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Yong-Man Kim 1 Article
Cytological Evaluation and REBA HPV-ID HPV Testing of Newly Developed Liquid-Based Cytology, EASYPREP: Comparison with SurePath
Youn Soo Lee, Gyungyub Gong, Jin Hee Sohn, Ki Sung Ryu, Jung Hun Lee, Shin Kwang Khang, Kyung-Ja Cho, Yong-Man Kim, Chang Suk Kang
Korean J Pathol. 2013;47(3):265-274.   Published online June 25, 2013
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AbstractAbstract PDF

The objective of this study was to evaluate a newly-developed EASYPREP liquid-based cytology method in cervicovaginal specimens and compare it with SurePath.


Cervicovaginal specimens were prospectively collected from 1,000 patients with EASYPREP and SurePath. The specimens were first collected by brushing for SurePath and second for EASYPREP. The specimens of both methods were diagnosed according to the Bethesda System. Additionally, we performed to REBA HPV-ID genotyping and sequencing analysis for human papillomavirus (HPV) on 249 specimens.


EASYPREP and SurePath showed even distribution of cells and were equal in cellularity and staining quality. The diagnostic agreement between the two methods was 96.5%. Based on the standard of SurePath, the sensitivity, specificity, positive predictive value, and negative predictive value of EASYPREP were 90.7%, 99.2%, 94.8%, and 98.5%, respectively. The positivity of REBA HPV-ID was 49.4% and 95.1% in normal and abnormal cytological samples, respectively. The result of REBA HPV-ID had high concordance with sequencing analysis.


EASYPREP provided comparable results to SurePath in the diagnosis and staining quality of cytology examinations and in HPV testing with REBA HPV-ID. EASYPREP could be another LBC method choice for the cervicovaginal specimens. Additionally, REBA HPV-ID may be a useful method for HPV genotyping.


Citations to this article as recorded by  
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    Sasiprapa Liewchalermwong, Shina Oranratanaphan, Wichai Termrungruanglert, Surang Triratanachat, Patou Tantbirojn, Nakarin Kitkumthorn, Parvapan Bhattarakosol, Arkom Chaiwongkot
    Viruses.2022; 14(12): 2713.     CrossRef
  • Evaluation of nuclear chromatin using grayscale intensity and thresholded percentage area in liquid-based cervical cytology
    Hyekyung Lee, Myungein Han, Taejo Yoo, Chanho Jung, Hyun-Jin Son, Migyung Cho
    Diagnostic Cytopathology.2018; 46(5): 384.     CrossRef
  • Comparison of EASYPREP®and SurePath®in thyroid fine-needle aspiration
    Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae-Jung Kim, Eun Jung Lee, Chang Suk Kang
    Diagnostic Cytopathology.2016; 44(4): 283.     CrossRef

JPTM : Journal of Pathology and Translational Medicine