Journal of Pathology and Translational Medicine

Case Study

Erdheim-Chester Disease Involving Lymph Nodes and Liver Clinically Mimicking Lymphoma: A Case Report: Yeoun Eun Sung, Yoon Seo Lee, Jieun Lee, Kyo Young Lee; J Pathol Transl Med. 2018;52(3):183-190. Published online December 27, 2017; DOI: https://doi.org/10.4132/jptm.2017.10.16

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Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis and multisystem disease. First described in 1930, there are no more than 750 cases reported. The etiology remains unknown, but a majority of cases of ECD and Langerhans cell histiocytosis were found to have clonal mutations involving genes of the mitogen-activated protein kinase pathway. We recently encountered a 53-year-old male patient with extensive ECD involving the systemic lymph nodes, pleura, liver, and long bones clinically mimicking malignant lymphoma. Biopsies were performed at multiple sites, including a pleural mass, an external iliac lymph node, bone marrow, and the liver. Based on histopathological and immunohistochemical findings of positivity for CD68 and negativity for CD1a and S-100, the patient was diagnosed with ECD. Interferon-α was administered as the first-line treatment, but the patient rapidly progressed to hepatic failure after 2 months of treatment. We report this rare case of ECD clinically mimicking malignant lymphoma and diagnosed by careful pathological review.

Citations

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Erdheim Chester Disease Mimicking Lymphoma: A Case Report
Philipp Moritz Wunschel, Wolfgang Voss, Marc Keberle
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.2022; 194(03): 310. CrossRef
Erdheim–Chester Disease with Isolated CNS Involvement: A Systematic Review of the Literature
Anam Haque, Carlos A. Pérez, Thejasvi A. Reddy, Rajesh K. Gupta
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Clinical Case Reports.2021;[Epub] CrossRef
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Interferon-α

Reactions Weekly.2018; 1709(1): 128. CrossRef

Case Report

Chondroblastoma of the Lumbar Spine: A Case Report and Review of the Literature.: Sun A Kim, Kyung Ja Cho, Yong Koo Park, Jong Seok Lee, Heon Ju Kwon, Hyewon Chung, Mi Jung Kim; Korean J Pathol. 2011;45(5):532-536.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.532

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Abstract PDF

We report a case of chondroblastoma arising in the lumbar spine in a 25-year-old man who presented with low back pain of 5 years duration. Plain radiography and computed tomography revealed a well-defined osteolytic mass surrounded by marginal sclerosis in the third lumbar vertebra. The mass encroached on the left neural foramen on magnetic resonance imaging. Histologically, the tumor consisted of round to oval cells with eosinophilic cytoplasm and randomly scattered osteoclastic type giant cells. There were characteristic chicken-wire calcification and aneurysmal bone cyst-like changes. Chondroblastomas of the lumbar spine are extremely rare, and only nine cases have been reported. Spinal chondroblastoma should be distinguished from other benign bone tumors, because it tends to show aggressive biological behavior with high recurrence and mortality rates.

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Chondroblastoma of Thoracic Vertebrae: a Case Report and Review of the Literature
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World Journal of Surgical Oncology.2023;[Epub] CrossRef
Commentary on Letter to the Editor concerning “Management of cranial chondroblastoma in adults; a pooled analysis” by Amr Muhammed et al.
Amr Muhammed
American Journal of Otolaryngology.2021; 42(1): 102749. CrossRef
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Journal of Neuro-Oncology.2018; 140(1): 99. CrossRef
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Skeletal Radiology.2017; 46(3): 367. CrossRef

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