Journal of Pathology and Translational Medicine

Sangjeong Ahn

5 Articles

A Rare Case of Tumor-to-Tumor Metastasis of Thyroid Papillary Carcinoma within a Pulmonary Adenocarcinoma: Taebum Lee, Yoon Jin Cha, Sangjeong Ahn, Joungho Han, Young Mog Shim; J Pathol Transl Med. 2015;49(1):78-80. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.12.15

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Benign Neurofibroma/Schwannoma Hybrid Peripheral Nerve Sheath Tumor of the Ulnar Nerve Harboring a Metastatic Papillary Thyroid Carcinoma Deposit: A Case Report of Tumor-to-Tumor Metastasis
Juan M. Colazo, Alexander N. Perez, Anthony D. Judice, Julia Quirion, Carlos N. Prieto-Granada, Ginger E. Holt, Samir Sami Amr
Case Reports in Pathology.2022; 2022: 1. CrossRef
A case of colorectal cancer with intratumoral metastasis to primary lung cancer
Yasushi Cho, Mitsuhito Kaji, Shunsuke Nomura, Yusuke Motohashi, Masaaki Sato, Motoya Takeuchi
The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 576. CrossRef
Tumor-to-tumor metastasis: metastatic invasive lobular carcinoma of the breast within adenocarcinoma of the lung
Myoung Jae Kang, Ae Ri An, Myoung Ja Chung, Kyoung Min Kim
Journal of Pathology and Translational Medicine.2020; 54(2): 188. CrossRef
Metastatic Renal Cell Neoplasm Within a Papillary Thyroid Carcinoma as Incidental Finding in an Asymptomatic Patient: a Case Report
Maria-Rosa Bella-Cueto, Mireia Pascua-Solé, Albert Cano-Palomares, M. Àngels Cabezuelo-Hernandez, Maria-Rosa Escoda-Giralt, Santiago Barcons-Vilaplana, Paula Serret-Miralles, Carmen Caral-Vanaclocha, Xavier Guirao-Garriga, Joan Prats-Lopez, Meritxell Meda
SN Comprehensive Clinical Medicine.2020; 2(7): 978. CrossRef
Squamous cell carcinoma of the lung and pulmonary metastasis of papillary thyroid carcinoma: a case report
Arya Aminorroaya, Mohsen Khoshniatnikoo, Hossein Farrokhpour, Jamshid Vafaeimanesh, Mohammad Bagherzadeh
Journal of Medical Case Reports.2019;[Epub] CrossRef
Prostatic adenocarcinoma (PCa) metastasizing to renal cell carcinoma (RCC) with periureteral tumor deposit: A case of tumor-to-tumor metastasis (TTM)
Jenissa Amor Dionisio Arceño, Jonathan Salcedo Mendoza, Josefino Cortez Castillo, Jeffrey Santos So
Human Pathology: Case Reports.2017; 8: 27. CrossRef
Dual malignancy in a thyroid; papillary thyroid carcinoma and small lymphocytic lymphoma; a report of a case with a cyto-histologic correlation
Omar I. Ahmed, Ziyan T. Salih
Diagnostic Cytopathology.2017; 45(9): 851. CrossRef
Reactivity of thyroid papillary carcinoma cells to thyroid stimulating hormone-dominated endocrine therapy
Yuqin Ma, Xia Zhang, Yutao Wang
Oncology Letters.2017;[Epub] CrossRef

Myxoid Solitary Fibrous Tumor of the Central Nervous System: Haeri Han, Sangjeong Ahn, Won Hwangbo, Yang Seok Chae; Korean J Pathol. 2013;47(6):505-506. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.505

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Cervical Myxoid Solitary Fibrous Tumor: Report of an Unusual Variant and a Brief Overview of the Literature
Bingcheng Wu, Sok Yan Tay, Fredrik Petersson
Head and Neck Pathology.2020; 14(3): 852. CrossRef

Myxoid Liposarcoma with Cartilaginous Differentiation: A Case Study with Cytogenetical Analysis: Hyunchul Kim, Won Hwangbo, Sangjeong Ahn, Suhjin Kim, Insun Kim, Chul Hwan Kim; Korean J Pathol. 2013;47(3):284-288. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.284

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Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.

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Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement
Kayo Suzuki, Taketoshi Yasuda, Kenta Watanabe, Takeshi Hori, Masahiko Kanamori, Tomoatsu Kimura
Oncology Letters.2017;[Epub] CrossRef

Naked Cuticle Drosophila 1 Expression in Histologic Subtypes of Small Adenocarcinoma of the Lung: Sangjeong Ahn, Won Hwangbo, Hyunchul Kim, Chul Hwan Kim; Korean J Pathol. 2013;47(3):211-218. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.211

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Background

Naked cuticle Drosophila 1 (NKD1) has been related to non-small cell lung cancer in that decreased NKD1 levels have been associated with both poor prognosis and increased invasive quality.

Methods

Forty cases of lung adenocarcinoma staged as Tis or T1a were selected. Cases were subclassified into adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and small adenocarcinoma (SAD). Immunohistochemical studies for NKD1 were performed.

Results

Forty samples comprised five cases of AIS (12.5%), eight of MIA (20.0%), and 27 of SAD (67.5%). AIS and MIA showed no lymph node metastasis and 100% disease-free survival, whereas among 27 patients with SAD, 2 (7.4%) had lymph node metastasis, and 3 (11.1%) died from the disease. Among the 40 cases, NKD1-reduced expression was detected in 8 (20%) samples, whereas normal expression was found in 15 (37.5%) and overexpression in 17 (42.5%). Loss of NKD1 expression was significantly associated with lymph node metastasis (p=0.001). All cases with predominant papillary pattern showed overexpression of NKD1 (p=0.026).

Conclusions

Among MIA and SAD, MIA had better outcomes than SAD. Down-regulated NKD1 expression was closely associated with nodal metastasis, and overexpression was associated with papillary predominant adenocarcinoma.

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Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma
Yu‐Ting Wang, Il‐Chi Chang, Chih‐Yi Chen, Jiun‐Yi Hsia, Frank Cheau‐Feng Lin, Wan‐Ru Chao, Tuan‐Ying Ke, Ya‐Ting Chen, Chih‐Jung Chen, Min‐Shu Hsieh, Shiu‐Feng Huang
Thoracic Cancer.2023; 14(6): 592. CrossRef
MicroRNA-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1
Qiang Qu, Xiangdong Chu, Peng Wang
Cell Biology International.2017; 41(3): 287. CrossRef
Downregulation of NKD1 in human osteosarcoma and its clinical significance
Xiang Chen, Ping Xu, Jianwei Zhu, Fan Liu
Molecular Medicine Reports.2017;[Epub] CrossRef
Lung Adenocarcinoma Staging Using the 2011 IASLC/ATS/ERS Classification: A Pooled Analysis of Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma
Madhusmita Behera, Taofeek K. Owonikoko, Anthony A. Gal, Conor E. Steuer, Sungjin Kim, Rathi N. Pillai, Fadlo R. Khuri, Suresh S. Ramalingam, Gabriel L. Sica
Clinical Lung Cancer.2016; 17(5): e57. CrossRef
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells
Jie Li, Sheng Zhang, Qing Hu, Kang Zhang, Jianbin Jin, Xuqing Zheng, Zhenyu Yin, Xiaomin Wang
Scientific Reports.2016;[Epub] CrossRef
NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma
Sheng Zhang, Jie Li, Xiaomin Wang
Tumor Biology.2016; 37(10): 14059. CrossRef
Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma
Sheng Zhang, Jie Li, Zhen-Yu Yin, Ping-Guo Liu, Wen-Xiu Zhao, Cheng-Rong Xie, Bi-Xin Zhao, Xiao-Min Wang
APMIS.2015; 123(4): 315. CrossRef
Early lung cancer with lepidic pattern
Wilko Weichert, Arne Warth
Current Opinion in Pulmonary Medicine.2014; 20(4): 309. CrossRef
Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors
Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
Korean Journal of Pathology.2014; 48(1): 17. CrossRef
The New 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Resected Specimens: Clinicopathologic Relevance and Emerging Issues
Seung Yeon Ha, Mee Sook Roh
Korean Journal of Pathology.2013; 47(4): 316. CrossRef

EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast: Won Hwangbo, Jeong Hyeon Lee, Sangjeong Ahn, Seojin Kim, Kyong Hwa Park, Chul Hwan Kim, Insun Kim; Korean J Pathol. 2013;47(2):107-115. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.107

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Background

The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer treatment.

Methods

A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification.

Results

EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2⁺, EGFR⁺, cytokeratin 5/6^- (CK5/6^-) group, 11.2% of the HER-2^-, EGFR⁺, CK5/6^- group, and 19.1% of the HER-2^-, EGFR⁺, CK5/6⁺ group. FISH-positive cases were detected in 8.3% of the EGFR protein 1⁺ expression cases, 15.9% of 2⁺ expression cases, and 38.5% of 3⁺ expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6.

Conclusions

EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.

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Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells
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Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer
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Evaluation of lapatinib cytotoxicity and genotoxicity on MDA-MB-231 breast cancer cell line
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Environmental Toxicology and Pharmacology.2019; 71: 103207. CrossRef
Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
Jiasheng Xu, Jingjing Guo, Yangkai Jiang, Yujun Liu, Kaili Liao, Zhonghua Fu, Zhenfang Xiong
Cancer Medicine.2019; 8(10): 4722. CrossRef
Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome
Ge Yan, Mohamed E.M. Saeed, Sebastian Foersch, Jose Schneider, Wilfried Roth, Thomas Efferth
Oncotarget.2019; 10(20): 1918. CrossRef
A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways
Xiao Sun, Xiao-bin Zhuo, Yi-ping Hu, Xuan Zheng, Qing-jie Zhao
Molecular and Cellular Biochemistry.2018; 449(1-2): 47. CrossRef
lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway
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Biomedicine & Pharmacotherapy.2017; 94: 644. CrossRef
Copy Number Profiling of MammaPrint™ Genes Reveals Association with the Prognosis of Breast Cancer Patients
Areej Fatima, Fomaz Tariq, Muhammad Faraz Arshad Malik, Muhammad Qasim, Farhan Haq
Journal of Breast Cancer.2017; 20(3): 246. CrossRef
Evaluation of serum epidermal growth factor receptor (EGFR) in correlation to circulating tumor cells in patients with metastatic breast cancer
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter A. Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
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EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib
James P. De Andrade, Jung M. Park, Vivian W. Gu, George W. Woodfield, Mikhail V. Kulak, Allison W. Lorenzen, Vincent T. Wu, Sarah E. Van Dorin, Philip M. Spanheimer, Ronald J. Weigel
Molecular Cancer Therapeutics.2016; 15(3): 503. CrossRef
Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
H J Lee, A N Seo, E J Kim, M H Jang, Y J Kim, J H Kim, S-W Kim, H S Ryu, I A Park, S-A Im, G Gong, K H Jung, H J Kim, S Y Park
British Journal of Cancer.2015; 112(1): 103. CrossRef
Epidermal growth factor receptor protein overexpression and gene amplification are associated with aggressive biological behaviors of esophageal squamous cell carcinoma
GANG LIN, XIAO-JIANG SUN, QIAN-BO HAN, ZHUN WANG, YA-PING XU, JIA-LEI GU, WEI WU, GU ZHANG, JIN-LIN HU, WEN-YONG SUN, WEI-MIN MAO
Oncology Letters.2015; 10(2): 901. CrossRef
Immunohistochemical Classification of Primary and Secondary Glioblastomas
Kyu Sang Lee, Gheeyoung Choe, Kyung Han Nam, An Na Seo, Sumi Yun, Kyung Ju Kim, Hwa Jin Cho, Sung Hye Park
Korean Journal of Pathology.2013; 47(6): 541. CrossRef
A Comparison of Tumor Biology in Primary Ductal CarcinomaIn SituRecurring as Invasive Carcinoma versus a NewIn Situ
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International Journal of Breast Cancer.2013; 2013: 1. CrossRef

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