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Volume 46(3); June 2012
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Original Articles
Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors
Soomin Ahn, Jae Jun Lee, Sang Yun Ha, Chang Ohk Sung, Jhingook Kim, Joungho Han
Korean J Pathol. 2012;46(3):221-225.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.221
  • 7,696 View
  • 72 Download
  • 26 Citations
AbstractAbstract PDF
Background

Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.

Methods

We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.

Results

It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.

Conclusions

In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

Citations

Citations to this article as recorded by  
  • Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)
    Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen
    Seminars in Cancer Biology.2022; 79: 141.     CrossRef
  • Multiple electrolyte disturbances as the presenting feature of multiple endocrine neoplasia type 1 (MEN-1)
    Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E Drakou, Royce P Vincent, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
    Endocrinology, Diabetes & Metabolism Case Reports.2022;[Epub]     CrossRef
  • Metastatic Thymic Carcinoid: Does Surgeon Have a Primary Role?
    Kumud Gupta, Ravindra K. Dewan, Vinitha Viswambharan Nair, Rajat Saxena, Shaleen Prasad
    The Indian Journal of Chest Diseases and Allied Sciences.2022; 56(4): 255.     CrossRef
  • A resected case of large cell neuroendocrine carcinoma of the thymus
    Masashi Umeda, Takahiko Misao, Tomoya Senoh, Yoshinobu Shikatani, Motoi Aoe
    The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 766.     CrossRef
  • Thymic neuroendocrine tumours
    Jan von der Thüsen
    Diagnostic Histopathology.2022;[Epub]     CrossRef
  • Treatment strategy and prognostic analysis of spinal metastases from thymomas: A retrospective study from a single center
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, Siyuan Yao, Yipeng Wang, Yong Liu
    Clinical Neurology and Neurosurgery.2020; 196: 106056.     CrossRef
  • Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy
    Takeaki Hidaka, Saki Okuzumi, Ako Matsuhashi, Hidenori Takahashi, Kazunori Hata, Seiichiro Shimizu, Yoshinobu Iwasaki
    Internal Medicine.2019; 58(4): 563.     CrossRef
  • Surgical management of spinal metastases of thymic carcinoma
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2019; 98(3): e14198.     CrossRef
  • Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature
    Shogo Ogata, Ryo Maeda, Masaki Tomita, Yuichiro Sato, Takanori Ayabe, Kunihide Nakamura
    International Journal of Surgery Case Reports.2019; 60: 53.     CrossRef
  • Metastatic or locally advanced mediastinal neuroendocrine tumours
    Aadil Adnan, Shreyas Kudachi, Sudha Ramesh, Kumar Prabhash, Sandip Basu
    Nuclear Medicine Communications.2019; 40(9): 947.     CrossRef
  • Results of treatment for thymic neuroendocrine tumours: multicentre clinicopathological study†
    Naoko Ose, Hajime Maeda, Masayoshi Inoue, Eiichi Morii, Yasushi Shintani, Hiroshi Matsui, Hirohito Tada, Tositeru Tokunaga, Kenji Kimura, Yasushi Sakamaki, Yukiyasu Takeuchi, Kenjiro Fukuhara, Hiroshi Katsura, Teruo Iwasaki, Meinoshin Okumura
    Interactive CardioVascular and Thoracic Surgery.2018; 26(1): 18.     CrossRef
  • Patterns of Failure Following Postoperative Radiation Therapy Based on “Tumor Bed With Margin” for Stage II to IV Type C Thymic Epithelial Tumor
    Kyung Hwa Lee, Jae Myoung Noh, Yong Chan Ahn, Dongryul Oh, Jhingook Kim, Young Mog Shim, Jung-ho Han
    International Journal of Radiation Oncology*Biology*Physics.2018; 102(5): 1505.     CrossRef
  • Resected thymic large cell neuroendocrine carcinoma: report of a case
    Hiromitsu Domen, Yasuhiro Hida, Masaaki Sato, Haruka Takahashi, Tatsuru Ishikawa, Yosuke Shionoya, Midori Hashimoto, Kaoru Nishiyama, Yuma Aoki, Kazuho Inoko, Syotaro Furukawa, Kazuomi Ichinokawa, Hidehisa Yamada
    Surgical Case Reports.2018;[Epub]     CrossRef
  • Successful treatment of malignant thymoma with sacrum metastases
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2018; 97(51): e13796.     CrossRef
  • Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report
    Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
    Journal of Medical Case Reports.2017;[Epub]     CrossRef
  • Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift
    Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Paolo Bidoli, Stefania Canova, Diego Cortinovis, Maria Ida Abbate, Fiorella Calabrese, Nazarena Nannini, Francesca Lunardi, Giulio Rossi, Stefano La Rosa, Carlo Capella, Elena Tamborini, Federica Perrone,
    Virchows Archiv.2017; 471(1): 31.     CrossRef
  • Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report
    Efared Boubacar, Gabrielle Atsame-Ebang, Sani Rabiou, Ammor Fatimazahra, Asmae Mazti, Ibrahim S. Sidibé, Layla Tahiri, Nawal Hammas, Ouadnouni Yassine, Smahi Mohamed, Chbani Laila, El Fatemi Hinde
    Journal of Medical Case Reports.2017;[Epub]     CrossRef
  • Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver
    Yoriko Nomura, Osamu Nakashima, Jun Akiba, Sachiko Ogasawara, Shogo Fukutomi, Rin Yamaguchi, Hironori Kusano, Masayoshi Kage, Koji Okuda, Hirohisa Yano
    Journal of Clinical Pathology.2017; 70(7): 563.     CrossRef
  • Retrosternal goiter and thymic carcinoid: A rare co-existence
    Abdulsalam Yaseen Taha, Nezar A. Almahfooz, Hassanain H. Khudair
    Journal of the Egyptian Society of Cardio-Thoracic Surgery.2017; 25(4): 369.     CrossRef
  • A case of large-cell neuroendocrine carcinoma of the thymus involving a patient with long-term survival after surgery
    Qiuming Kan, Kohei Tagawa, Teruaki Ishida, Mitsuyo Nishimura, Katsuhiko Aoyama
    The Journal of the Japanese Association for Chest Surgery.2017; 31(7): 927.     CrossRef
  • Neuroendokrine Neoplasien des Mediastinums
    L. Brcic, M. Heidinger, H. Popper
    Der Pathologe.2016; 37(5): 434.     CrossRef
  • Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
    Pier Luigi Filosso, Xiaopan Yao, Usman Ahmad, Yilei Zhan, James Huang, Enrico Ruffini, William Travis, Marco Lucchi, Andreas Rimner, Alberto Antonicelli, Francesco Guerrera, Frank Detterbeck
    The Journal of Thoracic and Cardiovascular Surgery.2015; 149(1): 103.     CrossRef
  • Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
    Young Bae Choi, Go Eun Bae, Na Hee Lee, Jung-Sun Kim, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
    Journal of Korean Medical Science.2015; 30(8): 1062.     CrossRef
  • Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi-institutional clinicopathologic study
    Philipp Ströbel, Andreas Zettl, Konstantin Shilo, Wen-Yu Chuang, Andrew G. Nicholson, Yoshihiro Matsuno, Anthony Gal, Rolf Hubert Laeng, Peter Engel, Carlo Capella, Mirella Marino, John Kwok-Cheung Chan, Andreas Rosenwald, William Travis, Teri J. Franks,
    Genes, Chromosomes and Cancer.2014; 53(9): 738.     CrossRef
  • Disseminated large cell neuroendocrine carcinoma associated with ectopic adrenocorticotropic hormone secretion
    A Van der Walt, K Huddle, S Pather, A Korb
    Journal of Endocrinology, Metabolism and Diabetes of South Africa.2014; 19(1): 40.     CrossRef
  • Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
    Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
    Korean Journal of Pathology.2013; 47(5): 433.     CrossRef
Proposal for Creating a Guideline for Cancer Registration of Microinvasive Tumors of the Breast and Ovary (II)
Jin Hee Sohn, Gyungyub Gong, Kyu Rae Kim, Chang Suk Kang, Youn Soo Lee, Jin Man Kim, Woo Hee Jung, Kwang Sun Suh
Korean J Pathol. 2012;46(3):226-232.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.226
  • 8,132 View
  • 47 Download
  • 2 Citations
AbstractAbstract PDF
Background

Cancer registration in Korea has a longer than 30-years of history, during which time cancer registration has improved and become well-organized. Cancer registries are fundamental for cancer control and multi-center collaborative research. However, there have been discrepancies in assigning behavior codes. Thus, we intend to propose appropriate behavior codes for the International Classification of Disease Oncology, 3rd edition (ICD-O-3) for microinvasive tumors of the ovary and breast not only to improve the quality of the cancer registry but also to prevent conflicts.

Methods

As in series I, two pathology study groups and the Cancer Registration Committee of the Korean Society of Pathologists (KSP) participated. To prepare a questionnaire on provisional behavior code, the relevant subjects were discussed in the workshop, and consensus was obtained by convergence of opinion from members of KSP.

Results

Microinvasive tumor of the breast should be designated as a microinvasive carcinoma which was proposed as malignant tumor (/3). Serous borderline tumor with microinvasion of the ovary was proposed as borderline tumor (/1), and mucinous borderline tumor with microinvasion of the ovary as either borderline (/1) or carcinoma (/3) according to the tumor cell nature.

Conclusions

Some issues should be elucidated with the accumulation of more experience and knowledge. Here, however, we present our second proposal.

Citations

Citations to this article as recorded by  
  • Update on the Proposal for Creating a Guideline for Cancer Registration of the Gastrointestinal Tumors (I-2)
    Eun Sun Jung, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Won Ae Lee, Hee Eun Lee, Sunhoo Park, Jin Hee Sohn, So-Young Jin
    Korean Journal of Pathology.2012; 46(5): 443.     CrossRef
  • A Proposal for Creating a Guideline for Cancer Registration of the Fibromatosis, PEComa Group, Malignant LymphomaIn Situand Dendritic Cell Tumors (III)
    Changyoung Yoo, Chang Suk Kang, Yoon La Choi, Hye Yoon Kang, Jin Man Kim, Young Hye Koh, Joo Hee Lee, Seung Sook Lee, In Sun Kim, Dong Hoon Kim, Yong Ku Park, Jin Hee Sohn
    Korean Journal of Pathology.2012; 46(5): 436.     CrossRef
Urinary Decoy Cell Grading and Its Clinical Implications
Myoung Ju Koh, Beom Jin Lim, Songmi Noh, Yon Hee Kim, Hyeon Joo Jeong
Korean J Pathol. 2012;46(3):233-236.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.233
  • 6,867 View
  • 39 Download
  • 4 Citations
AbstractAbstract PDF
Background

Examination of urine for decoy cells (DCs) is a useful screening test for polyomavirus (PV) activation. We explored the significance of the amount of DCs in persistent shedding, PV nephropathy and acute rejection.

Methods

A case-controlled study was performed in 88 renal allograft patients who had DCs detected at least once in four or more urine samples.

Results

Fifty one patients were classified into the high-grade shedding group (HG) and 37 patients into the low-grade shedding group (LG) according to DC shedding (≥10 or <10 DCs/10 high power field [HPF]). DC shedding of more than three consecutive months was significantly more prevalent in the HG as compared with their LG counterparts (p<0.0001). Urinary DCs were present for more than one year in 29.4% of the HG and 8.1% of the LG. Real-time polymerase chain reaction for PV was higher in both urine (51.4% vs. 11.1%) and plasma (9.1% vs. 0%) of the HG than the LG. The prevalence of PV nephropathy was higher in the HG than the LG (p=0.019). However, there was no significant difference in the prevalence of acute rejection.

Conclusions

Shedding of ≥10 DCs/10 HPF is associated with sustained shedding, polymerase chain reaction positivity and PV nephropathy, but not a predictor of acute rejection.

Citations

Citations to this article as recorded by  
  • BK Virus-Associated Nephropathy after Renal Transplantation
    Yasuhito Funahashi
    Pathogens.2021; 10(2): 150.     CrossRef
  • Diagnostic utility of urine cytology in detection of decoy cells in renal transplant patients: Report of five cases and review of literature
    Santosh Tummidi, Kanchan Kothari, Mona Agnihotri, Leena Naik, Amey Rojekar
    Diagnostic Cytopathology.2020; 48(3): 222.     CrossRef
  • Association of Pretransplant BK Polyomavirus Antibody Status with BK Polyomavirus Infection After Kidney Transplantation: A Prospective Cohort Pilot Study of 47 Transplant Recipients
    Yu Hisadome, Hiroshi Noguchi, Yuki Nakafusa, Kukiko Sakihama, Takanori Mei, Keizo Kaku, Yasuhiro Okabe, Kosuke Masutani, Yuki Ohara, Kazuyuki Ikeda, Yoshinao Oda, Masafumi Nakamura
    Transplantation Proceedings.2020; 52(6): 1762.     CrossRef
  • Association Between the Polyomaviruses Titers and Decoy Cell Positivity Rates After Renal Transplantation
    Y. Funahashi, M. Kato, T. Fujita, S. Ishida, A. Mori, M. Gotoh
    Transplantation Proceedings.2016; 48(3): 921.     CrossRef
Cyclooxygenase-2 Expression and Its Prognostic Significance in Clear Cell Renal Cell Carcinoma
Ji Won Lee, Jeong Hwan Park, Ja Hee Suh, Kyung Han Nam, Ji-Young Choe, Hae Yoen Jung, Ji Yoen Chae, Kyung Chul Moon
Korean J Pathol. 2012;46(3):237-245.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.237
  • 6,761 View
  • 33 Download
  • 13 Citations
AbstractAbstract PDF
Background

The prognostic value of cyclooxygenase-2 (COX-2) in human renal cell carcinoma (RCC) remains unclear. The purposes of this study are to elucidate the clinical significance of COX-2 in clear cell RCC (CCRCC) and to assess the treatment effect of COX-2 inhibition on CCRCC cell lines.

Methods

Using tumor samples obtained from 137 patients who had undergone nephrectomy at Seoul National University Hospital, we evaluated COX-2 expression on immunohistochemistry. Moreover, we performed the cell proliferation assay using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) and cell invasion assay. Thus, we evaluated the effect of meloxicam, an inhibitor of COX-2, in two human CCRCC cell lines.

Results

Cancer-specific survival (p=0.038) and progression-free survival (p=0.031) were shorter in the COX-2 high expression group. A multivariate logistic regression model showed that COX-2 expression was an independent risk factor for pTNM stage and Fuhrman nuclear grade. The MTT assay revealed that COX-2 inhibition led to the suppression of the proliferation of CCRCC cell lines. Moreover, it also reduced their invasion capacity.

Conclusions

This study postulates that COX-2 is a poor prognostic indicator in human CCRCC, suggesting that COX-2 inhibition can be a potential therapy in CCRCC.

Citations

Citations to this article as recorded by  
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    Journal of Ethnopharmacology.2022; 284: 114740.     CrossRef
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    Journal of Ethnopharmacology.2021; 268: 113547.     CrossRef
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    Jefferson da Rocha Tenório, Leorik Pereira da Silva, Marília Gabriela de Aguiar Xavier, Thalita Santana, George João Ferreira do Nascimento, Ana Paula Veras Sobral
    European Archives of Oto-Rhino-Laryngology.2018; 275(9): 2341.     CrossRef
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    S. Carvalho, A. L. Stoll, S. L. Priestnall, A. Suarez-Bonnet, K. Rassnick, S. Lynch, I. Schoepper, G. Romanelli, P. Buracco, M. Atherton, E. M. de Merlo, A. Lara-Garcia
    Veterinary and Comparative Oncology.2017; 15(4): 1280.     CrossRef
  • Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib
    Arancha Cebrián, Teresa Gómez del Pulgar, María José Méndez-Vidal, María Luisa Gonzálvez, Nuria Lainez, Daniel Castellano, Iciar García-Carbonero, Emilio Esteban, Maria Isabel Sáez, Rosa Villatoro, Cristina Suárez, Alfredo Carrato, Javier Munárriz-Ferránd
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  • COX-2 expression in ovarian cancer: an updated meta-analysis
    Haiming Sun, Xuelong Zhang, Donglin Sun, Xueyuan Jia, Lidan Xu, Yuandong Qiao, Yan Jin
    Oncotarget.2017; 8(50): 88152.     CrossRef
  • COX-2 Expression in Renal Cell Carcinoma and Correlations with Tumor Grade, Stage and Patient Prognosis
    Hedieh Moradi Tabriz, Marzieh Mirzaalizadeh, Shahram Gooran, Farzaneh Niki, Maryam Jabri
    Asian Pacific Journal of Cancer Prevention.2016; 17(2): 535.     CrossRef
  • Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma
    Kosuke Saito, Eri Arai, Keiko Maekawa, Masaki Ishikawa, Hiroyuki Fujimoto, Ryo Taguchi, Kenji Matsumoto, Yae Kanai, Yoshiro Saito
    Scientific Reports.2016;[Epub]     CrossRef
  • Intratumoral expression of cyclooxygenase-2 (COX-2) is a negative prognostic marker for patients with cutaneous melanoma
    Łukasz Kuźbicki, Dariusz Lange, Agata Stanek-Widera, Barbara W. Chwirot
    Melanoma Research.2016; 26(5): 448.     CrossRef
  • New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
    Honor J. Hugo, C. Saunders, R. G. Ramsay, E. W. Thompson
    Journal of Mammary Gland Biology and Neoplasia.2015; 20(3-4): 109.     CrossRef
  • The role of prostaglandin E2 in renal cell cancer development: future implications for prognosis and therapy
    Katarzyna Kaminska, Cezary Szczylik, Fei Lian, Anna M Czarnecka
    Future Oncology.2014; 10(14): 2177.     CrossRef
  • Genomics and epigenomics of clear cell renal cell carcinoma: Recent developments and potential applications
    Małgorzata Rydzanicz, Tomasz Wrzesiński, Hans A.R. Bluyssen, Joanna Wesoły
    Cancer Letters.2013; 341(2): 111.     CrossRef
  • Quantitative Assessment of the Association of COX-2 (Cyclooxygenase-2) Immunoexpression with Prognosis in Human Osteosarcoma: A Meta-Analysis
    Zhe Wang, Maolin He, Zengming Xiao, Hao Wu, Yang Wu, Dominique Heymann
    PLoS ONE.2013; 8(12): e82907.     CrossRef
Frequency of BRAF Mutation and Clinical Relevance for Primary Melanomas
Hyoun Wook Lee, Ki Hoon Song, Jin Woo Hong, Su Young Jeon, Dong Yeob Ko, Ki Ho Kim, Hyuk Chan Kwon, Suee Lee, Sung Hyun Kim, Dae Cheol Kim
Korean J Pathol. 2012;46(3):246-252.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.246
  • 6,636 View
  • 39 Download
  • 11 Citations
AbstractAbstract PDF
Background

This study was conducted to clarify the frequency of the BRAF mutation in primary melanomas and its correlation with clinicopathologic parameters.

Methods

We analyzed the frequency of BRAF mutation in patients with primary cutaneous melanoma (n=58) or non-cutaneous one (n=27) by performing dual priming oligonucleotide-based multiplex real-time polymerase chain reaction to isolate and to purify the DNA from the formalin-fixed and paraffin-embedded tumors.

Results

The BRAF mutation was found in 17.2% (10/58) of patients with primary cutaneous melanoma and 11.1% (3/27) of those with non-cutaneous melanoma. The frequency of BRAF mutation was not correlated with any clinicopathologic parameters with the exception of the patient age. The frequency of the BRAF mutation was significantly higher in patients younger than 60 years as compared with those older than 60 years (p=0.005).

Conclusions

Compared with previous reports, our results showed that the frequency of the BRAF mutation was relatively lower in patients with primary cutaneous melanoma. Besides, our results also showed that the frequency of the BRAF mutation had an inverse correlation with the age. Further studies are warranted to exclude methodological bias, to elucidate the difference in the frequency of the BRAF mutation from the previous reports from a Caucasian population and to provide an improved understanding of the molecular pathogenesis of malignant melanoma.

Citations

Citations to this article as recorded by  
  • Genetic characteristics and response to systemic therapies of acral lentiginous melanoma at a tertiary care center—a retrospective review
    Taylor Jamerson, Vito W. Rebecca, Crystal Aguh
    Journal of the National Medical Association.2022; 114(1): 7.     CrossRef
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    Ehiaghe L. Anaba
    Dermatologic Therapy.2021;[Epub]     CrossRef
  • BRAF, KIT, and NRAS Mutations of Acral Melanoma in White Patients
    Emi Dika, Giulia Veronesi, Annalisa Altimari, Mattia Riefolo, Giulia Maria Ravaioli, Bianca Maria Piraccini, Martina Lambertini, Elena Campione, Elisa Gruppioni, Michelangelo Fiorentino, Barbara Melotti, Manuela Ferracin, Annalisa Patrizi
    American Journal of Clinical Pathology.2020; 153(5): 664.     CrossRef
  • Clinical Application of Next-Generation Sequencing–Based Panel to BRAF Wild-Type Advanced Melanoma Identifies Key Oncogenic Alterations and Therapeutic Strategies
    Changhee Park, Miso Kim, Min Jung Kim, Hyeongmin Kim, Chan-Young Ock, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Jong-Il Kim, Dae Seog Heo
    Molecular Cancer Therapeutics.2020; 19(3): 937.     CrossRef
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    Kyueng-Whan Min, Ji-Young Choe, Mi Jung Kwon, Hye Kyung Lee, Ho Suk Kang, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Yun Joong Kim, Nan Young Kim, Ho Young Kim
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  • Acral melanoma: correlating the clinical presentation to the mutational status
    Giulia M. Ravaioli, Emi Dika, Martina Lambertini, Marco A. Chessa, Pier Alessandro Fanti, Annalisa Patrizi
    Giornale Italiano di Dermatologia e Venereologia.2019;[Epub]     CrossRef
  • Sunrise in melanoma management: Time to focus on melanoma burden in Asia
    John Wen-Cheng Chang, Jun Guo, Chia-Yen Hung, Si Lu, Sang Joon Shin, Richard Quek, Anthony Ying, Gwo Fuang Ho, Huu Sau Nguyen, Boman Dhabhar, Virote Sriuranpong, Maria Luisa Tiambeng, Nugroho Prayogo, Naoya Yamazaki
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  • Detection ofBRAF,NRAS,KIT,GNAQ,GNA11andMAP2K1/2mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis
    Marina Emelyanova, Lilit Ghukasyan, Ivan Abramov, Oxana Ryabaya, Evgenia Stepanova, Anna Kudryavtseva, Asiya Sadritdinova, Cholpon Dzhumakova, Tatiana Belysheva, Sergey Surzhikov, Lyudmila Lyubchenko, Alexander Zasedatelev, Tatiana Nasedkina
    Oncotarget.2017; 8(32): 52304.     CrossRef
  • Metaanalysis of BRAF mutations and clinicopathologic characteristics in primary melanoma
    Soo Young Kim, Soo Nyung Kim, Hyung Jin Hahn, Yang Won Lee, Yong Beom Choe, Kyu Joong Ahn
    Journal of the American Academy of Dermatology.2015; 72(6): 1036.     CrossRef
  • Diagnostic Effectiveness of PCR-based Tests DetectingBRAFMutation for Treating Malignant Melanoma: A Systematic Review
    Hae-Won Shin, Ryeo-Jin Ko, Min Lee, Hee-Young Bang, Kye-Chul Kwon, Jong-Woo Park, Sun-Hoe Koo
    Laboratory Medicine Online.2014; 4(4): 203.     CrossRef
  • KIT, NRAS, BRAF and PTEN mutations in a sample of Swedish patients with acral lentiginous melanoma
    Abdlsattar Zebary, Katarina Omholt, Ismini Vassilaki, Veronica Höiom, Diana Lindén, Lisa Viberg, Lena Kanter-Lewensohn, Carolina Hertzman Johansson, Johan Hansson
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The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions
Sangho Lee, Hyunchul Kim, Hyesun Kim, Chulhwan Kim, Insun Kim
Korean J Pathol. 2012;46(3):253-260.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.253
  • 8,095 View
  • 75 Download
  • 5 Citations
AbstractAbstract PDF
Background

Immunohistochemical staining for p16INK4a and Ki-67 has been used to improve the accuracy in making a diagnosis of the uterine cervix cancer on biopsy. This study was conducted to examine the usefulness of these markers in the pathological diagnosis based on cervical biopsy.

Methods

We selected a consecutive series of 111 colposcopically directed cervical punch biopsies. Using these biopsy samples, we performed an immunohistochemical staining for p16INK4a and Ki-67 to establish a diagnosis. The slides were circulated among four pathologists in a sequential order: the hematoxylin and eosin (H&E) slide, H&E slide and p16INK4a-stained slide, and H&E slide, p16INK4a- and Ki-67-stained slides.

Results

The overall rates of the concordance in the first, the second, and the third diagnoses were 77.5%, 82.0%, and 82.0%, respectively. The rate of the concordance in the diagnosis of cervical intraepithelial neoplasm (CIN) 2/3 was increased from 62.2% to 73.0%. But there was a variability in the rate of the revision of the diagnosis between the pathologists. With the application of criteria for interpreting the expressions of p16INK4a and Ki-67, benign and CIN 1 lesions showed a p16INK4a expression score of 0 or 1. But CIN 2 and CIN 3 lesions showed a p16INK4a expression score of 2 and 3, respectively.

Conclusions

The immunostain for p16INK4a and Ki-67 might be useful in reducing an inter-observer variability. But criteria for interpreting both markers should be strictly applied.

Citations

Citations to this article as recorded by  
  • Possible role of negative human papillomavirus E6/E7 mRNA as a predictor of regression of cervical intraepithelial neoplasia 2 lesions in hr-HPV positive women
    Maria Teresa Bruno, Nazario Cassaro, Salvatore Giovanni Vitale, Arianna Guaita, Sara Boemi
    Virology Journal.2022;[Epub]     CrossRef
  • Evaluation of p16, human papillomavirus capsid protein L1 and Ki-67 in cervical intraepithelial lesions: Potential utility in diagnosis and prognosis
    Hanan AlSaeid Alshenawy
    Pathology - Research and Practice.2014; 210(12): 916.     CrossRef
  • Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia
    Tae Eun Kim, Hwal Woong Kim, Kyung Eun Lee
    Korean Journal of Pathology.2014; 48(1): 24.     CrossRef
  • Detection and pathological value of papillomavirus DNA and p16INK4A and p53 protein expression in cervical intraepithelial neoplasia
    JINGBO WU, XIAO-JING LI, WEI ZHU, XIU-PING LIU
    Oncology Letters.2014; 7(3): 738.     CrossRef
  • p16INK4a Immunohistochemistry in Cervical Biopsy Specimens
    Miriam Reuschenbach, Nicolas Wentzensen, Maaike G. Dijkstra, Magnus von Knebel Doeberitz, Marc Arbyn
    American Journal of Clinical Pathology.2014; 142(6): 767.     CrossRef
The Expression of Pigment Epithelium-Derived Factor in Bladder Transitional Cell Carcinoma
Tae Jung Jang, Sung Woo Kim, Kyung Seop Lee
Korean J Pathol. 2012;46(3):261-265.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.261
  • 5,131 View
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  • 3 Citations
AbstractAbstract PDF
Background

Pigment epithelium-derived factor (PEDF) is an anti-angiogenic factor. The purpose of this study is to examine the involvement of PEDF in the angiogenesis and biological behavior of bladder transitional cell carcinoma (TCC).

Methods

We examined the expression of PEDF in 99 bladder TCCs and ten non-neoplastic tissues, and evaluated microvessel density (MVD).

Results

The positive immunoreactivity for PEDF was seen in normal urothelium in 60% (6/10) and TCC in 13% (13/99). The PEDF expression had a significant correlation with MVD, i.e., a low MVD in 42% (5/12), a middle MVD in 11% (8/76) and a high MVD 0% (0/11) of tumors. The PEDF expression was not significantly correlated with the differentiation and invasion of TCC, but the degree of MVD was significantly higher in both high grade TCC and the pT2 tumors.

Conclusions

The degree of PEDF expression is significantly higher in normal bladder urothelium than bladder TCC; it is inversely correlated with the angiogenesis; and it is not related to the differentiation and progression of TCC. It can therefore be concluded that bladder TCC would initially occur if there is a lack of the PEDF expression.

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  • Association of pigment epithelium derived factor expression with cancer progression and prognosis: a meta-analysis study
    Guo Cheng, Crystal Song
    Discover Oncology.2021;[Epub]     CrossRef
  • Level of mitoses in non-muscle invasive papillary urothelial carcinomas (pTa and pT1) at initial bladder biopsy is a simple and powerful predictor of clinical outcome: a multi-center study in South Korea
    Ji Eun Kwon, Nam Hoon Cho, Yeong-Jin Choi, So Dug Lim, Yong Mee Cho, Sun Young Jun, Sanghui Park, Young A. Kim, Sung-Sun Kim, Mi Sun Choe, Jung-dong Lee, Dae Yong Kang, Jae Y. Ro, Hyun-Jung Kim
    Diagnostic Pathology.2017;[Epub]     CrossRef
  • Endogenous Gastric-Resident Mesenchymal Stem Cells Contribute to Formation of Cancer Stroma and Progression of Gastric Cancer
    Eun-Kyung Kim, Hye-Jung Kim, Young-Il Yang, Jong Tae Kim, Min-Young Choi, Chang Soo Choi, Kwang-Hee Kim, Jeong-Han Lee, Won-Hee Jang, Soon-Ho Cheong
    Korean Journal of Pathology.2013; 47(6): 507.     CrossRef
Metastatic Carcinomas to the Oral Cavity and Oropharynx
Su-Jin Shin, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho
Korean J Pathol. 2012;46(3):266-271.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.266
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  • 16 Citations
AbstractAbstract PDF
Background

Metastases to the oral/oropharynx are very rare and their diagnosis is challenging.

Methods

We reviewed pathologic data for malignant tumors of the oral/oropharynx that were diagnosed at the Asan Medical Center, Seoul, Korea from 1995 until 2010.

Results

Twenty-nine cases of oral/oropharyngeal metastases were retrieved, comprising 2.0% of 1,445 malignancies. The most common primary sites were the liver and lung, followed by the stomach, colon, breast, prostate, and kidney. The gingiva was the most common metastatic site, followed by the tonsil/pillar, mandible, tongue, tongue base, palate mucosa, mouth floor, and buccal mucosa. Intervals between detection of primary tumors and metastases were variable, from -1 month to 104 months. Ten patients with lung (7 cases), liver, stomach, and kidney carcinomas manifested with oral/oropharyngeal metastases as the first sign of systemic metastases. The majority of patients had died within one year of the onset of an oral/oropharyngeal metastasis, but exceptionally long-lived cases were also present. The survival periods of patients with lung cancers were longer than those of patients with non-pulmonary tumors.

Conclusions

An awareness of the incidence, common primary sites, metastatic subsites, and metastatic courses or patterns of oral/oropharyngeal metastases is helpful in the diagnosis of metastatic carcinomas.

Citations

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    MK Jawanda, R Narula, S Gupta, P Gupta
    Journal of Oral and Maxillofacial Pathology.2022; 26(1): 133.     CrossRef
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    Yuan Huang, Yanqiu Bao, Dongyuan Xu, Lan Liu
    Journal of International Medical Research.2022; 50(7): 030006052211134.     CrossRef
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    Nusaybah Elsherif, Predrag Jeremic, Tim Blackburn
    Dental Update.2021; 48(10): 846.     CrossRef
  • Recurrent clear cell carcinoma of the tongue base with high grade transformation in a pregnant patient
    Emad M. Al Haj Ali, Ahmed M. Ibrahim, Tamer A. Ghanem, Christian E. Keller
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(2): 104.     CrossRef
  • Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!
    Stephen M. Smith, Matthew Old, O. Hans Iwenofu
    Head and Neck Pathology.2017; 11(2): 234.     CrossRef
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    Li-Jun Xue, Xiao-Bei Mao, Jian Geng, Ya-Nan Chen, Qian Wang, Xiao-Yuan Chu
    Case Reports in Medicine.2017; 2017: 1.     CrossRef
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    Luca Valle, Joel Thomas, Chul Kim, Eva Szabo, G. Thomas Brown, Deborah Citrin, Arun Rajan
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    Gianfilippo Nifosì, Hubert Bressand, Antonio Fabrizio Nifosì, Lorenzo Nifosì, Pierre Damseaux
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    Lei Jiang, Taoying Gu, Fang Liu, Lijuan Luan, Hongcheng Shi
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    Masaharu NOI, Yoshizou TSUDA, Shota SAITO, Takeshi ADACHI, Tomoki HIGO, Gaku YAMAMOTO
    Japanese Journal of Oral and Maxillofacial Surgery.2016; 62(2): 62.     CrossRef
  • Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature
    Sibel Elif Gultekin, Burcu Senguven, Ipek Isik Gonul, Begum Okur, Reinhard Buettner
    Journal of Oral and Maxillofacial Surgery.2016; 74(10): 2007.e1.     CrossRef
  • A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass
    Min Jung Kwon, Soo Hyung Ryu, Soo Yeon Jo, Chul Hoon Kwak, Won Jae Yoon, Jeong Seop Moon, Hye Kyung Lee
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    Tae Min You, Kee-Deog Kim, Ho-Gul Jeong, Wonse Park
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    Yukihiro Nakanishi, Bo Xu, Charles LeVea
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  • Primary Squamous Cell Carcinoma of Lung Leading to Metastatic Jaw Tumor
    Chintamaneni Raja Lakshmi, M. Sudhakara Rao, Sujana Mulk Bhavana, Sivan Sathish
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Case Reports
Tumor Budding and Recurrence in Submucosal Invasive Colorectal Cancers of Favorable Histology: Case Reports of Two Early Colorectal Cancers with Advanced Recurrences
Heae Surng Park, Hee Jin Chang, Ji Won Park, Byung Chang Kim, Dae Kyung Sohn, Chang Won Hong, Ji-Yeon Baek, Sun Young Kim, Hyo Seong Choi, Jae Hwan Oh
Korean J Pathol. 2012;46(3):272-277.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.272
  • 6,703 View
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  • 3 Citations
AbstractAbstract PDF

Complete resection of submucosal invasive colorectal cancer (SICC) showing favorable histology is regarded as curative. We report on two cases of SICC showing recurrence within 5 years despite complete resection. The first patient was a 68-year-old woman with well differentiated rectal adenocarcinoma invading the superficial submucosa, which recurred after 4.7 years. The second patient was a 53-year-old man with pT1N0 moderately differentiated colonic adenocarcinoma. He developed widespread tumor recurrence after 3.9 years. Retrospective pathologic review of the original tumors showed multiple foci of tumor budding at the invasive front. Immunohistochemical staining for D2-40 of deeper levels of the paraffin blocks showed rare foci of small lymphatic invasion. Tumor budding at the invasive front may be an important indicator for SICC aggressiveness or may reflect early lymphatic invasion. More aggressive pathologic examination and follow-up is required for patients with SICC showing tumor budding, even in the absence of unfavorable histologic findings.

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  • Estudio de factores histológicos predictivos de metástasis ganglionar locorregional en adenocarcinoma colorrectal mínimamente invasivo pT1
    Isidro Machado, Miriam Valera-Alberni, Fernando Martínez de Juan, José A. López-Guerrero, Alfonso García Fadrique, Julia Cruz, Carmen Martínez Lapiedra, Fernanda Maia de Alcantara, Ricardo Yaya, Jorge Campos, Carlos Fernández-Martos, Rafael Estevan
    Gastroenterología y Hepatología.2016; 39(1): 1.     CrossRef
  • Histological factors predicting loco-regional lymph node metastasis in early invasive colorectal adenocarcinoma pT1
    Isidro Machado, Miriam Valera-Alberni, Fernando Martínez de Juan, José A. López-Guerrero, Alfonso García Fadrique, Julia Cruz, Carmen Martínez Lapiedra, Fernanda Maia de Alcantara, Ricardo Yaya, Jorge Campos, Carlos Fernández-Martos, Rafael Estevan
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    Viktor H Koelzer, Inti Zlobec, Alessandro Lugli
    Colorectal Cancer.2014; 3(4): 387.     CrossRef
Squamoid Eccrine Ductal Carcinoma of the Scalp
Yong-Han Jung, Hye-Jung Jo, Mi-Seon Kang
Korean J Pathol. 2012;46(3):278-281.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.278
  • 7,810 View
  • 66 Download
  • 9 Citations
AbstractAbstract PDF

Squamoid eccrine ductal carcinoma (SEDC) is an exceedingly rare tumor that shows both squamous and adnexal ductal differentiation. We report a case of this unusual tumor occurring on the occiput of a 53-year-old man. A histopathological examination revealed a nodular lesion infiltrating the dermis and subcutaneous tissue with numerous duct-like structure and squamoid differentiation foci. Five months later, the patient presented with a palpable mass at the site of the previous excision and the right side of the neck. Sono-guided fine needle aspiration of the right neck mass was performed and was diagnosed as a metastastasis of a lymph node. A right neck node dissection and re-excision of the occiput was performed. The histopathological findings were similar, but squamoid differentiation was more prominent than that in the previous lesion. Because of the rarity of SEDC, little is known about its biological behavior and optimal treatment.

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  • Squamoid Eccrine Ductal Carcinoma: Treatment and Outcomes
    Megan M. Lim, Jillian A. Macdonald
    The American Journal of Dermatopathology.2022; 44(4): 249.     CrossRef
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    Cardwell Gavin, Brinker Alyson
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  • Carcinoma ecrino: dos casos de una neoplasia inusual y revisión de la literatura
    Clara Matas-Nadal, Josep Manel Fernández-Armenteros, Felip Vilardell, Josep Manel Casanova, Rafael S. Aguayo Ortiz
    Piel.2020; 35(3): 159.     CrossRef
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    Zeynep Bayramoğlu, Betül Ünal
    The European Research Journal.2020;[Epub]     CrossRef
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    Sunmin Yim, Yun Ho Lee, Seoung Wan Chae, Won‐Serk Kim
    Clinical Case Reports.2019; 7(7): 1409.     CrossRef
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    Hsien Chan, Vicki Howard, Denis Moir, Delwyn Dyall-Smith
    Australasian Journal of Dermatology.2016; 57(3): e117.     CrossRef
  • Squamoid Eccrine Ductal Carcinoma
    Michiel P.J. van der Horst, Adriana Garcia-Herrera, Dorota Markiewicz, Blanca Martin, Eduardo Calonje, Thomas Brenn
    American Journal of Surgical Pathology.2016; 40(6): 755.     CrossRef
  • Squamoid eccrine ductal carcinoma
    Maria Isabel Ramos Saraiva, Marcella Amaral Horta Barbosa Vieira, Larissa Karine Leite Portocarrero, Rafael Cavanellas Fraga, Priscila Kakizaki, Neusa Yuriko Sakai Valente
    Anais Brasileiros de Dermatologia.2016; 91(6): 799.     CrossRef
  • Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma)
    E. Frouin, M.D. Vignon-Pennamen, B. Balme, B. Cavelier-Balloy, U. Zimmermann, N. Ortonne, A. Carlotti, L. Pinquier, J. André, B. Cribier
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Papillary Carcinoma of Thyroid Metastatic to Adenocarcinoma In Situ of Lung: Report of an Unusual Case
Kyoung Min Kim, Yo Na Kim, Hyun Hee Chu, Heung Yong Jin, Min Ho Kim, Myoung Ja Chung
Korean J Pathol. 2012;46(3):282-286.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.282
  • 6,043 View
  • 34 Download
  • 6 Citations
AbstractAbstract PDF

The tumor-to-tumor metastasis is a rare event. The lung tumors are the most common donor tumors in tumor-to-tumor metastasis, but are exceedingly rare as a recipient. Here, we report a case of papillary thyroid carcinoma (PTC) metastasizing to adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma) of the lung in a 44-year-old woman who underwent total thyroidectomy for PTC 8 years ago. To the best of our knowledge, the present case is the first case reporting on PTC metastasized to AIS. A review of the relevant literature is presented.

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    Yasushi Cho, Mitsuhito Kaji, Shunsuke Nomura, Yusuke Motohashi, Masaaki Sato, Motoya Takeuchi
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    Myoung Jae Kang, Ae Ri An, Myoung Ja Chung, Kyoung Min Kim
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    Maria-Rosa Bella-Cueto, Mireia Pascua-Solé, Albert Cano-Palomares, M. Àngels Cabezuelo-Hernandez, Maria-Rosa Escoda-Giralt, Santiago Barcons-Vilaplana, Paula Serret-Miralles, Carmen Caral-Vanaclocha, Xavier Guirao-Garriga, Joan Prats-Lopez, Meritxell Meda
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    Taebum Lee, Yoon Jin Cha, Sangjeong Ahn, Joungho Han, Young Mog Shim
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Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases
Eun Su Park, Young Eun Kim, Cheol Keun Park, Takashi Yao, Ryoji Kushima, Kyoung-Mee Kim
Korean J Pathol. 2012;46(3):287-291.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.287
  • 8,374 View
  • 88 Download
  • 19 Citations
AbstractAbstract PDF

Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.

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    Mark A Benedict, Gregory Y Lauwers, Dhanpat Jain
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    In Ji Song, Jin Woo Joo, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee
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    Yoshinori Sato, Takashi Fujino, Akira Kasagawa, Ryo Morita, Shun-ichiro Ozawa, Yasumasa Matsuo, Tadateru Maehata, Hiroshi Yasuda, Masayuki Takagi, Fumio Itoh
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    Eleanor Lewin, Philip Daroca, Sanjay Sikka, Tong Wu, Yukihiro Nakanishi
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    Masaki Miyazawa, Mitsuru Matsuda, Masaaki Yano, Yasumasa Hara, Fumitaka Arihara, Yosuke Horita, Koichiro Matsuda, Akito Sakai, Yatsugi Noda
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    Tae-In Lee
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    Rajkumar Vajpeyi, Jyoti Dekate
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Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: Report of Two Cases and Review of the Literature
Youngran Kang, Wonkyung Jung, In-Gu Do, Eui Jin Lee, Min Hyeong Lee, Kyoung-Mee Kim, Jongsang Choi
Korean J Pathol. 2012;46(3):292-296.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.292
  • 7,168 View
  • 53 Download
  • 27 Citations
AbstractAbstract PDF

Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a recently recognized entity. Because of its rarity, only 22 cases have been reported in the English-language literature and most of these are single case reports. We report two cases of gastric PAMT. The tumor cells were bland and plexiform arranged in a myxoid stroma, which was positive for alcian blue. Immunohistochemically, the tumor cells were positive for smooth muscle actin, but negative for c-kit, CD34, desmin, S-100 protein, epithelial membrane antigen, neurofilament, and protein kinase C-theta. Mutation analyses for exon 9, 11, 13, and 17 of KIT genes and 12, 14, and 18 of the platelet-derived growth factor receptor alpha (PDGFRA) genes were performed and the tumors were wild-type for mutation.

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Osteoclast-like Giant Cell Tumor of Parotid Gland with a Carcinomatous Component: A Case Report
Jung Wook Yang, Hyeon Cheol Kim, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jin Pyeong Kim, Gyung Hyuck Ko
Korean J Pathol. 2012;46(3):297-301.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.297
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AbstractAbstract PDF

The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected parotid gland contained a 1.8 cm-sized well-circumscribed brownish tumor. Histologically the tumor consisted of evenly distributed osteoclast-like giant cells, mononuclear cells and two small foci of a carcinomatous component. The osteoclast-like giant cells and mononuclear cells were positive for vimentin and CD68, and the carcinomatous component was positive for cytokeratin and epithelial membrane antigen. There was no metastatic lesion in the cervical lymph nodes. We believe this is the first case in Korea of an osteoclast-like giant cell tumor of the parotid gland.

Citations

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Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report
Sunhee Chang, Mee Joo, Hanseong Kim
Korean J Pathol. 2012;46(3):302-305.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.302
  • 7,547 View
  • 46 Download
  • 13 Citations
AbstractAbstract PDF

Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear : cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE.

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JPTM : Journal of Pathology and Translational Medicine