Abstract

Clinical and laboratory observation were made in a case of paroxysmal nocturnal hemoglobinuria(PNH). The patient was 20-years old male college student, who was admitted with chief complaint of general weakness with dyspnea on exertion and dark brown urine. The peripheral blood revealed severe anemia with reticulocytosis, moderate increased bilirubin, positive Ham’s test and positive on sucrose hemolysis test. Marked homoglobinuria and hemosiderinuria on urinalysis and the bone marrow aspiration showed normocellular with markedly erythroid hyperplasia. The findings of chest X-ray and ECG were in normal limits. He was treated with packed cell transfusion and dischared with clinical improvement of hemoglobinuria.