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Eun Ah Jung 4 Articles
Coexistence of Intrapulmonary Bronchogenic Cyst and Congenital Cystic Adenomatoid Malformation: A Case Report.
Mee Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Ki Hyun Seo, Seock Yeol Lee, Young Tong Kim
Korean J Pathol. 2011;45(1):92-95.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.92
  • 2,381 View
  • 15 Download
  • 1 Citations
AbstractAbstract PDF
Congenital cystic lesions of the lung are uncommon and a conjunction of two or more lesions is very rare. We report here on a case of coexisting intrapulmonary bronchogenic cyst and congenital cystic adenomatoid malformation in a 13-year-old female with a cystic mass in the right upper lobe of the lung. Computed tomography showed a cystic lesion measuring 2.5 cm with an air fluid level and surrounding multicystic lesions in the right upper lobe. On gross examination, the cut surface showed a cystic mass containing inspissated mucinous material, and the cystic mass was surrounded by multiple small cysts. Microscopically, the larger cystic cavity was lined with pseudostratified ciliated columnar epithelium. The submucosal tissue contained mucinous glands and plates of cartilage. The surrounding smaller cysts or irregular spaces were lined with bronchiolar-type respiratory epithelium. We propose that this hybrid lung lesion may represent the missing link in a common embryologic pathway determined by the timing of mesenchymal and epithelial interactions.

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Citations to this article as recorded by  
  • Case 2: Coexisting Cystic Lesions of Lung in a Term Neonate: A Management Dilemma
    Bichitrananda Raut, Aakriti Soni, Susanta Kumar Badatya, Satish Saluja, Manoj Modi, Arun Soni
    NeoReviews.2018; 19(9): e542.     CrossRef
Spindle Cell Epithelioma, a So-called Benign Mixed Tumor of the Vagina: A Case Report.
Mee Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Seung Ha Yang, Jeong Ja Kwak
Korean J Pathol. 2010;44(6):670-674.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.670
  • 3,172 View
  • 49 Download
AbstractAbstract PDF
We report a case of spindle cell epithelioma, a so-called benign mixed tumor of the vagina. The patient was a 35-year-old nulliparous woman who presented with a polypoid mass in the posterior wall of the lower vagina just above the hymenal ring. The tumor was relatively well-defined with an expansile margin and composed of stromal-type spindle cells with a myxoid stroma arranged in short fascicles and an irregular cord-like or reticular pattern. A few glandular structures lined by cuboidal cells with squamous metaplasia were also noted. Cellular atypia was not conspicuous and mitosis was not found. We examined this tumor immunohistochemically to identify the histogenesis. The coexpression of epithelial and mesenchymal markers in stromal-type spindle cells suggested a multipotential cell origin for this tumor. The patient has been well with no signs of recurrence during the 12 months after surgery.
Clinicopathological Significance of S100A4 Expression in Non-small Cell Lung Carcinomas.
Eun Ah Jung, Hyun Deuk Cho, Ji Hye Lee, Mee Hye Oh
Korean J Pathol. 2010;44(5):477-482.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.477
  • 3,108 View
  • 18 Download
  • 6 Citations
AbstractAbstract PDF
BACKGROUND
S100A4 has been implicated in invasion and metastasis of various malignant tumors. The aim of this study was to investigate whether or not S100A4 plays an important role in non-small cell lung carcinomas (NSCLCs).
METHODS
Sixty-seven patients with NSCLC including 37 with squamous cell carcinomas (SCCs) and 30 with adenocarcinomas (ADs) who had undergone surgical resection were analyzed. S100A4 expression was analyzed by immunohistochemistry using tissue microarray blocks.
RESULTS
S100A4 expression was positive in 56 (83.6%) of 67 NSCLC cases. ADs were more frequently S100A4 positive than SCCs (p = 0.017). However, no significant correlation was observed between S100A4 expression and age, gender, pT, pN or tumor, node and metastasis (TNM) stage. Two distant metastatic cases revealed an S100A4 positive reaction. Kaplan-Meier survival curves with the log-rank test showed no correlation with 3-year survival (p = 0.782) or 5-year survival (p = 0.227) in either group of patients according to S100A4 expression.
CONCLUSIONS
S100A4 expression was not correlated with age, gender, pT, pN or TNM stage or survival in patients with NSCLCs. Therefore, S100A4 expression may not be useful as a prognostic marker for NSCLCs. However, S100A4 expression showed a higher positivity in ADs than in SCCs.

Citations

Citations to this article as recorded by  
  • Clinicopathological and prognostic value of S100A4 expression in non-small cell lung cancer: a meta-analysis
    Jing Zhang, Yanhui Gu, Xiaoli Liu, Ximin Rao, Guichuan Huang, Yao Ouyang
    Bioscience Reports.2020;[Epub]     CrossRef
  • S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation
    TENG HUA, SHUANGGE LIU, XIAOYAN XIN, LIQIONG CAI, RUI SHI, SHUQI CHI, DILU FENG, HONGBO WANG
    Oncology Reports.2016; 35(6): 3419.     CrossRef
  • Prognostic value of cytoplasmic expression of S100A4 protein in endometrial carcinoma
    HYE IN CHONG, JEONG HEE LEE, MAN SOO YOON, DONG SOO SUH, KYUNGBIN KIM, JEE YEON KIM, KYUNG UN CHOI
    Oncology Reports.2014; 31(6): 2701.     CrossRef
  • Clinical significance of E-cadherin, ╬▓-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma
    Hua Zhang, Jun Liu, Dongsheng Yue, Liuwei Gao, Daowei Wang, Hongdian Zhang, Changli Wang
    Journal of Clinical Pathology.2013; 66(11): 937.     CrossRef
  • Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer
    Ane Kongsgaard Rud, Marius Lund-Iversen, Gisle Berge, Odd Terje Brustugun, Steinar K Solberg, Gunhild M M├Žlandsmo, Kjetil Boye
    BMC Cancer.2012;[Epub]     CrossRef
  • Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer
    Ho Won Lee, Eui Han Kim, Mee-Hye Oh
    Korean Journal of Pathology.2012; 46(5): 470.     CrossRef
Calcifying Aponeurotic Fibroma of the Elbow: A Case Report.
Mee Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Jong Kyu Han, Yong Koo Park
Korean J Pathol. 2009;43(1):75-78.
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.1.75
  • 3,171 View
  • 28 Download
AbstractAbstract PDF
Calcifying aponeurotic fibroma is a rare soft tissue tumor that mostly occurs in the distal extremities of children and adolescents. We report here on a case of calcifying aponeurotic fibroma of the right elbow in an 8-year-old boy, and the tumor was diagnosed by surgical excision. The patient complained of painless swelling and mild limitation of the range of motion of the elbow joint. Radiologically, the mass was ill-defined and showed stippled calcification with shallow bony erosion. Microscopically, the tumor was composed of spindle cells with nodular deposits of hyalination and calcification, and these deposits were surrounded by palisading polygonal plump cells. Immunohistochemically, the tumor showed a diffuse positive expression for CD99 and negativity for smooth muscle actin, S-100 protein and CD34. The patient has been well with no signs of recurrence during the 42 months after surgery.

JPTM : Journal of Pathology and Translational Medicine