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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2017.07.26    [Epub ahead of print]
Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Hyo Jung An1, Gyung Hyuck Ko2,3,4, Jeong-Hee Lee2,3,4, Jong Sil Lee2,3,4, Dong Chul Kim2,3,4, Jung Wook Yang4, Min Hye Kim4, Jin Pyeong Kim2,3,5, Eun Jung Jung2,3,6, Dae Hyun Song1,2,3
1Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea
2Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea
3Department of Pathology, Gyeongsang Institute of Health Science, Jinju, Korea
4Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea
5Deparment of Otorhinolaryngology, Gyeongsang National University Changwon Hospital, Changwon, Korea
6Department of Surgery, Gyeongsang National University Changwon Hospital, Changwon, Korea
Corresponding Author: Dae Hyun Song ,Tel: +82-55-214-3150, Fax: +82-55-214-3174, Email: golgy@hanmail.net
Received: June 14, 2017;  Revised: July 24, 2017  Accepted: July 25, 2017.  Published online: October 3, 2017.
ABSTRACT

Background:
The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis.
Methods:
Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009. Tissue microarray blocks were made using representative paraffin blocks of classical PTCs excluding follicular variants. Two pathologists graded the proportion and intensity of PD-L1 and PD-1 expression in both tumor and inflammatory cells. According to their proportions, positive PTC cells were scored as negative (0%), grade 1 (1%–50%), and grade 2 (51%–100%). Similarly, positive inflammatory cells were graded as negative (0%), grade 1 (1%–10%), and grade 2 (11%–20%). The intensity of each protein expression was simplified as positive or negative.
Results:
A statistically significant correlation exists between the proportions of PD-1 and PD-L1 expression both in papillary carcinoma (p=.001) and peritumoral lymphoid cells in the thyroid (p<.001). In addition, the proportion of PD-L1 expression in PTC cells was closely related to metastatic LNs (p=.036).
Conclusions:
PD-L1 is a valuable predictive marker for LN metastasis in PTC. Immunomodulating therapies that inhibit PD-L1 might be an option for patients with LN metastasis.
Key Words: Programmed death-ligand 1; Carcinoma, papillary; Thyroid; Lymph nodes; Neoplasm metastasis