- An Adult Case of Bartter Syndrome Type III Presenting with Proteinuria
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Eun Jung Cha, Won Min Hwang, Sung-Ro Yun, Moon Hyang Park
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J Pathol Transl Med. 2016;50(2):160-164. Published online January 11, 2016
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DOI: https://doi.org/10.4132/jptm.2015.08.31
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- Bartter syndrome (BS) I–IV is a rare autosomal recessive disorder affecting salt reabsorption in the thick ascending limb of the loop of Henle. This report highlights clinicopathological findings and genetic studies of classic BS in a 22-year-old female patient who presented with persistent mild proteinuria for 2 years. A renal biopsy demonstrated a mild to moderate increase in the mesangial cells and matrix of most glomeruli, along with marked juxtaglomerular cell hyperplasia. These findings suggested BS associated with mild IgA nephropathy. Focal tubular atrophy, interstitial fibrosis, and lymphocytic infiltration were also observed. A genetic study of the patient and her parents revealed a mutation of the CLCNKB genes. The patient was diagnosed with BS, type III. This case represents an atypical presentation of classic BS in an adult patient. Pathologic findings of renal biopsy combined with genetic analysis and clinicolaboratory findings are important in making an accurate diagnosis.
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Citations
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- Bartter syndrome with multiple renal and liver cysts: a case report
Yemei He, Yue Zhou, Weihua Wu, Yue Chen, Santao Ou International Urology and Nephrology.2022; 55(1): 225. CrossRef - Bartter’s syndrome: clinical findings, genetic causes and therapeutic approach
Flavia Cristina Carvalho Mrad, Sílvia Bouissou Morais Soares, Luiz Alberto Wanderley de Menezes Silva, Pedro Versiani dos Anjos Menezes, Ana Cristina Simões-e-Silva World Journal of Pediatrics.2021; 17(1): 31. CrossRef - Association of Adult-Onset Bartter Syndrome With Undifferentiated Connective Tissue Disorder
Nida Saleem, Humaira Nasir, Danyal Hassan, Momena Manzoor Cureus.2021;[Epub] CrossRef - Acquired autoimmune Bartter syndrome in a patient with primary hypothyroidism
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Yanhan Li, Chengcheng Wu, Jie Gu, Dong Li, Yanling Yang Molecular Medicine Reports.2019;[Epub] CrossRef - Pathophysiology of antenatal Bartterʼs syndrome
Martin Kömhoff, Kamel Laghmani Current Opinion in Nephrology and Hypertension.2017; 26(5): 419. CrossRef
- Dedifferentiated Endometrioid Adenocarcinoma of the Uterus: Highly Aggressive and Poor Prognostic Tumor
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Shin Young Park, Moon Hyang Park, Hyoung Suk Ko, Eun Jung Cha, Jang Sihn Sohn, Un Suk Jung, Chul Jung Kim, Jin Suk Kim
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Korean J Pathol. 2014;48(4):327-330. Published online August 26, 2014
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DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.327
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Amir‐Hossein Akbari, Lu Wang, Robert A. Soslow, Rajmohan Murali Cancer Cytopathology.2021; 129(2): 121. CrossRef - Magnetic resonance imaging findings in 11 cases of dedifferentiated endometrial carcinoma of the uterus
Nao Kikkawa, Kimiteru Ito, Hiroshi Yoshida, Mayumi Kobayashi Kato, Yuko Kubo, Yasuyuki Onishi, Haruto Sugawara, Tomoyasu Kato, Masahiko Kusumoto Japanese Journal of Radiology.2021; 39(5): 477. CrossRef - High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
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Pooja Pandita, Xiyin Wang, Devin E. Jones, Kaitlyn Collins, Shannon M. Hawkins Cancers.2019; 11(11): 1665. CrossRef - Dedifferentiated endometrioid adenocarcinoma with trophoblastic components and elevated serum alfa-fetoprotein
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- Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study
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Hyoungsuk Ko, Shin Young Park, Eun Jung Cha, Jang Sihn Sohn
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Korean J Pathol. 2013;47(3):289-292. Published online June 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.289
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Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.
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Citations
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Eduardo Dantas, Diva Yamaguti, Kendi Yamazaki Gastroenterología y Hepatología (English Edition).2021; 44(8): 579. CrossRef - Polypoid Gastric Heterotopia of Colon
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