Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Yong Kil Hong 1 Article
The Predictive Value of Pathologic Features in Pituitary Adenoma and Correlation with Pituitary Adenoma Recurrence
Jee Soon Kim, Youn Soo Lee, Min Jung Jung, Yong Kil Hong
J Pathol Transl Med. 2016;50(6):419-425.   Published online October 6, 2016
  • 6,934 View
  • 224 Download
  • 16 Citations
AbstractAbstract PDF
The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater than 3%, and extensive p53 immunoreactivity. However, aPAs that exhibit all of these features are rare and the predictive value for recurrence in pituitary adenomas (PAs) remains uncertain. Thus, we sought to characterize pathological features of PAs that correlated with recurrence.
One hundred and sixty-seven cases of surgically resected PA or aPA were retrieved from 2011 to 2013 in Seoul St. Mary’s Hospital. Among them, 28 cases were confirmed to be recurrent, based on pathologic or radiologic examination. The pathologic characteristics including mitosis, invasion, Ki-67 LI and p53 immunoreactivity were analyzed in relation to recurrence.
Analysis of the pathologic features indicated that only Ki-67 LI over 3% was significantly associated with tumor recurrence (p = .02). The cases with at least one pathologic feature showed significantly higher recurrence rates (p < .01). Analysis indicated that cases with two pathologic features, Ki-67 LI over 3% and extensive p53 immunoreactivity 20% or more, were significantly associated with tumor recurrence (p < .01).
Based on these results, PA tumor recurrence can be predicted by using mitosis, invasion, Ki-67 LI (3%), or extensive p53 immunoreactivity (≥ 20%). Assessment of these features is recommended for PA diagnosis for more accurate prediction of recurrence.


Citations to this article as recorded by  
  • Ki-67/MIB-1 and Recurrence in Pituitary Adenoma
    Kent Tadokoro, Colten Wolf, Joseph Toth, Cara Joyce, Meharvan Singh, Anand Germanwala, Chirag Patel
    Journal of Neurological Surgery Part B: Skull Base.2022; 83(S 02): e580.     CrossRef
  • Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas
    Su Jung Kum, Hye Won Lee, Soon Gu Kim, Hyungsik Park, Ilseon Hwang, Sang Pyo Kim
    Journal of Pathology and Translational Medicine.2022; 56(1): 22.     CrossRef
  • A Preoperative MRI-Based Radiomics-Clinicopathological Classifier to Predict the Recurrence of Pituitary Macroadenoma Within 5 Years
    Yu Zhang, Yuqi Luo, Xin Kong, Tao Wan, Yunling Long, Jun Ma
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Endoscopic Endonasal Pituitary Surgery For Nonfunctioning Pituitary Adenomas: Long-Term Outcomes and Management of Recurrent Tumors
    Anne-Laure Bernat, Pénélope Troude, Stefano Maria Priola, Ahmad Elsawy, Faisal Farrash, Ozgur Mete, Shereen Ezzat, Sylvia L. Asa, John De Almeida, Allan Vescan, Eric Monteiro, Joao Paulo Almeida, Gelareh Mohammed Zadeh, Fred Gentili
    World Neurosurgery.2021; 146: e341.     CrossRef
  • A Nomogram for Preoperatively Predicting the Ki-67 Index of a Pituitary Tumor: A Retrospective Cohort Study
    Xiangming Cai, Junhao Zhu, Jin Yang, Chao Tang, Feng Yuan, Zixiang Cong, Chiyuan Ma
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Comparative Proteomic Study Shows the Expression of Hint-1 in Pituitary Adenomas
    Carolina Carrillo-Najar, Daniel Rembao-Bojórquez, Martha L. Tena-Suck, Sergio Zavala-Vega, Noemí Gelista-Herrera, Miguel A. Ramos-Peek, Juan L. Gómez-Amador, Febe Cazares-Raga, Fidel de la Cruz Hernández-Hernández, Alma Ortiz-Plata
    Diagnostics.2021; 11(2): 330.     CrossRef
  • Prediction of recurrence in solid nonfunctioning pituitary macroadenomas: additional benefits of diffusion-weighted MR imaging
    Ching-Chung Ko, Tai-Yuan Chen, Sher-Wei Lim, Yu-Ting Kuo, Te-Chang Wu, Jeon-Hor Chen
    Journal of Neurosurgery.2020; 132(2): 351.     CrossRef
  • Pituitary tumors: epidemiology and clinical presentation spectrum
    Marta Araujo-Castro, Víctor Rodríguez Berrocal, Eider Pascual-Corrales
    Hormones.2020; 19(2): 145.     CrossRef
  • Ki67 in endocrine neoplasms: to count or not to count, this is the question! A systematic review from the English language literature
    E. Guadagno, E. D’Avella, P. Cappabianca, A. Colao, M. Del Basso De Caro
    Journal of Endocrinological Investigation.2020; 43(10): 1429.     CrossRef
  • Study of Simple Immunohistochemical Cytocolorimetric Assay Application for More Accurate Assessment of Prognosis in Patients with Pituitary Adenomas
    Pavel V. Nikitin, Marina V. Ryzhova, Lyudmila V. Shishkina, Svetlana V. Shugay, Irina V. Zubova
    World Neurosurgery.2019; 122: e1047.     CrossRef
  • The Prognostic Roles of the Ki-67 Proliferation Index, P53 Expression, Mitotic Index, and Radiological Tumor Invasion in Pituitary Adenomas
    Rovshan Hasanov, Berna İmge Aydoğan, Saba Kiremitçi, Esra Erden, Sevim Güllü
    Endocrine Pathology.2019; 30(1): 49.     CrossRef
  • Residual Tumor Confers a 10-Fold Increased Risk of Regrowth in Clinically Nonfunctioning Pituitary Tumors
    Jelena Maletkovic, Asmaa Dabbagh, Dongyun Zhang, Abdul Zahid, Marvin Bergsneider, Marilene B Wang, Michael Linetsky, Noriko Salamon, William H Yong, Harry V Vinters, Anthony P Heaney
    Journal of the Endocrine Society.2019; 3(10): 1931.     CrossRef
  • Atypical pituitary adenoma: a clinicopathologic case series
    Martin J. Rutkowski, Ryan M. Alward, Rebecca Chen, Jeffrey Wagner, Arman Jahangiri, Derek G. Southwell, Sandeep Kunwar, Lewis Blevins, Han Lee, Manish K. Aghi
    Journal of Neurosurgery.2018; 128(4): 1058.     CrossRef
  • Both invasiveness and proliferation criteria predict recurrence of non-functioning pituitary macroadenomas after surgery: a retrospective analysis of a monocentric cohort of 120 patients
    Julie Lelotte, Anne Mourin, Edward Fomekong, Alex Michotte, Christian Raftopoulos, Dominique Maiter
    European Journal of Endocrinology.2018; 178(3): 237.     CrossRef
  • Letter to the Editor. Atypical pituitary adenoma
    Lauren E. Rotman, T. Brooks Vaughan, James R. Hackney, Kristen O. Riley
    Journal of Neurosurgery.2018; 129(6): 1657.     CrossRef
  • Molecular targeted therapies in adrenal, pituitary and parathyroid malignancies
    Anna Angelousi, Georgios K Dimitriadis, Georgios Zografos, Svenja Nölting, Gregory Kaltsas, Ashley Grossman
    Endocrine-Related Cancer.2017; 24(6): R239.     CrossRef

JPTM : Journal of Pathology and Translational Medicine