Primary endometrial squamous cell carcinoma (PESCC) is an extremely rare tumor with unclear pathogenesis. A 54-year-old postmenopausal woman presented with a 6-month history of vaginal bleeding. The patient was provisionally diagnosed with uterine submucosal leiomyoma. This was followed by total hysterectomy with a bilateral salpingo-oophorectomy under the laparoscopic guidance. Histopathologically, the tumor was PESCC which was accompanied by a lack of the tumor in the uterine cervix. The tumor showed positive immunoreactivity for p^16INK4a. But there was no evidence of human papillomavirus (HPV) on in situ hybridization and HPV DNA chip analysis. We also present a review of the relevant literature on Korean women.

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• Primary endometrial squamous cell carcinoma (PESCC): Review of the literature and case report
  Kuang-Han Liu, Chia-Chin Tsai, Krystal Baysan Lin, Pei-Shen Huang
  Taiwanese Journal of Obstetrics and Gynecology.2025; 64(1): 159.     CrossRef
• p16 Block Type Overexpression, p53 Wild Type Reactivity, and Cervical Involvement do not Always Exclude the Diagnosis of Primary Endometrial Squamous Cell Carcinoma (PESCC)
  Daniela Fanni, Clara Gerosa, Michele Peiretti, Valerio Mais, Elena Massa, Stefano Angioni, Gavino Faa
  International Journal of Gynecological Pathology.2024; 43(2): 200.     CrossRef
• Pathogenetic characteristics of endometrioid adenocarcinoma of uterus at present stage
  T. I. Moiseenko, S. V. Shatalova, E. M. Nepomnyashchaya, V. A. Bandovkina, M. L. Adamyan
  Medical alphabet.2024; (36): 35.     CrossRef
• Case report: Clinicopathological characteristic of two cases of primary endometrial squamous cell carcinoma and review of the literature
  Hui-Bin Zhang, Li-Hua Lin, Qiu-Ping Lin, Yuan-Qing Lin, Dan Luo, Shu-Xia Xu
  Frontiers in Oncology.2024;[Epub]     CrossRef
• Treatment of primary squamous cell carcinoma of the endometrium and review of previous literature: A case report
  Liyun Song, Qi Wu, Suning Bai, Ren Xu, Xiaona Wang, Yanyan Yang
  Medicine.2023; 102(17): e33667.     CrossRef
• Prevalence of human papilloma virus and Chlamydia trachomatis in endometrial and cervical carcinoma: a comparative study in North Indian women
  Heena Gautam, Sumita Mehta, Nidhi Nayar, Neha Kumar, Syed Akhtar Husain, Mausumi Bharadwaj
  Systems Biology in Reproductive Medicine.2023; 69(6): 399.     CrossRef
• PAX8 Positivity, Abnormal p53 Expression, and p16 Negativity in a Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of the Literature
  Daniela Fanni, Michele Peiretti, Valerio Mais, Elena Massa, Clara Gerosa, Francesca Ledda, Maria Luisa Fais, Gavino Faa, Stefano Angioni
  International Journal of Gynecological Pathology.2022; 41(4): 431.     CrossRef
• Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations
  Mark R. Hopkins, Doreen N. Palsgrove, Brigitte M. Ronnett, Russell Vang, Jeffrey Lin, Tricia A. Murdock
  American Journal of Surgical Pathology.2022; 46(12): 1611.     CrossRef
• Primary squamous cell carcinoma of the endometrium—Case report with cytological characteristics in direct and indirect endometrial samples
  Sanda Rajhvajn, Ana Barišić, Lada Škopljanac‐Mačina, Danijela Jurič, Vesna Mahovlić
  Cytopathology.2021; 32(6): 823.     CrossRef
• Primary squamous cell carcinoma of the endometrium associated with human papilloma virus in a young woman: a case report
  Tchin Darré, Abdoul-Samadou Aboubakari, Lantam Sonhaye, Baguilane Douaguibe, Akila Bassowa, Gado Napo-Koura
  Journal of Medical Case Reports.2019;[Epub]     CrossRef
• Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age
  Chao Zhang, Hongyan Zhang, Linqing Yang, Yunfei Wang, Xiaoyu Li, Jinfeng Guo, Jing Xu
  Medicine.2018; 97(48): e13418.     CrossRef
• S100P is Overexpressed in Squamous Cell and Adenosquamous Carcinoma Subtypes of Endometrial Cancer and Promotes Cancer Cell Proliferation and Invasion
  Hongfei Jiang, Hang Hu, Fan Lin, Yoon Pin Lim, Yunfen Hua, Xiaomei Tong, Songying Zhang
  Cancer Investigation.2016; 34(10): 477.     CrossRef
• Überraschung in der Abradatdiagnostik
  U. Kellner, A. Kellner, U. Cirkel
  Der Pathologe.2015; 36(3): 317.     CrossRef