- A Rare Case of Recurrent Metastatic Solid Pseudopapillary Neoplasm of the Pancreas
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Hye Seung Lee, Han Kyeom Kim, Bong Kyung Shin, Jin Hyuk Choi, Yoo Jin Choi, Ha Yeon Kim
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J Pathol Transl Med. 2017;51(1):87-91. Published online August 6, 2016
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DOI: https://doi.org/10.4132/jptm.2016.06.16
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- A 61-year-old woman visited our hospital for bilateral multiple lung nodules and a mass in her thorax. She had a long history of multiple metastatic recurrences of solid pseudopapillary neoplasm (SPN); 24 years previously, the patient had undergone pylorus-preserving pancreaticoduodenectomy for a 9.9 × 8.6 cm mass in the pancreatic head. The tumor was diagnosed as an SPN. Nine years later, metastatic nodules were found on computed tomography in the patient’s liver and peritoneum and were excised. She subsequently underwent an additional eight metastatectomy procedures in diverse organs. For the presented event, the lung nodules were removed. The prevalence of malignant SPN in the general population is 5%–15%. However, multiple metastatic recurrence of malignant SPN is rare; the lung is a particularly rare site of metastasis, found in only three cases in the literature. Here, we describe this exceptional case and provide a literature review.
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Citations
Citations to this article as recorded by  - Curative Resection for Metastatic Solid Pseudopapillary Neoplasm of Pancreas—a Case Series
Aparna M. Jagannathan, Manbha L. Rymbai, Abhilasha Anand, Anoop Paul, Borna Das, Thomas Alex Kodiatte, Frederick L. Vyas, Ravish Sanghi Raju, Philip Joseph
Indian Journal of Surgical Oncology.2023;[Epub] CrossRef - Diagnosis and treatment of solid pseudopapillary neoplasm of the pancreas in children: A report of 18 cases
Ayiguzaili Maimaijiang, Haiyun Wang, Wanfu Li, Yaqi Wang
Frontiers in Pediatrics.2022;[Epub] CrossRef - Large tumor size, lymphovascular invasion, and synchronous metastasis are associated with the recurrence of solid pseudopapillary neoplasms of the pancreas
Goeun Lee, You-Na Sung, Sung Joo Kim, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Jihun Kim, Sang Soo Lee, Song Cheol Kim, Seung-Mo Hong
HPB.2021; 23(2): 220. CrossRef - Solid-Pseudopapillary Neoplasm of the Pancreas: A 63-Case Analysis of Clinicopathologic and Immunohistochemical Features and Risk Factors of Malignancy
Hongchun Chen, Yuchen Huang, Ningning Yang, Wentian Yan, Ruxue Yang, Shan Zhang, Panpan Yang, Nan Li, Zhenzhong Feng
Cancer Management and Research.2021; Volume 13: 3335. CrossRef - Minimally Invasive Approach for Pancreatic Solid Pseudopapillary Neoplasm and Initially Undiagnosed Slowly Progressing Liver Tumor
Shohei Takaichi, Yoshifumi Iwagami, Shogo Kobayashi, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi
Pancreas.2020; 49(8): e70. CrossRef - Rare Solid Tumor of the Exocrine Pancreas: A Pictorial Review
Marco Dioguardi Burgio, Maxime Ronot, Valérie Vilgrain
Seminars in Ultrasound, CT and MRI.2019; 40(6): 483. CrossRef - The Stomach: a Rare Site for Metastatic Solid Pseudopapillary Neoplasm of the Pancreas
Prajwala S. Prakash, Dexter Yak Seng Chan, Krishnakumar Madhavan
Journal of Gastrointestinal Surgery.2018; 22(4): 759. CrossRef - European evidence-based guidelines on pancreatic cystic neoplasms
Gut.2018; 67(5): 789. CrossRef
- Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer
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Jinhyuk Choi, Chungyeul Kim, Hye Seung Lee, Yoo Jin Choi, Ha Yeon Kim, Jinhwan Lee, Hyeyoon Chang, Aeree Kim
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J Pathol Transl Med. 2016;50(6):442-450. Published online October 10, 2016
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DOI: https://doi.org/10.4132/jptm.2016.07.08
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10,806
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- Background
Human papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast.
Methods
Meta-analysis was performed in 22 case-control studies for HPV infection in breast cancer. A total of 123 breast cancers, nine intraductal papillomas and 13 nipple tissues of patients with proven cervical HPV infection were tested by real-time polymerase chain reaction to detect 28 subtypes of HPV. Breast cancers were composed of 106 formalin-fixed and paraffin embedded (FFPE) breast cancer samples and 17 touch imprint cytology samples of breast cancers.
Results
The overall odds ratio between breast cancer and HPV infection was 5.43 (95% confidence interval, 3.24 to 9.12) with I2 = 34.5% in meta-analysis of published studies with case-control setting and it was statistically significant. HPV was detected in 22 cases of breast cancers (17.9%) and two cases of intaductal papillomas (22.2%). However, these cases had weak positivity.
Conclusions
These results failed to serve as significant evidence to support the relationship between HPV and breast cancer. Further study with larger epidemiologic population is merited to determine the relationship between HPV and breast cancer.
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Citations
Citations to this article as recorded by - Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence
Ikuko Kato, Jilei Zhang, Jun Sun
Cancers.2022; 14(2): 425. CrossRef - Breast cancer association with oncogenic papillomaviruses: papillomaviral DNA detection in breast cancer cells
G. M. Volgareva
Advances in Molecular Oncology.2022; 9(2): 10. CrossRef - Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease
Erika Maldonado-Rodríguez, Marisa Hernández-Barrales, Adrián Reyes-López, Susana Godina-González, Perla I. Gallegos-Flores, Edgar L. Esparza-Ibarra, Irma E. González-Curiel, Jesús Aguayo-Rojas, Adrián López-Saucedo, Gretel Mendoza-Almanza, Jorge L. Ayala-
Current Issues in Molecular Biology.2022; 44(8): 3648. CrossRef - Risk Role of Breast Cancer in Association with Human Papilloma Virus among Female Population in Taiwan: A Nationwide Population-Based Cohort Study
Chia-Hsin Liu, Chi-You Liao, Ming-Hsin Yeh, James Cheng-Chung Wei
Healthcare.2022; 10(11): 2235. CrossRef - HPV-Associated Breast Cancer: Myth or Fact?
Erik Kudela, Eva Kudelova, Erik Kozubík, Tomas Rokos, Terezia Pribulova, Veronika Holubekova, Kamil Biringer
Pathogens.2022; 11(12): 1510. CrossRef - Assessment of Human Papillomavirus Infection and Risk Factors in Egyptian Women With Breast Cancer
Nabila El-Sheikh, Nahla O Mousa, Amany M Tawfeik, Alaa M Saleh, Iman Elshikh, Mohamed Deyab, Faten Ragheb, Manar M Moneer, Ahmed Kawashti, Ahmed Osman, Mohamed Elrefaei
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Hua Guo, Juan P. Idrovo, Jin Cao, Sudarshana Roychoudhury, Pooja Navale, Louis J. Auguste, Tawfiqul Bhuiya, Silvat Sheikh-Fayyaz
Clinical Breast Cancer.2021; 21(6): e638. CrossRef - Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?
Rancés Blanco, Diego Carrillo-Beltrán, Juan P. Muñoz, Alejandro H. Corvalán, Gloria M. Calaf, Francisco Aguayo
Biology.2021; 10(8): 804. CrossRef - Systematic review and meta-analysis of the papillomavirus prevalence in breast cancer fresh tissues
Geilson Gomes de Oliveira, Ana Katherine Gonçalves, José Eleutério, Luiz Gonzaga Porto Pinheiro
Breast Disease.2021; 41(1): 123. CrossRef - Is human papillomavirus associated with breast cancer or papilloma presenting with pathologic nipple discharge?
Fatih Levent Balci, Cihan Uras, Sheldon Marc Feldman
Cancer Treatment and Research Communications.2019; 19: 100122. CrossRef - Is the HPV virus responsible for the development of breast cancer?
Erik Kudela, Marcela Nachajova, Jan Danko
The Breast Journal.2019; 25(5): 1053. CrossRef - Absence of Human Papillomavirus in Benign and Malignant Breast Tissue
Maryam Kazemi Aghdam, Seyed Alireza Nadji, Azadeh Alvandimanesh, Maliheh Khoddami, Yassaman Khademi
Iranian Journal of Pathology.2019; 14(4): 279. CrossRef - Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)
James S. Lawson, Brian Salmons, Wendy K. Glenn
Frontiers in Oncology.2018;[Epub] CrossRef - Viral infections and breast cancer – A current perspective
O.M. Gannon, A. Antonsson, I.C. Bennett, N.A. Saunders
Cancer Letters.2018; 420: 182. CrossRef - Prevalence of EBV, HPV and MMTV in Pakistani breast cancer patients: A possible etiological role of viruses in breast cancer
Wasifa Naushad, Orooj Surriya, Hajra Sadia
Infection, Genetics and Evolution.2017; 54: 230. CrossRef
- Sclerosing Perivascular Epithelioid Cell Tumor of the Lung: A Case Report with Cytologic Findings
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Ha Yeon Kim, Jin Hyuk Choi, Hye Seung Lee, Yoo Jin Choi, Aeree Kim, Han Kyeom Kim
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J Pathol Transl Med. 2016;50(3):238-242. Published online April 11, 2016
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DOI: https://doi.org/10.4132/jptm.2016.02.19
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7,317
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- Benign perivascular epithelioid cell tumor (PEComa) of the lung is a rare benign neoplasm, a sclerosing variant of which is even rarer. We present a case of 51-year-old man who was diagnosed with benign sclerosing PEComa by percutaneous fine needle aspiration cytology and biopsy. The aspirate revealed a few cell clusters composed of bland-looking polygonal or spindle cells with fine granular or clear cytoplasm. Occasional fine vessel-like structures with surrounding hyalinized materials were seen. The patient later underwent wedge resection of the lung. The histopathological study of the resected specimen revealed sheets of polygonal cells with clear vacuolated cytoplasm, variably sized thin blood vessels, and densely hyalinized stroma. In immunohistochemical studies, reactivity of tumor cells for human melanoma black 45 and Melan-A further supported the diagnosis of benign sclerosing PEComa. To the best of our knowledge, this is the first case of benign sclerosing PEComa described in lung.
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Citations
Citations to this article as recorded by - Cytopathology of rare gastric mesenchymal neoplasms: A series of 25 cases and review of literature
Carla Saoud, Peter B. Illei, Momin T. Siddiqui, Syed Z. Ali
Cytopathology.2023; 34(1): 15. CrossRef - Retroperitoneal Sclerosing Angiomyolipoma with Long-Term Follow up: A Case Report with Unique Clinicopathologic and Genomic Profile
Liwei Jia, Vandana Panwar, Michelle Parmley, Elena Lucas, Ivan Pedrosa, Payal Kapur
International Journal of Surgical Pathology.2022; 30(1): 86. CrossRef - Perivascular epithelioid cell tumor of the lung: A case report and literature review
Shaofu Yu, Shasha Zhai, Qian Gong, Xiaoping Hu, Wenjuan Yang, Liyu Liu, Yi Kong, Lin Wu, Xingxiang Pu
Thoracic Cancer.2022; 13(17): 2542. CrossRef - Cytopathology of extra-renal perivascular epithelioid cell tumor (PEComa): a series of 7 cases and review of the literature
Sintawat Wangsiricharoen, Tatianna C. Larman, Paul E. Wakely, Momin T. Siddiqui, Syed Z. Ali
Journal of the American Society of Cytopathology.2021; 10(2): 175. CrossRef - Clear cell sugar tumour: a rare tumour of the lung
Sarah Page, Matthew S. Yong, Alka Sinha, Pankaj Saxena
ANZ Journal of Surgery.2020;[Epub] CrossRef - Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit
Panagiotis Paliogiannis, Giuseppe Palmieri, Francesco Tanda, Antonio Cossu
Journal of Pathology and Translational Medicine.2017; 51(1): 7. CrossRef
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