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Ji Heui Kim 1 Article
A sinonasal yolk sac tumor in an adult
Jaehoon Shin, Ji Heui Kim, Kyeong Cheon Jung, Kyung-Ja Cho
J Pathol Transl Med. 2022;56(3):152-156.   Published online January 26, 2022
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AbstractAbstract PDF
Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.


Citations to this article as recorded by  
  • Yolk sac tumor of postpubertal-type does not exhibit immunohistochemical loss of SMARCB1/INI1 and SMARCA4/BRG1…but choriocarcinoma?
    Costantino Ricci, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Eugenia Franchini, Francesco Massari, Veronica Mollica, Federico Mineo Bianchi, Maurizio Colecchia, Andres Martin Acosta, Michelangelo Fiorentino
    Pathology - Research and Practice.2023; 241: 154269.     CrossRef
  • A Novel Successful Case of Nasal and Sinus Yolk Sac Tumor With SMARCB1 (INI-1) Deficiency: A Case Report
    Tianyu He, Zhiyu Wang, Hongbo Su, Sihan Li, Zheng He
    Cureus.2022;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine