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A Rare Case of Pulmonary Arteriovenous Hemangioma Presenting as a Peribronchial Mass

A Rare Case of Pulmonary Arteriovenous Hemangioma Presenting as a Peribronchial Mass

Article information

J Pathol Transl Med. 2016;50(3):243-245
Publication date (electronic) : 2015 November 17
doi : https://doi.org/10.4132/jptm.2015.10.15
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
1Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Joungho Han, MD Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea Tel: +82-2-3410-2765, Fax: +82-2-3410-0025, E-mail: hanjho@skku.edu
Received 2015 July 29; Revised 2015 September 16; Accepted 2015 October 15.

Vascular tumors in the lung are unusual. The majority of previous reports described cases of multiple or solitary lymphangiomas or capillary and cavernous hemangiomas [1-4]. To date, there has been only one report describing arteriovenous malformation/hemangioma (AVMH) in the middle mediastinum [5]. Herein, we report an unusual case of pulmonary AVMH presenting as a peribronchial mass.

CASE REPORT

A 62-year-old man presented with a 1-month history of sputum and fatigue. He was afebrile, and routine physical examinations were within normal limits. He is an ex-smoker with a 40-pack years smoking history and denied any other medical history. Routine laboratory tests showed no abnormality. Chest computed tomography (CT) identified a 45-mm-sized mass-like lesion located centrally in the apical segment of the left upper lobe (Fig. 1A). Although the CT findings were not diagnostic, the possibility of infectious condition was favored rather than neoplastic. The patient took antibiotics for 45 days, but experienced no symptom relief, and follow-up chest CT showed no interval change of the lesion. Additional positron emission tomography was performed to characterize the lesion. A 55×24-mm-sized soft tissue mass showed mild heterogeneous fludeoxyglucose uptake in the lesion, suggesting malignancy (Fig. 1A). Under the clinical impression of lung cancer, left upper lobectomy was planned. Although video-assisted thoracoscopic surgery was initially attempted during the operation, it was converted to thoracotomy due to mediastinal pleural adhesion.

Fig. 1.

Arteriovenous malformation/hemangioma (AVMH) of the lung. (A) Chest computed tomography reveals a mass-like lesion measuring 45 mm, and the lesion shows mild heterogeneous fludeoxyglucose uptake on positron emission tomography scan. (B) On the cut section of the lobectomy specimen, an ill-defined rubbery mass-like lesion (black arrows) is noted adjacent to dilated bronchial lumen with mucin impaction (white arrow). Microscopically, the lesion grows between the bronchial mucosa and cartilage plate (C) and consists of multiple thick and prominent vessels of various sizes, consistent with the diagnosis of AVMH (D). (E) Elastic stain visualizes no definite elastic lamina.

On the cut section of the lobectomy specimen, the dilated lumen of the lobar bronchus was packed with necrotic and mucoid material (Fig. 1B). Bronchiectasis was noted along the bronchial tree. There was no definite endobronchial lesion. Interestingly, serial cut sections of the peribronchial area revealed an ill-defined white-yellow rubbery mass-like lesion that measured approximately 2.8 cm in total extent and had pinpoint-sized spaces (Fig. 1B). Microscopically, the lesion consisted of multiple thick and prominent vessels with intervening connective tissue, and it grew between bronchial mucosa and hyaline cartilage plates (Fig. 1C). The vessels were variably sized, up to 4 mm in diameter with a thickness of up to 0.8 mm (Fig. 1D). Elastic stain visualized no definite elastic lamina, which implied the lesion to be composed of arterialized vein (Fig. 1E). These histologic findings were characteristic of AVMH. The patient was discharged without any postoperative complication. This study was approved by the Institutional Review Board of Samsung Medical Center (IRB File No. SMC 2015-07-194).

DISCUSSION

Vascular tumors of the lung are extremely rare. We presented an unusual case of pulmonary AVMH clinically mimicking lung cancer. This hemangioma presented as a peribronchial mass leading to post-obstructive bronchiectasis with mucin impaction.

The recent World Health Organization classification introduces four entities of vascular neoplasm in the mediastinum: lymphangioma, hemangioma, epithelioid hemangioendothelioma, and angiosarcoma [6]. Of the benign entities, lymphangioma is composed of medium- or small-sized lymphatic channels filled with lymphatic fluid, and hemangioma can be cavernous or capillary. To date, there have been only a few reports of multiple or solitary lymphangiomas and hemangiomas in the lung [1-4]. The present tumor had histologic features of AVMH characterized by complex thick-walled vessels. To the best of our knowledge, this is the first report describing AVMH arising in the peribronchial soft tissue. Deep-seated AVMH usually arises in the limbs or head and neck. Mizutani et al. [5] previously reported arteriovenous hemangioma in the middle mediastinum.

The literature review showed that abnormal communications between pulmonary arteries and pulmonary veins have been given various names including pulmonary arteriovenous fistulae, arteriovenous aneurysm, and AVMH [7,8]. Among these, pulmonary arteriovenous fistulae refer to abnormally dilated vessels that provide a right-to-left shunt between the pulmonary artery and pulmonary vein, thereby bypassing the pulmonary capillary bed [8]. Pulmonary arteriovenous fistulae are mostly congenital, and the majority of patients have hereditary hemorrhagic telangiectasia [8]. These lesions have been described as pulmonary AVMH in several reports [7,8]. On the other hand, AVMH is different from arteriovenous fistulae in that AVMH is an acquired tumor-like condition characterized by complex thick-walled vessels with no evidence of fistula formation. In the present case, there was no evidence of obvious fistula or shunt formation on chest CT. To avoid misunderstanding and confusion, clarification of terminology for pulmonary vascular lesion is warranted.

Notes

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

References

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Article information Continued

Fig. 1.

Arteriovenous malformation/hemangioma (AVMH) of the lung. (A) Chest computed tomography reveals a mass-like lesion measuring 45 mm, and the lesion shows mild heterogeneous fludeoxyglucose uptake on positron emission tomography scan. (B) On the cut section of the lobectomy specimen, an ill-defined rubbery mass-like lesion (black arrows) is noted adjacent to dilated bronchial lumen with mucin impaction (white arrow). Microscopically, the lesion grows between the bronchial mucosa and cartilage plate (C) and consists of multiple thick and prominent vessels of various sizes, consistent with the diagnosis of AVMH (D). (E) Elastic stain visualizes no definite elastic lamina.