Intraductal carcinoma of the prostate (IDC-P) is defined as a proliferation of prostate adenocarcinoma cells distending and spanning the lumen of pre-existing benign prostatic ducts and acini, with at least focal preservation of basal cells. Studies demonstrate that IDC-P is strongly associated with high-grade (Gleason grades 4/5), large-volume invasive prostate cancers. In addition, recent genetic studies indicate that IDC-P represents intraductal spread of invasive carcinoma, rather than a precursor lesion. Some of the architectural patterns in IDC-P exhibit architectural overlap with one of the main differential diagnoses, high-grade prostatic intraepithelial neoplasia (HGPIN). In these instances, additional diagnostic criteria for IDC-P, including marked nuclear pleomorphism, non-focal comedonecrosis (>1 duct showing comedonecrosis), markedly distended normal ducts/acini, positive nuclear staining for ERG, and cytoplasmic loss of PTEN by immunohistochemistry, can help make the distinction. This distinction between IDC-P and HGPIN is of critical importance because IDC-P has an almost constant association with invasive carcinoma and has negative clinical implications, including shorter relapse-free survival, early biochemical relapse, and metastatic failure rate after radiotherapy. Therefore, IDC-P should be reported in prostate biopsies and radical prostatectomies, regardless of the presence of an invasive component. This article will review the history, diagnostic criteria, molecular genetics, and clinical significance of IDC-P.

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Pathologists play an increasingly important role in personalized medicine for patients with lung cancer as a result of the newly recognized relationship between histologic classification and molecular change. In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) proposed a new architectural classification for invasive lung adenocarcinomas to provide uniform terminology and diagnostic criteria. This review highlighted the evolution of the classification of lung adenocarcinomas in resected specimens with special respect to both histologic subtyping and invasion. Histologic subtyping of lung adenocarcinoma has been updated based on five major predominant patterns. New concepts of adenocarcinoma in situ and minimally invasive adenocarcinomas have been introduced to define the condition of patients who are expected to have excellent survival. Although the new IASLC/ATS/ERS classification has promising clinical relevance, significant clarification remains necessary for the definitions of subtyping and invasion. More precise definitions and subsequent better education on the interpretation of terminology will be helpful for future studies.

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Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas.

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Peritoneal loose bodies (PLBs) are usually discovered incidentally during laparotomy or autopsy. A few cases of giant PLBs presenting with various symptoms have been reported in the literature. Here, we describe a case of a giant PLB incidentally found in the pelvic cavity of a 50-year-old man. Computed tomography revealed a free ovoid mass in the pelvic cavity that consisted of central dense, heterogeneous calcifications and peripheral soft tissue. The mass was an egg-shaped, hard, glistening concretion measuring 7.5×7.0×6.8 cm and weighing 160 g. This concretion consisted of central necrotic fatty tissue surrounded by concentrically laminated, acellular, fibrous material. Small PLBs usually do not require any specific treatment. However, if PLBs cause alimentary or urinary symptoms due to their large size, surgical removal may be recommended. It is essential for clinicians to be aware of this entity and its characteristic features to establish the correct diagnosis.

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  Nilu Malpani Dhoot, Shivaraj Afzalpurkar, Usha Goenka, Vinay Mahendra, Enam Murshed Khan, Arpita Sutradhar, Mahesh Goenka
  Radiology Case Reports.2020; 15(10): 1895.     CrossRef
• A giant peritoneal loose body impacted in the pelvic cavity, a rare and interesting finding during laparotomy
  Ayad A. Mohammed
  International Journal of Surgery: Global Health.2020; 3(6): e24.     CrossRef
• Giant Mobile Intraperitoneal Loose Body
  Mohd Ilyas, Mohd Yaqoob Wani, Musaib Ahmad Dar, Feroze A. Shaheen
  ACG Case Reports Journal.2019; 6(1): e00006.     CrossRef
• Giant peritoneal loose body in a patient with end-stage renal disease
  Nadejda Cojocari, Leonard David
  SAGE Open Medical Case Reports.2018; 6: 2050313X1877093.     CrossRef
• Two giant peritoneal loose bodies were simultaneously found in one patient: A case report and review of the literature
  Qingxing Huang, Aihong Cao, Jun Ma, Zhenhua Wang, Jianhong Dong
  International Journal of Surgery Case Reports.2017; 36: 74.     CrossRef
• Laparoscopic extraction of a giant peritoneal loose body: Case report and review of literature
  Keiso Matsubara, Yuji Takakura, Takashi Urushihara, Takashi Nishisaka, Toshiyuki Itamoto
  International Journal of Surgery Case Reports.2017; 39: 188.     CrossRef
• Symptomatic giant peritoneal loose body in the pelvic cavity: A case report
  Andreas Elsner, Mikolaj Walensi, Maya Fuenfschilling, Robert Rosenberg, Robert Mechera
  International Journal of Surgery Case Reports.2016; 21: 32.     CrossRef
• A Case of a Peritoneal Loose Body with the Maximum Diameter of 50 mm
  Yoshihiro MOCHIZUKI, Hiroshi IINO, Michio HARA, Syugo SHIBA, Makoto SUDO, Naoki OISHI, Tetsuo KONDO
  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2016; 77(10): 2552.     CrossRef
• Giant peritoneal loose body in the pelvic cavity confirmed by laparoscopic exploration: a case report and review of the literature
  Hong Zhang, Yun-zhi Ling, Ming-ming Cui, Zhi-xiu Xia, Yong Feng, Chun-sheng Chen
  World Journal of Surgical Oncology.2015;[Epub]     CrossRef

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

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• Extraocular sebaceous carcinoma arising in a mature cystic teratoma of ovary: A case report and review of literature
  Sara Pakbaz, Tanya Chawla, Marcus Q Bernardini, Liat Hogen, Marjan Rouzbahman
  Human Pathology Reports.2022; 27: 300592.     CrossRef
• Sebaceous adenoma occurring within an intracranial dermoid cyst
  Takashi Minamisaka, Johji Imura, Keitaro Shiraishi, Kohji Takagi, Takahiko Tomia, Sinichi Tanaka, Akira Noguchi, Takuya Akai, Kyo Noguchi, Satoshi Kuroda
  Neuropathology.2022; 42(4): 289.     CrossRef
• Malignant transformation of mature cystic teratoma of the ovary
  Doaa Atwi, Maria Kamal, Michael Quinton, Lewis A. Hassell
  Journal of Obstetrics and Gynaecology Research.2022; 48(12): 3068.     CrossRef
• Sebaceous Carcinoma Arising in Ovarian Teratoma: First Report Associated With Germline Mismatch Repair Gene Mutation
  Jacinta Murray, Patrick McIlwaine, Patrick J. Morrison, W. Glenn McCluggage
  International Journal of Gynecological Pathology.2022; 41(6): 608.     CrossRef
• Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases
  Prashanth Giridhar, Lakhan Kashyap, Supriya Mallick, Ashish Dutt Upadhyay, Goura K. Rath
  International Journal of Dermatology.2020; 59(4): 494.     CrossRef
• Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma
  Alvin Ho-Kwan Cheung, Chit Chow, Mei-Yung Yu, Wendy Wai-Tak Law, Peggy Pui-Ying Law, Paul Cheung-Lung Choi, Wei Kang, Ka-Fai To
  Pathology.2019; 51(1): 67.     CrossRef
• Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature
  Elkin Fabián Dorado-Roncancio, Oscar Joel Carrillo-Garibaldi
  Obstetrics & Gynecology International Journal.2019;[Epub]     CrossRef
• A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
  Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada, Masahide Ohmichi
  Journal of Ovarian Research.2018;[Epub]     CrossRef
• Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
  Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
  Gynecologic Oncology Reports.2018; 26: 37.     CrossRef

Uterine rhabdomyosarcoma (RMS) typically presents as a mixed epithelial and mesenchymal tumors. Pure RMSs of the female genital tract are uncommon. Spindle cell variant of RMS is a rare morphologic subtype of embryonal RMS and mostly occurs in the paratesticular region of children. Here, we present a case of uterine spindle cell RMS in a 76-year-old woman. The tumor, 20×15×7 cm in size, was highly necrotic and adherent to the colon and rectum. Tumor cells were mostly spindle-shaped, and isolated rhabdomyoblasts were scattered. Immunohistochemical stains for myoglobin and myo-D1 showed diffuse positivity for tumor cells. The patient died only of disease three months after diagnosis.

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• Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations
  Jennifer A. Bennett, Zehra Ordulu, Robert H. Young, Andre Pinto, Koen Van de Vijver, Eike Burandt, Pankhuri Wanjari, Rajeev Shah, Leanne de Kock, William D. Foulkes, W. Glenn McCluggage, Lauren L. Ritterhouse, Esther Oliva
  Modern Pathology.2021; 34(9): 1750.     CrossRef
• Vaginal embryonal rhabdomyosarcoma in young woman: A case report and literature review
  Lalya Issam, Laatitioui Sana, Essadi Ismail, El Omrani Abdelhamid, Khouchani Mouna
  Archives of Cancer Science and Therapy.2020; 4(1): 034.     CrossRef
• Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients
  Maha AT Elsebaie, Zeinab Elsayed
  Archives of Gynecology and Obstetrics.2018; 297(3): 559.     CrossRef
• Spindle cell sarcoma – a rare diagnosis
  SK Kathpalia, Manju Mehrotra, Pinky Jena, Archana H Deshpande
  Women's Health.2018;[Epub]     CrossRef
• Malignant mesenchymal tumors of the uterus – time to advocate a genetic classification
  Birgit Rommel, Carsten Holzmann, Jörn Bullerdiek
  Expert Review of Anticancer Therapy.2016; 16(11): 1155.     CrossRef
• Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications
  AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
  International Journal of Oncology.2016; 48(5): 1815.     CrossRef
• Primary third ventricular tumor in an 18‐year‐old man
  Tianping Yu, Mengni Zhang, Qiao Zhou, Jing Gong, Ling Nie, Xueqin Chen, Ni Chen
  Neuropathology.2015; 35(6): 599.     CrossRef
• Rhabdomyosarcoma of vulva in a young lady
  Tapesh Bhattacharyya, Firuza D. Patel, Radhika Srinivasan, Bhavana Rai, Pradeep Saha, R. Nijhawan
  Journal of Cancer Research and Therapeutics.2015; 11(3): 650.     CrossRef
• Uterine sarcoma in a 14year-old girl presenting with uterine rupture
  Jane Özcan, Özlem Dülger, Latif Küpelioğlu, Ali İhsan Gönenç, Aynur Erşahin
  Gynecologic Oncology Reports.2014; 10: 44.     CrossRef

Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called "unusual" variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.

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• GTF2Imutation in micronodular thymoma with lymphoid stroma
  Andrea Bille, Katherine Fryer, Andrew Wallace, Daisuke Nonaka
  Journal of Clinical Pathology.2024; 77(2): 125.     CrossRef
• Thymic epithelial tumours: histopathological classification and differential diagnosis
  Jan von der Thüsen
  Histopathology.2024; 84(1): 196.     CrossRef
• Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases
  Diana M. Oramas, Cesar A. Moran
  International Journal of Surgical Pathology.2021; 29(4): 352.     CrossRef
• Two cases of resection of micronodular thymoma with lymphoid stroma
  Seiji Omura, Kyohei Masai, Kaoru Kaseda, Keisuke Asakura, Tomoyuki Hishida, Hisao Asamura
  The Journal of the Japanese Association for Chest Surgery.2021; 35(6): 705.     CrossRef
• Two surgical cases of micronodular thymoma with lymphoid stroma
  Yusuke Kita, Yoshimasa Tokunaga, Taku Okamoto
  The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 166.     CrossRef
• Thoracoscopic Thymectomy for Large Thymic Cyst: Myasthenia Gravis With Thymoma Concealed by Thymic Cyst
  Motoki Yano, Hiroki Numanami, Takashi Akiyama, Rumiko Taguchi, Chihiro Furuta, Akari Iwakoshi, Masayuki Haniuda
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• A resected case of micronodular thymoma with lympoid stroma
  Hiromitsu Domen, Yasuhiro Hida, Yasunari Takakuwa, Yuki Iijima, Kazuomi Ichinokawa, Hidehisa Yamada
  The Journal of the Japanese Association for Chest Surgery.2019; 33(5): 504.     CrossRef
• Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases
  Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
  Diagnostic Pathology.2018;[Epub]     CrossRef
• Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review
  Linlin Qu, Yan Xiong, Qian Yao, Bo Zhang, Ting Li
  Thoracic Cancer.2017; 8(6): 734.     CrossRef
• Cystic Micronodular Thymoma. Report of a Case
  Mlika M
  Journal of Clinical, Medical and Experimental Images.2017; 1(1): 001.     CrossRef
• A Rare Case of Mixed Type A Thymoma and Micronodular Thymoma with Lymphoid Stroma
  Yoon Jin Cha, Joungho Han, Jimin Kim, Kyung Soo Lee, Young Mog Shim
  Journal of Pathology and Translational Medicine.2015; 49(1): 75.     CrossRef
• Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation
  Wadad S Mneimneh, Yesim Gökmen-Polar, Kenneth A Kesler, Patrick J Loehrer Sr, Sunil Badve
  Modern Pathology.2015; 28(11): 1415.     CrossRef

Hydatid cysts (echinococcosis) are caused by an infestation with larval tapeworms of the genus Echinococcus. The disease is extensively distributed worldwide, and it has been rarely reported in Korea. We describe the cytologic features of a case of hepatic hydatid cyst in a 28-year-old male. Computed tomography revealed a cystic mass in the right lobe of the liver. A right hemihepatectomy was performed. The aspirated fluid from the hepatic cystic mass was clear. The smears showed protoscolices, hooklets, and a laminated membrane.

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• Chemical compounds, antioxidant and scolicidal potencies of Thymus fontanesii essential oil
  Sidi Mohammed Ammar Selles, Belkacem Tahar Belhamiti, Mokhtaria Kouidri, Amar Ait Amrane, Yamina Kadari, Zohra Kaddour, Souad Kabrit
  Experimental Parasitology.2024; 257: 108699.     CrossRef
• A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease
  Amarendra Kumar Shukla, Amrutha Peter, Veerendra Arya, Vineet Dwivedi, Manish Kumar Gupta, Nimish Rai, Pawan Tiwari, Jitendra Kishore Bhargava
  Journal of Parasitic Diseases.2022; 46(4): 941.     CrossRef
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  The Korean Journal of Gastroenterology.2021; 77(1): 35.     CrossRef
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  The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
• Cytology of hydatid cyst mimicking intra‐abdominal sarcoma, diagnosed by fine‐needle aspiration
  Busra Ozbek, Nadir Paksoy
  Diagnostic Cytopathology.2018; 46(4): 362.     CrossRef
• Clinical Update on Parasitic Diseases
  Min Seo
  Korean Journal of Medicine.2013; 85(5): 469.     CrossRef

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• Pleomorphic adenoma of the trachea: A case report
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• Pleomorphic adenoma of the trachea: A case report and review of the literature
  Qian-Nuan Liao, Ze-Kui Fang, Shu-Bing Chen, Hui-Zhen Fan, Li-Chang Chen, Xi-Ping Wu, Xi He, Hua-Peng Yu
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• Pleomorphic adenoma of the trachea: A case report and review of the literature
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• Obstructive tracheal neoplasm
  Badreeddine Alami, Saïd Boujraf, Mohamed Smahi, Mounia Serraj, Moulay Youssef Alaoui Lamrani, Meryem Boubbou, Mustapha Maaroufi
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• Tracheal pleomorphic adenoma with coexisting pulmonary tuberculoma
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