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Hee Jeong Kim 3 Articles
Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas
Junyoung Shin, Hee Jeong Kim, Dae-Yeon Kim, Gyungyub Gong, Kyung-Ja Cho
J Pathol Transl Med. 2019;53(5):308-316.   Published online August 2, 2019
DOI: https://doi.org/10.4132/jptm.2019.07.22
  • 4,224 View
  • 93 Download
  • 4 Citations
AbstractAbstract PDF
Background
Primary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation.
Methods
Upon reviewing Asan Medical Center’s pathology database between 2000 and 2018, 41 PBS cases were retrieved, including three cases of primary RMS of the breast. Their clinicopathological features were analyzed, and the literature related to PBS and primary RMS of the breast was reviewed.
Results
We identified three primary breast RMS cases from our institution database, comprising 7.3% of PBS: one case each of spindle cell/sclerosing RMS (ssRMS), alveolar RMS (aRMS), and embryonal RMS (eRMS). All cases involved adolescents or young adults (14, 16, and 25 years, respectively) who underwent mastectomy or radiotherapy and were confirmed using immunohistochemical testing for myogenin, desmin, and myogenic differentiation. The ssRMS patient experienced recurrence at the operation site 4 months post-surgery despite undergoing concurrent chemoradiotherapy. The aRMS patient had multiple metastases at diagnosis and showed FAX3-FOXO1 fusion transcripts; she died 22 months after the diagnosis. The eRMS patient had enlarged axillary lymph nodes; post-radiotherapy, the lesion recurred as multiple metastases to the bone and lung. She died 18 months post-diagnosis.
Conclusions
Our experience on RMS cases suggests that spindle cell or small round cell malignancy in breasts of young female should raise suspicion for the possibility of primary or secondary RMS. To our knowledge, this is the second report of primary breast ssRMS and it may help clinicians who encounter this rare disease in the future.

Citations

Citations to this article as recorded by  
  • High-Grade Spindle Cell Lesions of the Breast
    Esther Yoon, Qingqing Ding, Kelly Hunt, Aysegul Sahin
    Surgical Pathology Clinics.2022; 15(1): 77.     CrossRef
  • Primary Small Cell Malignancies of the Breast: Are They Rare Malignancies?
    Kemal Behzatoğlu, Fernando Schmitt
    Acta Cytologica.2022; 66(4): 347.     CrossRef
  • Recurrent malignant phyllodes tumor of the breast: An extremely rare case of recurrence with only rhabdomyosarcoma components
    Jia Han, Shuice Liu, Akihoro Shioya, Motona Kumagai, Emi Morioka, Miki Noguchi, Masafumi Inokuchi, Sohsuke Yamada
    SAGE Open Medical Case Reports.2022; 10: 2050313X2211166.     CrossRef
  • Primary rhabdomyosarcoma: An extremely rare and aggressive variant of male breast cancer
    Cătălin Bogdan Satală, Ioan Jung, Tivadar Jr Bara, Patricia Simu, Iunius Simu, Madalina Vlad, Rita Szodorai, Simona Gurzu
    World Journal of Clinical Cases.2020; 8(19): 4466.     CrossRef
WITHDRAWN:Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review
Junyoung Shin, Hee Jeong Kim, Dae-Yeon Kim, Gyungyub Gong, Kyung-Ja Cho
Received August 6, 2018  Accepted September 13, 2018  Published online October 4, 2018  
DOI: https://doi.org/10.4132/jptm.2018.09.14
  • 2,772 View
  • 62 Download
  • 1 Citations

Citations

Citations to this article as recorded by  
  • Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case
    Helen J. Trihia, Natasa Novkovic, Ioannis Provatas, Anastasios Mavrogiorgis, Evangelos Lianos
    Case Reports in Pathology.2019; 2019: 1.     CrossRef

JPTM : Journal of Pathology and Translational Medicine