Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
So Youn Jung 1 Article
Primary Malignant Melanoma of the Breast: A Report of Two Cases
Jiwon Koh, Jihyeon Lee, So Youn Jung, Han Sung Kang, Tak Yun, Youngmee Kwon
J Pathol Transl Med. 2019;53(2):119-124.   Published online November 26, 2018
  • 5,765 View
  • 151 Download
  • 3 Citations
AbstractAbstract PDFSupplementary Material
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation like melanin pigments. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF V600E. However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF V600E. These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, the possibility of this entity should be considered in malignant epithelioid neoplasms in the breast parenchyma.


Citations to this article as recorded by  
  • Malignant melanoma of the breast: controversies in the diagnosis and therapeutic management of a rare nosologic entity
    Aikaterini Mastoraki, Dimitrios Schizas, Ilias Giannakodimos, Athanasios Rebakos, Ioannis Margaris, Ioannis Katsaros, Ilias Vagios, Pantelis Vassiliu, Emmanouil Pikoulis
    International Journal of Dermatology.2020; 59(9): 1057.     CrossRef
  • Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives
    Matías Chacón, Yanina Pfluger, Martín Angel, Federico Waisberg, Diego Enrico
    Cancers.2020; 12(9): 2362.     CrossRef
  • Primary Melanoma of the Breast Parenchyma: An Oncoplastic Approach
    Emma Snashall, Tamara Kiernan, Aenone Harper-Machin, Rieka Taghizadeh
    Plastic and Reconstructive Surgery - Global Open.2020; 8(12): e3276.     CrossRef

JPTM : Journal of Pathology and Translational Medicine