Journal of Pathology and Translational Medicine

Case Study

Micronodular Thymoma with Lymphoid Stroma in a Multilocular Thymic Cyst: A Case Study: Na Rae Kim, Jae Ik Lee, Seung Yeon Ha; Korean J Pathol. 2013;47(4):392-394. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.392

7,075 View
70 Download
12 Crossref

Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called "unusual" variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.

Citations

Citations to this article as recorded by

GTF2Imutation in micronodular thymoma with lymphoid stroma
Andrea Bille, Katherine Fryer, Andrew Wallace, Daisuke Nonaka
Journal of Clinical Pathology.2024; 77(2): 125. CrossRef
Thymic epithelial tumours: histopathological classification and differential diagnosis
Jan von der Thüsen
Histopathology.2024; 84(1): 196. CrossRef
Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases
Diana M. Oramas, Cesar A. Moran
International Journal of Surgical Pathology.2021; 29(4): 352. CrossRef
Two cases of resection of micronodular thymoma with lymphoid stroma
Seiji Omura, Kyohei Masai, Kaoru Kaseda, Keisuke Asakura, Tomoyuki Hishida, Hisao Asamura
The Journal of the Japanese Association for Chest Surgery.2021; 35(6): 705. CrossRef
Two surgical cases of micronodular thymoma with lymphoid stroma
Yusuke Kita, Yoshimasa Tokunaga, Taku Okamoto
The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 166. CrossRef
Thoracoscopic Thymectomy for Large Thymic Cyst: Myasthenia Gravis With Thymoma Concealed by Thymic Cyst
Motoki Yano, Hiroki Numanami, Takashi Akiyama, Rumiko Taguchi, Chihiro Furuta, Akari Iwakoshi, Masayuki Haniuda
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(3): e34. CrossRef
A resected case of micronodular thymoma with lympoid stroma
Hiromitsu Domen, Yasuhiro Hida, Yasunari Takakuwa, Yuki Iijima, Kazuomi Ichinokawa, Hidehisa Yamada
The Journal of the Japanese Association for Chest Surgery.2019; 33(5): 504. CrossRef
Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases
Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
Diagnostic Pathology.2018;[Epub] CrossRef
Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review
Linlin Qu, Yan Xiong, Qian Yao, Bo Zhang, Ting Li
Thoracic Cancer.2017; 8(6): 734. CrossRef
Cystic Micronodular Thymoma. Report of a Case
Mlika M
Journal of Clinical, Medical and Experimental Images.2017; 1(1): 001. CrossRef
A Rare Case of Mixed Type A Thymoma and Micronodular Thymoma with Lymphoid Stroma
Yoon Jin Cha, Joungho Han, Jimin Kim, Kyung Soo Lee, Young Mog Shim
Journal of Pathology and Translational Medicine.2015; 49(1): 75. CrossRef
Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation
Wadad S Mneimneh, Yesim Gökmen-Polar, Kenneth A Kesler, Patrick J Loehrer Sr, Sunil Badve
Modern Pathology.2015; 28(11): 1415. CrossRef

Short Case Report

Squamous Cell Carcinoma Arising in a Thymic Cyst : A Brief Case Report.: Chang Ohk Sung, Joungho Han, Ji Yeon Kim, Young Mog Shim, Tae Sung Kim; Korean J Pathol. 2009;43(3):260-262.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.260

3,192 View
18 Download
1 Crossref

Abstract PDF

We present here the case of a 73-year-old man with squamous cell carcinoma that arose in a thymic cyst, and this was incidentally found by chest radiography. Computed tomography revealed a 3.6 cm-sized predominantly cystic lesion with a mural nodule at the antero-superior mediastinum. The resected specimen was a well demarcated cystic mass with a solid mural nodule. Microscopically, the nodule was determined to be invasive squamous cell carcinoma that had originated from the benign squamous epithelium lining the thymic cyst.

Citations

Citations to this article as recorded by

Multilocular Thymic Cyst with Prominent Lymphoid Follicular Hyperplasia: A Case Report
Na-Ra Yoon, Ji Yun Jeong, Joungho Han, Jhingook Kim, Chin A Yi
Journal of Lung Cancer.2012; 11(1): 45. CrossRef

Case Report

Thymic Cysts: Two cases report.: Seong Nam Kim, Mi Kyung Kim, Yong Wook Park, Jae Hyung Yoo, Kye Yong Song; Korean J Pathol. 1991;25(6):576-580.

1,733 View
28 Download

Abstract PDF: Thymic cyst is relatively rare tumor which usually occurs in the neck or mediastinum. Cervical thymic cyst is usually situated laterally and deep to the anterior border of the sternocleidomastoid muscle, simulating a branchial cyst. Thymic cyst of the mediastinum is usually detected incidentally and differential diagnoses include cystic degeneration of thymoma, and cystic teratoma. Two case of a cervical and a mediastinal thymic cysts were reported. The one was a cervical thymic cyst developed slowly growing mass in a 53-year-old male a for 10 years. The cyst was unilocular and measures 5.4x2.9x2.8 cm with columnar or squamous cell linings. The other is a mediastinal thymic cyst developed in a 37-year-old female with chest discomfort for 7 months. The cyst was uniocular and measures 2.8x2.2x2.0 cm. The epithelial lining of the cyst was largely desquamated and covered by macrophages with cholesterol granuloma. Involutional thymic stissue in their walls were noted in both cysts. In both cases presence of thymic tissue in the wall of the cyst thought to be the most important diagnostic feature.

First
Prev
Page of 1
Next
Last

Search