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Ki Hyung Kim 2 Articles
Prognostic Significance of CD109 Expression in Patients with Ovarian Epithelial Cancer
So Young Kim, Kyung Un Choi, Chungsu Hwang, Hyung Jung Lee, Jung Hee Lee, Dong Hoon Shin, Jee Yeon Kim, Mee Young Sol, Jae Ho Kim, Ki Hyung Kim, Dong Soo Suh, Byung Su Kwon
J Pathol Transl Med. 2019;53(4):244-252.   Published online May 2, 2019
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  • 113 Download
  • 3 Citations
AbstractAbstract PDF
Ovarian epithelial cancer (OEC) is the second-most common gynecologic malignancy. CD109 expression is elevated in human tumor cell lines and carcinomas. A previous study showed that CD109 expression is elevated in human tumor cell lines and CD109 plays a role in cancer progression. Therefore, this study aimed to determine whether CD109 is expressed in OEC and can be useful in predicting the prognosis.
Immunohistochemical staining for CD109 and reverse transcription-quantitative polymerase chain reaction was performed. Then we compared CD109 expression and chemoresistance, overall survival, and recurrence-free survival of OEC patients. Chemoresistance was evaluated by dividing into good-response group and poor-response group by the time to recurrence after chemotherapy.
CD109 expression was associated with overall survival (p = .020), but not recurrence-free survival (p = .290). CD109 expression was not an independent risk factor for overall survival due to its reliability (hazard ratio, 1.58; p = .160; 95% confidence interval, 0.82 to 3.05), although we found that CD109 positivity was related to chemoresistance. The poor-response group showed higher rates of CD109 expression than the good-response group (93.8% vs 66.7%, p = .047). Also, the CD109 mRNA expression level was 2.88 times higher in the poor-response group as compared to the good-response group (p = .001).
Examining the CD109 expression in patients with OEC may be helpful in predicting survival and chemotherapeutic effect.


Citations to this article as recorded by  
  • CD109 facilitates progression and 5-fluorouracil resistance of nasopharyngeal carcinoma
    Zhenwei Zhu, Fang Zhou, Cheng Mao
    Materials Express.2022; 12(9): 1189.     CrossRef
  • Usefulness of CD109 expression as a prognostic biomarker in patients with cancer
    Hyun Min Koh, Hyun Ju Lee, Dong Chul Kim
    Medicine.2021; 100(11): e25006.     CrossRef
  • Serum CD109 levels reflect the node metastasis status in head and neck squamous cell carcinoma
    Sumitaka Hagiwara, Eiichi Sasaki, Yasuhisa Hasegawa, Hidenori Suzuki, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe, Masahide Takahashi, Nobuhiro Hanai
    Cancer Medicine.2021; 10(4): 1335.     CrossRef
The Role of TWIST in Ovarian Epithelial Cancers
Kyungbin Kim, Eun Young Park, Man Soo Yoon, Dong Soo Suh, Ki Hyung Kim, Jeong Hee Lee, Dong Hoon Shin, Jee Yeon Kim, Mee Young Sol, Kyung Un Choi
Korean J Pathol. 2014;48(4):283-291.   Published online August 26, 2014
  • 6,488 View
  • 39 Download
  • 10 Citations
AbstractAbstract PDF

Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.


We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters.


The expression of TWIST, E-cadherin, HIF1α, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1α expression and reduced E-cadherin expression. The altered HIF1α/TWIST/E-cadherin pathway was associated with lower overall survival (OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS.


Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia-mediated EMT, which involves the HIF1α/TWIST/E-cadherin pathway may play an important role in the progression of OEC.


Citations to this article as recorded by  
  • E-Cadherin Expression in Relation to Clinicopathological Parameters and Survival of Patients with Epithelial Ovarian Cancer
    Michal Kielbik, Izabela Szulc-Kielbik, Magdalena Klink
    International Journal of Molecular Sciences.2022; 23(22): 14383.     CrossRef
  • Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer
    Danchen Wu, Asish Dasgupta, Austin D. Read, Rachel E.T. Bentley, Mehras Motamed, Kuang-Hueih Chen, Ruaa Al-Qazazi, Jeffrey D. Mewburn, Kimberly J. Dunham-Snary, Elahe Alizadeh, Lian Tian, Stephen L. Archer
    Free Radical Biology and Medicine.2021; 170: 150.     CrossRef
  • Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
    Shing Yau Tam, Vincent W. C. Wu, Helen K. W. Law
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Expression of selected epithelial–mesenchymal transition transcription factors in serous borderline ovarian tumors and type I ovarian cancers
    Pawel Sadlecki, Jakub Jóźwicki, Paulina Antosik, Marek Grabiec
    Tumor Biology.2018; 40(6): 101042831878480.     CrossRef
  • Expression and prognostic significance of epithelial-mesenchymal transition-related markers and phenotype in serous ovarian cancer
    In Hye Song, Kyu-Rae Kim, Sehun Lim, Seok-Hyung Kim, Chang Ohk Sung
    Pathology - Research and Practice.2018; 214(10): 1564.     CrossRef
  • Transcription factors controlling E-cadherin down-regulation in ovarian cancer
    Holly Russell, Md Zahidul Islam Pranjol
    Bioscience Horizons: The International Journal of Student Research.2018;[Epub]     CrossRef
  • Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF‐κB‐mediated IKKβ expression
    Yi‐Hui Wu, Yu‐Fang Huang, Tzu‐Hao Chang, Cheng‐Yang Chou
    International Journal of Cancer.2017; 141(11): 2305.     CrossRef
  • MicroRNA-219-5p inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells by targeting the Twist/Wnt/β-catenin signaling pathway
    Chunyan Wei, Xi Zhang, Sai He, Bianli Liu, Hongfang Han, Xuejun Sun
    Gene.2017; 637: 25.     CrossRef
  • Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism
    Zi Chen, Dongwen Xu, Tao Zhang
    International Journal of Oncology.2017; 51(3): 851.     CrossRef
  • Is overexpression of TWIST, a transcriptional factor, a prognostic biomarker of head and neck carcinoma? Evidence from fifteen studies
    Xianlu Zhuo, Huanli Luo, Aoshuang Chang, Dairong Li, Houyu Zhao, Qi Zhou
    Scientific Reports.2015;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine