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Volume 47(4); August 2013
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Review & Perspectives
Intraductal Carcinoma of Prostate: A Comprehensive and Concise Review
Jordan A. Roberts, Ming Zhou, Yong Wok Park, Jae Y. Ro
Korean J Pathol. 2013;47(4):307-315.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.307
  • 10,158 View
  • 106 Download
  • 10 Citations
AbstractAbstract PDF

Intraductal carcinoma of the prostate (IDC-P) is defined as a proliferation of prostate adenocarcinoma cells distending and spanning the lumen of pre-existing benign prostatic ducts and acini, with at least focal preservation of basal cells. Studies demonstrate that IDC-P is strongly associated with high-grade (Gleason grades 4/5), large-volume invasive prostate cancers. In addition, recent genetic studies indicate that IDC-P represents intraductal spread of invasive carcinoma, rather than a precursor lesion. Some of the architectural patterns in IDC-P exhibit architectural overlap with one of the main differential diagnoses, high-grade prostatic intraepithelial neoplasia (HGPIN). In these instances, additional diagnostic criteria for IDC-P, including marked nuclear pleomorphism, non-focal comedonecrosis (>1 duct showing comedonecrosis), markedly distended normal ducts/acini, positive nuclear staining for ERG, and cytoplasmic loss of PTEN by immunohistochemistry, can help make the distinction. This distinction between IDC-P and HGPIN is of critical importance because IDC-P has an almost constant association with invasive carcinoma and has negative clinical implications, including shorter relapse-free survival, early biochemical relapse, and metastatic failure rate after radiotherapy. Therefore, IDC-P should be reported in prostate biopsies and radical prostatectomies, regardless of the presence of an invasive component. This article will review the history, diagnostic criteria, molecular genetics, and clinical significance of IDC-P.

Citations

Citations to this article as recorded by  
  • Detection limits of significant prostate cancer using multiparametric MR and digital rectal examination in men with low serum PSA: Up-date of the Italian Society of Integrated Diagnostic in Urology
    Andrea B. Galosi, Erika Palagonia, Simone Scarcella, Alessia Cimadamore, Vito Lacetera, Rocco F. Delle Fave, Angelo Antezza, Lucio Dell'Atti
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    Histopathology.2019; 74(7): 1081.     CrossRef
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  • Comedonecrosis Revisited
    Samson W. Fine, Hikmat A. Al-Ahmadie, Ying-Bei Chen, Anuradha Gopalan, Satish K. Tickoo, Victor E. Reuter
    American Journal of Surgical Pathology.2018; 42(8): 1036.     CrossRef
  • Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy
    Guang-Qian Xiao, Pamela D. Unger
    International Journal of Surgical Pathology.2017; 25(4): 344.     CrossRef
  • Exposure to maternal obesogenic diet worsens some but not all pre-cancer phenotypes in a murine genetic model of prostate cancer
    Theresa Okeyo-Owuor, Emily Benesh, Scott Bibbey, Michaela Reid, Jacques Halabi, Siobhan Sutcliffe, Kelle Moley, Shree Ram Singh
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    The Prostate.2016; 76(4): 394.     CrossRef
  • Intraduktales Karzinom der Prostata
    G. Kristiansen, M. Varma, G. Seitz
    Der Pathologe.2016; 37(1): 27.     CrossRef
  • A Better Understating of the Morphological Features and Molecular Characteristics of Intraductal Carcinoma Helps Clinicians Further Explain Prostate Cancer Aggressiveness
    Rodolfo Montironi, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Francesco Montorsi
    European Urology.2015; 67(3): 504.     CrossRef
  • Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion
    Kosuke Miyai, Mukul K. Divatia, Steven S. Shen, Brian J. Miles, Alberto G. Ayala, Jae Y. Ro
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The New 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Resected Specimens: Clinicopathologic Relevance and Emerging Issues
Seung Yeon Ha, Mee Sook Roh
Korean J Pathol. 2013;47(4):316-325.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.316
  • 7,739 View
  • 69 Download
  • 9 Citations
AbstractAbstract PDF

Pathologists play an increasingly important role in personalized medicine for patients with lung cancer as a result of the newly recognized relationship between histologic classification and molecular change. In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) proposed a new architectural classification for invasive lung adenocarcinomas to provide uniform terminology and diagnostic criteria. This review highlighted the evolution of the classification of lung adenocarcinomas in resected specimens with special respect to both histologic subtyping and invasion. Histologic subtyping of lung adenocarcinoma has been updated based on five major predominant patterns. New concepts of adenocarcinoma in situ and minimally invasive adenocarcinomas have been introduced to define the condition of patients who are expected to have excellent survival. Although the new IASLC/ATS/ERS classification has promising clinical relevance, significant clarification remains necessary for the definitions of subtyping and invasion. More precise definitions and subsequent better education on the interpretation of terminology will be helpful for future studies.

Citations

Citations to this article as recorded by  
  • Radiomics for Classifying Histological Subtypes of Lung Cancer Based on Multiphasic Contrast-Enhanced Computed Tomography
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    Yasmeen M. Butt, Timothy Craig Allen
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  • Expression of EGFR and Molecules Downstream to PI3K/Akt, Raf-1-MEK-1-MAP (Erk1/2), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution
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    Analytical Cellular Pathology.2014; 2014: 1.     CrossRef
  • Usual Interstitial Pneumonia with Lung Cancer: Clinicopathological Analysis of 43 Cases
    Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Kyeongman Jeon, Man Pyo Chung, Jhingook Kim, Joungho Han
    Korean Journal of Pathology.2014; 48(1): 10.     CrossRef
  • Cytoplasmic YAP Expression is Associated with Prolonged Survival in Patients with Lung Adenocarcinomas and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment
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Original Articles
Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases
Yoon Yang Jung, Min Eui Hong, Joungho Han, Tae Sung Kim, Jhingook Kim, Young-Mog Shim, Hojoong Kim
Korean J Pathol. 2013;47(4):326-331.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.326
  • 6,607 View
  • 55 Download
  • 13 Citations
AbstractAbstract PDF
Background

It has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic.

Methods

We reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features.

Results

The present study included five female and two male patients, with ages ranging from 16 to 81 years (mean age, 44.9 years). The clinical presentation varied according to tumor size and location. Patients with more centrally (trachea or main bronchus) located tumors experienced respiratory symptoms (80%) more often than patients with more peripherally (lobar or segmental bronchus) located tumors (0%). Histologically, the tumors were composed of spindle cells that stained with S100 protein. Some of the tumors showed typical Antoni A areas with Verocay body formation. Five of six patients (83.3%) underwent complete tumor removal by rigid bronchoscopy.

Conclusions

Pathologists should consider endobronchial schwannoma in the differential diagnosis of a spindle cell tumor involving the bronchus. Additionally, our results showed that rigid bronchoscopy is an effective tool for tumor removal in endobronchial schwannoma patients.

Citations

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  • Treatment of primary tracheal schwannoma with endoscopic resection: A case report
    Yong-Shuai Shen, Xiang-Dong Tian, Yi Pan, Hua Li
    World Journal of Clinical Cases.2022; 10(28): 10279.     CrossRef
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  • Endobronchial schwannoma in adult: A case report
    Touil Imen, Boudaya Mohamed Sadok, Aloui Raoudha, Souhir Ksissa, Brahem Yosra, Ben Attig Yosr, Ksontini Meriem, Bouchareb Soumaya, Keskes Boudawara Nadia, Boussoffara Leila, Knani Jalel
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    World Journal of Clinical Cases.2021; 9(17): 4388.     CrossRef
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    Daibing Zhou, Xiaoyan Xing, Jie Fan, Youzhi Zhang, Jie Liu, Yi Gong
    Thoracic Cancer.2020; 11(8): 2335.     CrossRef
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    Li Zhang, Wen Tang, Qing-Shan Hong, Pei-feng Lv, Kui-Ming Jiang, Rui Du
    Respiratory Medicine Case Reports.2020; 30: 101047.     CrossRef
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    Huiguo Chen, Kai Zhang, Mingjun Bai, Haifeng Li, Jian Zhang, Lijia Gu, Weibin Wu
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SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
Korean J Pathol. 2013;47(4):332-339.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.332
  • 8,915 View
  • 60 Download
  • 35 Citations
AbstractAbstract PDF
Background

Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1.

Methods

Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray.

Results

Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of β-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of β-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), β-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival.

Conclusions

SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with β-catenin and survivin rather than p53.

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The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development
Tae Jung Jang, Jeong Bae Park, Jong Im Lee
Korean J Pathol. 2013;47(4):340-347.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.340
  • 8,601 View
  • 64 Download
  • 35 Citations
AbstractAbstract PDF
Background

The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC.

Methods

We performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon.

Results

CD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth.

Conclusions

The present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.

Citations

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Comparison of Three BRAF Mutation Tests in Formalin-Fixed Paraffin Embedded Clinical Samples
Soomin Ahn, Jeeyun Lee, Ji-Youn Sung, So Young Kang, Sang Yun Ha, Kee-Taek Jang, Yoon-La Choi, Jung-Sun Kim, Young Lyun Oh, Kyoung-Mee Kim
Korean J Pathol. 2013;47(4):348-354.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.348
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AbstractAbstract PDF
Background

Recently, BRAF inhibitors showed dramatic treatment outcomes in BRAF V600 mutant melanoma. Therefore, the accuracy of BRAF mutation test is critical.

Methods

BRAF mutations were tested by dual-priming oligonucleotide-polymerase chain reaction (DPO-PCR), direct sequencing and subsequently retested with a real-time PCR assay, cobas 4800 V600 mutation test. In total, 64 tumors including 34 malignant melanomas and 16 papillary thyroid carcinomas were analyzed. DNA was extracted from formalin-fixed paraffin embedded tissue samples and the results of cobas test were directly compared with those of DPO-PCR and direct sequencing.

Results

BRAF mutations were found in 23 of 64 (35.9%) tumors. There was 9.4% discordance among 3 methods. Out of 6 discordant cases, 4 cases were melanomas; 3 cases were BRAF V600E detected only by cobas test, but were not detected by DPO-PCR and direct sequencing. One melanoma patient with BRAF mutation detected only by cobas test has been on vemurafenib treatment for 6 months and showed a dramatic response to vemurafenib. DPO-PCR failed to detect V600K mutation in one case identified by both direct sequencing and cobas test.

Conclusions

In direct comparison of the currently available DPO-PCR, direct sequencing and real-time cobas test for BRAF mutation, real-time PCR assay is the most sensitive method.

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ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion
Sehun Kim, Hyung Kyu Park, Ho Young Jung, So-Young Lee, Kyueng-Whan Min, Wook Youn Kim, Hye Seung Han, Wan Seop Kim, Tae Sook Hwang, So Dug Lim
Korean J Pathol. 2013;47(4):355-364.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.355
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AbstractAbstract PDF
Background

ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.

Methods

Fifteen cases of surgically resected colorectal cancers with hepatic metastasis were selected and the most representative sections for LVI detection were immunostained with ERG, CD31, and D2-40. Eight pathologists independently evaluated LVI status on hematoxylin and eosin (H&E) and the corresponding immunostained sections and then convened for a consensus meeting. The results were analyzed by kappa (κ) statistics.

Results

The average rate of LVI positivity was observed in 43% with H&E only, 10% with CD31, 29% with D2-40, and 16% with ERG. Agreement among pathologists was fair for H&E only (κ=0.27), D2-40 (κ=0.21), ERG (κ=0.23), and was moderate for CD31 (κ=0.55). Consensus revealed that ERG nuclear immunoreactivity showed better visual contrast of LVI detection than the other staining, with improved agreement and LVI detection rate (κ=0.65, LVI positivity rate 80%).

Conclusions

The present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis.

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Cytological Findings of the Micropapillary Variant of Urothelial Carcinoma: A Comparison with Typical High-Grade Urothelial Carcinoma
Kyu-Ho Kim, Chang-Hwan Choi, Jee-Young Han, Lucia Kim, Suk-Jin Choi, In-Suh Park, Joon-Mee Kim, Young-Chae Chu
Korean J Pathol. 2013;47(4):365-371.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.365
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AbstractAbstract PDF
Background

Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC).

Methods

The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli.

Results

Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli.

Conclusions

The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei than that of HGUC. These features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.

Citations

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Case Studies
Rhabdoid Colorectal Carcinomas: Reports of Two Cases
Sang Hwa Lee, Hyesil Seol, Wook Youn Kim, So Dug Lim, Wan Seop Kim, Tae Sook Hwang, Hye Seung Han
Korean J Pathol. 2013;47(4):372-377.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.372
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  • 12 Citations
AbstractAbstract PDF

Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas.

Citations

Citations to this article as recorded by  
  • A Rare Case of Undifferentiated Rhabdoid Carcinoma of the Colon
    Syed Alishan Nasir, Ronak Patel, Lalaine Ruiz, Michael Bush
    Cureus.2022;[Epub]     CrossRef
  • INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature
    Masatsugu Kojima, Toru Miyake, Tomoyuki Ueki, Hiroyuki Ohta, Ryoji Kushima, Masanori Shiohara, Hiroo Mizuta, Hiroya Iida, Tsuyoshi Yamaguchi, Sachiko Kaida, Katsushi Takebayashi, Hiromitsu Maehira, Yusuke Nishina, Tomoharu Shimizu, Eiji Mekata, Masaji Tan
    Surgical Case Reports.2021;[Epub]     CrossRef
  • Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report
    Yuya Ashitomi, Mitsuhiro Yano, Michihisa Kono, Takefumi Suzuki, Ichiro Kawamura, Shinji Okazaki, Yukinori Kamio, Osamu Hachiya, Yuka Urano, Fuyuhiko Motoi
    Surgical Case Reports.2020;[Epub]     CrossRef
  • BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas
    Bolzacchini, Digiacomo, Marrazzo, Sahnane, Maragliano, Gill, Albarello, Sessa, Furlan, Capella
    Cancers.2019; 11(9): 1252.     CrossRef
  • Pathologic complete response to bevacizumab-FOLFIRI in metastatic colonic undifferentiated carcinoma with rhabdoid features
    Tien-Chan Hsieh, Hung-Wei Liu, Chao-Wen Hsu
    Journal of Cancer Research and Practice.2019; 6(3): 140.     CrossRef
  • Extraordinary disease-free survival in a rare malignant extrarenal rhabdoid tumor: a case report and review of the literature
    Francesco D’Amico, Alessandra Bertacco, Maurizio Cesari, Claudia Mescoli, Giorgio Caturegli, Gabriel Gondolesi, Umberto Cillo
    Journal of Medical Case Reports.2018;[Epub]     CrossRef
  • Tumor rabdoide extrarrenal maligno de colon: presentación de 3 casos y revisión de la literatura
    María José Sánchez-de las Matas Garre, José García Solano, Pablo Conesa Zamora, Fidel Fernández Fernández, Miguel Pérez-Guillermo
    Revista Española de Patología.2016; 49(2): 119.     CrossRef
  • Poorly differentiated cecal adenocarcinoma showing prominent rhabdoid feature combined with appendiceal mucinous cystadenoma: A case report and review of the literature
    IN-JU CHO, SUNG-SOO KIM, YOUNG-DON MIN, MUN-WHAN NOH, RAN HONG
    Oncology Letters.2015; 9(4): 1527.     CrossRef
  • A Rare Case of Undifferentiated Carcinoma of the Colon with Rhabdoid Features: A Case Report and Review of the Literature
    E. Moussaly, J. P. Atallah
    Case Reports in Oncological Medicine.2015; 2015: 1.     CrossRef
  • Case Report of Rhabdoid Colon Cancer and Review of Literature
    Aparna Kalyan, Gurleen Pasricha, Dulabh Monga, Aatur Singhi, Nathan Bahary
    Clinical Colorectal Cancer.2015; 14(1): e5.     CrossRef
  • Malignant Rhabdoid Tumor of the Colon: A Case Report
    Elena Romera Barba, Ainhoa Sánchez Pérez, Carlos Duque Pérez, José Antonio García Marcilla, José Luis Vázquez Rojas
    Cirugía Española (English Edition).2014; 92(9): 638.     CrossRef
  • Tumor rabdoide maligno de colon: a propósito de un caso☆
    Elena Romera Barba, Ainhoa Sánchez Pérez, Carlos Duque Pérez, José Antonio García Marcilla, José Luis Vázquez Rojas
    Cirugía Española.2014; 92(9): 638.     CrossRef
A Giant Peritoneal Loose Body
Hyun-Soo Kim, Ji-Youn Sung, Won Seo Park, Youn Wha Kim
Korean J Pathol. 2013;47(4):378-382.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.378
  • 6,023 View
  • 46 Download
  • 13 Citations
AbstractAbstract PDF

Peritoneal loose bodies (PLBs) are usually discovered incidentally during laparotomy or autopsy. A few cases of giant PLBs presenting with various symptoms have been reported in the literature. Here, we describe a case of a giant PLB incidentally found in the pelvic cavity of a 50-year-old man. Computed tomography revealed a free ovoid mass in the pelvic cavity that consisted of central dense, heterogeneous calcifications and peripheral soft tissue. The mass was an egg-shaped, hard, glistening concretion measuring 7.5×7.0×6.8 cm and weighing 160 g. This concretion consisted of central necrotic fatty tissue surrounded by concentrically laminated, acellular, fibrous material. Small PLBs usually do not require any specific treatment. However, if PLBs cause alimentary or urinary symptoms due to their large size, surgical removal may be recommended. It is essential for clinicians to be aware of this entity and its characteristic features to establish the correct diagnosis.

Citations

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  • A Large Intraperitoneal Free Body in a 69-Year-Old Indian Man: a Case Study
    Siddhartha Sankar Bhattacharjee, Promit Chakraborty
    Indian Journal of Surgery.2022; 84(1): 206.     CrossRef
  • Peritoneal loose body presenting as a hepatic mass: A case report and review of the literature
    Yang Wen, Min-jie Shang, Yan-qing Ma, Song-hua Fang, Yuan Chen
    Open Medicine.2021; 16(1): 1356.     CrossRef
  • Peritoneal Loose Body in a Patient With Ampullary Adenocarcinoma
    A.V. Pradeep, Abdul Razik, Ankur Goyal, Atin Kumar, Virinder Kumar Bansal, Asuri Krishna
    ACG Case Reports Journal.2021; 8(11): e00680.     CrossRef
  • Exploratory laparoscopy as first choice procedure for the diagnosis of giant peritoneal loose body: a case report
    RuiBin Li, ZhiHeng Wan, HaoTian Li
    Journal of International Medical Research.2020; 48(10): 030006052095471.     CrossRef
  • A rare peritoneal egg: Case report with literature review
    Nilu Malpani Dhoot, Shivaraj Afzalpurkar, Usha Goenka, Vinay Mahendra, Enam Murshed Khan, Arpita Sutradhar, Mahesh Goenka
    Radiology Case Reports.2020; 15(10): 1895.     CrossRef
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    Ayad A. Mohammed
    International Journal of Surgery: Global Health.2020; 3(6): e24.     CrossRef
  • Giant Mobile Intraperitoneal Loose Body
    Mohd Ilyas, Mohd Yaqoob Wani, Musaib Ahmad Dar, Feroze A. Shaheen
    ACG Case Reports Journal.2019; 6(1): e00006.     CrossRef
  • Giant peritoneal loose body in a patient with end-stage renal disease
    Nadejda Cojocari, Leonard David
    SAGE Open Medical Case Reports.2018; 6: 2050313X1877093.     CrossRef
  • Two giant peritoneal loose bodies were simultaneously found in one patient: A case report and review of the literature
    Qingxing Huang, Aihong Cao, Jun Ma, Zhenhua Wang, Jianhong Dong
    International Journal of Surgery Case Reports.2017; 36: 74.     CrossRef
  • Laparoscopic extraction of a giant peritoneal loose body: Case report and review of literature
    Keiso Matsubara, Yuji Takakura, Takashi Urushihara, Takashi Nishisaka, Toshiyuki Itamoto
    International Journal of Surgery Case Reports.2017; 39: 188.     CrossRef
  • Symptomatic giant peritoneal loose body in the pelvic cavity: A case report
    Andreas Elsner, Mikolaj Walensi, Maya Fuenfschilling, Robert Rosenberg, Robert Mechera
    International Journal of Surgery Case Reports.2016; 21: 32.     CrossRef
  • A Case of a Peritoneal Loose Body with the Maximum Diameter of 50 mm
    Yoshihiro MOCHIZUKI, Hiroshi IINO, Michio HARA, Syugo SHIBA, Makoto SUDO, Naoki OISHI, Tetsuo KONDO
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2016; 77(10): 2552.     CrossRef
  • Giant peritoneal loose body in the pelvic cavity confirmed by laparoscopic exploration: a case report and review of the literature
    Hong Zhang, Yun-zhi Ling, Ming-ming Cui, Zhi-xiu Xia, Yong Feng, Chun-sheng Chen
    World Journal of Surgical Oncology.2015;[Epub]     CrossRef
Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary
Hyo Jeong An, Yong Han Jung, Hye Kyoung Yoon, Soo Jin Jung
Korean J Pathol. 2013;47(4):383-387.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.383
  • 5,776 View
  • 42 Download
  • 9 Citations
AbstractAbstract PDF

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

Citations

Citations to this article as recorded by  
  • Extraocular sebaceous carcinoma arising in a mature cystic teratoma of ovary: A case report and review of literature
    Sara Pakbaz, Tanya Chawla, Marcus Q Bernardini, Liat Hogen, Marjan Rouzbahman
    Human Pathology Reports.2022; 27: 300592.     CrossRef
  • Sebaceous adenoma occurring within an intracranial dermoid cyst
    Takashi Minamisaka, Johji Imura, Keitaro Shiraishi, Kohji Takagi, Takahiko Tomia, Sinichi Tanaka, Akira Noguchi, Takuya Akai, Kyo Noguchi, Satoshi Kuroda
    Neuropathology.2022; 42(4): 289.     CrossRef
  • Malignant transformation of mature cystic teratoma of the ovary
    Doaa Atwi, Maria Kamal, Michael Quinton, Lewis A. Hassell
    Journal of Obstetrics and Gynaecology Research.2022; 48(12): 3068.     CrossRef
  • Sebaceous Carcinoma Arising in Ovarian Teratoma: First Report Associated With Germline Mismatch Repair Gene Mutation
    Jacinta Murray, Patrick McIlwaine, Patrick J. Morrison, W. Glenn McCluggage
    International Journal of Gynecological Pathology.2022; 41(6): 608.     CrossRef
  • Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases
    Prashanth Giridhar, Lakhan Kashyap, Supriya Mallick, Ashish Dutt Upadhyay, Goura K. Rath
    International Journal of Dermatology.2020; 59(4): 494.     CrossRef
  • Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma
    Alvin Ho-Kwan Cheung, Chit Chow, Mei-Yung Yu, Wendy Wai-Tak Law, Peggy Pui-Ying Law, Paul Cheung-Lung Choi, Wei Kang, Ka-Fai To
    Pathology.2019; 51(1): 67.     CrossRef
  • Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature
    Elkin Fabián Dorado-Roncancio, Oscar Joel Carrillo-Garibaldi
    Obstetrics & Gynecology International Journal.2019;[Epub]     CrossRef
  • A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
    Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada, Masahide Ohmichi
    Journal of Ovarian Research.2018;[Epub]     CrossRef
  • Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
    Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
    Gynecologic Oncology Reports.2018; 26: 37.     CrossRef
Spindle Cell Rhabdomyosacoma of Uterus: A Case Study
Dae Woon Kim, Jung Hwan Shin, Ho Jung Lee, Young Ok Hong, Jong Eun Joo, Eun Kyung Kim
Korean J Pathol. 2013;47(4):388-391.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.388
  • 6,922 View
  • 34 Download
  • 8 Citations
AbstractAbstract PDF

Uterine rhabdomyosarcoma (RMS) typically presents as a mixed epithelial and mesenchymal tumors. Pure RMSs of the female genital tract are uncommon. Spindle cell variant of RMS is a rare morphologic subtype of embryonal RMS and mostly occurs in the paratesticular region of children. Here, we present a case of uterine spindle cell RMS in a 76-year-old woman. The tumor, 20×15×7 cm in size, was highly necrotic and adherent to the colon and rectum. Tumor cells were mostly spindle-shaped, and isolated rhabdomyoblasts were scattered. Immunohistochemical stains for myoglobin and myo-D1 showed diffuse positivity for tumor cells. The patient died only of disease three months after diagnosis.

Citations

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  • Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations
    Jennifer A. Bennett, Zehra Ordulu, Robert H. Young, Andre Pinto, Koen Van de Vijver, Eike Burandt, Pankhuri Wanjari, Rajeev Shah, Leanne de Kock, William D. Foulkes, W. Glenn McCluggage, Lauren L. Ritterhouse, Esther Oliva
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    Lalya Issam, Laatitioui Sana, Essadi Ismail, El Omrani Abdelhamid, Khouchani Mouna
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  • Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients
    Maha AT Elsebaie, Zeinab Elsayed
    Archives of Gynecology and Obstetrics.2018; 297(3): 559.     CrossRef
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    SK Kathpalia, Manju Mehrotra, Pinky Jena, Archana H Deshpande
    Women's Health.2018;[Epub]     CrossRef
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    Birgit Rommel, Carsten Holzmann, Jörn Bullerdiek
    Expert Review of Anticancer Therapy.2016; 16(11): 1155.     CrossRef
  • Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications
    AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
    International Journal of Oncology.2016; 48(5): 1815.     CrossRef
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    Tianping Yu, Mengni Zhang, Qiao Zhou, Jing Gong, Ling Nie, Xueqin Chen, Ni Chen
    Neuropathology.2015; 35(6): 599.     CrossRef
  • Uterine sarcoma in a 14year-old girl presenting with uterine rupture
    Jane Özcan, Özlem Dülger, Latif Küpelioğlu, Ali İhsan Gönenç, Aynur Erşahin
    Gynecologic Oncology Reports.2014; 10: 44.     CrossRef
Micronodular Thymoma with Lymphoid Stroma in a Multilocular Thymic Cyst: A Case Study
Na Rae Kim, Jae Ik Lee, Seung Yeon Ha
Korean J Pathol. 2013;47(4):392-394.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.392
  • 6,499 View
  • 60 Download
  • 11 Citations
AbstractAbstract PDF

Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called "unusual" variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.

Citations

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  • GTF2Imutation in micronodular thymoma with lymphoid stroma
    Andrea Bille, Katherine Fryer, Andrew Wallace, Daisuke Nonaka
    Journal of Clinical Pathology.2022; : jcp-2022-208655.     CrossRef
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    Diana M. Oramas, Cesar A. Moran
    International Journal of Surgical Pathology.2021; 29(4): 352.     CrossRef
  • Two cases of resection of micronodular thymoma with lymphoid stroma
    Seiji Omura, Kyohei Masai, Kaoru Kaseda, Keisuke Asakura, Tomoyuki Hishida, Hisao Asamura
    The Journal of the Japanese Association for Chest Surgery.2021; 35(6): 705.     CrossRef
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    Yusuke Kita, Yoshimasa Tokunaga, Taku Okamoto
    The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 166.     CrossRef
  • Thoracoscopic Thymectomy for Large Thymic Cyst: Myasthenia Gravis With Thymoma Concealed by Thymic Cyst
    Motoki Yano, Hiroki Numanami, Takashi Akiyama, Rumiko Taguchi, Chihiro Furuta, Akari Iwakoshi, Masayuki Haniuda
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(3): e34.     CrossRef
  • A resected case of micronodular thymoma with lympoid stroma
    Hiromitsu Domen, Yasuhiro Hida, Yasunari Takakuwa, Yuki Iijima, Kazuomi Ichinokawa, Hidehisa Yamada
    The Journal of the Japanese Association for Chest Surgery.2019; 33(5): 504.     CrossRef
  • Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases
    Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
    Diagnostic Pathology.2018;[Epub]     CrossRef
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    Linlin Qu, Yan Xiong, Qian Yao, Bo Zhang, Ting Li
    Thoracic Cancer.2017; 8(6): 734.     CrossRef
  • Cystic Micronodular Thymoma. Report of a Case
    Mlika M
    Journal of Clinical, Medical and Experimental Images.2017; 1(1): 001.     CrossRef
  • A Rare Case of Mixed Type A Thymoma and Micronodular Thymoma with Lymphoid Stroma
    Yoon Jin Cha, Joungho Han, Jimin Kim, Kyung Soo Lee, Young Mog Shim
    Journal of Pathology and Translational Medicine.2015; 49(1): 75.     CrossRef
  • Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation
    Wadad S Mneimneh, Yesim Gökmen-Polar, Kenneth A Kesler, Patrick J Loehrer Sr, Sunil Badve
    Modern Pathology.2015; 28(11): 1415.     CrossRef
Fine Needle Aspiration Cytology of Hepatic Hydatid Cyst: A Case Study
Ae Ri Kim, Seok Ju Park, Mi Jin Gu, Joon Hyuk Choi, Hong Jin Kim
Korean J Pathol. 2013;47(4):395-398.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.395
  • 10,427 View
  • 72 Download
  • 5 Citations
AbstractAbstract PDF

Hydatid cysts (echinococcosis) are caused by an infestation with larval tapeworms of the genus Echinococcus. The disease is extensively distributed worldwide, and it has been rarely reported in Korea. We describe the cytologic features of a case of hepatic hydatid cyst in a 28-year-old male. Computed tomography revealed a cystic mass in the right lobe of the liver. A right hemihepatectomy was performed. The aspirated fluid from the hepatic cystic mass was clear. The smears showed protoscolices, hooklets, and a laminated membrane.

Citations

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  • A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease
    Amarendra Kumar Shukla, Amrutha Peter, Veerendra Arya, Vineet Dwivedi, Manish Kumar Gupta, Nimish Rai, Pawan Tiwari, Jitendra Kishore Bhargava
    Journal of Parasitic Diseases.2022; 46(4): 941.     CrossRef
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    Wan Chul Kim, Jae Uk Shin, Su Sin Jin
    The Korean Journal of Gastroenterology.2021; 77(1): 35.     CrossRef
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    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
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    Busra Ozbek, Nadir Paksoy
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    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
Brief Case Report
Pleomorphic Adenoma of the Trachea: A Case Report
Ki-Sung Park, Woo Jung Sung
Korean J Pathol. 2013;47(4):399-401.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.399
  • 7,112 View
  • 33 Download
  • 8 Citations
PDF

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    Y. El Hassani, L. Belliraj, A. Miry, M. Haloua, N. Hammas, Y. Ouadnouni, M.Y. Alaoui Lamrani, M. Boubbou, H. El Fatemi, M. Serraj, M. Smahi, B. Amara, M. Maaroufi, B. Alami
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    Qian-Nuan Liao, Ze-Kui Fang, Shu-Bing Chen, Hui-Zhen Fan, Li-Chang Chen, Xi-Ping Wu, Xi He, Hua-Peng Yu
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  • Pleomorphic adenoma of the trachea: A case report and review of the literature
    Qian-Nuan Liao, Ze-Kui Fang, Shu-Bing Chen, Hui-Zhen Fan, Li-Chang Chen, Xi-Ping Wu, Xi He, Hua-Peng Yu
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    Yeungnam University Journal of Medicine.2018; 35(1): 114.     CrossRef
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    Zhixing Zhu, Xihua Lian, Dongyong Yang
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JPTM : Journal of Pathology and Translational Medicine