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Joon-Mee Kim 2 Articles
Cytological Findings of the Micropapillary Variant of Urothelial Carcinoma: A Comparison with Typical High-Grade Urothelial Carcinoma
Kyu-Ho Kim, Chang-Hwan Choi, Jee-Young Han, Lucia Kim, Suk-Jin Choi, In-Suh Park, Joon-Mee Kim, Young-Chae Chu
Korean J Pathol. 2013;47(4):365-371.   Published online August 26, 2013
  • 5,474 View
  • 37 Download
  • 4 Citations
AbstractAbstract PDF

Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC).


The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli.


Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli.


The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei than that of HGUC. These features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.


Citations to this article as recorded by  
  • Cytologic features of micropapillary variant urothelial carcinoma in urinary tract cytology: Case series and review of literature
    Nancy Y. Greenland, Yue Peng, Poonam Vohra, Z. Laura Tabatabai
    Diagnostic Cytopathology.2022;[Epub]     CrossRef
  • Cyto-histo correlations of plasmacytoid and micropapillary variants of high-grade urothelial carcinoma: do they fit well in The Paris System for reporting urinary cytology?
    Liye Suo, Ivonne Vega, Michael Thrall
    Journal of the American Society of Cytopathology.2021; 10(1): 20.     CrossRef
  • A case report of urothelial carcinoma with combined micropapillary and plasmacytoid morphology in the urinary bladder
    Sanghui Park, Min-Sun Cho, Kwang Hyun Kim
    Diagnostic Cytopathology.2016; 44(2): 124.     CrossRef
  • Two cases with the micropapillary variant of urothelial carcinoma of the urinary bladder
    Akiko KAGOTANI, Mitsuaki ISHIDA, Muneo IWAI, Nozomi IWAMOTO, Nozomi KASUGA, Yuji HAYASHI, Yoshimitsu MIYAHIRA, Ryoji KUSHIMA
    The Journal of the Japanese Society of Clinical Cytology.2016; 55(3): 165.     CrossRef
Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
Jee-Young Han, Kyu-Ho Kim, Lucia Kim, Suk-Jin Choi, In-Suh Park, Joon-Mee Kim, Young-Chae Chu, Sang-Min Yoon
Korean J Pathol. 2012;46(2):210-214.   Published online April 25, 2012
  • 6,951 View
  • 44 Download
  • 3 Citations
AbstractAbstract PDF

Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of primary clear cell adenocarcinoma of the female urethra with its cytological findings. A 54-year-old woman presented with a painless gross hematuria lasting 3 months. On vaginal sonography, there was a sausage-like, elongated mass in the urethra, measuring 3.8×4.3 cm. The voided urine cytology revealed small clusters of rounded or papillary cells. The necrotic debris and inflammatory cells were present within some clusters of tumor cells. These tumor cells were enlarged and had abundant clear or granular cytoplasm with cytoplasmic vacuoles. The nucleus was granular and contained vesicular chromatin with prominent nucleoli. The hobnail cells and hyaline globules were also present as in a histologic section. The histologic findings were compatible with clear cell adenocarcinoma. The tumor showed distinctive cytological features. Cytologically, however, it is necessary to make a differential diagnosis from other adenocarcinoma or high-grade urothelial carcinoma.


Citations to this article as recorded by  
  • Cytological and histological findings of upper tract mucinous urothelial carcinoma with clear cell component: A case report and review of literature
    Go Kobayashi, Naohiro Uraoka, Kazuhiro Sentani, Jun Shibata, Ryosuke Nobuhiro, Yoichi Saito, Daiki Taniyama, Masanori Hanamoto, Hiroyuki Nose, Naohide Oue
    Diagnostic Cytopathology.2022;[Epub]     CrossRef
  • Presentación de reporte de caso: adenocarcinoma de célula clara de uretra
    Nataly González, Yuly Ramirez, Jose Szelezsán, Daniel Rojas
    Revista Urología Colombiana / Colombian Urology Journal.2018; 27(02): 191.     CrossRef
  • Clear Cell Adenocarcinoma of the Urethra: Review of the Literature
    Anthony Kodzo-Grey Venyo
    International Journal of Surgical Oncology.2015; 2015: 1.     CrossRef

JPTM : Journal of Pathology and Translational Medicine