao, Max Costa, Hong Sun, Xiaogang Zhao
    Oncogene.2024; 43(12): 899.     CrossRef
  • The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics
    Chenise O’Garro, Loveth Igbineweka, Zonaira Ali, Mihaly Mezei, Shiraz Mujtaba
    Biomolecules.2021; 11(3): 455.     CrossRef
  • Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development
    Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita
    Molecular and Cellular Biology.2020;[Epub]     CrossRef
  • The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis
    Jiaming Su, Fei Wang, Yong Cai, Jingji Jin
    International Journal of Molecular Sciences.2016; 17(1): 99.     CrossRef
  • Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma
    LIN ZHU, JIAXING YANG, LINHONG ZHAO, XUE YU, LINGYAO WANG, FEI WANG, YONG CAI, JINGJI JIN
    International Journal of Oncology.2015; 46(6): 2535.     CrossRef
  • Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells
    Da Liu, Donglu Wu, Linhong Zhao, Yang Yang, Jian Ding, Liguo Dong, Lianghai Hu, Fei Wang, Xiaoming Zhao, Yong Cai, Jingji Jin, Tim Thomas
    PLOS ONE.2015; 10(10): e0141014.     CrossRef
  • The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth
    Jin Zhang, Hui Liu, Hao Pan, Yuan Yang, Gang Huang, Yun Yang, Wei-Ping Zhou, Ze-Ya Pan
    Biochemical and Biophysical Research Communications.2014; 452(3): 575.     CrossRef
  • Regulation and function of histone acetyltransferase MOF
    Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li
    Frontiers of Medicine.2014; 8(1): 79.     CrossRef
  • The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti‐drug responses in human non‐small cell lung cancer
    Zhiwei Chen, Xiangyun Ye, Naiwang Tang, Shengping Shen, Ziming Li, Xiaomin Niu, Shun Lu, Ling Xu
    British Journal of Pharmacology.2014; 171(13): 3196.     CrossRef
  • Correlation of low expression of hMOF with clinicopathological features of colorectal carcinoma, gastric cancer and renal cell carcinoma
    LINGLING CAO, LIN ZHU, JIAXING YANG, JIAMING SU, JINSONG NI, YUJUN DU, DA LIU, YANFANG WANG, FEI WANG, JINGJI JIN, YONG CAI
    International Journal of Oncology.2014; 44(4): 1207.     CrossRef
  • Coactivator MYST1 Regulates Nuclear Factor-κB and Androgen Receptor Functions During Proliferation of Prostate Cancer Cells
    Anbalagan Jaganathan, Pratima Chaurasia, Guang-Qian Xiao, Marc Philizaire, Xiang Lv, Shen Yao, Kerry L. Burnstein, De-Pei Liu, Alice C. Levine, Shiraz Mujtaba
    Molecular Endocrinology.2014; 28(6): 872.     CrossRef
  • A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first
    NING LIU, RUI ZHANG, XIAOMING ZHAO, JIAMING SU, XIAOLEI BIAN, JINSONG NI, YING YUE, YONG CAI, JINGJI JIN
    Oncology Letters.2013; 6(2): 393.     CrossRef
  • Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma
    Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang, Jingji Jin
    Journal of Experimental & Clinical Cancer Research.2013;[Epub]     CrossRef

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