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Volume 45(4); August 2011
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Original Articles
Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer.
Seol Bong Yoo, Xianhua Xu, Hyun Ju Lee, Sanghoon Jheon, Choon Taek Lee, Gheeyoung Choe, Jin Haeng Chung
Korean J Pathol. 2011;45(4):329-335.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.329
  • 4,191 View
  • 32 Download
  • 9 Crossref
AbstractAbstract PDF
BACKGROUND
Alterations in the phosphatase and tensin homolog (PTEN) are correlated with tumor progression. Downregulation of PTEN is related to drug resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the prognostic significance of PTEN in patients with NSCLC and its correlation with EGFR.
METHODS
Two hundred eighty eight surgically resected NSCLC samples, including 168 adenocarcinomas (ADCs), 99 squamous cell carcinomas (SCCs) and 21 other NSCLCs were analyzed for the PTEN. The results were correlated with other clinicopathological variables including EGFR amplification and mutation.
RESULTS
Loss of PTEN was detected in 42.4% of NSCLCs, specifically 28.6% of ADCs, 66.7% of SCCs, and 38.1% of others. Loss of PTEN was significantly associated with SCC, smoking, male gender, and higher stage. In a multivariate analysis, loss of PTEN was significantly associated with short progression-free survival (p=0.037). No association between PTEN and EGFR was observed.
CONCLUSIONS
These results suggest that loss of PTEN results in shorter progression-free survival in patients with NSCLC, and loss of PTEN is more associated with SCC, smoking, male gender, and higher T stage by the 7th tumor, node and metastasis staging system but not EGFR status.

Citations

Citations to this article as recorded by  
  • Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer
    Jia Yee Lee, Richie R. Bhandare, Sai H.S. Boddu, Afzal B. Shaik, Lakshmana Prabu Saktivel, Gaurav Gupta, Poonam Negi, Muna Barakat, Sachin Kumar Singh, Kamal Dua, Dinesh Kumar Chellappan
    Biomedicine & Pharmacotherapy.2024; 173: 116275.     CrossRef
  • Alterations in the PI3K Pathway Drive Resistance to MET Inhibitors in NSCLC Harboring MET Exon 14 Skipping Mutations
    Philippe Jamme, Marie Fernandes, Marie-Christine Copin, Clotilde Descarpentries, Fabienne Escande, Angela Morabito, Valérie Grégoire, Matthieu Jamme, Simon Baldacci, David Tulasne, Zoulika Kherrouche, Alexis B. Cortot
    Journal of Thoracic Oncology.2020; 15(5): 741.     CrossRef
  • PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
    Francesca Luongo, Francesca Colonna, Federica Calapà, Sara Vitale, Micol E. Fiori, Ruggero De Maria
    Cancers.2019; 11(8): 1076.     CrossRef
  • PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
    Anastasios Gkountakos, Giulia Sartori, Italia Falcone, Geny Piro, Ludovica Ciuffreda, Carmine Carbone, Giampaolo Tortora, Aldo Scarpa, Emilio Bria, Michele Milella, Rafael Rosell, Vincenzo Corbo, Sara Pilotto
    Cancers.2019; 11(8): 1141.     CrossRef
  • PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature
    Jian Xiao, Cheng-Ping Hu, Bi-Xiu He, Xi Chen, Xiao-Xiao Lu, Ming-Xuan Xie, Wei Li, Shu-Ya He, Shao-Jin You, Qiong Chen
    Oncotarget.2016; 7(36): 57832.     CrossRef
  • Alteration of the E-cadherin/β-Catenin Complex Predicts Poor Response to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment
    Seol Bong Yoo, Yu Jung Kim, Hyojin Kim, Yan Jin, Ping-Li Sun, Sanghoon Jheon, Jong Seok Lee, Jin-Haeng Chung
    Annals of Surgical Oncology.2013; 20(S3): 545.     CrossRef
  • High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas
    Ping‐Li Sun, Yan Jin, Hyojin Kim, Choon‐Taek Lee, Sanghoon Jheon, Jin‐Haeng Chung
    Cancer Cytopathology.2013; 121(6): 311.     CrossRef
  • Impact of HER2 and PTEN Simultaneous Deregulation in Non-small Cell Lung Carcinoma: Correlation with Biological Behavior
    Ioannis Panagiotou, Stavros N. Georgiannos, Evangelos Tsiambas, Andreas Karameris, Marios Konstantinou, Andreas C. Lazaris, Nikolaos Kavantzas, George Vilaras, Efstratios Patsouris
    Asian Pacific Journal of Cancer Prevention.2012; 13(12): 6311.     CrossRef
  • Expression of the Mammalian Target of Rapamycin Pathway Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma
    Hyun-Soo Kim, Gou Young Kim, Sung-Jig Lim, Youn Wha Kim
    Pathobiology.2012; 79(2): 84.     CrossRef
The Significance of Ventricular Volume in the Evaluation of Secondary Cardiomyopathy at Autopsy.
Joo Young Na, Byung Woo Min, Yeong Hui Kim, Seung Hyun Chung, Young Jik Lee, Hyung Seok Kim, Jong Tae Park
Korean J Pathol. 2011;45(4):336-347.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.336
  • 2,819 View
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AbstractAbstract PDF
BACKGROUND
The weight, shape and consistency of the heart, and the thickness of the ventricular wall are used as parameters for evaluating postmortem heart and diagnosing cardiomyopathy at autopsy.
METHODS
The weight and volume of the ventricles and the thickness of the left ventricular wall of 58 hearts were measured and analyzed.
RESULTS
In the group of dilated hearts, the ventricular weight, ventricular volume, ventricular volume/ventricular weight, and left ventricular volume/right ventricular volume increased, whereas ventricular wall thickness decreased. In the group of hypertrophied hearts, the ventricular weight, ventricular volume, and thickness of the ventricular wall increased but ventricular volume/ventricular weight and left ventricular volume/right ventricular volume did not change significantly. In the group of undetermined hearts, it was later found that four of the cases should have been included in the dilated heart group and another two cases in the hypertrophied heart group.
CONCLUSIONS
In addition to conventional methods, the measuring ventricular volume is useful for evaluating a postmortem heart and may suggest postmortem differential diagnoses of dilated or hypertrophied forms of secondary cardiomyopathies.
Human Papillomavirus Prevalence in Gangwon Province Using Reverse Blot Hybridization Assay.
Dongsup Lee, Sunghyun Kim, Sangjung Park, Hyunwoo Jin, Tae Ue Kim, Kwang Hwa Park, Hyeyoung Lee
Korean J Pathol. 2011;45(4):348-353.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.348
  • 3,306 View
  • 25 Download
  • 6 Crossref
AbstractAbstract PDF
BACKGROUND
Human papillomavirus (HPV) plays an important role in the development of cervical carcinoma. Although there is a general agreement that high levels of HPV are related to cervical cancer, the prevalence and distribution of HPV genotypes seems to vary by geographical region. This study was designed to investigate the prevalence of HPV genotypes in Gangwon Province, Korea.
METHODS
In total, 342 samples were examined by Pap smear and HPV-ID(R) reverse blot hybridization assay (REBA) (M&D, Wonju, Korea).
RESULTS
Overall HPV positivity was 80.9% and 64.4% in women with abnormal and normal cytology by REBA, respectively. The five most common HPV types were: HPV 16, 53, 58, 56, and 33 in samples with abnormal cytology, and HPV 16, 53, 58, 70, and 18 in samples with normal cytology.
CONCLUSIONS
The REBA can provide useful data regarding prevalence of HPV genotypes. Gangwon Province showed high prevalence of HPV infection in women. The most common HPV type in Gangwon Province was HPV16, and HPV 53, 58, 56, 70 were frequently present.

Citations

Citations to this article as recorded by  
  • Human Papillomavirus (HPV69/HPV73) Coinfection associated with Simultaneous Squamous Cell Carcinoma of the Anus and Presumed Lung Metastasis
    Stephanie Shea, Marina Muñoz, Stephen C. Ward, Mary B. Beasley, Melissa R Gitman, Michael D Nowak, Jane Houldsworth, Emilia Mia Sordillo, Juan David Ramirez, Alberto E. Paniz Mondolfi
    Viruses.2020; 12(3): 349.     CrossRef
  • Distribution of Oncogenic Human Papillomavirus Genotypes at High Grade Cervical Lesions above CIN 2 Grade with Histological Diagnosis
    Geehyuk Kim, Sungyoung Park, Hye-young Wang, Sunghyun Kim, Sangjung Park, Kwangmin Yu, Boohyung Lee, Seung-Ju Ahn, Eun-Joong Kim, Dongsup Lee
    Biomedical Science Letters.2016; 22(2): 37.     CrossRef
  • Human Papillomavirus Prevalence and Distribution according to Age among Korean and Chinese Women
    Geehyuk Kim, Sunghyun Kim, Sunyoung Park, Sangjung Park, Han Lin, Yubo Ren, Li Yingxue, In Soo Lee, Jae Dal Lee, Dongsup Lee
    Korean Journal of Clinical Laboratory Science.2015; 47(4): 259.     CrossRef
  • Comparison of Methods for Measuring Histamine by ELISA and HPLC-MS Assay In Vitro
    In Hee Lee, Yoo Hyun Kim
    Korean Journal of Clinical Laboratory Science.2015; 47(4): 306.     CrossRef
  • Diagnostic Performance of HPV E6/E7 mRNA and HPV DNA Assays for the Detection and Screening of Oncogenic Human Papillomavirus Infection among Woman with Cervical Lesions in China
    Hye-young Wang, Dongsup Lee, Sunyoung Park, Geehyuk Kim, Sunghyun Kim, Lin Han, Ren Yubo, Yingxue Li, Kwang Hwa Park, Hyeyoung Lee
    Asian Pacific Journal of Cancer Prevention.2015; 16(17): 7633.     CrossRef
  • Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas
    Na Rae Kim, Myunghee Kang, Soon Pyo Lee, Hyunchul Kim, Jungsuk An, Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho
    Korean Journal of Pathology.2014; 48(1): 43.     CrossRef
The Significance of MicroRNA Let-7b, miR-30c, and miR-200c Expression in Breast Cancers.
Sung Min Chun, Hee Jung Park, Chul Hwan Kim, Insun Kim
Korean J Pathol. 2011;45(4):354-360.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.354
  • 3,087 View
  • 46 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
MicroRNA (miRNA) is a class of noncoding protein RNA as a promising biomarker for various diseases. In this study, the expression of let-7b, miR-30c, and miR-200c was studied in breast cancer tissues to evaluate the potential relationship with known clinicopathological parameters.
METHODS
Quantitative real-time polymerase chain reaction was performed to determine the expression level of three miRNAs in 37 pairs of noncancerous normal and cancer tissues and an additional 38 cancer tissues from patients with invasive ductal carcinoma.
RESULTS
miR-200c expression was higher in cancer tissues compared to noncancerous normal tissues, and its ratio was correlated with patient age at surgery, type of surgery, and Ki-67 expression. The expression level of let-7b in cancer tissues was inversely correlated with lymph node metastasis, histological grade, and Ki-67 expression but positively correlated with estrogen and progesterone receptor expression. miR-200c expression level was positively correlated with Her-2 expression. The miR-30c expression level in breast cancer was not correlated with any parameters.
CONCLUSIONS
miR-200c and let-7b could be used as biomarkers in patients with breast cancer, but its pathological mechanism should be determined.

Citations

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  • High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer
    Jarline Encarnación, Carmen Ortiz, Ralphdy Vergne, Wanda Vargas, Domenico Coppola, Jaime Matta
    International Journal of Molecular Sciences.2016; 17(6): 865.     CrossRef
Association of CD57+ Natural Killer Cells with Better Overall Survival in DLBCL Patients.
Jeong Hyeon Lee, Yoon Jin Kwak, Chul Hwan Kim, Insun Kim
Korean J Pathol. 2011;45(4):361-370.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.361
  • 2,591 View
  • 22 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Malignant tumor cells may evoke the innate and adaptive immune systems. Various immune cells are involved in this immune reaction, and tumor infiltrating lymphocytes, macrophages, natural killer (NK) cells are associated with patient prognosis for solid tumors.
METHODS
Seventy-eight patients who were diagnosed with diffuse large B cell lymphoma (DLBCL) between 2001 and 2009 were selected. CD57+ NK cells, CD68+ tumor associated macrophages (TAMs), and CD4+ and CD8+ T cells were evaluated in tissue sections using immunohistochemical staining and compared with clinical parameters including age, gender, performance status, clinical stage, serum lactic dehydrogenase level, number of extranodal sites, international prognostic index score, chemotherapy response, and survival.
RESULTS
Patients with high numbers of CD57+ NK cells had a significantly higher overall survival rate than patients with low numbers of CD57+ NK cells. However, no significant difference was observed between the number of CD57+ NK cells and other prognostic parameters. The number of CD68+ TAMs and CD4+ or CD8+ T cells was not significantly correlated with prognostic factors in patients with DLBCL.
CONCLUSIONS
An evaluation of tumor infiltrating CD57+ NK cells is recommended as a prognostic indicator in patients with DLBCL.

Citations

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  • The prognostic value of tumor-associated macrophages detected by immunostaining in diffuse large B cell lymphoma: A meta-analysis
    Mei Lin, Shupei Ma, Lingling Sun, Zhiqiang Qin
    Frontiers in Oncology.2023;[Epub]     CrossRef
Prognostic Significance and Nature of Rhabdoid Features in Renal Cell Carcinoma.
Misun Choe, Ji Young Park, Ilseon Hwang, Sang Pyo Kim
Korean J Pathol. 2011;45(4):371-378.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.371
  • 3,165 View
  • 22 Download
AbstractAbstract PDF
BACKGROUND
Recent reports have indicated that renal cell carcinoma (RCC) with rhabdoid features follows an aggressive clinical course. We investigated the prognostic significance and nature of the rhabdoid component.
METHODS
We retrospectively analyzed the incidence and clinicopathologic characteristics of RCC with rhabdoid features in 174 radical nephrectomy cases. The specimens were examined histologically and immunohistochemically.
RESULTS
Twelve of the 174 RCC cases (6.9%) showed rhabdoid features. Histologically, all the tumors with rhabdoid features were of the clear cell type. The presence of rhabdoid features was significantly associated with higher Fuhrman's nuclear grade and higher pathologic tumor stage at presentation. Among the 12 patients who showed the rhabdoid component, nine (75%) developed metastasis and seven (58.3%) died of disease-related causes. The presence of rhabdoid features was independently associated with metastasis and disease-related mortality. The rhabdoid cells were positive for vimentin; variably positive for pan-cytokeratin, epithelial membrane antigen, and CD10; and negative for cytokeratin 7, smooth muscle actin, desmin, E-cadherin, and c-Kit. No case showed loss of integrase interactor-1; one was p53 positive, and five were insulin-like growth factor mRNA binding protein 3 positive. The Ki-67 labeling index was 1-25% (mean, 5.5%).
CONCLUSIONS
The rhabdoid component is an independent prognostic factor for metastasis of RCC; therefore, identification of this component is critical.
Insulin-like Growth Factor II mRNA-Binding Protein 3 Expression in Benign and Premalignant Lesions and Carcinomas of the Stomach.
Dae Hyun Song, Jung Wook Yang, Dong Chul Kim, Jong Sil Lee, Jeong Hee Lee, Sang Ho Jeong, Gyung Hyuck Ko
Korean J Pathol. 2011;45(4):379-385.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.379
  • 3,220 View
  • 21 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Recent studies have demonstrated that insulin-like growth factor II mRNA-binding protein 3 (IMP3) is expressed in malignant tumors of various organs but not in normal tissue. We investigated IMP3 expression in various benign lesions, premalignant lesions and carcinomas of the stomach.
METHODS
IMP3 immunohistochemical staining was performed on 24 benign gastric lesions, 24 gastric adenomas, and 322 gastric carcinomas.
RESULTS
IMP3 was not expressed in benign gastric lesions including adenomas with low-grade dysplasia, but was expressed in 17% of adenomas with high-grade dysplasia, and in 44% of carcinomas. As the carcinomas were in the advanced stage, they expressed IMP3 more frequently and strongly. Patients with IMP3-positive tumors had poorer survival than those with negative tumors.
CONCLUSIONS
IMP3 expression in gastric carcinoma may be related to tumor invasion and metastasis, and is an independent risk factor for poor prognosis.

Citations

Citations to this article as recorded by  
  • IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
    Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee
    Korean Journal of Pathology.2014; 48(2): 108.     CrossRef
  • Role of combination of insulin-like growth factor II messenger RNA-binding protein 3 and claudin-1 immunostaining in differentiation between endometrial endometrioid carcinoma and uterine serous carcinoma
    Maha M. Shamloula, Dareen A. Mohamed, Ayman El-Dorf
    Egyptian Journal of Pathology.2013; 33(2): 237.     CrossRef
The Histone Acetyltransferase hMOF is Overexpressed in Non-small Cell Lung Carcinoma.
Joon Seon Song, Sung Min Chun, Ji Young Lee, Dong Kwan Kim, Yong Hee Kim, Se Jin Jang
Korean J Pathol. 2011;45(4):386-396.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.386
  • 4,439 View
  • 54 Download
  • 13 Crossref
AbstractAbstract PDF
BACKGROUND
One of the histone acetyltransferases (HATs) family of proteins, human MOF (hMOF, MYST1), is involved in histone H4 acetylation, particularly at lysine 16 (H4K16Ac), an epigenetic mark of active genes. Dysregulation of the epigenetic mark influences cellular biology and possibly leads to oncogenesis. We examined the involvement of hMOF and H4K16Ac in primary non-small cell lung cancer (NSCLC).
METHODS
Reverse transcription polymerase chain reaction using fresh-frozen lung cancer tissues and lung cancer cell lines and immunohistochemistry for hMOF and H4K16Ac via tissue microarray of 551 formalin-fixed paraffin-embedded NSCLC tissue blocks were conducted.
RESULTS
hMOF mRNA was frequently overexpressed in lung cancer tissues, compared with normal lung tissues (10/20, 50%). NSCLC tissues were positive for hMOF in 37.6% (184/489) and H4K16Ac in 24.7% (122/493) of cases. hMOF protein expression was tightly correlated with the H4K16Ac level in tumors (p<0.001). Knockdown of hMOF mRNA with siRNA led to a significant inhibition of growth in the Calu-6 cell line.
CONCLUSIONS
hMOF was frequently expressed in NSCLC and was correlated with H4K16Ac. To our knowledge, this is the first study that has focused on the expression status of HATs and hMOF in NSCLC. Our results clearly suggest a potential oncogenic role of the gene and support its utility as a potential therapeutic target.

Citations

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  • Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling
    Peichao Li, Lingxiao Yang, Sun Young Park, Fanrong Liu, Alex H. Li, Yilin Zhu, Huacong Sui, Fengyuan Gao, Lingbing Li, Lan Ye, Yongxin Zou, Zhongxian Tian, Yunpeng Zhao, Max Costa, Hong Sun, Xiaogang Zhao
    Oncogene.2024; 43(12): 899.     CrossRef
  • The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics
    Chenise O’Garro, Loveth Igbineweka, Zonaira Ali, Mihaly Mezei, Shiraz Mujtaba
    Biomolecules.2021; 11(3): 455.     CrossRef
  • Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development
    Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita
    Molecular and Cellular Biology.2020;[Epub]     CrossRef
  • The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis
    Jiaming Su, Fei Wang, Yong Cai, Jingji Jin
    International Journal of Molecular Sciences.2016; 17(1): 99.     CrossRef
  • Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma
    LIN ZHU, JIAXING YANG, LINHONG ZHAO, XUE YU, LINGYAO WANG, FEI WANG, YONG CAI, JINGJI JIN
    International Journal of Oncology.2015; 46(6): 2535.     CrossRef
  • Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells
    Da Liu, Donglu Wu, Linhong Zhao, Yang Yang, Jian Ding, Liguo Dong, Lianghai Hu, Fei Wang, Xiaoming Zhao, Yong Cai, Jingji Jin, Tim Thomas
    PLOS ONE.2015; 10(10): e0141014.     CrossRef
  • The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth
    Jin Zhang, Hui Liu, Hao Pan, Yuan Yang, Gang Huang, Yun Yang, Wei-Ping Zhou, Ze-Ya Pan
    Biochemical and Biophysical Research Communications.2014; 452(3): 575.     CrossRef
  • Regulation and function of histone acetyltransferase MOF
    Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li
    Frontiers of Medicine.2014; 8(1): 79.     CrossRef
  • The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti‐drug responses in human non‐small cell lung cancer
    Zhiwei Chen, Xiangyun Ye, Naiwang Tang, Shengping Shen, Ziming Li, Xiaomin Niu, Shun Lu, Ling Xu
    British Journal of Pharmacology.2014; 171(13): 3196.     CrossRef
  • Correlation of low expression of hMOF with clinicopathological features of colorectal carcinoma, gastric cancer and renal cell carcinoma
    LINGLING CAO, LIN ZHU, JIAXING YANG, JIAMING SU, JINSONG NI, YUJUN DU, DA LIU, YANFANG WANG, FEI WANG, JINGJI JIN, YONG CAI
    International Journal of Oncology.2014; 44(4): 1207.     CrossRef
  • Coactivator MYST1 Regulates Nuclear Factor-κB and Androgen Receptor Functions During Proliferation of Prostate Cancer Cells
    Anbalagan Jaganathan, Pratima Chaurasia, Guang-Qian Xiao, Marc Philizaire, Xiang Lv, Shen Yao, Kerry L. Burnstein, De-Pei Liu, Alice C. Levine, Shiraz Mujtaba
    Molecular Endocrinology.2014; 28(6): 872.     CrossRef
  • A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first
    NING LIU, RUI ZHANG, XIAOMING ZHAO, JIAMING SU, XIAOLEI BIAN, JINSONG NI, YING YUE, YONG CAI, JINGJI JIN
    Oncology Letters.2013; 6(2): 393.     CrossRef
  • Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma
    Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang, Jingji Jin
    Journal of Experimental & Clinical Cancer Research.2013;[Epub]     CrossRef
Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma.
Kyung Hwa Lee, Soong Lee, Hyeon Min Lee, Seung Chul Back, Sung Bum Cho, Jae Hyuk Lee
Korean J Pathol. 2011;45(4):397-405.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.397
  • 3,332 View
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AbstractAbstract PDF
BACKGROUND
The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their prognostic significance.
METHODS
Livin, XIAP, and SMAC/DIABLO expression was assessed by immunohistochemistry in 159 colorectal carcinomas. Correlations between protein expression and clinicopathological features were evaluated. The survival data analysis was estimated according to the Kaplan-Meier method.
RESULTS
Increased expression of IAPs in cancer tissues compared to surrounding nonneoplastic counterparts was observed in 67 cases (42.1%) for Livin, 50 cases (31.4%) for XIAP, and 68 cases (42.8%) for SMAC. A significant correlation was found between Livin expression and tumor differentiation, and SMAC expression and tumor location. The recurrence-free and overall survival of patients with low Livin expression were inferior to those of patients with high Livin expression (p=0.054 and 0.095, respectively). High XIAP expression was significantly associated with shorter progression-free survival (p= 0.041).
CONCLUSIONS
Our study demonstrated that altered expression of IAP family members, including Livin, XIAP, and SMAC, is frequent in colorectal carcinoma. This result suggests that high Livin expression and low XIAP expression may be a favorable prognostic implication related to patient survival.

Citations

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  • A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer
    Pierina Cetraro, Julio Plaza-Diaz, Alex MacKenzie, Francisco Abadía-Molina
    Cancers.2022; 14(7): 1671.     CrossRef
Fine-Needle Aspiration Cytology of the Nodal Marginal Zone Lymphoma.
Seung Kyu Choi, Ji Eun Kwon, Young Hyeh Ko
Korean J Pathol. 2011;45(4):406-411.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.406
  • 2,787 View
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AbstractAbstract PDF
BACKGROUND
Nodal marginal zone lymphoma (NMZL) is a rare B-cell neoplasm consisting of heterogeneous cellular components and residual B-cell follicles. Because of such histological features, it is difficult to diagnose NMZL by fine needle aspiration (FNA) cytology. We reviewed FNA cytology of NMZL to identify a cytological clue to avoid misdiagnosing NMZL.
METHODS
Histological, cytological, and clinical findings of seven cases of NMZL were reviewed.
RESULTS
Most cases showed nodular aggregates of lymphohistiocytes derived from the germinal center irrespective of histological pattern. The cellular components were heterogeneous and composed of mature small lymphocytes, intermediate and large lymphocytes, immunoblasts, tingible body macrophages, and follicular dendritic cells. Intermediate-sized neoplastic cells with a pale nucleus were observed but difficult to identify because of admixed non-neoplastic cells, which outnumbered neoplastic cells. Except for one case with a high proportion of intermediate-sized cells, the other six cases were initially diagnosed as reactive hyperplasia. A flow cytometric analysis was performed in two cases and failed to demonstrate a monoclonal B-cell population.
CONCLUSIONS
The FNA showing a reactive hyperplasia-like smear pattern should be carefully observed by experienced cytopathologists to identify intermediate-sized neoplastic cells. Clinical information including the size of the lymph nodes is important to avoid a misdiagnosis.
Case Reports
Parotid Gland Carcinosarcoma with Osteosarcoma as a Sarcomatous Component: A Case Report with Fine Needle Aspiration Cytologic Findings.
Se Min Jang, Young Jin Jun, Hulin Han, Ki Seok Jang, Seung Sam Paik
Korean J Pathol. 2011;45(4):412-416.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.412
  • 3,228 View
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  • 1 Crossref
AbstractAbstract PDF
Carcinosarcoma of the salivary glands is a rare malignant tumor showing both malignant epithelial and mesenchymal components. Herein, we present a carcinosarcoma of the parotid gland in a 67-year-old man consisting of osteosarcoma and adenocarcinoma components with fine needle aspiration cytological findings. The tumor was composed predominantly of osteosarcoma and small areas of adenocarcinomatous components and a hyalinized nodule reminiscent of pleomorphic adenoma. The tumor showed infiltrative growth features with perineural, lymphatic, and vascular invasion. Despite postoperative adjuvant radiation therapy, multiple metastatic lesions occurred in the both lungs 5 months after surgery. As salivary gland carcinosarcoma has been known to demonstrate highly aggressive behavior, an accurate pathological diagnosis is prerequisite for appropriate treatment.

Citations

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  • Carcinosarcoma of the parotid gland with abdominal metastasis: a case report and review of literature
    Chang Gok Woo, Seung-Myoung Son
    World Journal of Surgical Oncology.2018;[Epub]     CrossRef
Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation Manifested as a Soft Tissue Mass: Incidental Discovery on Histological Examination.
Sang Yun Ha, Yoon La Choi, Sung Joo Kim, Young Hye Ko
Korean J Pathol. 2011;45(4):417-422.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.417
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  • 5 Crossref
AbstractAbstract PDF
We report an extraordinary case of diffuse large B-cell lymphoma arising in a cystic necrotic mass in a 35-year-old man who presented with a soft tissue mass at the site of previous surgery. A benign mass was surgically removed 17 years ago, after which a cystic lesion gradually developed at the same site. The resected mass appeared as a thick-walled cyst filled with brown necrotic and hemorrhagic material. On microscopic examination, the cyst wall was primarily necrotic tissue with some aggregates of large atypical lymphoid cells. These atypical cells were diffusely positive for CD20 and showed a high proliferation index, Epstein-Barr virus positivity, and clonal rearrangement of the immunoglobulin gene. His present condition was diagnosed as Epstein-Barr virus-associated diffuse large B-cell lymphoma arising from chronic inflammation. It is important to be aware of the clinical manifestations and histological features of this rare disease in light of diagnosis and treatment.

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  • EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review
    Tin Wai Ho, Wah Cheuk, John K.C. Chan
    International Journal of Surgical Pathology.2023; 31(7): 1420.     CrossRef
  • Diffuse Large B Cell Lymphoma in a Prosthetic Aortic Graft
    David Bell, David Marshman
    Heart, Lung and Circulation.2017; 26(2): e4.     CrossRef
  • Fibrin-associated EBV-positive Large B-Cell Lymphoma
    Daniel F. Boyer, Penelope A. McKelvie, Laurence de Leval, Kerstin L. Edlefsen, Young-Hyeh Ko, Zachary A. Aberman, Alexandra E. Kovach, Aneal Masih, Ha T. Nishino, Lawrence M. Weiss, Alan K. Meeker, Valentina Nardi, Maryknoll Palisoc, Lina Shao, Stefania P
    American Journal of Surgical Pathology.2017; 41(3): 299.     CrossRef
  • Malignant Lymphoma Mimicking an Infection After Shoulder Surgery
    Jabari Ian Justin Martin, Jasmine Bauknight, Vincent Desiderio, Bahman Sadr
    Journal of the American Academy of Orthopaedic Surgeons.2017; 25(4): 314.     CrossRef
  • Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
    Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
    Korean Journal of Pathology.2014; 48(2): 81.     CrossRef
Primary Hepatic Neuroblastoma: A Case Report.
Geunyoung Jung, Jihun Kim
Korean J Pathol. 2011;45(4):423-427.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.423
  • 3,685 View
  • 19 Download
  • 2 Crossref
AbstractAbstract PDF
Neuroblastoma is a malignant tumor of primordial neural crest origin. It usually develops along the sympathetic nervous system, such as the adrenal glands or paramedian sympathetic chain and metastasizes to the liver most frequently. However, a primary hepatic neuroblastoma has not been reported yet. Here, we report a case of 29-year-old woman who presented with a solitary hepatic mass. Grossly, the mass was large, creamy, rubbery firm, and showed focal hemorrhage and central cavitation. Microscopically, the tumor cells were arranged in small nests of spindle to ovoid cells with abundant neuropil. The neuroblastic nature of the tumor was confirmed by immunohistochemistry and electron microscopy. No extrahepatic mass was found, despite a thorough systemic survey such as chest and abdominopelvic computed tomography (CT) scans and a whole body positron emission tomography-CT study. To the best of our knowledge, this is the first report of a bona fide primary hepatic neuroblastoma.

Citations

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  • Primary hepatic neuroblastoma in a 19-month-old child: A case report
    Jovana Dimić, Dejan Skorić, Aleksandar Sretenović, Slaviša Đuričić
    Medicinska istrazivanja.2022; 55(2): 41.     CrossRef
  • Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
    Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
    Korean Journal of Pathology.2013; 47(5): 433.     CrossRef
Cytologic Features and BRAF Mutation of Hyalinizing Trabecular Adenoma of the Thyroid: A Case Report with Review of the Literature.
Se Min Jang, Young Ha Oh, Yoon Kyung Jeon, Yong Wook Park, Moon Hyang Park
Korean J Pathol. 2011;45(4):428-433.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.428
  • 3,171 View
  • 26 Download
  • 2 Crossref
AbstractAbstract PDF
A hyalinizing trabecular adenoma (HTA) is a rare benign thyroid tumor of follicular epithelial cell origin with a trabecular-alveolar growth pattern and marked intratrabecular hyalinization. The cytological and histological features of HTA are very similar to those of papillary and medullary carcinomas of the thyroid. Therefore, an accurate diagnosis of HTA is important to avoid unnecessary and potentially harmful management of patients. However, the results of BRAF gene mutation analysis shown by many studies are distinctly different between HTAs and papillary thyroid carcinomas. Herein, we describe a rare case of HTA of the thyroid in a 49-year-old female and consider its characteristic cytological features and BRAF gene mutation analysis results with a brief review of the literature.

Citations

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  • Hyalinizing trabecular tumor, a rare histologically unique tumor of the thyroid, coexisting with papillary thyroid carcinoma
    Chiu-Hsuan Cheng
    Tzu Chi Medical Journal.2021; 33(2): 198.     CrossRef
  • A Case of Hyalinizing Trabecular Tumor of the Thyroid Gland
    Kun Woo Kim, Sang Joon Lee, Phil-Sang Chung, Junghwan Moon
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2012; 55(12): 795.     CrossRef
Bile Ductular Proliferation in the Gastric Wall after Gastric Ulcer Penetration into the Liver.
Eun Jung Cha
Korean J Pathol. 2011;45(4):434-436.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.434
  • 2,446 View
  • 11 Download
AbstractAbstract PDF
Liver penetration is one of the most serious complications of peptic ulcer diseases but is rarely encountered. A 57-year-old man was admitted to our hospital for further evaluation of a gastric malignancy. One month before admission, he was diagnosed with an adenocarcinoma by endoscopic biopsy at other hospital. A subtotal gastrectomy was performed to confirm malignancy and relieve the epigastric pain. Histologically, single glands were located between the ulcer base and attached liver tissue and stained positively for cytokeratin 19. The pathologic diagnosis was a gastric ulcer and bile ductular proliferation in the liver and gastric wall. Here, this report is the first Korean case of liver penetration of a gastric ulcer.

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