Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
C. Soon Lee 1 Article
Radiotherapy Response in Microsatellite Instability Related Rectal Cancer
Joo-Shik Shin, Thein Ga Tut, Tao Yang, C. Soon Lee
Korean J Pathol. 2013;47(1):1-8.   Published online February 25, 2013
  • 8,961 View
  • 73 Download
  • 26 Citations
AbstractAbstract PDF

Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified. At the cellular level, radiation injury initiates a complex molecular network of DNA damage response (DDR) pathways that leads to cell cycle arrest, attempts at re-constituting the damaged DNA and should this fail, then apoptosis. This review presents the details which suggest the roles of DNA mismatch repair proteins, the lack of which define a distinct subset of colorectal cancers with microsatellite instability (MSI), in the DDR pathways. Hence routine assessment of the MSI status in rectal cancers may potentially serve as a predictor of radiotherapy response, thereby improving patient stratification in the administration of this otherwise toxic treatment.


Citations to this article as recorded by  
  • Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients
    Mingzhu Sun, Jayne Moquet, Michele Ellender, Simon Bouffler, Christophe Badie, Rachel Baldwin-Cleland, Kevin Monahan, Andrew Latchford, David Lloyd, Susan Clark, Nicola A. Anyamene, Elizabeth Ainsbury, David Burling
    Familial Cancer.2023; 22(1): 61.     CrossRef
  • Rectal Cancer in Patients with Hereditary Nonpolyposis Colorectal Cancer Compared with Sporadic Cases: Response to Neoadjuvant Chemoradiation and Local Recurrence
    Khaled M Madbouly, Sameh Hany Emile, Yasmine Amr Issa
    Journal of the American College of Surgeons.2022; 234(5): 793.     CrossRef
  • Not All Patients With Locally Advanced Rectal Cancer Benefit From Neoadjuvant Therapy
    Carolyn Chang, Jonathan T. Bliggenstorfer, Jessie Liu, Jennifer Shearer, Paul Dreher, Katherine Bingmer, Sharon L. Stein, Emily Steinhagen
    The American Surgeon.2022; : 000313482211094.     CrossRef
  • Molecular Recognition and Quantification of MLH1, MSH2, MSH6, PMS2, and KRAS in Biological Samples
    Raluca-Ioana Stefan-van Staden, Ruxandra-Maria Ilie-Mihai, Maria Coros, Stela Pruneanu
    ECS Sensors Plus.2022; 1(3): 031606.     CrossRef
  • Magnetic resonance imaging downstaging, pathological response, and microsatellite instability status in patients with signet-ring cell carcinoma rectum undergoing preoperative long-course chemoradiation
    B Rajkrishna, Saikat Das, Dipti Masih, Tharani Putta, Rajat Raghunath, ThomasSamuel Ram
    Current Medical Issues.2022; 20(3): 154.     CrossRef
  • Biomarkers and cell-based models to predict the outcome of neoadjuvant therapy for rectal cancer patients
    Aylin Alkan, Tobias Hofving, Eva Angenete, Ulf Yrlid
    Biomarker Research.2021;[Epub]     CrossRef
  • Microsatellite Instability (MSI) as an Independent Predictor of Pathologic Complete Response (PCR) in Locally Advanced Rectal Cancer
    Shaakir Hasan, Paul Renz, Rodney E. Wegner, Gene Finley, Moses Raj, Dulabh Monga, James McCormick, Alexander Kirichenko
    Annals of Surgery.2020; 271(4): 716.     CrossRef
  • Delivery of Personalized Care for Locally Advanced Rectal Cancer: Incorporating Pathological, Molecular Genetic, and Immunological Biomarkers Into the Multimodal Paradigm
    Éanna J. Ryan, Ben Creavin, Kieran Sheahan
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
    Shu-Biao Ye, Yi-Kan Cheng, Lin Zhang, Yi-Feng Zou, Ping Chen, Yan-Hong Deng, Yan Huang, Jian-Hong Peng, Xiao-Jian Wu, Ping Lan
    npj Precision Oncology.2020;[Epub]     CrossRef
  • Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer
    Renu Verma, Puja Sakhuja, Ritu Srivastava, Prakash Chand Sharma
    Asia-Pacific Journal of Oncology.2020; : 1.     CrossRef
  • Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
    Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S. Roxburgh, Karuna Ganesh, Shu Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane L. Reidy-Lagunes, Anna M. Varghese, Arnold Markowitz, Chao Wu, Bryan Szeglin, Charles-Etienne Gabriel Sauvé
    Clinical Cancer Research.2020; 26(13): 3271.     CrossRef
  • The Mismatch Repair System (MMR) in Head and Neck Carcinogenesis and Its Role in Modulating the Response to Immunotherapy: A Critical Review
    Maria Cilona, Luca Giovanni Locatello, Luca Novelli, Oreste Gallo
    Cancers.2020; 12(10): 3006.     CrossRef
  • Genetics of rectal cancer and novel therapies: primer for radiologists
    Sebastian Mondaca, Rona Yaeger
    Abdominal Radiology.2019; 44(11): 3743.     CrossRef
  • Mismatch repair deficiency as a predictive marker for response to adjuvant radiotherapy in endometrial cancer
    Casper Reijnen, Heidi V.N. Küsters-Vandevelde, Clemens F. Prinsen, Leon F.A.G. Massuger, Marc P.M.L. Snijders, Stefan Kommoss, Sara Y. Brucker, Janice S. Kwon, Jessica N. McAlpine, Johanna M.A. Pijnenborg
    Gynecologic Oncology.2019; 154(1): 124.     CrossRef
  • Mismatch Repair System Deficiency Is Associated With Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
    Nicolas Meillan, Dewi Vernerey, Jérémie H. Lefèvre, Gilles Manceau, Magali Svrcek, Jeremy Augustin, Jean-François Fléjou, Olivier Lascols, Jean-Marc Simon, Romain Cohen, Philippe Maingon, Jean-Baptiste Bachet, Florence Huguet
    International Journal of Radiation Oncology*Biology*Physics.2019; 105(4): 824.     CrossRef
  • Promoter methylation and expression of DNA repair genes MGMT and ERCC1 in tissue and blood of rectal cancer patients
    Sally M. Shalaby, Amal S. El-Shal, Lobna A. Abdelaziz, Eman Abd-Elbary, Mostafa M. Khairy
    Gene.2018; 644: 66.     CrossRef
  • RBBP 6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
    Chao Xiao, Yupeng Wang, Miao Zheng, Jian Chen, Guohe Song, Zhijie Zhou, Chongzhi Zhou, Xing Sun, Lin Zhong, Erxun Ding, Yi Zhang, Liu Yang, Gang Wu, Shifeng Xu, Hong Zhang, Xiaoliang Wang
    Cancer Science.2018; 109(4): 1075.     CrossRef
  • Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K)
    Stefan Eder, Annette Arndt, Andreas Lamkowski, Wassiliki Daskalaki, Alexis Rump, Markus Priller, Felicitas Genze, Eva Wardelmann, Matthias Port, Konrad Steinestel
    Cancer Letters.2017; 385: 160.     CrossRef
  • The current value of determining the mismatch repair status of colorectal cancer: A rationale for routine testing
    E. Ryan, K. Sheahan, B. Creavin, H.M. Mohan, D.C. Winter
    Critical Reviews in Oncology/Hematology.2017; 116: 38.     CrossRef
  • Exploration of Mutation and DNA Methylation of Polo-Like Kinase 1 (PLK1) in Colorectal Cancer
    Wayne Ng, Joo-Shik Shin, Bin Wang, Cheok Soon Lee
    Open Journal of Pathology.2017; 07(03): 45.     CrossRef
  • Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland
    Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Małgorzata Ławniczak, Andrzej Białek, Elżbieta Urasińska
    Medical Science Monitor.2016; 22: 2886.     CrossRef
  • DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics
    Nicole de Rosa, Miguel A. Rodriguez-Bigas, George J. Chang, Jula Veerapong, Ester Borras, Sunil Krishnan, Brian Bednarski, Craig A. Messick, John M. Skibber, Barry W. Feig, Patrick M. Lynch, Eduardo Vilar, Y. Nancy You
    Journal of Clinical Oncology.2016; 34(25): 3039.     CrossRef
  • miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1
    Guangsheng Zhai, Gaozhong Li, Bo Xu, Tongfu Jia, Yinping Sun, Jianbo Zheng, Jianbin Li
    Bioscience Reports.2016;[Epub]     CrossRef
  • Predictive and prognostic biomarkers for neoadjuvant chemoradiotherapy in locally advanced rectal cancer
    S.H. Lim, W. Chua, C. Henderson, W. Ng, J.-S. Shin, L. Chantrill, R. Asghari, C.S. Lee, K.J. Spring, P. de Souza
    Critical Reviews in Oncology/Hematology.2015; 96(1): 67.     CrossRef
  • Potential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers
    Ruth Exner, Walter Pulverer, Martina Diem, Lisa Spaller, Laura Woltering, Martin Schreiber, Brigitte Wolf, Markus Sonntagbauer, Fabian Schröder, Judith Stift, Fritz Wrba, Michael Bergmann, Andreas Weinhäusel, Gerda Egger
    British Journal of Cancer.2015; 113(7): 1035.     CrossRef
  • Study of Liver Transplant Rejection in Alcoholism-Induced Cirrhosis
    J. Tinoco González, C. Bernal Bellido, G. Jimenez Riera, V. Camacho Marente, L.M. Marín Gómez, G. Suárez Artacho, J.M. Álamo Martínez, J. Serrano Díez-Canedo, R.J. Padillo Ruíz, M.A. Gómez Bravo
    Transplantation Proceedings.2013; 45(10): 3650.     CrossRef

JPTM : Journal of Pathology and Translational Medicine