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Tae Eun Kim 1 Article
Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia
Tae Eun Kim, Hwal Woong Kim, Kyung Eun Lee
Korean J Pathol. 2014;48(1):24-29.   Published online February 25, 2014
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AbstractAbstract PDF

This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia with HPV 52 and 58 infections.


A total of three hundred fifteen cases were analyzed using the HPV DNA chip test for HPV genotypes, and of these, we retrospectively examined p16 and p53 expression in 62 cases of cervical tissues infected with HPV 52 and 58 using immunohistochemistry.


HPV 52 and 58 genotypes were identified in 62 (54.9%) out of 113 high-risk, HPV-infected cases. Of the cases examined, there were 19 single HPV 52 infections (16.8%), 23 single HPV 58 infections (20.4%), 4 multiple HPV 52 infections (3.5%), and 16 multiple HPV-58 infections (14.2%). Immunoreactivity of p16 and p53 was observed in 41 (66.1%) and 23 (37.1%) of the 62 cases of cervical neoplasia infected with HPV 52 and 58 genotypes, respectively.


This study demonstrates a high prevalence of HPV 52 and 58 genotypes, in addition to HPV 16, among high-risk strains of cervical neoplasia in Korea. These findings suggest that development of more vaccines would be beneficial for the prevention of the various HPV genotypes.


Citations to this article as recorded by  
  • Usefulness Analysis of Urine Samples for Early Screening of Human Papilloma Virus Infection
    Yoon Sung Choi, Hyunwoo Jin, Kyung Eun Lee
    Journal of Cancer Prevention.2019; 24(4): 240.     CrossRef
  • Relationship between Expression of P16 and Ki-67 and Persistent Infection of HPV in Cervical Carcinoma Patients
    群欢 黄
    Advances in Clinical Medicine.2018; 08(08): 776.     CrossRef
  • Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea
    Youn Jin Choi, Eun Young Ki, Chuqing Zhang, Wendy C. S. Ho, Sung-Jong Lee, Min Jin Jeong, Paul K. S. Chan, Jong Sup Park, Xuefeng Liu
    PLOS ONE.2016; 11(12): e0168178.     CrossRef

JPTM : Journal of Pathology and Translational Medicine