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Joo Han Lim 2 Articles
Prognostic Implication of Semi-quantitative Immunohistochemical Assessment of CD20 Expression in Diffuse Large B-Cell Lymphoma
Chang Hwan Choi, Young Hoon Park, Joo Han Lim, Suk Jin Choi, Lucia Kim, In Suh Park, Jee Young Han, Joon Mee Kim, Young Chae Chu
J Pathol Transl Med. 2016;50(2):96-103.   Published online February 15, 2016
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  • 102 Download
  • 11 Citations
AbstractAbstract PDF
Immunohistochemical demonstration of CD20 in diffuse large B-cell lymphoma (DLBCL) is prerequisite not only for the diagnosis but also for assigning patients to rituximab-containing chemotherapy. However, little is known about the impact of abundance of CD20 expression assessed by immunohistochemistry on the clinical outcome of DLBCL. We performed a semi-quantitative immunohistochemical analysis of CD20 expression in DLBCL to examine the prognostic implication of the level of CD20 expression. Methods: Pre-treatment diagnostic tissue samples from 48 DLBCL patients who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen were represented in a tissue microarray and immunostained for CD20. The relative abundance of CD20 expression was semi-quantitatively scored using a web-based ImmunoMembrane plug-in. Receiver operating characteristic curve analysis was used to determine a prognostically relevant cut-off score in order to dichotomize the patients into CD20-high versus CD20-low groups. Results: The levels of CD20 expression were heterogeneous among the patients, with a wide and linear distribution of scores. Patients in CD20-low group showed significantly poor clinical outcome. Conclusions: The levels of CD20 expression in DLBCL are heterogeneous among the patients with DLBCL. A subgroup of the patients with CD20 expression levels below the cut-off score showed poor clinical outcome.


Citations to this article as recorded by  
  • Prognostic molecular biomarkers in diffuse large B-cell lymphoma in the rituximab era and their therapeutic implications
    Sotirios G. Papageorgiou, Thomas P. Thomopoulos, Ioannis Katagas, Anthi Bouchla, Vassiliki Pappa
    Therapeutic Advances in Hematology.2021; 12: 204062072110139.     CrossRef
  • Novel tumour–infiltrating lymphocyte-related risk stratification based by flow cytometry for patients with de novo angioimmunoblastic T cell lymphoma
    Qiqi Zhu, Xueqin Deng, Wenqing Yao, Zihang Chen, Yunxia Ye, Limin Gao, Wenyan Zhang, Weiping Liu, Sha Zhao
    Annals of Hematology.2021; 100(3): 715.     CrossRef
  • Induced CD20 Expression on B-Cell Malignant Cells Heightened the Cytotoxic Activity of Chimeric Antigen Receptor Engineered T Cells
    Yingxi Xu, Saisai Li, Ying Wang, Jia Liu, Xinhe Mao, Haiyan Xing, Zheng Tian, Kejing Tang, Xiaolong Liao, Qing Rao, Dongsheng Xiong, Min Wang, Jianxiang Wang
    Human Gene Therapy.2019; 30(4): 497.     CrossRef
  • Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma
    Xing Dai, Yu-Jing Wu, Xiao-Yi Jia, Yan Chang, Hua-Xun Wu, Chun Wang, Wei Wei
    Hematology.2019; 24(1): 544.     CrossRef
  • The implications of TrkA and MET aberrations in de novo salivary duct carcinoma
    Hyang Joo Ryu, Yoon Woo Koh, Sun Och Yoon
    Human Pathology.2018; 81: 18.     CrossRef
  • Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity
    Hyang Joo Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
    Head & Neck.2018;[Epub]     CrossRef
  • Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL
    Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Lauren F. Raney, Paula L. Pinzon, Olga C. Lozano, Alba M. Campos, Niyireth Peñaloza, Julio Solano, Maria V. Herrera, Jovanny Zabaleta, Sandra Quijano
    Journal of Experimental & Clinical Cancer Research.2017;[Epub]     CrossRef
  • Implications of infiltrating immune cells within bone marrow of patients with diffuse large B-cell lymphoma
    Juhyeon Jeong, Eun Ji Oh, Woo Ick Yang, Soo Jeong Kim, Sun Och Yoon
    Human Pathology.2017; 64: 222.     CrossRef
  • Architectural patterns of p16 immunohistochemical expression associated with cancer immunity and prognosis of head and neck squamous cell carcinoma
    Hyang Joo Ryu, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Sun Och Yoon
    APMIS.2017; 125(11): 974.     CrossRef
  • New developments in the pathology of malignant lymphoma. A review of the literature published from January–April 2016
    J. Han van Krieken
    Journal of Hematopathology.2016; 9(2): 73.     CrossRef
  • Diffuse large B-cell lymphoma: R-CHOP failure—what to do?
    Bertrand Coiffier, Clémentine Sarkozy
    Hematology.2016; 2016(1): 366.     CrossRef
The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
Korean J Pathol. 2014;48(4):263-269.   Published online August 26, 2014
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  • 48 Download
  • 10 Citations
AbstractAbstract PDF

Epithelial mesenchymal transition (EMT) has an important role in invasion and metastasis of tumor cells. The purpose of this study was to evaluate the roles of EMT-associated proteins on progression and metastasis as a prognostic/predictive factor in curatively-resected (R0) head and neck squamous cell carcinoma (HNSCC).


A total of 118 patients who received curative surgery for HNSCC at Inha University Hospital between January 1996 and December 2011 were included. We used protein immunohistochemistry to evaluate the expression of E-cadherin, vimentin, and EZH2 on tissue microarrays. Also, we reviewed all medical records and analyzed the relationship between the expression of EMT-associated proteins and prognosis.


The E-cadherin-negative group showed more moderate/poor differentiation of cancer cell type than the higher E-cadherin-expressing group (p=.016) and high EZH2 expression was significantly correlated with nodal metastasis (p=.012). Our results demonstrate a significant association between high expression of EZH2 and vimentin and presence of distant progression (p=.026). However, expression of E-cadherin, vimentin, and EZH2 was not significantly associated with overall survival.


These findings suggest that an EMT-associated protein expression profile is correlated with aggressiveness of disease and prognosis, and could be a useful marker for determination of additional treatment in curatively-resected HNSCC patients.


Citations to this article as recorded by  
  • Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer
    Samar M. Abdel Raouf, Taiseer R. Ibrahim, Lobna A. Abdelaziz, Mohamed I. Farid, Salem Y Mohamed
    Journal of Gastrointestinal Cancer.2021; 52(1): 90.     CrossRef
  • HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin signaling axis
    Kyungmin Lee, Jae Won Chang, Chan Oh, Lihua Liu, Seung-Nam Jung, Ho-Ryun Won, Young Il Kim, Ki-Sang Rha, Bon Seok Koo
    European Journal of Surgical Oncology.2020; 46(6): 1066.     CrossRef
  • EZH2 overexpression in head and neck cancer is related to lymph node metastasis
    Julie C. Nienstedt, Cornelia Schroeder, Till Clauditz, Ronald Simon, Guido Sauter, Adrian Muenscher, Marco Blessmann, Henning Hanken, Christina Pflug
    Journal of Oral Pathology & Medicine.2018; 47(3): 240.     CrossRef
  • MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
    Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu, Xiaomeng Song
    Cancer Cell International.2018;[Epub]     CrossRef
  • HMGA2 is associated with the aggressiveness of tongue squamous cell carcinoma
    H Zhang, Z Tang, C Deng, Y He, F Wu, O Liu, C Hu
    Oral Diseases.2017; 23(2): 255.     CrossRef
  • miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin
    Lizandra Jimenez, Jihyeon Lim, Berta Burd, Thomas M. Harris, Thomas J. Ow, Nicole Kawachi, Thomas J. Belbin, Ruth Angeletti, Michael B. Prystowsky, Geoffrey Childs, Jeffrey E. Segall
    The American Journal of Pathology.2017; 187(7): 1523.     CrossRef
  • Functional and therapeutic significance of EZH2 in urological cancers
    Xiaobing Liu, Qingjian Wu, Longkun Li
    Oncotarget.2017; 8(23): 38044.     CrossRef
  • EZH2, an on–off valve in signal network of tumor cells
    Shanshan Sun, Feng Yu, Lun Zhang, Xuan Zhou
    Cellular Signalling.2016; 28(5): 481.     CrossRef
  • High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
    Si-Hyong Jang, Jong Eun Lee, Mee-Hye Oh, Ji-Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee
    Journal of Breast Cancer.2016; 19(1): 53.     CrossRef
  • EZH2 promotes invasion and metastasis of laryngeal squamous cells carcinoma via epithelial-mesenchymal transition through H3K27me3
    HuaNan Luo, Yuan Jiang, SiJing Ma, HuanHuan Chang, ChunXi Yi, Hui Cao, Ying Gao, HaiLi Guo, Jin Hou, Jing Yan, Ying Sheng, XiaoYong Ren
    Biochemical and Biophysical Research Communications.2016; 479(2): 253.     CrossRef

JPTM : Journal of Pathology and Translational Medicine