At present, the demand of clinical biochemisty has increased because the highly developed clinical medicine requires a very strong scientific basis to establish correct diagnosis, treatment and evaluation of the progress of patient. Clinical Chemistry lab seems to be the most important nucleus of laboratory functions in accordance with the tremendous increases in both bulk and kinds of the test requested. However it is still difficult to perform satisfactory biochemical tests with accuracy and precision due to the errors during daily procedures. With the world wide quality control system applies to clinical biochemistry, it is still not so satisfactory in Korea. There might be a number of factors bringing errors in biochemical determination including sample process, glassware and instrument, reagent, standard solution, and personal technic etc. We made, a rough survey, to detect the causes of errors, mainly with pipet, photometer, densitometer and personal technic and the followings are the findings with tables and figures accompanying.