Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Articles and issues > Author index
Search
Ji Eun Kim 8 Articles
Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma
Soyeon Choi, Yoo Jin Lee, Yunsuk Choi, Misung Kim, Hyun-Jung Kim, Ji Eun Kim, Sukjoong Oh, Seoung Wan Chae, Hee Jeong Cha, Jae-Cheol Jo
J Pathol Transl Med. 2022;56(5):281-288.   Published online September 13, 2022
DOI: https://doi.org/10.4132/jptm.2022.07.26
  • 1,047 View
  • 56 Download
AbstractAbstract PDF
Background
The aim of the present study was to evaluate the prognostic significance of B-cell lymphocyte kinase (BLK) expression for survival outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP.
Methods
We retrospectively analyzed the medical records of 89 patients from two tertiary referral hospitals. The expression of BLK, SYK, and CDK1 were evaluated in a semiquantitative method using an H-score, and the proportions of BCL2 and C-MYC were evaluated.
Results
A total of 89 patients received R-CHOP chemotherapy as a first-line chemotherapy. The expression rates of BLK in tumor cells was 39.2% (n = 34). BLK expression status was not significantly associated with clinical variables; however, BLK expression in tumor cells was significantly associated with the expression of both C-MYC and BCL2 (p = .003). With a median follow-up of 60.4 months, patients with BLK expression had significantly lower 5-year progression-free survival (PFS) and overall survival rates (49.8% and 60.9%, respectively) than patients without BLK expression (77.3% and 86.7%, respectively). In multivariate analysis for PFS, BLK positivity was an independent poor prognostic factor (hazard ratio, 2.208; p = .040).
Conclusions
Here, we describe the clinicopathological features and survival outcome according to expression of BLK in DLBCL. Approximately 39% of DLBCL patients showed BLK positivity, which was associated as a predictive marker for poor prognosis in patients who received R-CHOP chemotherapy.
The Expression of Adipophilin Is Frequently Found in Solid Subtype Adenocarcinoma and Is Associated with Adverse Outcomes in Lung Adenocarcinoma
Sun Ah Shin, Hee Young Na, Ji Young Choe, Doohyun Chung, Mira Park, Sohee Oh, Ji Eun Kim
J Pathol Transl Med. 2018;52(6):357-362.   Published online October 4, 2018
DOI: https://doi.org/10.4132/jptm.2018.09.13
  • 4,205 View
  • 100 Download
  • 3 Citations
AbstractAbstract PDF
Background
The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma.
Methods
Expression levels of adipophilin, heat shock protein 27 (HSP27), carbonic anhydrase IX, and hypoxia-inducible factor 1α were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed.
Results
A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression-free survival (PFS) (median PFS, 17.2 months vs 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS.
Conclusions
Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.

Citations

Citations to this article as recorded by  
  • Prognostic and clinicopathologic significance of PLIN2 in cancers: A systematic review with meta-analysis
    Ming-Lin Li, Han-Yong Luo, Zi-Wei Quan, Le-Tian Huang, Jia-He Wang
    The International Journal of Biological Markers.2023; : 039361552211475.     CrossRef
  • Adipophilin expression in cutaneous malignant melanoma is associated with high proliferation and poor clinical prognosis
    Masakazu Fujimoto, Ibu Matsuzaki, Kazuchika Nishitsuji, Yuki Yamamoto, Daisuke Murakami, Takanori Yoshikawa, Ayaka Fukui, Yuuki Mori, Masaru Nishino, Yuichi Takahashi, Yoshifumi Iwahashi, Kenji Warigaya, Fumiyoshi Kojima, Masatoshi Jinnin, Shin-ichi Murat
    Laboratory Investigation.2020; 100(5): 727.     CrossRef
  • The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma
    Hideaki Hirai, Yuichiro Tada, Masato Nakaguro, Daisuke Kawakita, Yukiko Sato, Tomotaka Shimura, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Chihiro Fushimi, Akira Shimizu, Isaku Okamoto, Soichiro Takase, Takuro Okada, Hiro
    Virchows Archiv.2020; 477(2): 291.     CrossRef
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
Hyun-Jung Kim, Young Hyeh Ko, Ji Eun Kim, Seung-Sook Lee, Hyekyung Lee, Gyeongsin Park, Jin Ho Paik, Hee Jeong Cha, Yoo-Duk Choi, Jae Ho Han, Jooryung Huh
J Pathol Transl Med. 2017;51(4):352-358.   Published online June 5, 2017
DOI: https://doi.org/10.4132/jptm.2017.03.15
  • 14,026 View
  • 936 Download
  • 53 Citations
AbstractAbstract PDF
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.

Citations

Citations to this article as recorded by  
  • Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer
    Al-Hassan M. Mustafa, Oliver H. Krämer, Lynette Daws
    Pharmacological Reviews.2023; 75(1): 35.     CrossRef
  • Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A
    Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M. Guardia, Amy Kullas, Kevin Crosby, Robin R. Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D. Rosenzweig, Juan S. Bonifac
    Autophagy.2023; 19(2): 678.     CrossRef
  • Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes
    Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martínez-Ruiz, Javier Florido, Germaine Escames, Matthias Schürmann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jörn Kalinowski,
    BMC Cancer.2023;[Epub]     CrossRef
  • Outcomes of programmed death protein-1 inhibitors treatment of chronic active Epstein Barr virus infection: A single center retrospective analysis
    Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Successful treatment by using a modified SMILE regimen and autologous hematopoietic stem cell transplantation in a pediatric primary EBV-positive nodular NK/T cell lymphoma patient
    Jian Li, Juxin Ye, Yongren Wang, Jun Wang, Yongjun Fang
    Annals of Hematology.2022; 101(2): 433.     CrossRef
  • Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders
    Lisa R. Forbes, Olive S. Eckstein, Nitya Gulati, Erin C. Peckham-Gregory, Nmazuo W. Ozuah, Joseph Lubega, Nader K. El-Mallawany, Jennifer E. Agrusa, M. Cecilia Poli, Tiphanie P. Vogel, Natalia S. Chaimowitz, Nicholas L. Rider, Emily M. Mace, Jordan S. Ora
    Journal of Allergy and Clinical Immunology.2022; 149(2): 758.     CrossRef
  • EBV-positive B-cell ulcerative proliferation in the oral cavity associated with EBV-negative follicular lymphoma in a patient with common variable immunodeficiency: A case report and review of the literature
    Waleed A. Alamoudi, Antoine Azar, Stefan K. Barta, Faizan Alawi, Takako I. Tanaka, Eric T. Stoopler, Thomas P. Sollecito
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 133(1): e10.     CrossRef
  • Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity
    Federico Scarmozzino, Marco Pizzi, Marta Sbaraglia, Luisa Santoro, Luca Frison, Silvia Nalio, Laura Bonaldi, Livio Trentin, Angelo Paolo Dei Tos
    Applied Sciences.2022; 12(3): 1290.     CrossRef
  • High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome
    Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Case Report of a Novel NFkB Mutation in a Lymphoproliferative Disorder Patient
    Khashayar Danandeh, Parnian Jabbari, Elham Rayzan, Samaneh Zoghi, Sepideh Shahkarami, Raul Jimenez Heredia, Ana Krolo, Bibi Shahin Shamsian, Kaan Boztug, Nima Rezaei
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(10): 1040.     CrossRef
  • When to suspect inborn errors of immunity in Epstein–Barr virus–related lymphoproliferative disorders
    Keith A. Sacco, Luigi D. Notarangelo, Ottavia M. Delmonte
    Clinical Microbiology and Infection.2022;[Epub]     CrossRef
  • EBV-associated diseases: Current therapeutics and emerging technologies
    Srishti Chakravorty, Behdad Afzali, Majid Kazemian
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Clinical and genetic characterization of Epstein-Barr virus–associated T/NK-cell lymphoproliferative diseases
    Hui Luo, Dan Liu, Wenbing Liu, Jin Jin, Xiaoman Bi, Peiling Zhang, Jia Gu, Miao Zheng, Min Xiao, Xin Liu, Jianfeng Zhou, Qian-Fei Wang
    Journal of Allergy and Clinical Immunology.2022;[Epub]     CrossRef
  • Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders
    Akihiro Ohmoto, Shigeo Fuji
    Blood Reviews.2021; 49: 100807.     CrossRef
  • Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review
    Kyoichi Obata, Tatsuo Okui, Sawako Ono, Koki Umemori, Shoji Ryumon, Kisho Ono, Mayumi Yao, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki
    Diagnostics.2021; 11(8): 1375.     CrossRef
  • Primary age‐related EBV‐associated effusion‐based lymphoma successfully treated with rituximab and thoracentesis
    Justin J. Kuhlman, Muhamad Alhaj Moustafa, Alexander J. Tun, David M. Menke, Han W. Tun, Liuyan Jiang
    Clinical Case Reports.2021;[Epub]     CrossRef
  • Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
    Shimaa Hassan AbdelAziz Soliman, Arturo Orlacchio, Fabio Verginelli
    Microorganisms.2021; 9(6): 1179.     CrossRef
  • Spontaneous regression of chronic epstein –Barr virus infection-related lymphoproliferative disease
    Bharti Kumari, Akshata Rao, ManickaSaravanan Subramanian, AparajitBallav Dey
    Journal of the Indian Academy of Geriatrics.2021; 17(1): 40.     CrossRef
  • The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection
    Jérémy Barben, Alain Putot, Anca-Maria Mihai, Jérémie Vovelle, Patrick Manckoundia
    Viruses.2021; 13(1): 115.     CrossRef
  • B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
    Maria T. Cencioni, Miriam Mattoscio, Roberta Magliozzi, Amit Bar-Or, Paolo A. Muraro
    Nature Reviews Neurology.2021; 17(7): 399.     CrossRef
  • Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts
    Laura J. Janke, Denise M. Imai, Heather Tillman, Rosalinda Doty, Mark J. Hoenerhoff, Jiajie J. Xu, Zachary T. Freeman, Portia Allen, Natalie Wall Fowlkes, Ilaria Iacobucci, Kirsten Dickerson, Charles G. Mullighan, Peter Vogel, Jerold E. Rehg
    Veterinary Pathology.2021; 58(1): 181.     CrossRef
  • Viral coinfections in COVID‐19
    Parisa S. Aghbash, Narges Eslami, Milad Shirvaliloo, Hossein B. Baghi
    Journal of Medical Virology.2021; 93(9): 5310.     CrossRef
  • Genetic predisposition to lymphomas: Overview of rare syndromes and inherited familial variants
    Bartosz Szmyd, Wojciech Mlynarski, Agata Pastorczak
    Mutation Research/Reviews in Mutation Research.2021; 788: 108386.     CrossRef
  • Acute Epstein‐Barr virus associated haemophagocytosis in an Asian female: What is the diagnosis?
    Soumya Ojha, Guiyi Ho, Cheryl X. Q. Lim, Siok B. Ng, Sanjay Mel
    American Journal of Hematology.2021; 96(11): 1541.     CrossRef
  • Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
    Xinle Cui, Clifford M. Snapper
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma
    Mostafa F. Mohammed Saleh, Ahmed Kotb, Ghada E. M. Abdallah, Ibrahim N. Muhsen, Riad El Fakih, Mahmoud Aljurf
    Current Oncology.2021; 28(6): 5480.     CrossRef
  • Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder
    Sizhu Wang, Yinghuan Dai, Jie Zhang, Dalian Ou, Chunhui Ouyang, Fanggen Lu
    Medicine.2020; 99(3): e18764.     CrossRef
  • Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
    Joana R. Lérias, Georgia Paraschoudi, Eric de Sousa, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Epstein Barr Virus-associated Pediatric Neoplasms
    Mozhgan Hashemieh, Fariba Shirvani
    Archives of Pediatric Infectious Diseases.2020;[Epub]     CrossRef
  • Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood
    Atif Saleem, Rohan Joshi, Li Lei, Lhara Lezama, Shyam S. Raghavan, Nastaran Neishaboori, Mohana Roy, Joe Schroers-Martin, Gregory W. Charville, Christian Kunder, Brent Tan, Beth A. Martin, Yasodha Natkunam
    Human Pathology: Case Reports.2020; 19: 200356.     CrossRef
  • Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease
    Luca Roncati, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti
    Annals of Hematology.2020; 99(8): 1945.     CrossRef
  • Epstein-Barr Virus and the Eye
    Emmett T. Cunningham, Manfred Zierhut
    Ocular Immunology and Inflammation.2020; 28(4): 533.     CrossRef
  • An atypical systemic form of chronic active EBV infection
    Neha Gupta, Adam Bagg
    Leukemia & Lymphoma.2020; 61(12): 3030.     CrossRef
  • A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02–Expressing Individuals
    Louise C. Rowntree, Thi H. O. Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A. Mifsud
    The Journal of Immunology.2020; 205(6): 1524.     CrossRef
  • Chronic active Epstein–Barr virus infection manifesting as coronary artery aneurysm and uveitis
    Haijuan Xiao, Bing Hu, Rongmu Luo, Huili Hu, Junmei Zhang, Weiying Kuang, Rui Zhang, Li Li, Gang Liu
    Virology Journal.2020;[Epub]     CrossRef
  • Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
    Yuki Yatsushiro, Takuro Nishikawa, Aki Saito, Yozo Nakazawa, Ken-Ichi Imadome, Shunsuke Nakagawa, Yuichi Kodama, Yasuhiro Okamoto, Hirokazu Kanegane, Yoshifumi Kawano
    Journal of Pediatric Hematology/Oncology.2019; 41(1): e44.     CrossRef
  • Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
    Moussab Tatfi, Olivier Hermine, Felipe Suarez
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • The factors associated with the early diagnosis of nasal NK/T-cell lymphoma with prominent ocular symptoms and general nasal NKTL
    Zhen zhen Hu, Ying Wang
    American Journal of Otolaryngology.2019; 40(3): 353.     CrossRef
  • Unusual lymphoid malignancy and treatment response in two children with Down syndrome
    Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL)
    Kelsey Sokol, Saritha Kartan, William T. Johnson, Onder Alpdogan, Neda Nikbakht, Bradley M. Haverkos, Jerald Gong, Pierluigi Porcu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
    Hani Nakhoul, Zhen Lin, Xia Wang, Claire Roberts, Yan Dong, Erik Flemington, Blossom Damania
    mSphere.2019;[Epub]     CrossRef
  • Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
    Granato, Gilardini Montani, Zompetta, Santarelli, Gonnella, Romeo, D’Orazi, Faggioni, Cirone
    Biomolecules.2019; 9(9): 482.     CrossRef
  • Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
    Hyekyung Lee, Hyunbin Shin, Nae Yu Kim, Hyun Sik Park, Jinsung Park
    Cancer Research and Treatment.2019; 51(4): 1666.     CrossRef
  • EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review
    Yanhua Zhou, Yanlin Zhang, Haiying Zhao, Xuan Cui, Yongqiu Wei, Yongdong Wu, Shutian Zhang, Ye Zong
    International Journal of Colorectal Disease.2019; 34(11): 1989.     CrossRef
  • Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas
    Jungang Chen, Samantha Kendrick, Zhiqiang Qin
    Viruses.2019; 11(12): 1161.     CrossRef
  • Rapidly Fatal Encephalitis Associated with Atypical Lymphoid Proliferations of the Basal Ganglia Subsequent to Aneurysmal Subarachnoid Hemorrhage
    Ayesha Kar, Evin L. Guilliams, Joshua A. Cuoco, Eric A. Marvin
    Clinics and Practice.2019; 9(4): 1187.     CrossRef
  • Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease
    Sonja Wörner, Hans-Konrad Mueller-Hermelink, Hans-Ullrich Voelker
    Pathology - Research and Practice.2018; 214(2): 207.     CrossRef
  • Primary Intestinal Epstein–Barr Virus-associated Natural Killer/T-cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease
    Zhujun Wang, Wenyan Zhang, Chengxin Luo, Min Zhu, Yu Zhen, Jingxi Mu, Yan Zhang, Renwei Hu, Yufang Wang, Zhonghui Wen, Qin Ouyang, Shuyuan Xiao, Hu Zhang
    Journal of Crohn's and Colitis.2018; 12(8): 896.     CrossRef
  • Downregulation of CD5 and dysregulated CD8+T-cell activation
    Taizo Wada
    Pediatrics International.2018; 60(9): 776.     CrossRef
  • Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options
    Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller, Claudia Wickenhauser
    BMC Cancer.2018;[Epub]     CrossRef
  • Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
    Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gr
    Blood.2018; 132(7): 694.     CrossRef
  • Gammaherpesviral infections in patients with immunological disorders
    Anna Żuk-Wasek, Maciej Przybylski, Natalia Żeber, Grażyna Młynarczyk, Tomasz Dzieciątkowski
    Postępy Mikrobiologii - Advancements of Microbiology.2018; 57(2): 145.     CrossRef
  • COMPARATIVE ANALYSIS OF SEROLOGICAL MARKERS OF HERPES VIRUSES AND QUANTITATIVE IMMUNOGLOBULINOPATHIES IN PRIMARY PATIENTS WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA
    N. G. Chernova, D. S. Tihomirov, N. P. Soboleva, S. A. Mariina, Y. V. Sidorova, M. N. Sinitsyna, V. N. Dvirnyk, S. M. Kulikov, T. A. Tupoleva, E. E. Zvonkov
    Problems of Virology.2018; 63(4): 171.     CrossRef
Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives
Yoon Kyung Jeon, Sun Och Yoon, Jin Ho Paik, Young A Kim, Bong Kyung Shin, Hyun-Jung Kim, Hee Jeong Cha, Ji Eun Kim, Jooryung Huh, Young-Hyeh Ko
J Pathol Transl Med. 2017;51(3):224-241.   Published online May 10, 2017
DOI: https://doi.org/10.4132/jptm.2017.04.09
  • 14,422 View
  • 607 Download
  • 9 Citations
AbstractAbstract PDF
Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.

Citations

Citations to this article as recorded by  
  • Thymus and lung mucosa-associated lymphoid tissue lymphoma with adenocarcinoma of the lung: a case report and literature review
    Yu Pang, Daosheng Li, Yiqian Chen, Qinqin Liu, Yuheng Wu, Qingliang Teng, Yuyu Liu
    World Journal of Surgical Oncology.2023;[Epub]     CrossRef
  • A comparison of capillary electrophoresis and next-generation sequencing in the detection of immunoglobulin heavy chain H and light chain κ gene rearrangements in the diagnosis of classic hodgkin’s lymphoma
    Juan-Juan Zhang, Yu-Xin Xie, Li-Lin Luo, Xuan-Tao Yang, Yi-Xing Wang, Yue Cao, Zheng-Bo Long, Wan-Pu Wang
    Bioengineered.2022; 13(3): 5868.     CrossRef
  • Lymphoproliferative disorder involving body fluid: diagnostic approaches and roles of ancillary studies
    Jiwon Koh, Sun Ah Shin, Ji Ae Lee, Yoon Kyung Jeon
    Journal of Pathology and Translational Medicine.2022; 56(4): 173.     CrossRef
  • Diagnostic Workup of Primary Cutaneous B Cell Lymphomas: A Clinician's Approach
    Giulia Tadiotto Cicogna, Martina Ferranti, Mauro Alaibac
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates
    Alexandra C. Hristov, Nneka I. Comfere, Claudia I. Vidal, Uma Sundram
    Journal of Cutaneous Pathology.2020; 47(11): 1103.     CrossRef
  • Primary lung mucosa-associated lymphoid tissue lymphoma accompanied by multiple sclerosis
    Ke-Ke Yu, Lei Zhu, Ji-Kai Zhao, Rui-Ying Zhao, Yu-Chen Han
    Chinese Medical Journal.2019; 132(13): 1625.     CrossRef
  • Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
    Woojoo Lee, Eun Shin, Bo-Hyung Kim, Hyunchul Kim, Riccardo Dolcetti
    PLOS ONE.2019; 14(11): e0225096.     CrossRef
  • Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T-cell and B-cell lymphoproliferative disorders
    Nneka Comfere, Uma Sundram, Maria Yadira Hurley, Brian Swick
    Journal of Cutaneous Pathology.2018; 45(1): 39.     CrossRef
  • A Next-Generation Sequencing Primer—How Does It Work and What Can It Do?
    Yuriy O. Alekseyev, Roghayeh Fazeli, Shi Yang, Raveen Basran, Thomas Maher, Nancy S. Miller, Daniel Remick
    Academic Pathology.2018; 5: 2374289518766521.     CrossRef
Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen with Extensive Histiocytic Granulomas and Necrosis: A Case Report and Literature Review
Hyun-Jung Kim, Ji Eun Kim, Gu-Hyun Kang, Jung Yeon Kim, Kyeongmee Park
Korean J Pathol. 2013;47(6):599-602.   Published online December 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.599
  • 6,313 View
  • 48 Download
  • 10 Citations
PDF

Citations

Citations to this article as recorded by  
  • Case report: Hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma: A rare case and minireview of the literature
    Fan Ding, Chao Wang, Chi Xu, Hui Tang
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Inflammatory pseudotumor-like follicular dendritic cell sarcoma: Literature review of 67 cases
    Hao Wu, Peng Liu, Xiao-Ran Xie, Jing-Shu Chi, Huan Li, Can-Xia Xu
    World Journal of Meta-Analysis.2021; 9(1): 1.     CrossRef
  • Granuloma With an Underlying Lymphoma: A Diagnostic Challenge and a Wider Histologic Spectrum Including Adult T-Cell Leukemia/Lymphoma
    Chih-Ying Wu, Ren-Ching Wang, Bo-Jung Chen, Wei-Yu Chen, Jie-Yang Jhuang, Ming-Chih Chang, Yu-Hung Wu, Norihiro Nakada, Kennosuke Karube, Shih-Sung Chuang
    Applied Immunohistochemistry & Molecular Morphology.2020; 28(4): 316.     CrossRef
  • A Case of Laparoscopically Resected EBV-related Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor of the Spleen
    Tomoya HIRAI, Yuki HOMMA, Yasuhiro SHIMIZU, Takahumi KUMAMOTO, Ryusei MATSUYAMA, Shoji YAMANAKA, Itaru ENDO
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2020; 81(8): 1631.     CrossRef
  • Histiocytic and Dendritic Cell Neoplasms
    Zenggang Pan, Mina L. Xu
    Surgical Pathology Clinics.2019; 12(3): 805.     CrossRef
  • Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases
    Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li
    World Journal of Gastrointestinal Oncology.2019; 11(12): 1231.     CrossRef
  • Diagnosis of EBV-Associated Inflammatory Pseudotumor in the Spleen: A Case Report
    Dmitrii Il'ich Chebotarev, A.M. Kovrigina, S.M. Korzhova, K.I. Danishyan, K.R. Sabirov
    Clinical oncohematology.2019; 12(4): 68.     CrossRef
  • Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia
    Aline Caldart Tregnago, Diogo Lago Morbeck, Felipe D’Almeida Costa, Antonio Hugo José Froes M. Campos, Fernando Augusto Soares, José Vassallo
    Applied Cancer Research.2017;[Epub]     CrossRef
  • Clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen
    Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
    Histopathology.2016; 68(6): 858.     CrossRef
  • Inflammatory pseudotumour-like follicular dendritic cell tumour of the spleen
    R. Nishiyama, S. Baba, Y. Watahiki, H. Maruo
    Case Reports.2015; 2015(mar12 1): bcr2014206373.     CrossRef
Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosin
Hyun Ju Lee, Xianhua Xu, Hyojin Kim, Yan Jin, Pingli Sun, Ji Eun Kim, Jin-Haeng Chung
Korean J Pathol. 2013;47(1):52-60.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.52
  • 9,533 View
  • 69 Download
  • 31 Citations
AbstractAbstract PDF
Background

The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).

Methods

Sixty-one NSCLC patients treated with EGFR TKIs were identified to investigate somatic mutations in the EGFR gene (exons 18-21).

Results

Mutations in the EGFR gene were detected in 38 of the 61 patients (62%) by DS, 35 (57%) by PNA clamping and 37 (61%) by pyrosequencing. A total of 44 mutations (72%) were found by at least one of the three methods, and the concordances among the results were relatively high (82-85%; kappa coefficient, 0.713 to 0.736). There were 15 discordant cases (25%) among the three different methods.

Conclusions

All three EGFR mutation tests had good concordance rates (over 82%) for FFPE samples. These results suggest that if the DNA quality and enrichment of tumor cells are assured, then DS, PNA clamping, and pyrosequencing are appropriate methods for the detection of EGFR mutations.

Citations

Citations to this article as recorded by  
  • Recent Trends of Lung Cancer in Korea
    Jae Guk Lee, Ho Cheol Kim, Chang-Min Choi
    Tuberculosis and Respiratory Diseases.2021; 84(2): 89.     CrossRef
  • Predictive value of KRAS mutation and excision repair cross-complementing 1 (ERCC1) protein overexpression in patients with colorectal cancer administered FOLFOX regimen
    Sun Min Park, Sung Bong Choi, Yoon Suk Lee, In Kyu Lee
    Asian Journal of Surgery.2021; 44(5): 715.     CrossRef
  • Recent advances in diagnostic technologies in lung cancer
    Hye Jung Park, Sang Hoon Lee, Yoon Soo Chang
    The Korean Journal of Internal Medicine.2020; 35(2): 257.     CrossRef
  • Afatinib is effective in the treatment of lung adenocarcinoma with uncommon EGFR p.L747P and p.L747S mutations
    Sheng-Kai Liang, Jen-Chung Ko, James Chih-Hsin Yang, Jin-Yuan Shih
    Lung Cancer.2019; 133: 103.     CrossRef
  • Biomarker Testing for Patients With Advanced Non–Small Cell Lung Cancer: Real-World Issues and Tough Choices
    Nathan A. Pennell, Maria E. Arcila, David R. Gandara, Howard West
    American Society of Clinical Oncology Educational Book.2019; (39): 531.     CrossRef
  • Evaluation of EGFR mutations in NSCLC with highly sensitive droplet digital PCR assays
    Xi‑Wen Jiang, Wei Liu, Xiao‑Ya Zhu, Xiao‑Xie Xu
    Molecular Medicine Reports.2019;[Epub]     CrossRef
  • Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
    Jae-Uk Song, Jonghoo Lee
    Yonsei Medical Journal.2018; 59(2): 211.     CrossRef
  • Distribution of KRAS, DDR2, and TP53 gene mutations in lung cancer: An analysis of Iranian patients
    Zahra Fathi, Seyed Ali Javad Mousavi, Raheleh Roudi, Farideh Ghazi, Sumitra Deb
    PLOS ONE.2018; 13(7): e0200633.     CrossRef
  • EGFR T790M mutation testing within the osimertinib AURA Phase I study
    Simon Dearden, Helen Brown, Suzanne Jenkins, Kenneth S. Thress, Mireille Cantarini, Rebecca Cole, Malcolm Ranson, Pasi A. Jänne
    Lung Cancer.2017; 109: 9.     CrossRef
  • Molecular Testing of Lung Cancers
    Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
    Journal of Pathology and Translational Medicine.2017; 51(3): 242.     CrossRef
  • Mutations of the Epidermal Growth Factor Receptor Gene in Triple-Negative Breast Cancer
    Aeri Kim, Min Hye Jang, Soo Jung Lee, Young Kyung Bae
    Journal of Breast Cancer.2017; 20(2): 150.     CrossRef
  • Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
    Oh Jung Kwon, Min Hyeok Lee, Sung Ju Kang, Seul Gi Kim, In Beom Jeong, Ji Yun Jeong, Eun Jung Cha, Do Yeun Cho, Young Jin Kim, Ji Woong Son
    Yeungnam University Journal of Medicine.2017; 34(2): 270.     CrossRef
  • Generation of lung cancer cell lines harboring EGFR T790M mutation by CRISPR/Cas9-mediated genome editing
    Mi-Young Park, Min Hee Jung, Eun Young Eo, Seokjoong Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young Jae Cho, Jin Haeng Chung, Cheol Hyeon Kim, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee
    Oncotarget.2017; 8(22): 36331.     CrossRef
  • Comparison of EGFR mutation detection between the tissue and cytology using direct sequencing, pyrosequencing and peptide nucleic acid clamping in lung adenocarcinoma: Korean multicentre study
    Kyueng-Whan Min, Wan-Seop Kim, Se Jin Jang, Yoo Duk Choi, Sunhee Chang, Soon Hee Jung, Lucia Kim, Mee Sook Roh, Choong Sik Lee, Jung Weon Shim, Mi Jin Kim, Geon Kook Lee
    QJM.2016; 109(3): 167.     CrossRef
  • Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis
    Yi-Lin Chen, Chung-Ta Lee, Cheng-Chan Lu, Shu-Ching Yang, Wan-Li Chen, Yang-Cheng Lee, Chung-Hsien Yang, Shu-Ling Peng, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho, Javier S Castresana
    PLOS ONE.2016; 11(6): e0158125.     CrossRef
  • IDH Mutation Analysis in Ewing Sarcoma Family Tumors
    Ki Yong Na, Byeong-Joo Noh, Ji-Youn Sung, Youn Wha Kim, Eduardo Santini Araujo, Yong-Koo Park
    Journal of Pathology and Translational Medicine.2015; 49(3): 257.     CrossRef
  • Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer
    XIANHUA XU, JI EUN KIM, PING-LI SUN, SEOL BONG YOO, HYOJIN KIM, YAN JIN, JIN-HAENG CHUNG
    Experimental and Therapeutic Medicine.2015; 9(2): 311.     CrossRef
  • Detection of EGFR-TK Domain–activating Mutations in NSCLC With Generic PCR-based Methods
    Rajendra B. Shahi, Sylvia De Brakeleer, Jacques De Grève, Caroline Geers, Peter In’t Veld, Erik Teugels
    Applied Immunohistochemistry & Molecular Morphology.2015; 23(3): 163.     CrossRef
  • Frequent aerogenous spread with decreased E-cadherin expression of ROS1- rearranged lung cancer predicts poor disease-free survival
    Yan Jin, Ping-Li Sun, Soo Young Park, Hyojin Kim, Eunhyang Park, Gilhyang Kim, Sukki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
    Lung Cancer.2015; 89(3): 343.     CrossRef
  • Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma
    Eunhyang Park, Soo Young Park, Hyojin Kim, Ping-Li Sun, Yan Jin, Suk Ki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
    Journal of Pathology and Translational Medicine.2015; 49(5): 382.     CrossRef
  • Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
    Seong-Hoon Yoon, Yoo-Duk Choi, In-Jae Oh, Kyu-Sik Kim, Hayoung Choi, Jinsun Chang, Hong-Joon Shin, Cheol-Kyu Park, Young-Chul Kim
    Cancer Research and Treatment.2015; 47(4): 661.     CrossRef
  • Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey
    Sang Hwa Lee, Wan Seop Kim, Yoo Duk Choi, Jeong Wook Seo, Joung Ho Han, Mi Jin Kim, Lucia Kim, Geon Kook Lee, Chang Hun Lee, Mee Hye Oh, Gou Young Kim, Sun Hee Sung, Kyo Young Lee, Sun Hee Chang, Mee Sook Rho, Han Kyeom Kim, Soon Hee Jung, Se Jin Jang
    Journal of Pathology and Translational Medicine.2015; 49(6): 481.     CrossRef
  • Novel EGFR mutation-specific antibodies for lung adenocarcinoma: Highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R mutation in exon 21 by immunohistochemistry
    An Na Seo, Tae-In Park, Yan Jin, Ping-Li Sun, Hyojin Kim, Hyun Chang, Jin-Haeng Chung
    Lung Cancer.2014; 83(3): 316.     CrossRef
  • Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non-small-cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage
    Tae-Jung Kim, Chan Kwon Park, Chang Dong Yeo, Kihoon Park, Chin Kook Rhee, Jusang Kim, Seung Joon Kim, Sang Haak Lee, Kyo-Young Lee, Hyoung-Kyu Yoon
    Journal of Surgical Oncology.2014; 110(3): 245.     CrossRef
  • Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity
    Sung-Jun Ko, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Tae Jung Kim, Kyung Won Lee, Kwhanmien Kim, Sanghoon Jheon, Hyojin Kim, Jae Ho Lee, Choon-Taek Lee
    BMC Cancer.2014;[Epub]     CrossRef
  • Cytoplasmic YAP Expression is Associated with Prolonged Survival in Patients with Lung Adenocarcinomas and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment
    Ping-Li Sun, Ji Eun Kim, Seol Bong Yoo, Hyojin Kim, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung
    Annals of Surgical Oncology.2014; 21(S4): 610.     CrossRef
  • Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer
    Marcin Nicoś, Tomasz Powrózek, Paweł Krawczyk, Bożena Jarosz, Beata Pająk, Marek Sawicki, Krzysztof Kucharczyk, Tomasz Trojanowski, Janusz Milanowski
    Medical Oncology.2014;[Epub]     CrossRef
  • Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas
    A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
    British Journal of Cancer.2014; 110(11): 2688.     CrossRef
  • KRASMutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
    Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
    Korean Journal of Pathology.2014; 48(2): 100.     CrossRef
  • Guideline Recommendations forEGFRMutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
    Hyo Sup Shim, Jin-Haeng Chung, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Geon Kook Lee, Soon-Hee Jung, Se Jin Jang
    Korean Journal of Pathology.2013; 47(2): 100.     CrossRef
  • Immunohistochemical Classification of Primary and Secondary Glioblastomas
    Kyu Sang Lee, Gheeyoung Choe, Kyung Han Nam, An Na Seo, Sumi Yun, Kyung Ju Kim, Hwa Jin Cho, Sung Hye Park
    Korean Journal of Pathology.2013; 47(6): 541.     CrossRef
Expression of c-Met Is Different along the Location and Associated with Lymph Node Metastasis of Head and Neck Carcinoma
Ji-Young Choe, Ji Yun Yun, Soo-Jeong Nam, Ji Eun Kim
Korean J Pathol. 2012;46(6):515-522.   Published online December 26, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.515
  • 5,849 View
  • 42 Download
  • 17 Citations
AbstractAbstract PDF
Background

Activation of the c-Met pathway is involved in cancer progression and the prognosis. We aimed to identify any association of c-Met protein expression with a number of clinicopathologic variables including infection of human papillomavirus and Epstein-Barr virus (EBV) in head and neck carcinomas (HNCa).

Methods

Eighty-two cases were enrolled in this study. Expression of c-Met and p16 was investigated immunohistochemically. EBV was detected by in situ hybridization and amplification of the c-Met gene by fluorescence in situ hybridization.

Results

The c-Met protein was expressed in 41.5% (34/82), and gene amplification was found in 1.4% (1/71). High expression of c-Met was associated with the primary location of the tumor; the hypopharynx showed the highest expression, followed by the oral cavity, larynx, and nasal cavity. Squamous cell carcinoma expressed c-Met more frequently than undifferentiated carcinoma. Also, p16 immunoreactivity or EBV infection was associated with the tumor location and well-differentiated histologic type, but were not linked to c-Met expression. The patients with positive c-Met expression showed frequent lymph node metastasis.

Conclusions

Activation of the c-Met pathway might be involved in a subset of HNCa. Cases showing positive c-Met expression should be carefully monitored because of the high probability of lymph node metastasis.

Citations

Citations to this article as recorded by  
  • Nadir paranazal sinüs kanserlerinde yeni tanımlanan reseptör tirozin kinaz mutasyonları ve potansiyel fonksiyonel etkileri
    Bakiye GÖKER BAGCA, Sercan GÖDE, Göksel TURHAL, Neslihan Pınar ÖZATEŞ, Ali VERAL, Cumhur GÜNDÜZ, Çığır Biray AVCI
    Ege Tıp Dergisi.2023; : 139.     CrossRef
  • The Emerging Role of c-Met in Carcinogenesis and Clinical Implications as a Possible Therapeutic Target
    Antonio Faiella, Ferdinando Riccardi, Giacomo Cartenì, Martina Chiurazzi, Livia Onofrio, Rengyun Liu
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • NK4 Regulates Laryngeal Squamous Cell Carcinoma Cell Properties and Inhibits Tumorigenicity by Modulating the DKK1/Wnt/β-Catenin Axis
    Shoukai Zhang, Hulai Wei, Xiaoqin Ha, Yueyu Zhang, Yufen Guo
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis
    Marcos Antonio Pereira de Lima, Álife Diêgo Lima Silva, Antônio Carlos Silva do Nascimento Filho, Thiago Lima Cordeiro, João Pedro de Souza Bezerra, Maria Aline Barroso Rocha, Sally de França Lacerda Pinheiro, Roberto Flávio Fontenelle Pinheiro Junior, Ma
    Pathogens.2021; 10(11): 1429.     CrossRef
  • The roles of PTEN, cMET, and p16 in resistance to cetuximab in head and neck squamous cell carcinoma
    Alexandre A. B. A. da Costa, Felipe D’Almeida Costa, Daniel Vilarim Araújo, Marcos Pedro Guedes Camandaroba, Victor Hugo Fonseca de Jesus, Audrey Oliveira, Ana Caroline Fonseca Alves, Carlos Stecca, Larissa Machado, Andrea Cruz Feraz de Oliveira, Thiago B
    Medical Oncology.2019;[Epub]     CrossRef
  • Role of c‐Met expression on prognosis of head and neck cancer: A literature review and meta‐analysis
    Lei Li, Zhijun Sun, Xin Huang, Xiao Li, Lihua Sun, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Limin Mao, Guolin Li
    Head & Neck.2019; 41(6): 1999.     CrossRef
  • MET Genomic Alterations in Head and Neck Squamous Cell Carcinoma (HNSCC): Rapid Response to Crizotinib in a Patient with HNSCC with a Novel MET R1004G Mutation
    Lisa Pei Chu, Debra Franck, Christine A. Parachoniak, Jeffrey P. Gregg, Michael G. Moore, D. Gregory Farwell, Shyam Rao, Andreas M. Heilmann, Rachel L. Erlich, Jeffrey S. Ross, Vincent A. Miller, Siraj Ali, Jonathan W. Riess
    The Oncologist.2019; 24(10): 1305.     CrossRef
  • Understanding c-MET signalling in squamous cell carcinoma of the head & neck
    P. Szturz, E. Raymond, C. Abitbol, S. Albert, A. de Gramont, S. Faivre
    Critical Reviews in Oncology/Hematology.2017; 111: 39.     CrossRef
  • Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data
    Petr Szturz, Marie Budíková, Jan B. Vermorken, Ivana Horová, Břetislav Gál, Eric Raymond, Armand de Gramont, Sandrine Faivre
    Oral Oncology.2017; 74: 68.     CrossRef
  • Activated HGF-c-Met Axis in Head and Neck Cancer
    Levi Arnold, Jonathan Enders, Sufi Thomas
    Cancers.2017; 9(12): 169.     CrossRef
  • Clinicopathological impacts of high c-Met expression in head and neck squamous cell carcinoma: a meta-analysis and review
    Jung Han Kim, Bum Jun Kim, Hyeong Su Kim
    Oncotarget.2017; 8(68): 113120.     CrossRef
  • High expression of c‑Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
    Mei Jiang, Hui Zhang, He Xiao, Zhimin Zhang, Dan Que, Jia Luo, Jian Li, Bijing Mao, Yuanyuan Chen, Meilin Lan, Ge Wang, Hualiang Xiao
    Oncology Letters.2017;[Epub]     CrossRef
  • Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies
    Alexander Muckenhuber, Galina Babitzki, Marlene Thomas, Gabriele Hölzlwimmer, Magdalena Zajac, Moritz Jesinghaus, Frank Bergmann, Jens Werner, Albrecht Stenzinger, Wilko Weichert
    Pancreas.2016; 45(8): 1167.     CrossRef
  • Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma
    Maria J. De Herdt, Stefan M. Willems, Berdine van der Steen, Rob Noorlag, Esther I. Verhoef, Geert J.L.H. van Leenders, Robert J.J. van Es, Senada Koljenović, Robert J. Baatenburg de Jong, Leendert H.J. Looijenga
    Oncotarget.2016; 7(11): 13167.     CrossRef
  • Biological, diagnostic and therapeutic relevance of the MET receptor signaling in head and neck cancer
    Lluís Nisa, Daniel Matthias Aebersold, Roland Giger, Yitzhak Zimmer, Michaela Medová
    Pharmacology & Therapeutics.2014; 143(3): 337.     CrossRef
  • Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances
    Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Hyung Sik Shin, Ji Hyun Kwon, Dong Jin Lee, Jin Hwan Kim, Seong Jin Cho, Eun Sook Nam
    Human Pathology.2014; 45(7): 1327.     CrossRef
  • Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1
    Anja Mai, Ghaffar Muharram, Rachel Barrow-McGee, Habib Baghirov, Juha Rantala, Stéphanie Kermorgant, Johanna Ivaska
    Journal of Cell Science.2014; 127(9): 1938.     CrossRef
Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression
Young A Kim, Meesoo Chang, Young Joo Park, Ji Eun Kim
Korean J Pathol. 2012;46(1):55-60.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.55
  • 7,235 View
  • 52 Download
  • 5 Citations
AbstractAbstract PDF
Background

Overexpression of survivin, a member of the inhibitors of apoptosis protein, has been reported in various carcinomas, and its interaction with cyclooxygenase 2 (COX-2) results in accelerated tumor progression. The purpose of this study is to investigate the immunohistochemical expression of survivin and COX-2 in benign and malignant thyroid tissues and to define its association with pathologic and clinical features.

Methods

We examined expression of survivin and COX-2 by immunohistochemistry in 334 benign and malignant thyroid tissues and evaluated their clinical significance.

Results

Expression of survivin showed an increase along the spectrum of thyroid carcinoma progression; rarely positive in adenomatous goiter, moderately positive in papillary carcinoma, and strongly positive in anaplastic carcinoma (AC). Papillary microcarcinoma revealed the highest COX-2 positivity and AC demonstrated the lowest positivity among thyroid cancers. Node negative carcinomas showed higher COX-2 expression than node positive tumors. Survivin expression did not correlate with COX-2.

Conclusions

Our findings suggest that survivin overexpression may be related to the pathogenesis of AC and can be a predictor of disease progression. COX-2 may be involved in the early phase of thyroid carcinoma.

Citations

Citations to this article as recorded by  
  • Survivin as a diagnostic and therapeutic marker for thyroid cancer
    Mohammad-Reza Mahmoudian-Sani, Arash Alghasi, Ali Saeedi-Boroujeni, Akram Jalali, Mohammad Jamshidi, Ali Khodadadi
    Pathology - Research and Practice.2019; 215(4): 619.     CrossRef
  • TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway
    Xiaoyan Fu, Huayong Zhang, Zhipeng Chen, Zhongyuan Yang, Dingbo Shi, Tianrun Liu, Weichao Chen, Fan Yao, Xuan Su, Wuguo Deng, Miao Chen, Ankui Yang
    Cell Death & Disease.2019;[Epub]     CrossRef
  • Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma
    Marija Milkovic Perisa, Bozena Sarcevic, Koraljka Gall Troselj, Kresimir Grsic, Sanda Sitic, Sven Seiwerth
    Oncology Letters.2017; 13(5): 3547.     CrossRef
  • The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma
    Min Hye Jang, Kyeong Cheon Jung, Hye Sook Min
    Journal of Pathology and Translational Medicine.2015; 49(2): 112.     CrossRef
  • Evaluation of survivin expression and its prognostic value in papillary thyroid carcinoma
    Sonja Selemetjev, Tijana Isic Dencic, Ilona Marecko, Jelena Jankovic, Ivan Paunovic, Svetlana Savin, Dubravka Cvejic
    Pathology - Research and Practice.2014; 210(1): 30.     CrossRef

JPTM : Journal of Pathology and Translational Medicine