Journal of Pathology and Translational Medicine

Review

Standardization of the pathologic diagnosis of appendiceal mucinous neoplasms: Dong-Wook Kang, Baek-hui Kim, Joon Mee Kim, Jihun Kim, Hee Jin Chang, Mee Soo Chang, Jin-Hee Sohn, Mee-Yon Cho, So-Young Jin, Hee Kyung Chang, Hye Seung Han, Jung Yeon Kim, Hee Sung Kim, Do Youn Park, Ha Young Park, So Jeong Lee, Wonae Lee, Hye Seung Lee, Yoo Na Kang, Younghee Choi; J Pathol Transl Med. 2021;55(4):247-264. Published online July 8, 2021; DOI: https://doi.org/10.4132/jptm.2021.05.28

9,373 View
724 Download
9 Web of Science
7 Crossref

Although the understanding of appendiceal mucinous neoplasms (AMNs) and their relationship with disseminated peritoneal mucinous disease have advanced, the diagnosis, classification, and treatment of AMNs are still confusing for pathologists and clinicians. The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists (GPSG-KSP) proposed a multicenter study and held a workshop for the “Standardization of the Pathologic Diagnosis of the Appendiceal Mucinous Neoplasm” to overcome the controversy and potential conflicts. The present article is focused on the diagnostic criteria, terminologies, tumor grading, pathologic staging, biologic behavior, treatment, and prognosis of AMNs and disseminated peritoneal mucinous disease. In addition, GPSG-KSP proposes a checklist of standard data elements of appendiceal epithelial neoplasms to standardize pathologic diagnosis. We hope the present article will provide pathologists with updated knowledge on how to handle and diagnose AMNs and disseminated peritoneal mucinous disease.

Citations

Citations to this article as recorded by

Lower Gastrointestinal Bleeding Secondary to Appendiceal Mucinous Neoplasm: A Report of Two Cases and a Review of the Literature
Jesús Omar Soto Llanes, Samanta Kin Dosal Limón, Ana Jimena Iberri Jaime, Mario Zambrano Lara, Billy Jiménez Bobadilla
Cureus.2024;[Epub] CrossRef
Appendiceal perforation secondary to endometriosis with intestinal metaplasia: A case report
Minghua Wang, Jing Liu, Boxin Hu, Simin Wang, Ping Xie, Ping Li
Experimental and Therapeutic Medicine.2023;[Epub] CrossRef
Primary and secondary tumors of the peritoneum: key imaging features and differential diagnosis with surgical and pathological correlation
Javier Miguez González, Francesc Calaf Forn, Laura Pelegrí Martínez, Pilar Lozano Arranz, Rafael Oliveira Caiafa, Jordi Català Forteza, Lina Maria Palacio Arteaga, Ferrán Losa Gaspà, Isabel Ramos Bernadó, Pedro Barrios Sánchez, Juan Ramón Ayuso Colella
Insights into Imaging.2023;[Epub] CrossRef
Muzinöse Tumoren des Peritoneums
Anne Kristin Fischer, Andrea Tannapfel, Alexander Quaas
Die Chirurgie.2023; 94(10): 823. CrossRef
Landscape of Genetic Mutations in Appendiceal Cancers
Marian Constantin, Cristina Mătanie, Livia Petrescu, Alexandra Bolocan, Octavian Andronic, Coralia Bleotu, Mihaela Magdalena Mitache, Sorin Tudorache, Corneliu Ovidiu Vrancianu
Cancers.2023; 15(14): 3591. CrossRef
Delivery of an Incidental Appendiceal Mucinous Neoplasm
Madison Bowles, Jessica Y Ng, Hajir Nabi
Cureus.2022;[Epub] CrossRef
Unearthing novel fusions as therapeutic targets in solid tumors using targeted RNA sequencing
Sungbin An, Hyun Hee Koh, Eun Sol Chang, Juyoung Choi, Ji-Young Song, Mi-Sook Lee, Yoon-La Choi
Frontiers in Oncology.2022;[Epub] CrossRef

Original Article

Differential Immunohistochemical Profiles for Distinguishing Prostate Carcinoma and Urothelial Carcinoma: Woo Jin Oh, Arthur Minwoo Chung, Jee Soon Kim, Ji Heun Han, Sung Hoo Hong, Ji Yeol Lee, Yeong Jin Choi; J Pathol Transl Med. 2016;50(5):345-354. Published online August 7, 2016; DOI: https://doi.org/10.4132/jptm.2016.06.14

10,974 View
316 Download
25 Web of Science
28 Crossref

Abstract PDF

Background
The pathologic distinction between high-grade prostate adenocarcinoma (PAC) involving the urinary bladder and high-grade urothelial carcinoma (UC) infiltrating the prostate can be difficult. However, making this distinction is clinically important because of the different treatment modalities for these two entities.
Methods
A total of 249 patient cases (PAC, 111 cases; UC, 138 cases) collected between June 1995 and July 2009 at Seoul St. Mary’s Hospital were studied. An immunohistochemical evaluation of prostatic markers (prostate-specific antigen [PSA], prostate-specific membrane antigen [PSMA], prostate acid phosphatase [PAP], P501s, NKX3.1, and α-methylacyl coenzyme A racemase [AMACR]) and urothelial markers (CK34βE12, p63, thrombomodulin, S100P, and GATA binding protein 3 [GATA3]) was performed using tissue microarrays from each tumor.
Results
The sensitivities of prostatic markers in PAC were 100% for PSA, 83.8% for PSMA, 91.9% for PAP, 93.7% for P501s, 88.3% for NKX 3.1, and 66.7% for AMACR. However, the urothelial markers CK34βE12, p63, thrombomodulin, S100P, and GATA3 were also positive in 1.8%, 0%, 0%, 3.6%, and 0% of PAC, respectively. The sensitivities of urothelial markers in UC were 75.4% for CK34βE12, 73.9% for p63, 45.7% for thrombomodulin, 22.5% for S100P, and 84.8% for GATA3. Conversely, the prostatic markers PSA, PSMA, PAP, P501s, NKX3.1, and AMACR were also positive in 9.4%, 0.7%, 18.8%, 0.7%, 0%, and 8.7% of UCs, respectively.
Conclusions
Prostatic and urothelial markers, including PSA, NKX3.1, p63, thrombomodulin, and GATA3 are very useful for differentiating PAC from UC. The optimal combination of prostatic and urothelial markers could improve the ability to differentiate PAC from UC pathologically.

Citations

Citations to this article as recorded by

Unusual Perineal Metastasis in a Case of Prostate Cancer on 68Ga-PSMA-11 PET/CT
Ritanshu Solanki, Bhagwant Rai Mittal, Rajender Kumar, Aravindh Sekar, Narender Kumar
Clinical Nuclear Medicine.2024; 49(2): e73. CrossRef
NKX3.1 Expression in Non-Prostatic Tumors and Characterizing its Expression in Esophageal/Gastroesophageal Adenocarcinoma
Ansa Mehreen, Kiran G. Manjee, Divyangi Paralkar, Gladell P. Paner, Thanh Lan
Advances in Anatomic Pathology.2024; 31(3): 202. CrossRef
Clinical Management of Intraductal Carcinoma of the Prostate
Gabriel Wasinger, Olivier Cussenot, Eva Compérat
Cancers.2024; 16(9): 1650. CrossRef
Metastatic prostate cancer presenting as a posterior mediastinal mass: A rare presentation
Muhammad Haider, Arun Umesh Mahtani, Bachar Botrus, Foma Munoh Kenne, Madiha Fatima Master
Clinical Case Reports.2023;[Epub] CrossRef
Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma
Daeseon Yoo, Kyueng-Whan Min, Jung-Soo Pyo, Nae Yu Kim
Medicina.2023; 59(8): 1452. CrossRef
Primary high-grade urothelial carcinoma of prostate with prostatic hyperplasia: a rare case report and review of the literature
Liang Liu, Fu-zhen Sun, Pan-ying Zhang, Yu Xiao, Xiao Yue, Dong-Ming Wang, Qiang Wang
The Aging Male.2023;[Epub] CrossRef
Expression of Gata Binding Protein 3 as a Prognostic Factor in Urogenital Lesions and Its Association With Morphology
T Govardhan, Debahuti Mohapatra, Sujata Naik, Prateek Das, Pranita Mohanty, Ankita Pal
Cureus.2023;[Epub] CrossRef
Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component
Simone de Brot, Jennifer Lothion‐Roy, Llorenç Grau‐Roma, Emily White, Franco Guscetti, Mark A. Rubin, Nigel P. Mongan
Veterinary and Comparative Oncology.2022; 20(1): 38. CrossRef
Urothelial Carcinoma and Prostate-specific Membrane Antigen: Cellular, Imaging, and Prognostic Implications
Arsalan Tariq, Amy E. McCart Reed, Andrew Morton, Sima Porten, Ian Vela, Elizabeth D. Williams, John W. Yaxley, Peter C. Black, Matthew J. Roberts
European Urology Focus.2022; 8(5): 1256. CrossRef
Immunohistochemical Reactivity of Prostate-Specific Membrane Antigen in Salivary Gland Tumors
Haruto Nishida, Yoshihiko Kondo, Takahiro Kusaba, Hiroko Kadowaki, Tsutomu Daa
Head and Neck Pathology.2022; 16(2): 427. CrossRef
Weak NKX3.1 expression in a urothelial carcinoma: A diagnostic pitfall
Maryam Abdo, Robert Hoyt, Ashley Highfill, Daniel Mettman
Human Pathology Reports.2022; 27: 300599. CrossRef
Gene of the month: NKX3.1
Jon Griffin, Yuqing Chen, James W F Catto, Sherif El-Khamisy
Journal of Clinical Pathology.2022; 75(6): 361. CrossRef
Diagnostic Value of GATA3 and Uroplakin 3 in Differentiating Urothelial Carcinoma from Prostatic and Colorectal Carcinoma
Maha Salama, Dina A. Khairy
Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 514. CrossRef
Diagnostic challenges for the distinction of high-grade prostatic adenocarcinoma and high-grade urothelial carcinoma of simultaneous occurrences - A literature review
Shreyas Bhushan Jayade, Manana Jikurashvili
GEORGIAN SCIENTISTS.2022;[Epub] CrossRef
Cytomorphology, immunoprofile, and clinicopathologic correlation of metastatic prostatic carcinoma
Xiaoqi Lin, Qiuying Shi, Ximing J. Yang
Human Pathology.2022; 130: 36. CrossRef
Cutaneous Metastasis of Prostate Adenocarcinoma: A Rare Presentation of a Common Disease
Alexander Dills, Okechukwu Obi, Kevin Bustos, Jesse Jiang, Shweta Gupta
Journal of Investigative Medicine High Impact Case Reports.2021; 9: 232470962199076. CrossRef
Mining The Cancer Genome Atlas gene expression data for lineage markers in distinguishing bladder urothelial carcinoma and prostate adenocarcinoma
Ewe Seng Ch’ng
Scientific Reports.2021;[Epub] CrossRef
Immunohistochemical analysis of thrombomodulin expression in myocardial tissue from autopsy cases of ischemic heart disease
Takeshi Kondo, Motonori Takahashi, Gentaro Yamasaki, Marie Sugimoto, Azumi Kuse, Mai Morichika, Kanako Nakagawa, Makoto Sakurada, Migiwa Asano, Yasuhiro Ueno
Legal Medicine.2021; 51: 101897. CrossRef
Application and Pitfalls of Immunohistochemistry in Diagnosis of Challenging Genitourinary Cases
Jenny Ross, Guangyuan Li, Ximing J. Yang
Archives of Pathology & Laboratory Medicine.2020; 144(3): 290. CrossRef
New Screening Test Improves Detection of Prostate Cancer Using Circulating Tumor Cells and Prostate-Specific Markers
Karin Ried, Tasnuva Tamanna, Sonja Matthews, Peter Eng, Avni Sali
Frontiers in Oncology.2020;[Epub] CrossRef
An Unlikely Culprit: Gastric Metastasis from Primary Prostatic Adenocarcinoma
Eric Omar Then, Spoorthi Nutakki, Andrew Ofosu, Saad Saleem, Vijay Gayam, Tagore Sunkara, Vinaya Gaduputi
Journal of Gastrointestinal Cancer.2020; 51(3): 1081. CrossRef
MRI of prostatic urethral mucinous urothelial carcinoma: Expanding the differential diagnosis for T2 hyperintense prostatic masses
Neel Patel, Bryan R. Foster, Elena K. Korngold, Kyle Jensen, Kevin R. Turner, Fergus V. Coakley
Clinical Imaging.2020; 68: 68. CrossRef
Morphological and Immunohistochemical Biomarkers in Distinguishing Prostate Carcinoma and Urothelial Carcinoma: A Comprehensive Review
Francesca Sanguedolce, Davide Russo, Vito Mancini, Oscar Selvaggio, Beppe Calò, Giuseppe Carrieri, Luigi Cormio
International Journal of Surgical Pathology.2019; 27(2): 120. CrossRef
A Case of Metastatic Prostate Cancer to the Urethra That Resolved After Androgen Deprivation Therapy
Darren J. Bryk, Kenneth W. Angermeier, Eric A. Klein
Urology.2019; 129: e4. CrossRef
The Homeodomain Transcription Factor NKX3.1 Modulates Bladder Outlet Obstruction Induced Fibrosis in Mice
Mehul S. Patel, Diana K. Bowen, Nicholas M. Tassone, Andrew D. Gould, Kirsten S. Kochan, Paula R. Firmiss, Natalie A. Kukulka, Megan Y. Devine, Belinda Li, Edward M. Gong, Robert W. Dettman
Frontiers in Pediatrics.2019;[Epub] CrossRef
Cancer of unknown primary: Ancillary testing of cytologic and small biopsy specimens in the era of targeted therapy
Morgan L. Cowan, Christopher J. VandenBussche
Cancer Cytopathology.2018; 126(S8): 724. CrossRef
Glandular Tumors of the Urachus and Urinary Bladder: A Practical Overview of a Broad Differential Diagnosis
Alexander S. Taylor, Rohit Mehra, Aaron M. Udager
Archives of Pathology & Laboratory Medicine.2018; 142(10): 1164. CrossRef
S100P as a Marker for Urothelial Histogenesis: A Critical Review and Comparison With Novel and Traditional Urothelial Immunohistochemical Markers
Moushumi Suryavanshi, Julian Sanz-Ortega, Deepika Sirohi, Mukul K. Divatia, Chisato Ohe, Claudia Zampini, Daniel Luthringer, Steven C. Smith, Mahul B. Amin
Advances in Anatomic Pathology.2017; 24(3): 151. CrossRef

Editorial

Molecular Biologic Techniques in Cytopathologic Diagnosis.: Tae Sook Hwang; Korean J Pathol. 2009;43(5):387-392.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.387

4,019 View
43 Download
9 Crossref

Abstract PDF

Molecular diagnosis is an application of the knowledge on molecular mechanisms of disease to diagnosis, therapeutic decision-making, and prognostication. Basically any molecular diagnostic technique could be used in molecular diagnostic cytopathology. Currently applicable molecular techniques in the cytopathology field include PCR based molecular techniques (SSCP, DHPLC, RFLP, LOH, MSI, RT-PCR, QRT-PCR, allele-specific PCR, sequencing, and methylation analysis), FISH, cDNA microarray, aCGH, and reverse-phase protein microarray, etc. Exfoliative cytology as well as fine needle aspiration cytology specimen can be used for analysis. In order to obtain a successful result, collection of target cells without contamination of the blood cells, inflammatory cells including histiocytes, and stromal cells, and a good DNA yield are most important. Molecular diagosis finds its full meaning when interpreted by those who can combine the clinical background of the disease with morphological, immunocytochemical, and molecular diagnostic results. Therefore, these assays would fulfill their full potential when interpreted by the cytopathologists.

Citations

Citations to this article as recorded by

Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study
Hee-Young Yoon, Jeong-Seon Ryu, Yun Su Sim, Dojin Kim, Sung Yong Lee, Juwhan Choi, Sojung Park, Yon Ju Ryu, Jin Hwa Lee, Jung Hyun Chang, Jung Weon Lee
PLOS ONE.2020; 15(2): e0228925. CrossRef
Efficiency of EGFR mutation analysis for small microdissected cytological specimens using multitech DNA extraction solution
Seo Young Oh, Hoon Taek Lee
Cancer Cytopathology.2015; 123(7): 401. CrossRef
EGFR Analysis in Cytologic Samples of Lung Adenocarcinoma by Microdissection
Jeong Yeon Han, Hoon Taek Lee, Seo Young Oh
Korean Journal of Clinical Laboratory Science.2015; 47(3): 125. CrossRef
Improved DNA Extraction Method for Molecular Diagnosis from Smaller numbers of Cells
Seo Young Oh, Jeong Yeon Han, So Ra Lee, Hoon Taek Lee
Korean Journal of Clinical Laboratory Science.2014; 46(3): 99. CrossRef
Development of an Ammonium Sulfate DNA Extraction Method for Obtaining Amplifiable DNA in a Small Number of Cells and Its Application to Clinical Specimens
Seo Young Oh, Wook Youn Kim, Tae Sook Hwang, Hye Seung Han, So Dug Lim, Wan Seop Kim
BioMed Research International.2013; 2013: 1. CrossRef
Detection and comparison of peptide nucleic acid-mediated real-time polymerase chain reaction clamping and direct gene sequencing for epidermal growth factor receptor mutations in patients with non-small cell lung cancer
Hee Joung Kim, Kye Young Lee, Young-Chul Kim, Kyu-Sik Kim, Sung Yong Lee, Tae Won Jang, Min Ki Lee, Kyeong-Cheol Shin, Gwan Ho Lee, Jae Chol Lee, Jeong Eun Lee, Sun Young Kim
Lung Cancer.2012; 75(3): 321. CrossRef
Possible use and role of molecular techniques in fine-needle aspiration cytology (FNAC) practice
Fernando Schmitt, Helena Barroca
Diagnostic Histopathology.2011; 17(7): 286. CrossRef
Comparative Analysis of Peptide Nucleic Acid (PNA)-Mediated Real-Time PCR Clamping and DNA Direct Sequencing for EGFR Mutation Detection
Hee Joung Kim, Wan Seop Kim, Kyeong-Cheol Shin, Gwan Ho Lee, Mi-Jin Kim, Jeong Eun Lee, Kyu Sang Song, Sun Young Kim, Kye Young Lee
Tuberculosis and Respiratory Diseases.2011; 70(1): 21. CrossRef
PNA-Mediated PCR Clamping for the Detection of EGFR Mutations in Non-Small Cell Lung Cancer
Kye Young Lee, Hee Joung Kim, Sun Jong Kim, Gwang Ha Yoo, Won Dong Kim, Seo Young Oh, Wan Seop Kim
Tuberculosis and Respiratory Diseases.2010; 69(4): 271. CrossRef

First
Prev
Page of 1
Next
Last

Search