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Jun Sang Bae 4 Articles
Immunohistochemical Expression and Clinical Significance of Suggested Stem Cell Markers in Hepatocellular Carcinoma
Jong Jin Sung, Sang Jae Noh, Jun Sang Bae, Ho Sung Park, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon
J Pathol Transl Med. 2016;50(1):52-57.   Published online November 18, 2015
DOI: https://doi.org/10.4132/jptm.2015.10.09
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  • 11 Citations
AbstractAbstract PDF
Background
Increasing evidence has shown that tumor initiation and growth are nourished by a small subpopulation of cancer stem cells (CSCs) within the tumor mass. CSCs are posited to be responsible for tumor maintenance, growth, distant metastasis, and relapse after curative operation. We examined the expression of CSC markers in paraffin-embedded tissue sections of hepatocellular carcinoma (HCC) and correlated the results with clinicopathologic characteristics. Methods: Immunohistochemical staining for the markers believed to be expressed in the CSCs, including epithelial cell adhesion molecule (EpCAM), keratin 19 (K19), CD133, and CD56, was performed in 82 HCC specimens. Results: EpCAM expression was observed in 56% of the HCCs (46/82) and K19 in 6% (5/82). EpCAM expression in HCC significantly correlated with elevated α-fetoprotein level, microvessel invasion of tumor cells, and high histologic grade. In addition, Ep- CAM expression significantly correlated with K19 expression. The overall survival and relapsefree survival rates in patients with EpCAM-expressing HCC were relatively lower than those in patients with EpCAM-negative HCC. All but two of the 82 HCCs were negative for CD133 and CD56, respectively. Conclusions: Our results suggest that HCCs expressing EpCAM are associated with unfavorable prognostic factors and have a more aggressive clinical course than those not expressing EpCAM. Further, the expression of either CD133 or CD56 in paraffin-embedded HCC tissues appears to be rare.

Citations

Citations to this article as recorded by  
  • The clinical, prognostic and therapeutic significance of liver cancer stem cells and their markers
    Izabela Zarębska, Arkadiusz Gzil, Justyna Durślewicz, Damian Jaworski, Paulina Antosik, Navid Ahmadi, Marta Smolińska-Świtała, Dariusz Grzanka, Łukasz Szylberg
    Clinics and Research in Hepatology and Gastroenterology.2021; 45(3): 101664.     CrossRef
  • Detection of oncogenic mutations in paired circulating tumor DNA and circulating tumor cells in patients with hepatocellular carcinoma
    Zhouhong Ge, Jean C.A. Helmijr, Maurice P.H.M. Jansen, Patrick P.C. Boor, Lisanne Noordam, Maikel Peppelenbosch, Jaap Kwekkeboom, Jaco Kraan, Dave Sprengers
    Translational Oncology.2021; 14(7): 101073.     CrossRef
  • Hepatocellular Carcinoma Score and Subclassification Into Aggressive Subtypes Using Immunohistochemical Expression of p53, β-Catenin, CD133, and Ki-67
    Asmaa G. Abdou, Nanis S. Holah, Dina S. Elazab, Walaa G. El-Gendy, Mohammed T. Badr, Dalia R. Al-Sharaky
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(1): 20.     CrossRef
  • The prognostic significance of neuroendocrine markers and somatostatin receptor 2 in hepatocellular carcinoma
    Keigo Murakami, Hiroyuki Kumata, Shigehito Miyagi, Takashi Kamei, Hironobu Sasano
    Pathology International.2021; 71(10): 682.     CrossRef
  • Predictors of recurrence and survival of hepatocellular carcinoma: A prospective study including transient elastography and cancer stem cell markers
    Hend Ibrahim Shousha, Rabab Fouad, Tamer Mahmoud Elbaz, Dina Sabry, Mohamed Mahmoud Nabeel, Ahmed Hosni Abdelmaksoud, Aisha Mahmoud Elsharkawy, Zeinab Abdellatif Soliman, Ghada Habib, Ashraf Omar Abdelaziz
    Arab Journal of Gastroenterology.2020; 21(2): 95.     CrossRef
  • Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma
    Ya Li, Qiuju Han, Huajun Zhao, Quanjuan Guo, Jian Zhang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations
    An B. Luong, Huy Q. Do, Paola Tarchi, Deborah Bonazza, Cristina Bottin, Loraine Kay D. Cabral, Long D. C. Tran, Thao P. T. Doan, Lory S. Crocè, Hoa L. T. Pham, Claudio Tiribelli, Caecilia H. C. Sukowati
    Cells.2020; 9(12): 2672.     CrossRef
  • Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma
    Hirohisa Okabe, Tomoharu Yoshizumi, Yo-ichi Yamashita, Katsunori Imai, Hiromitsu Hayashi, Shigeki Nakagawa, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Toru Beppu, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara, Motoyuki
    PLOS ONE.2018; 13(9): e0203856.     CrossRef
  • Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma
    Chih‑Jan Ko, Chia‑Jung Li, Meng‑Yu Wu, Pei‑Yi Chu
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Clinicopathologic Significance of Survivin Expression in Relation to CD133 Expression in Surgically Resected Stage II or III Colorectal Cancer
    Wanlu Li, Mi-Ra Lee, EunHee Choi, Mee-Yon Cho
    Journal of Pathology and Translational Medicine.2017; 51(1): 17.     CrossRef
  • PIN1 in hepatocellular carcinoma is associated with TP53 gene status
    Jun Sang Bae, Sang Jae Noh, Kyoung Min Kim, Kyu Yun Jang, Ho Sung Park, Myoung Ja Chung, Byung-Hyun Park, Woo Sung Moon
    Oncology Reports.2016; 36(4): 2405.     CrossRef
Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication
Yo Na Kim, Ji Eun Choi, Jun Sang Bae, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Ho Sung Park
Korean J Pathol. 2012;46(5):454-462.   Published online October 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.454
  • 6,690 View
  • 36 Download
  • 7 Citations
AbstractAbstract PDF
Background

Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.

Methods

The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.

Results

Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.

Conclusions

Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.

Citations

Citations to this article as recorded by  
  • Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk
    Lik Hang Lee, Lindy Davis, Lourdes Ylagan, Angela R Omilian, Kristopher Attwood, Canan Firat, Jinru Shia, Philip B Paty, William G Cance
    JNCI: Journal of the National Cancer Institute.2022; 114(5): 732.     CrossRef
  • Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer
    Seyed-Mohammad Mazloomi, Mitra Foroutan-Ghaznavi, Vahid Montazeri, Gholamreza Tavoosidana, Ashraf Fakhrjou, Hojjatollah Nozad-Charoudeh, Saeed Pirouzpanah
    Cancer Cell International.2021;[Epub]     CrossRef
  • PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation
    Dan Tan, Wenpeng Zhang, Yu Tao, Yesseyeva Galiya, Mingliang Wang
    Acta Biochimica et Biophysica Sinica.2019; 51(4): 356.     CrossRef
  • Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells
    Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage, Konrad Steinestel
    Cancer Cell International.2019;[Epub]     CrossRef
  • Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway
    Xiaojian Zhang, Kun Liu, Tao Zhang, Zhenlei Wang, Xuan Qin, Xiaoqian Jing, Haoxuan Wu, Xiaopin Ji, Yonggang He, Ren Zhao
    Oncotarget.2017; 8(1): 1541.     CrossRef
  • Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis
    Xiao-Qing Zeng, Na Li, Li-Li Ma, Yu-Jen Tseng, Nai-Qing Zhao, Shi-Yao Chen, Han-Chung Wu
    PLOS ONE.2016; 11(9): e0162666.     CrossRef
  • Regulators of Actin Dynamics in Gastrointestinal Tract Tumors
    Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald
    Gastroenterology Research and Practice.2015; 2015: 1.     CrossRef
Expression of CHOP in Squamous Tumor of the Uterine Cervix
Hyun Hee Chu, Jun Sang Bae, Kyoung Min Kim, Ho Sung Park, Dong Hyu Cho, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Myoung Ja Chung
Korean J Pathol. 2012;46(5):463-469.   Published online October 25, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.463
  • 6,938 View
  • 37 Download
  • 5 Citations
AbstractAbstract PDF
Background

High-risk human papillomavirus (HR-HPV) infection and abnormal p53 expression are closely involved in carcinogenesis of squamous cell carcinoma (SqCC) of uterine cervix. Recent studies have suggested that virus-induced endoplasmic reticulum (ER) stress modulates various cell survival and cell death signaling pathways. The C/EBP homologous protein (CHOP) is associated with ER stress-mediated apoptosis and is also involved in carcinogenesis of several human cancers. We hypothesized that CHOP is involved in the carcinogenesis of uterine cervical cancer in association with HR-HPV and/or p53.

Methods

Immunohistochemistry was used to analyze CHOP and p53 protein expression of tissue sections from 191 patients with invasive cancer or preinvasive lesions of the uterine cervix (61 cases of SqCC, 66 cases of cervical intraepithelial neoplasia [CIN] III, and 64 cases of CIN I).

Results

CHOP was expressed in 59.4% of CIN I, 48.5% of CIN III, and 70.5% of SqCC cases. It was also significantly more frequent in invasive SqCC than in preinvasive lesions (p=0.042). Moreover, CHOP expression significantly correlated with HR-HPV infection and p53 expression (p=0.009 and p=0.038, respectively).

Conclusions

Our results suggest that CHOP is involved in the carcinogenesis of the uterine cervix SqCC via association with HR-HPV and p53.

Citations

Citations to this article as recorded by  
  • Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology
    Elif Guzel, Sefa Arlier, Ozlem Guzeloglu-Kayisli, Mehmet Tabak, Tugba Ekiz, Nihan Semerci, Kellie Larsen, Frederick Schatz, Charles Lockwood, Umit Kayisli
    International Journal of Molecular Sciences.2017; 18(4): 792.     CrossRef
  • Endoplasmic reticulum stress pathway PERK-eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF-κB
    Qiao Qiao, Chaonan Sun, Chuyang Han, Ning Han, Miao Zhang, Guang Li
    Cancer Science.2017; 108(7): 1421.     CrossRef
  • Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells
    Boyun Kim, Hee Seung Kim, Eun-Ji Jung, Jung Yun Lee, Benjamin K. Tsang, Jeong Mook Lim, Yong Sang Song
    Molecular Carcinogenesis.2016; 55(5): 918.     CrossRef
  • Down-regulation of C/EBP homologous protein (CHOP) expression in gastric cardia adenocarcinoma: Their relationship with clinicopathological parameters and prognostic significance
    Xiao-Juan Zhu, She-Gan Gao, San-Qiang Li, Zhen-Guo Shi, Zhi-Kun Ma, Shan-Shan Zhu, Xiao-Shan Feng
    Clinics and Research in Hepatology and Gastroenterology.2015; 39(3): 391.     CrossRef
  • MG289 in <i>Mycoplasma genitalium</i> Enhances Microbial Invasion and Bacterial Persistence in Benign Human Prostate Cells
    Wasia Rizwani, Leticia Reyes, Jeongsoon Kim, Steve Goodison, Charles J. Rosser
    Open Journal of Urology.2013; 03(06): 232.     CrossRef
Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication
Tack Kune You, Kyoung Min Kim, Sang Jae Noh, Jun Sang Bae, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Ho Sung Park
Korean J Pathol. 2012;46(4):331-340.   Published online August 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.331
  • 6,841 View
  • 51 Download
  • 13 Citations
AbstractAbstract PDF
Background

E-cadherin, cortactin, and matrix metalloproteinase (MMP)-9 have roles in tumor development or progression, but their expression has not been fully investigated in pseudoepitheliomatous hyperplasia (PEH) and squamous cell carcinoma (SCC) of the head and neck.

Methods

We evaluated the immunohistochemical expression of E-cadherin, cortactin, and MMP-9 in 29 cases of PEH and 97 cases of SCC. Additionally, we evaluated their relationship with clinicopathologic factors and prognostic implications in SCC.

Results

Thirty-five cases of SCC showed reduced expression of E-cadherin, whereas none of the PEH did. A total of 20 cases and 11 cases of SCC were immunoreactive for cortactin and MMP-9, respectively, whereas none of the PEH did. In SCC, reduced expression of E-cadherin was correlated with cortactin expression and invasion depth. Cortactin expression was correlated with differentiation, T classification, and recurrence and/or metastasis. MMP-9 expression was correlated with invasion depth. Cortactin expression was correlated with poor overall survival and relapse-free survival and it was an independent prognostic factor.

Conclusions

The reduced expression of E-cadherin and the expression of cortactin may be helpful for the differential diagnosis of PEH and SCC. Furthermore, cortactin expression in association with reduced E-cadherin expression is correlated with poor prognosis in SCC.

Citations

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    Sharof Tugizov
    Tissue Barriers.2021;[Epub]     CrossRef
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    Ricardo Tadeu Villa
    Journal of Dermatology & Cosmetology.2021; 5(2): 23.     CrossRef
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  • Prognostic and clinicopathological significance of CTTN /cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis
    Pablo Ramos‐García, Miguel Ángel González‐Moles, Ángela Ayén, Lucía González‐Ruiz, Isabel Ruiz‐Ávila, José Antonio Gil‐Montoya
    Head & Neck.2019; 41(6): 1963.     CrossRef
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    Oncotarget.2017; 8(50): 88232.     CrossRef
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    Oncology Letters.2016; 11(1): 782.     CrossRef
  • Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
    Sang Jae Noh, Hyun Ah Baek, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Min Ho Kim, Ju Hyung Lee, Myoung Ja Chung
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JPTM : Journal of Pathology and Translational Medicine