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Immunohistochemical Profile of Acute Cellular Rejection in Renal Allograft.
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HOME > J Pathol Transl Med > Volume 41(1); 2007 > Article
Original Article Immunohistochemical Profile of Acute Cellular Rejection in Renal Allograft.
Jongha Park, Seung Woon Byun, Eunsil Yu, Su Kil Park, Duck Jong Han, Yong Mee Cho
Journal of Pathology and Translational Medicine 2007;41(1):15-20
DOI: https://doi.org/
1Department of Nephrology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea.
2Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea. youngcho@amc.seoul.kr
3Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea.
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BACKGROUND
We wanted to find an adjunctive marker(s) in renal allograft biopsies for predicting acute cellular rejection (ACR), and so the expression patterns of immune-related molecules were compared between ACR, borderline ACR and non-ACR cases.
METHODS
The expression patterns of Fas ligand (FasL), HLA-DR, granzyme B, caspase-3, CD56, interferon stimulated growth factor-3 (ISGF-3), and CD53 were assessed via immunohistochemical study in 75 allograft biopsies from patients with ACR (n=19), borderline ACR (n=22), and non-ACR (n=34).
RESULTS
Compared to those of the non-ACR group, the ACR group revealed an elevated number of FasL positive interstitial inflammatory cells, HLA-DR positive tubular inflammatory cells, cytoplasmic caspase-3 positive tubular epithelial cells, granzyme B positive interstitial mononuclear inflammatory cells and CD53 positive interstitial inflammatory cells. The expression patterns of the borderline ACR group were similar to those of non-ACR group, except for the intensity of FasL in the tubular epithelial cells.
CONCLUSIONS
Immunohistochemical investigations of the adjunctive markers FasL, HLA-DR, granzyme B, caspase-3 and CD56 can be useful for making the diagnosis of ACR.

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