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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2017.07.25    [Epub ahead of print]
White Matter Injury of Prematurity: Its Mechanisms and Clinical Features
Young Ah Lee
Division of Pediatric Neurology, Department of Pediatrics, Beaumont Hospital, Oakland University School of Medicine, Royal Oak, MI, USA
Corresponding Author: Young Ah Lee ,Tel: +1-248-551-7370, Email: young.lee2@beaumont.org
Received: May 2, 2017;  Revised: July 19, 2017  Accepted: July 25, 2017.  Published online: August 11, 2017.
ABSTRACT
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.
Key Words: Brain; Prematurity; Injury; White matter; Periventricular leukomalacia
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