- Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer
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Sung Gwe Ahn, Joon Jeong, SoonWon Hong, Woo Hee Jung
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J Pathol Transl Med. 2015;49(5):355-363. Published online August 17, 2015
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DOI: https://doi.org/10.4132/jptm.2015.07.29
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- With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly considered in research or practice, tumor-infiltrating lymphocytes (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studies have provided evidence that the level of TILs has prognostic value and the potential for predictive value, particularly in triple-negative and human epidermal growth factor receptor 2–positive breast cancer. Moreover, the level of TILs has been associated with treatment outcome in patients undergoing neoadjuvant chemotherapy. To date, no standardized methodology for measuring TILs has been established. In this article, we review current issues and clinical evidence for the use of TILs in breast cancer.
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- Primary Mucinous Cystadenocarcinoma of the Breast: Cytologic Finding and Expression of MUC5 Are Different from Mucinous Carcinoma
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Sung Eun Kim, Ji Hye Park, SoonWon Hong, Ja Seung Koo, Joon Jeong, Woo-Hee Jung
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Korean J Pathol. 2012;46(6):611-616. Published online December 26, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.611
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6,648
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Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA. -
Citations
Citations to this article as recorded by - Mammary mucinous cystadenocarcinoma with long-term follow-up: molecular information and literature review
Ting Lei, Yong Qiang Shi, Tong Bing Chen
Diagnostic Pathology.2023;[Epub] CrossRef - Special Histologic Type and Rare Breast Tumors – Diagnostic Review and Clinico-Pathological Implications
Benjamin Yongcheng Tan, Elaine Hsuen Lim, Puay Hoon Tan
Surgical Pathology Clinics.2022; 15(1): 29. CrossRef - Mucinous cystadenocarcinoma of the breast: a new entity with broad differentials—a case report
Kanwalpreet Kaur, Ashini Shah, Jahnvi Gandhi, Priti Trivedi
Journal of the Egyptian National Cancer Institute.2022;[Epub] CrossRef - Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
Minjung Jung
Kosin Medical Journal.2022; 37(3): 176. CrossRef - Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature
Ekta Jain, Abhishek Kumar, Raajul Jain, Shivani Sharma
International Journal of Surgical Pathology.2021; 29(7): 740. CrossRef - Mucinous Cystadenocarcinoma of the Breast: Report of 2 Cases Including One With Long-Term Local Recurrence
Anupma Nayak, Ira J. Bleiweiss, Kimberly Dumoff, Tawfiqul A. Bhuiya
International Journal of Surgical Pathology.2018; 26(8): 749. CrossRef - Mucinous breast carcinoma with tall columnar cells
N Tsoukalas, M Kiakou, M Tolia, ID Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
The Annals of The Royal College of Surgeons of England.2018; 100(5): e132. CrossRef - Radiologic Findings of Primary Mucinous Cystadenocarcinoma of the Breast: A Report of Two Cases and a Literature Review
Minjung Seong, Eun Young Ko, Boo-Kyung Han, Soo Youn Cho, Eun Yoon Cho, Se Kyung Lee, Jeong Eon Lee
Journal of Breast Cancer.2016; 19(3): 330. CrossRef - Primary Mucinous Cystadenocarcinoma of the Breast with Endocervical-Like Mucinous Epithelium
Dong-Liang Lin, Ji-Lin Hu, Shi-Hong Shao, Dong-Mei Sun, Ji-Gang Wang
Breast Care.2013; 8(6): 445. CrossRef
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