- Molecular Testing for Gastrointestinal Cancer
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Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
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J Pathol Transl Med. 2017;51(2):103-121. Published online February 19, 2017
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DOI: https://doi.org/10.4132/jptm.2017.01.24
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- With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wildtype RAS (KRAS and NRAS exon 2–4). A BRAF mutation is required for predicting poor prognosis. Additionally, amplification of human epidermal growth factor receptor 2 (HER2) and MET is also associated with resistance to EGFR inhibitor in metastatic CRC patients. The BRAF V600E mutation is found in sporadic microsatellite unstable CRCs, and thus is helpful for ruling out Lynch syndrome. In addition, the KRAS mutation is a prognostic biomarker and the PIK3CA mutation is a molecular biomarker predicting response to phosphoinositide 3-kinase/AKT/mammalian target of rapamycin inhibitors and response to aspirin therapy in CRC patients. Additionally, HER2 testing should be performed in all recurrent or metastatic GCs. If the results of HER2 immunohistochemistry are equivocal, HER2 silver or fluorescence in situ hybridization testing are essential for confirmative determination of HER2 status. Epstein-Barr virus–positive GCs have distinct characteristics, including heavy lymphoid stroma, hypermethylation phenotype, and high expression of immune modulators. Recent advances in next-generation sequencing technologies enable us to examine various genetic alterations using a single test. Pathologists play a crucial role in ensuring reliable molecular testing and they should also take an integral role between molecular laboratories and clinicians.
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- Fine Needle Aspiration Cytology of Hepatic Hydatid Cyst: A Case Study
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Ae Ri Kim, Seok Ju Park, Mi Jin Gu, Joon Hyuk Choi, Hong Jin Kim
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Korean J Pathol. 2013;47(4):395-398. Published online August 26, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.395
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Hydatid cysts (echinococcosis) are caused by an infestation with larval tapeworms of the genus Echinococcus. The disease is extensively distributed worldwide, and it has been rarely reported in Korea. We describe the cytologic features of a case of hepatic hydatid cyst in a 28-year-old male. Computed tomography revealed a cystic mass in the right lobe of the liver. A right hemihepatectomy was performed. The aspirated fluid from the hepatic cystic mass was clear. The smears showed protoscolices, hooklets, and a laminated membrane.
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- A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease
Amarendra Kumar Shukla, Amrutha Peter, Veerendra Arya, Vineet Dwivedi, Manish Kumar Gupta, Nimish Rai, Pawan Tiwari, Jitendra Kishore Bhargava Journal of Parasitic Diseases.2022; 46(4): 941. CrossRef - Hepatic Hydatid Cyst: A Case Report
Wan Chul Kim, Jae Uk Shin, Su Sin Jin The Korean Journal of Gastroenterology.2021; 77(1): 35. CrossRef - An Imported Case of Disseminated Echinococcosis in Korea
Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh The Korean Journal of Parasitology.2019; 57(4): 429. CrossRef - Cytology of hydatid cyst mimicking intra-abdominal sarcoma, diagnosed by fine-needle aspiration
Busra Ozbek, Nadir Paksoy Diagnostic Cytopathology.2018; 46(4): 362. CrossRef - Clinical Update on Parasitic Diseases
Min Seo Korean Journal of Medicine.2013; 85(5): 469. CrossRef
- Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis
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Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon Mee Kim, Hye Seung Han, Won Ae Lee, Yoon Jung Choi, Dong Wook Kang, Sunhoo Park, Jae Hyuk Lee, Mee-Yon Cho
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Korean J Pathol. 2013;47(3):245-251. Published online June 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.245
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- Background
The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis. MethodsWe collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists. ResultsThe average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma. ConclusionsFurther research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.
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- Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
Yun Kyung Kang Clinical Endoscopy.2014; 47(5): 404. CrossRef
- Imprint Cytology of Soft Tissue Myoepithelioma: A Case Study
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Seok Ju Park, Ae Ri Kim, Mi Jin Gu, Joon Hyuk Choi, Duk Seop Shin
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Korean J Pathol. 2013;47(3):299-303. Published online June 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.299
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8,131
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Soft tissue myoepithelioma is a rare neoplasm composed of myoepithelial cells. Here, we describe the cytologic features of soft tissue myoepithelioma arising on the right forearm in an 18-year-old man. The excised tumor (3.0×1.8×1.5 cm) was well-demarcated, yellow-gray, soft, and myxoid. The cytologic smears showed round to spindle, epithelioid, and plasmacytoid cells in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin and eosinophilic or pale cytoplasm. The tumor cells demonstrated immunoreactivity for cytokeratin (AE1/AE3), epithelial membrane antigen, S100 protein, and glial fibrillary acidic protein. Electron microscopy showed intermediate filaments, desmosomes, and basal lamina.
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Paul E. Wakely, Momin T. Siddiqui Journal of the American Society of Cytopathology.2022; 11(1): 31. CrossRef -
Cytology‐histology
correlation of myoepithelial tumors harboring
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Ian A. Gelarden, Lucy Fu, Kai Lee Yap, Aida I. Richardson, Pauline M. Chou Diagnostic Cytopathology.2022;[Epub] CrossRef - A case of myoepithelial carcinoma of the left shoulder
Shuhei ISHII, Noriyuki FURUTA, Kyoko KOMATSU, Yoshiya SUGIURA, Noriko MOTOI, Yutaka TAKAZAWA, Yuko SUGIYAMA, Yuichi ISHIKAWA The Journal of the Japanese Society of Clinical Cytology.2018; 57(2): 129. CrossRef - Fine-needle aspiration of soft tissue myoepithelioma
Gang Wang, Tracy Tucker, Tony L. Ng, Carlos F. Villamil, Malcolm M. Hayes Diagnostic Cytopathology.2016; 44(2): 152. CrossRef - A case report of spindle cell myoepithelioma with extensive lipomatous metaplasia and thick collagen bundles in the submandibular gland
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Hassania Ameurtesse, Leila Chbani, JM Coindre, Hinde Elfatemi, Toufik Harmouch, Afaf Amarti Research.2014;[Epub] CrossRef
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