An investigation to evaluate the CRP test was performed as well as ESR with 77 cases of patient sera and 17 cases of normal controlsera. In CRP test, the capillary precipitation and slide agglutination methods were used. The positivity rate of capillary method and slide agglutination method were 50.6% and 39.0% respectively and the former appears to be more sensitive than the later. In 17 normal control sera, the capillary method revealed one case(5.9%) as positive while all cases were negative by slide agglutination method. Using another two-fold dilutions of 2+ reactive sera, the slide agglutination method showed reactivity up-to 1 : 128 and the capillary method up-to 1 : 4. In tuberculosis and malignancy, the results from the slide agglutination, capillary precipitation and ESR methods paralleled each other but not in other various diseases.