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Kristina Anna Bethania 1 Article
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type
Primariadewi Rustamadji, Elvan Wiyarta, Kristina Anna Bethania, Kusmardi Kusmardi
J Pathol Transl Med. 2021;55(4):271-278.   Published online June 14, 2021
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  • 4 Citations
AbstractAbstract PDF
Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST.
Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives.
Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity).
AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies.


Citations to this article as recorded by  
  • Exploring the Expression of Survivin on Neoadjuvant Chemotherapy in Invasive Breast Carcinoma
    Primariadewi Rustamadji, Elvan Wiyarta, Ineke Anggreani
    Open Access Macedonian Journal of Medical Sciences.2022; 10(B): 1440.     CrossRef
  • Effect of Omega-3-Rich Fish Oil on TNF-  Expression in Mice's Colonic Tissue Induced with Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS)
    Elvan Wiyarta, Kusmardi Kusmardi, Yurnadi Hanafi Midoen
    Research Journal of Pharmacy and Technology.2022; : 3179.     CrossRef
  • The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1
    Kusmardi Kusmardi, Elvan Wiyarta, Numlil Khaira Rusdi, Andi Muh. Maulana, Ari Estuningtyas, Hadi Sunaryo
    F1000Research.2021; 10: 902.     CrossRef
  • CD44 Variant Exon 6 Isoform Expression as a Potential Predictor of Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type
    Primariadewi Rustamadji, Elvan Wiyarta, Kristina A. Bethania, Rakesh Sathish Nair
    International Journal of Breast Cancer.2021; 2021: 1.     CrossRef

JPTM : Journal of Pathology and Translational Medicine