- Propylthiouracil-induced Hepatic Injury: A Case Report.
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Ji Eun Kwak, Han Seong Kim, Sun Hee Chang, Mee Joo, Je G Chi, Jin Soo Moon, Jong Guk Lee
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Korean J Pathol. 2006;40(4):289-291.
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 Abstract
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- Propylthiouracil (PTU) is one of the most widely used drugs for the treatment of the hyperthyroidism. However the liver damage is a rare adverse effect, which can be fatal. We present a case of PTU-induced hepatitis. A 13-year-old girl was diagnosed as having Graves' disease, for which PTU was administered. Three months after commencing PTU, she developed jaundice accompanied with elevated serum transaminases and total bilirubin levels. The viral markers were all negative. The pathologic findings of the liver biopsy included necrosis of hepatocytes predominantly around the central veins (i.e., zone 3 necrosis) and moderate to severe infiltration of lymphocytes in portal areas. After withdrawal of the PTU, clinical symptoms and liver function test results were improved gradually.
- Tracheal Agenesis: Report of an autopsy case.
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Kyeong Mee Park, Yoen Lim Suh, Shin Kwang Kang, Jong Guk Lee
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Korean J Pathol. 1992;26(3):283-287.
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Abstract
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- Tracheal gaenesis is an extremely rare congenital anomaly and is characterized by totally or partially undeveloped trachea. In many instances, the lesion has been associated with malformations in other organ systems. This anomaly is classified into 3 types based on developmental period of the respiratory tract. We report a case of tracheal agenesis with tracheoesophageal fistula in a 2-hour-old male.
Postmortem examination revealed that the upper and mid portion of the trachea was absent but 1 cm segment of the trachea above the carina was present. The proximal end to this trachea opened to the esophagus by a fistula, 1 cm in diameter. The well-formed larynx ended blindly in a fibrous sac at which thyroids and cartilage islands are noted.
Associated anomalies were bilobed right lung and single umbilical artery.
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