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doi: https://doi.org/10.4132/jptm.2017.01.23    [Epub ahead of print]
An Autopsy Case of Epstein-Barr Virus‒Associated Diffuse Large B-Cell Lymphoma of the Central Nervous System in an Immunocompromised Host
Sun-Young Park, Seong Ik Kim, Hannah Kim, Yoojin Lee, Sung-Hye Park
Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Corresponding Author: Sung-Hye Park ,Tel: +82-2-740-8278, Fax: +82-2-765-5600, Email: shparknp@snu.ac.kr
Received: September 15, 2016;  Revised: January 19, 2017  Accepted: January 23, 2017.  Published online: August 4, 2017.
ABSTRACT
Lymphomas arising in the central nervous system (CNS) of immunocompromised hosts represent non-Hodgkin's lymphomas exclusively associated with Epstein-Barr virus (EBV). Here we report an autopsy case of EBV-associated CNS diffuse large B-cell lymphoma (DLBCL) in a host suffering from systemic lupus erythematosus who underwent immunosuppressive therapy. After autopsy, EBV-associated CNS DLBCL as well as pulmonary mixed aspergillosis and Pneumocystis jirovecii pneumonia were added to the clinical impressions of complicated pneumonia and cerebral hemorrhage in this immunocompromised patient. In conclusion, complex disease processes were revealed by autopsy in this case, indicating that the clinicopathological correlations observed through autopsy can improve our understanding of disease progression and contribute to the management of similar patients in the future.
Key Words: Autopsy; Central nervous system; Lymphoma; Epstein-Barr virus; Immunocompromised host
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