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Kyung Seob Lee 1 Article
The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma.
Tae Jung Jang, Kyung Seob Lee
Korean J Pathol. 2009;43(3):206-211.
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  • 4 Citations
AbstractAbstract PDF
The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions.
The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry.
The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors.
This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.


Citations to this article as recorded by  
  • Assessment of survivin and p27 expression as potential prognostic markers in urothelial cell carcinoma of urinary bladder in Egyptian patients
    Noha Said Helal, Zeinab Omran, Mona Moussa
    African Journal of Urology.2022;[Epub]     CrossRef
  • Cyclooxygenase-2 Expression in Urinary Bladder Transitional Cell Carcinoma and its Association with Clinicopathological Characteristics
    Hedieh Moradi Tabriz, Golrokh Olfati, Seyed Ali Ahmadi, Sudabeh Yusefnia
    Asian Pacific Journal of Cancer Prevention.2013; 14(8): 4539.     CrossRef
  • High survivin expression in premalignant and malignant kidney lesions
    Tahany M. Shams, Samaka M. Rehab, Mokhtar Metawea
    Egyptian Journal of Pathology.2012; 32(1): 21.     CrossRef
  • Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas
    Tae Jung Jang, Woo Heon Cha, Kyung Seob Lee
    Virchows Archiv.2010; 457(3): 319.     CrossRef

JPTM : Journal of Pathology and Translational Medicine