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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2017.10.09    [Epub ahead of print]
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
Ji Hye Moon1, Kyoungbun Lee1, Han-Kwang Yang2,3, Woo Ho Kim1,3
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
3Department of Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Corresponding Author: Woo Ho Kim ,Email: woohokim@snu.ac.kr
Received: August 14, 2017;  Revised: September 26, 2017  Accepted: October 9, 2017.  Published online: December 27, 2017.
ABSTRACT
We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelimmnto adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea.
Key Words: Brunner glands, Adenocarcinoma, Duodenum