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- Pulmonary Calciphylaxis Associated with Acute Respiratory and Renal Failure Due to Cryptogenic Hypercalcemia: An Autopsy Case Report
- Na Rae Kim, Jin Won Seo, Young Hwan Lim, Hyoung Suk Ham, Wooseong Huh, Joungho Han
- Korean J Pathol. 2012;46(6):601-605. Published online December 26, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.601
- 7,497 View
- 45 Download
- 5 Crossref
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Abstract
PDF Metastatic calcification is rare; it is found during autopsy in patients who underwent hemodialysis. Diffuse calcium precipitation of small and medium-sized cutaneous vessels, known as calciphylaxis, can result in progressive tissue necrosis secondary to vascular calcification. This condition most commonly involves the skin; however, a rare occurrence of visceral calciphylaxis has been reported. Here we report on an autopsy case. Despite a thorough evaluation, and even performing an autopsy, the underlying cause of acute-onset hypercalcemia, resulting in the production of pulmonary calciphylaxis and metastatic renal calcification associated with acute respiratory and renal failure, could not be determined. Metastatic calcification often lacks specific symptoms, and the degree of calcification is a marker of the severity and chronicity of the disease. This unusual autopsy case emphasizes the importance of rapidly progressing visceral calciphylaxis, as well as its early detection.
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Citations
Citations to this article as recorded by
- Acute Respiratory Distress Syndrome Induced by Parathyroid Storm
Georgios Zagkotsis, Maria Markou, Panagiota Papanikolaou, Nikolaos Sabanis
Cureus.2021;[Epub] CrossRef - Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19
D. Pamart, M. Otekpo, M. Asfar, G. Duval, J. Gautier, Cédric Annweiler
The Journal of nutrition, health and aging.2021; 25(10): 1140. CrossRef - A rare case report of multiple myeloma presenting with paralytic ileus and type II respiratory failure due to hypercalcemic crisis
Yuchen Guo, Liang He, Yiming Liu, Xueyuan Cao
Medicine.2017; 96(52): e9215. CrossRef - Development of multiorganic calciphylaxis during teriparatide, vitamin D, and calcium treatment
A. Monegal, P. Peris, M. Alsina, J. Colmenero, N. Guañabens
Osteoporosis International.2016; 27(8): 2631. CrossRef - Calciphylaxis: from the disease to the diseased
Tiago M. Oliveira, João M. Frazão
Journal of Nephrology.2015; 28(5): 531. CrossRef
- Acute Respiratory Distress Syndrome Induced by Parathyroid Storm
- Functioning Parathyroid Carcinoma: A case report.
- Kyoung Chan Choi, Won Hee Choi
- Korean J Pathol. 1996;30(2):169-172.
- 1,383 View
- 12 Download
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Abstract
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- Parathyroid carcinoma is a relatively rare endocrine tumor, accounting for approximately 1 to 5% of patients with primary hyperparathyroidism. Patients with parathyroid carcinomas are often symptomatic, have markedly elevated calcium levels, and have a palpable cervical mass. They are equally distributed between the sexes and usually present 10 years before their benign counterparts. The diagnosis is suspected when the tumor is large, parathyroid hormone levels are high, and a palpable mass is present in the neck. Parathyroid carcinoma is often misdiagnosed preoperatively, suspected intraoperatively, and only confirmed postoperatively. We experienced a case of hyperfunctioning parathyroid carcinoma in a 36 year old man, which was confirmed microscopically. The tumor showed: 1) capsular and blood vessel invasion; 2) frequent mitotic figures in the parenchymal cells; 3) a trabecular pattern, and 4) intervening thick fibrous bands. Immunohistochemical stain of p53 may be one of the useful methods in identifying malignancy of parathyroid gland.
- Small Cell Carcinoma of the Ovary, Hypercalcemic Type, Large Cell Variant.
- Jong Sil Lee, Jong Hak Lee, Yu Kyung Kim, Sun Hoo Park, Gyung Hyuck Ko
- Korean J Pathol. 2001;35(5):440-443.
- 1,904 View
- 37 Download
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Abstract
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- We report the clinical and pathological features, including the immunohistochemical and electron microscopic findings, of a case of hypercalcemic type, large cell variant, ovarian small cell carcinoma. A 44-year-old woman complained of abdominal pain and dysmenorrhea. A mass on the left ovary was detected by computer tomographic scan. A total hysterectomy with bilateral salpingo-oophorectomy was done. Histologically, the tumor was predominantly composed of large cells with abundant eosinophilic cytoplasm and prominent nucleoli. Mucin-containing cells and myxoid stroma were also present. Typical follicle-like spaces with lined by small, closely packed epithelial cells with scanty cytoplasm were occasionally seen. No dense core granules were identified on electron microscopic examination.
- Small Cell Carcinoma of the Ovary: A case report.
- Young Bae Kim, Sook Hee Hong, Kyu Rae Kim
- Korean J Pathol. 1992;26(4):399-404.
- 1,515 View
- 12 Download
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Abstract
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- Small cell carcinoma of the ovary is rare malignancy occurring in women under 40 years of age(average, 23 years), which is associated with hypercalcemia in two thirds of cases. Its histogenesis is uncertain, but the possibilities of common epithelial, neuroendocrine, sex cord stromal and germ cell origin are suggested. All reported cases were proved to have rapid fatal course despite various therapy and 5 years suvival rate was only 10%. We report one case of a 20-year old woman with primary small cell carcinoma of the left ovary. The ovary was markedly enlarged and completely replaced by a mass, measuring 21x16x8 cm. Microscopic examination revealed dimorphic population of small and large malignant cell producing immature follicle-like structure which is characteristic of small cell carcinoma of the ovary. These pathological findings were similar to those of granulosa cell tumor, which is required to make differential diagnosis from small cell carcinoma. Immunohistochemical stains for cytokeratin and vimentin were positive, but those for S-100 protein and NSE were negative. One month after the initial operation, the tumor has recurred and the second and the second palliative operation followed by 3 cycles of chemotherapy was done. The patient showed disseminated metastasis at present time.
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