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Volume 47(5); October 2013
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Letter to the Editor
Perineural Involvement in Benign Mixed Tumor
Se Jin Jung, Jong Cheol Lee, Hye Jeong Choi, Hee Jeong Cha, Young Min Kim, Young Wha Koh, Jae Hee Suh
Korean J Pathol. 2013;47(5):403-404.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.403
  • 4,905 View
  • 37 Download
  • 2 Citations
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  • Benign Pleomorphic Adenoma in the Facial Nerve
    Gemma E. Hogg, Richard A. Steven, Patrick M. Spielmann
    Ear, Nose & Throat Journal.2020; 99(6): 361.     CrossRef
  • Benign pleomorphic adenoma of minor salivary gland showing perineural invasion: a rare entity
    Rahul Jayaram, Dipen Patel, Vijay Santhanam
    British Journal of Oral and Maxillofacial Surgery.2015; 53(1): 81.     CrossRef
Review & Perspective
Cytotechnologists and On-Site Evaluation of Adequacy
Jennifer A. Collins, Anna Novak, Syed Z. Ali, Matthew T. Olson
Korean J Pathol. 2013;47(5):405-410.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.405
  • 9,296 View
  • 62 Download
  • 22 Citations
AbstractAbstract PDF

While fine needle aspiration (FNA) is certainly not a new biopsy technique, recent developments in advanced imaging techniques, molecular testing, and targeted therapies have coincided with a rapid increase in the number of FNA procedures being performed. Concurrently, the demand for on-site evaluation of adequacy (OSEA) has also increased, outstripping the capacity of available cytopathologists at some institutions. Among the several alternatives to cytopathologist-performed OSEA, cytotechnologist-attended OSEA stands out because it preserves the representation of the pathology service at the time of the procedure. Herein, we review the current literature about OSEA and the necessity of cytotechnologists to expand access of this useful pathology service to a broader patient population. We also examine how cytotechnologists are likely to fit into the emerging practice of telecytology.

Citations

Citations to this article as recorded by  
  • Performance of Rapid On-Site Evaluation in Breast Fine-Needle Aspiration Biopsies: Identifying Areas of Diagnostic Challenge
    Vanda F. Torous, Silvia Huerta Lopez, Christine Xu, Brenda J. Sweeney, Martha B. Pitman
    Acta Cytologica.2022; 66(1): 1.     CrossRef
  • Role of cytotechnologists in rapid onsite adequacy assessment of cytology materials for diagnostic workup and specimen allocation for ancillary testing using a standardized protocol
    Russel Fetzer, Michelle Duey, Valerie Pena, Dana Wanzer, James Kirkpatrick, Donnie Chau, Venetia R. Sarode
    Journal of the American Society of Cytopathology.2020; 9(2): 67.     CrossRef
  • Review of different platforms to perform rapid onsite evaluation via telecytology
    Keluo Yao, Zaibo Li
    Cytopathology.2020; 31(5): 379.     CrossRef
  • Results from the 2019 American Society of Cytopathology survey on rapid onsite evaluation (ROSE)–part 2: subjective views among the cytopathology community
    Jennifer L. Sauter, Yigu Chen, Deepu Alex, Ronald Balassanian, Jackie Cuda, Melina B. Flanagan, Christopher C. Griffith, Peter Illei, Daniel N. Johnson, Cindy M. McGrath, Melissa L. Randolph, Jordan P. Reynolds, Amy J. Spiczka, Annemieke van Zante, Paul A
    Journal of the American Society of Cytopathology.2020; 9(6): 570.     CrossRef
  • Comparison of Number of Passes and Cytopathological Specimen Adequacy for Thyroid Fine-Needle Aspiration Biopsy in the Absence of an On-Site Pathologist
    Taha Yusuf Kuzan, Ceren Canbey Goret
    European Thyroid Journal.2020; 9(1): 49.     CrossRef
  • Rapid on-site evaluation using telecytology: A major cancer center experience
    Oscar Lin, Dorota Rudomina, Rusmir Feratovic, S. Joseph Sirintrapun
    Diagnostic Cytopathology.2019; 47(1): 15.     CrossRef
  • ROSE: Alternative for Cancelled and Inconclusive Cytopathologic Examinations, as Well as Professional Training at the UNESP-Botucatu Veterinary Hospital
    Fabiane Andrade Correia Neiva, Eduardo Eburnio, Paula de Sanctis, Nayara Maria Gil Mazzante, Noeme Sousa Rocha
    Open Journal of Veterinary Medicine.2019; 09(09): 121.     CrossRef
  • Endosonographer-driven dynamic telecytopathology of pancreatic lesions—a pilot study
    Benjamin Tharian, Konrad Krall, Xiang Zhu, Nayana George, Michael Chambers, Shyam Varadarajulu, Shantel Hebert-Magee
    Journal of the American Society of Cytopathology.2018; 7(2): 86.     CrossRef
  • Telecytology for rapid on-site evaluation: current status
    Oscar Lin
    Journal of the American Society of Cytopathology.2018; 7(1): 1.     CrossRef
  • Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment
    Lauren Pearson, Rachel E. Factor, Sandra K. White, Brandon S. Walker, Lester J. Layfield, Robert L. Schmidt
    Acta Cytologica.2018; 62(4): 244.     CrossRef
  • Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases
    Xue Yu Wang, Hema Mahajan, Nicole Dickinson, Carol Cox, Karen Byth, Angela Bayly, Michael A. Cahill, Nirmala Pathmanathan
    Diagnostic Cytopathology.2018; 46(11): 927.     CrossRef
  • Chapter 7 Image-Guided Fine-Needle Aspiration and Core Needle Biopsy of Neck Lymph Nodes: Techniques, Pearls, and Pitfalls
    Amir A. Borhani, Sara E. Monaco
    Seminars in Ultrasound, CT and MRI.2017; 38(5): 531.     CrossRef
  • Cytologic rapid on-site evaluation of transthoracic computed tomography–guided lung needle biopsies: who should perform ROSE? A cross-institutional analysis of procedural and diagnostic outcomes
    Jonathan D. Marotti, Kavitha P. Rao, Kathriel J. Brister, Edward J. Gutmann, Michael J. Tsapakos, Robert Sheiman, Helen H. Wang, Paul A. VanderLaan
    Journal of the American Society of Cytopathology.2015; 4(3): 160.     CrossRef
  • When Is Rapid On-Site Evaluation Cost-Effective for Fine-Needle Aspiration Biopsy?
    Robert L. Schmidt, Brandon S. Walker, Michael B. Cohen, Fernando Schmitt
    PLOS ONE.2015; 10(8): e0135466.     CrossRef
  • Cytotechnologist Performance for Screening Hürthle Cell Atypia in Indeterminate Thyroid Fine-Needle Aspirates
    Christopher J. VandenBussche, Christina Adams, Syed Z. Ali, Matthew T. Olson
    Acta Cytologica.2015; 59(5): 377.     CrossRef
  • Xylazine-ketamine immobilization and propofol anesthesia for surgical excision of sebaceous adenoma in a jaguar (Panthera onca)
    M. Bharathidasan, R. Thirumurugan, B. Justin William, R. S. George, A. Arunprasad, T. A. Kannan, S. Viramuthu
    Veterinary World.2014; 7(11): 986.     CrossRef
  • Inexpensive telecytology solutions that use the Raspberry Pi and the iPhone
    Radu Dudas, Christopher VandenBussche, Alex Baras, Syed Z. Ali, Matthew T. Olson
    Journal of the American Society of Cytopathology.2014; 3(1): 49.     CrossRef
  • Everything's Coming Up R.O.S.E.s
    Brian T. Collins
    Journal of the American Society of Cytopathology.2014; 3(2): 57.     CrossRef
  • A minimum fluid volume of 75 mL is needed to ensure adequacy in a pleural effusion: A retrospective analysis of 2540 cases
    Lisa M. Rooper, Syed Z. Ali, Matthew T. Olson
    Cancer Cytopathology.2014; 122(9): 657.     CrossRef
  • Cytotechnologist-attended on-site evaluation of adequacy for fine-needle aspiration of bone and soft tissue neoplasms
    Matthew T. Olson, Anna Novak, Thiraphon Boonyaarunnate, Hinna Shahid, John Kirby, Syed Z. Ali
    Journal of the American Society of Cytopathology.2014; 3(2): 60.     CrossRef
  • Accuracy of Cytotechnologist Evaluation of Specimen Adequacy and Screening Interpretation of Malignancy in Fine-Needle Aspiration of the Liver
    Aadil Ahmed, Anna B. Novak, Aisha Farhat Sheerin, Thiraphon Boonyaarunnate, Syed Z. Ali, Matthew T. Olson
    Acta Cytologica.2014; 58(4): 367.     CrossRef
  • Cytotechnologist Performance for Screening Microfollicular Atypia in Indeterminate Thyroid Fine-Needle Aspirates
    Christopher J. VandenBussche, Matthew T. Olson, Christina Adams, Syed Z. Ali
    Acta Cytologica.2014; 58(5): 432.     CrossRef
Original Articles
Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
Hyunchul Kim, Ja-June Jang, Dong-Sik Kim, Beom Woo Yeom, Nam Hee Won
Korean J Pathol. 2013;47(5):411-417.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.411
  • 7,180 View
  • 37 Download
  • 6 Citations
AbstractAbstract PDF
Background

Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.

Methods

We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.

Results

Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.

Conclusions

Although the new classification is now generally accepted, validation through follow-up studies is necessary.

Citations

Citations to this article as recorded by  
  • Relevance of morphological features for hepatocellular adenoma classification in pathology practice
    Carla Henriques Agostini, Osmar Damasceno Ribeiro, Arlete Fernandes, Adriana Caroli-Bottino, Vera Lucia Pannain
    Surgical and Experimental Pathology.2020;[Epub]     CrossRef
  • The molecular functions of hepatocyte nuclear factors – In and beyond the liver
    Hwee Hui Lau, Natasha Hui Jin Ng, Larry Sai Weng Loo, Joanita Binte Jasmen, Adrian Kee Keong Teo
    Journal of Hepatology.2018; 68(5): 1033.     CrossRef
  • Hepatocellular adenoma: Classification, variants and clinical relevance
    Paulette Bioulac-Sage, Christine Sempoux, Charles Balabaud
    Seminars in Diagnostic Pathology.2017; 34(2): 112.     CrossRef
  • A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice
    Brent K. Larson, Maha Guindi
    American Journal of Clinical Pathology.2017; 147(6): 557.     CrossRef
  • Hepatocellular Neoplasms Arising in Association With Androgen Use
    Sounak Gupta, Bita V. Naini, Richard Munoz, Rondell P. Graham, Benjamin R. Kipp, Michael S. Torbenson, Taofic Mounajjed
    American Journal of Surgical Pathology.2016; 40(4): 454.     CrossRef
  • Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
    Taofic Mounajjed, Saba Yasir, Patrice A Aleff, Michael S Torbenson
    Modern Pathology.2015; 28(9): 1265.     CrossRef
MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma
Po Eun Park, Ji Yun Jeong, Sun Zoo Kim, Ji Young Park
Korean J Pathol. 2013;47(5):418-425.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.418
  • 5,519 View
  • 33 Download
  • 5 Citations
AbstractAbstract PDF
Background

Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to be associated with the development of chromosome instability. MAD2 also has a signihicant role in cellular drug resistance to taxane chemotherapeutic agents.

Methods

Expression of MAD2 and p53 was investigated using immunohistochemistry in 85 cases of ovarian carcinomas. Clinicopathological data including progression-free survival were analyzed.

Results

A significant (p=.035) association was observed between the grade of serous carcinoma and the expression level of MAD2. While low-grade serous carcinoma showed a low-level expression of MAD2, high-grade serous carcinoma showed a high-level expression of MAD2. We also determined that low-level expression of MAD2 was associated with reduced progression-free survival (PFS) (p=.016) in high-grade serous carcinoma.

Conclusions

MAD2 expression in ovarian carcinoma is related to the grade of serous carcinoma and PFS of high-grade serous carcinoma. Expression level of MAD2 detected by immunohistochemistry may serve as an indicator in predicting the response of microtubule-interfering chemotherapeutic agents.

Citations

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  • The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer
    Mark Bates, Cathy D. Spillane, Michael F. Gallagher, Amanda McCann, Cara Martin, Gordon Blackshields, Helen Keegan, Luke Gubbins, Robert Brooks, Doug Brooks, Stavros Selemidis, Sharon O’Toole, John J. O’Leary, David Wai Chan
    PLOS ONE.2020; 15(12): e0243715.     CrossRef
  • Aneuploidy: Cancer strength or vulnerability?
    Giorgia Simonetti, Samantha Bruno, Antonella Padella, Elena Tenti, Giovanni Martinelli
    International Journal of Cancer.2019; 144(1): 8.     CrossRef
  • The association between MAD2 and prognosis in cancer: a systematic review and meta-analyses
    Tara Byrne, Helen G. Coleman, Janine A. Cooper, W. Glenn McCluggage, Amanda McCann, Fiona Furlong
    Oncotarget.2017; 8(60): 102223.     CrossRef
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    L Yang, S Feng, Y Yang
    Cancer Gene Therapy.2016; 23(12): 439.     CrossRef
  • Proteins of the mitotic checkpoint and spindle are related to chromosomal instability and unfavourable prognosis in patients with myelodysplastic syndrome
    Kelly Roveran Genga, Francisco Dário Rocha Filho, Francisco Valdeci de Almeida Ferreira, Juliana Cordeiro de Sousa, Fernando Sergio Studart, Silvia Maria Meira Magalhães, Fabíola Fernandes Heredia, Ronald Feitosa Pinheiro
    Journal of Clinical Pathology.2015; 68(5): 381.     CrossRef
Histologic Variations and Immunohistochemical Features of Metastatic Clear Cell Renal Cell Carcinoma
Cheol Lee, Jeong-Whan Park, Ja Hee Suh, Kyung Han Nam, Kyung Chul Moon
Korean J Pathol. 2013;47(5):426-432.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.426
  • 8,085 View
  • 67 Download
  • 15 Citations
AbstractAbstract PDF
Background

Due to advancements in treatment of metastatic and advanced renal cell carcinoma (RCC), it has become increasingly important to diagnose metastatic RCC and the specific subtype. In this study, we investigated the diverse histologic features of metastatic clear cell renal cell carcinoma (CCRCC) cases in comparison with corresponding primary lesions.

Methods

We identified 119 metastatic CCRCC cases from 81 corresponding primary lesions diagnosed between 1995 and 2010 and evaluated the diverse histologic and immunohistochemical features of these lesions.

Results

A total of 44 primary lesions (54.3%) had a non-clear cell component in addition to a typical clear cell component. Of the 119 metastatic lesions, 63 lesions (52.9%) contained a non-clear cell component, and 29 metastatic lesions were composed of a non-clear cell component only. Rhabdoid features were the most frequent non-clear cell histology among the metastatic lesions. Metastatic CCRCCs mainly showed positive CD10 and epithelial membrane antigen staining and negative cytokeratin 7 staining.

Conclusions

Metastatic CCRCC commonly showed a variety of histologic features. If there is a difficulty to diagnose metastatic CCRCC due to a variety of histologic features or small biopsy specimen, histologic review of the primary lesion and immunohistochemical analysis can help determine the correct diagnosis.

Citations

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    Jane Gay, Sarah Simpson, Patrick Rush, Alex Holliday
    JAAD Case Reports.2022; 21: 130.     CrossRef
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    Rory M. Bade, Jennifer L. Schehr, Hamid Emamekhoo, Benjamin K. Gibbs, Tamara S. Rodems, Matthew C. Mannino, Joshua A. Desotelle, Erika Heninger, Charlotte N. Stahlfeld, Jamie M. Sperger, Anupama Singh, Serena K. Wolfe, David J. Niles, Waddah Arafat, John
    Molecular Oncology.2021; 15(9): 2330.     CrossRef
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    International Journal of Surgery Case Reports.2020; 74: 268.     CrossRef
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    Steven L. Chang, Toni K. Choueiri, Lauren C. Harshman
    Urologic Oncology: Seminars and Original Investigations.2019; 37(8): 525.     CrossRef
  • Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study
    Shoujun Chen, Elba A. Turbat-Herrera, Guillermo A. Herrera, Meghna Chadha, Rodney E. Shackelford, Eric X. Wei
    Ultrastructural Pathology.2018; 42(4): 369.     CrossRef
  • The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma
    Rana R. McKay, Dominick Bossé, Wanling Xie, Stephanie A.M. Wankowicz, Abdallah Flaifel, Raphael Brandao, Aly-Khan A. Lalani, Dylan J. Martini, Xiao X. Wei, David A. Braun, Eliezer Van Allen, Daniel Castellano, Guillermo De Velasco, J. Connor Wells, Daniel
    Cancer Immunology Research.2018; 6(7): 758.     CrossRef
  • Implication of PHF2 Expression in Clear Cell Renal Cell Carcinoma
    Cheol Lee, Bohyun Kim, Boram Song, Kyung Chul Moon
    Journal of Pathology and Translational Medicine.2017; 51(4): 359.     CrossRef
  • Pulmonary metastasectomy from renal cell carcinoma including 3 cases with sarcomatoid component
    Tsuyoshi Ueno, Motohiro Yamashita, Shigeki Sawada, Ryujiro Sugimoto, Noriko Nishijima, Yoshifumi Sugawara, Iku Ninomiya
    General Thoracic and Cardiovascular Surgery.2016; 64(3): 149.     CrossRef
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    Aleksandra Semeniuk-Wojtaś, Rafał Stec, Cezary Szczylik
    Urologic Oncology: Seminars and Original Investigations.2016; 34(5): 215.     CrossRef
  • Concordance of Pathologic Features Between Metastatic Sites and the Primary Tumor in Surgically Resected Metastatic Renal Cell Carcinoma
    Sarah P. Psutka, John C. Cheville, Brian A. Costello, Suzanne B. Stewart-Merrill, Christine M. Lohse, Bradley C. Leibovich, Stephen A. Boorjian, R. Houston Thompson
    Urology.2016; 96: 106.     CrossRef
  • The Correlation of Tissue-Based Biomarkers in Primary and Metastatic Renal Cell Carcinoma Lesions: A Tissue Microarray Study
    Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
    The Korean Journal of Urological Oncology.2016; 14(3): 152.     CrossRef
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    YU ZOU, JINGJING XU, MINMING ZHANG
    Oncology Letters.2016; 11(5): 3273.     CrossRef
  • Genetic alterations in renal cell carcinoma with rhabdoid differentiation
    Carmen M. Perrino, Vishwanathan Hucthagowder, Michael Evenson, Shashikant Kulkarni, Peter A. Humphrey
    Human Pathology.2015; 46(1): 9.     CrossRef
  • High expression of APRIL correlates with poor prognosis in clear cell renal cell carcinoma
    Cheol Lee, Jeong-Whan Park, Ja Hee Suh, Kyung Chul Moon
    Pathology - Research and Practice.2015; 211(11): 824.     CrossRef
  • A Case of Cutaneous Metastasis from a Clear Cell Renal Cell Carcinoma with an Eosinophilic Cell Component to the Submandibular Region
    Yusuke Amano, Sumie Ohni, Toshiyuki Ishige, Taku Homma, Tsutomu Yamada, Nobuyuki Nishimori, Norimichi Nemoto
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Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
Korean J Pathol. 2013;47(5):433-442.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.433
  • 5,764 View
  • 36 Download
  • 1 Citations
AbstractAbstract PDF
Background

The aim of this study is to evaluate the histologic features of metastatic neuroblastic tumors (NTs) in bone marrow (BM) before and after chemotherapy in comparison with those of primary NTs.

Methods

A total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. There were 48 primary neoplasm biopsies, 48 BM biopsies before chemotherapy, 36 primary neoplasm excisional biopsies after chemotherapy, and 162 BM biopsies after chemotherapy.

Results

Metastatic NTs in BM before chemotherapy were composed of undifferentiated and/or differentiating neuroblasts, but had neither ganglion cells nor Schwannian stroma. Metastatic foci of BM after chemotherapy were found to have differentiated into ganglion cells or Schwannian stroma, which became more prominent after further cycles of chemotherapy. Persistence of NTs or tumor cell types in BM after treatment did not show statistically significant correlation to patients' outcome. However, three out of five patients who newly developed poorly differentiated neuroblasts in BM after treatment expired due to disease progression.

Conclusions

Metastatic NTs in BM initially consist of undifferentiated or differentiating neuroblasts regardless of the primary tumor subtype, and become differentiated after chemotherapy. Newly appearing poorly differentiated neuroblasts after treatment might be an indicator for poor prognosis.

Citations

Citations to this article as recorded by  
  • Postchemotherapy gross residual tumor in non‐high‐risk neuroblastoma: Clinical significance and the role of adjuvant therapy
    Eun Seop Seo, Hana Lim, Hee Won Cho, Hee Young Ju, Ji Won Lee, Keon Hee Yoo, Sanghoon Lee, Do Hoon Lim, Ki Woong Sung, Hong Hoe Koo
    Pediatric Blood & Cancer.2022;[Epub]     CrossRef
Progressive Increase of Regulatory T Cells and Decrease of CD8+ T Cells and CD8+ T Cells/Regulatory T Cells Ratio during Colorectal Cancer Development
Tae Jung Jang
Korean J Pathol. 2013;47(5):443-451.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.443
  • 7,235 View
  • 49 Download
  • 22 Citations
AbstractAbstract PDF
Background

We examined the distribution of CD8+ T cells and regulatory T cells (Tregs), measured the CD8+ T cell/Tregs ratio, investigated the relationship between Tregs and cyclooxygenase-2 (COX-2) expression during colorectal cancer (CRC) development.

Methods

We performed immunohistochemical staining for CD8, forkhead box P3, E-cadherin, and COX-2 in 32 cases of invasive CRC, 10 cases of intramucosal CRC, 27 cases of high-grade tubular adenoma, 22 cases of low-grade tubular adenoma, and 32 cases of non-neoplastic conditions.

Results

We observed a progressive increase in Tregs, and a decrease in CD8+ T cells and the CD8+ T cells/Tregs ratio during CRC development. The alterations were most severe in high-grade tubular adenoma and CRC. COX-2 expression was positively associated with Tregs infiltration. The degree of T cell infiltration differed among tumor compartment and the ratio in the tumor center was the lowest of all areas. The ratio and number of CD8+ T cells in the tumor center and the invasive front of invasive CRC were associated with gender, differentiation, node metastasis and tumor budding.

Conclusions

Alteration in the distribution of both CD8+T cells and Tregs may contribute to the generation of an immune environment suitable for the development and progression of CRC.

Citations

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    Frontiers in Oncology.2021;[Epub]     CrossRef
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    Fauzan Ali Zainal Abidin, Hermin Aminah Usman, Sri Suryanti, Bethy S Hernowo
    Clinical, Cosmetic and Investigational Dermatology.2021; Volume 14: 1783.     CrossRef
  • FOXP3 and CD25 double staining antibody cocktails identify regulatory T cells in different types of tumor tissues using tissue microarrays
    Xinmin Liu, Xiaohong Wang, Jianmin Ding, Yan Gao, Yiming Zhao, Ruihua Zhao, Qigang Sun, Songlin Zhang
    Annals of Diagnostic Pathology.2019; 38: 67.     CrossRef
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    Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Igna
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ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients
Cheol Lee, Jeong Whan Park, Ja Hee Suh, Kyung Han Nam, Kyung Chul Moon
Korean J Pathol. 2013;47(5):452-457.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.452
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AbstractAbstract PDF
Background

Recently, there have been a few reports of renal cell carcinoma (RCC) cases with anaplastic lymphoma kinase (ALK) gene fusion. In this study, we screened consecutively resected RCCs from a single institution for ALK protein expression by immunohistochemistry, and then we performed fluorescence in situ hybridization to confirm the ALK gene alteration in ALK immunohistochemistry-positive cases.

Methods

We screened 829 RCCs by ALK immunohistochemistry, and performed fluorescence in situ hybridization analysis using ALK dual-color break-apart rearrangement probe. Histological review and additional immunohistochemistry analyses were done in positive cases.

Results

One ALK-positive case was found. Initial diagnosis of this case was papillary RCC type 2. This comprises 0.12% of all RCCs (1/829) and 1.9% of papillary RCCs (1/53). This patient was a 44-year-old male with RCC found during routine health check-up. He was alive without evidence of disease 12 years after surgery. The tumor showed a papillary and tubular pattern, and showed positivity for CD10 (focal), epithelial membrane antigen, cytokeratin 7, pan-cytokeratin, PAX-2, and vimentin.

Conclusions

We found the first RCC case with ALK gene rearrangement in Korean patients by ALK immunohistochemistry among 829 RCCs. This case showed similar histological and immunohistochemical features to those of previous adult cases with ALK rearrangement, and showed relatively good prognosis.

Citations

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Diagnostic Utility of a Clonality Test for Lymphoproliferative Diseases in Koreans Using the BIOMED-2 PCR Assay
Young Kim, Yoo Duk Choi, Chan Choi, Jong-Hee Nam
Korean J Pathol. 2013;47(5):458-465.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.458
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AbstractAbstract PDF
Background

A clonality test for immunoglobulin (IG) and T cell receptor (TCR) is a useful adjunctive method for the diagnosis of lymphoproliferative diseases (LPDs). Recently, the BIOMED-2 multiplex polymerase chain reaction (PCR) assay has been established as a standard method for assessing the clonality of LPDs. We tested clonality in LPDs in Koreans using the BIOMED-2 multiplex PCR and compared the results with those obtained in European, Taiwanese, and Thai participants. We also evaluated the usefulness of the test as an ancillary method for diagnosing LPDs.

Methods

Two hundred and nineteen specimens embedded in paraffin, including 78 B cell lymphomas, 80 T cell lymphomas and 61 cases of reactive lymphadenitis, were used for the clonality test.

Results

Mature B cell malignancies showed 95.7% clonality for IG, 2.9% co-existing clonality, and 4.3% polyclonality. Mature T cell malignancies exhibited 83.8% clonality for TCR, 8.1% co-existing clonality, and 16.2% polyclonality. Reactive lymphadenitis showed 93.4% polyclonality for IG and TCR. The majority of our results were similar to those obtained in Europeans. However, the clonality for IGK of B cell malignancies and TCRG of T cell malignancies was lower in Koreans than Europeans.

Conclusions

The BIOMED-2 multiplex PCR assay was a useful adjunctive method for diagnosing LPDs.

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Fine Needle Aspiration Cytology of Parathyroid Lesions
Ilyeong Heo, Sunhoo Park, Chang Won Jung, Jae Soo Koh, Seung-Sook Lee, Hyesil Seol, Hee Seung Choi, Soo Youn Cho
Korean J Pathol. 2013;47(5):466-471.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.466
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AbstractAbstract PDF
Background

There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria.

Methods

We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011.

Results

Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information.

Conclusions

FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.

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    Filomena Cetani, Gianluca Frustaci, Liborio Torregrossa, Silvia Magno, Fulvio Basolo, Alberto Campomori, Paolo Miccoli, Claudio Marcocci
    World Journal of Surgical Oncology.2015;[Epub]     CrossRef
Case Studies
Abdominal Fibromatosis in a Young Child: A Case Study and Review of the Literature
Hyun Hee Chu, Pyoung Han Hwang, Yeon Jun Jeong, Myoung Ja Chung
Korean J Pathol. 2013;47(5):472-476.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.472
  • 6,540 View
  • 29 Download
  • 3 Citations
AbstractAbstract PDF

Fibromatoses comprise many different entities of well-differentiated fibroblastic proliferation with variable collagen production and form a firm nodular mass. Abdominal fibromatosis is distinguishable from other forms of fibromatosis because of its location and its tendency to occur in women of childbearing age during or following pregnancy. Abdominal fibromatosis in children is an extremely rare condition. A 15-month-old boy presented with an abdominal wall mass that had recently increased in size. Mass excision was perfomed. The tumor was 4.3×4.1 cm and partly circumscribed. Histologically, the tumor was composed of parallel long fascicles of spindle-cells with a uniform appearance. The edges of the resected mass were infiltrative, and the surgical margins were positive. Mitotic figures were <1/10 high power fields. No cellular atypia or necrosis was present. The tumor cells were positive for vimentin and nuclear β-catenin staining.

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    Shyam Srinivasan, Soumitra Saha
    Cancer Research, Statistics, and Treatment.2021; 4(4): 752.     CrossRef
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    Levent Cankorkmaz, Mehmet H. Atalar, H. Reyhan Eğilmez
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    Isidro Machado, Julia Cruz, Javier Lavernia, Fernando Carbonell
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Cotyledonoid Dissecting Leiomyoma of the Uterus with Intravascular Luminal Growth: A Case Study
Na Rae Kim, Chan Yong Park, Hyun Yee Cho
Korean J Pathol. 2013;47(5):477-480.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.477
  • 8,991 View
  • 58 Download
  • 4 Citations
AbstractAbstract PDF

Here, we report the case of a 43-year-old female who was diagnosed with a cotyledonoid dissecting leiomyoma (CDL) of the uterus. CDL is a recently described and extremely rare variant of a benign leiomyoma that can grossly masquerade as a malignancy. The 13-cm sized tumor was located primarily on the extrauterine surface as an intrauterine continuity, which showed dark red, congested, bulbous protuberances. It was multinodular appearance, encasing the bilateral adnexae and the left iliac vein. Microscopically, the nodules were separated by extensive hydropic degeneration. The nodules were composed of cigar-shaped spindle cells with no mitosis, cellular pleomorphism or coagulation necrosis. They also showed an intravascular luminal growth pattern. CDL with intravascular growth was diagnosed after excluding intravascular leiomyomatosis, disseminated peritoneal leiomyomatosis, and benign metastasizing leiomyoma. The present case is the second reported case of CDL in Korea. Recognition of this rare and bizarre, malignancy-mimicking leiomyoma is crucial to prevent inappropriate treatment.

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  • Cotyledonoid Leiomyoma Clinical Characteristics, Imaging Features, and Review of the Literature
    Francesca Buonomo, Sofia Bussolaro, Giorgio Giorda, Federico Romano, Stefania Biffi, Giuseppe Ricci
    Journal of Ultrasound in Medicine.2021; 40(7): 1459.     CrossRef
  • The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature
    Francesca Buonomo, Sofia Bussolaro, Clarice de Almeida Fiorillo, Giorgio Giorda, Federico Romano, Stefania Biffi, Giuseppe Ricci
    International Journal of Environmental Research and Public Health.2021; 18(16): 8521.     CrossRef
  • Cotyledonoid dissecting leiomyoma of the uterus: A report of four cases and a review of the literature
    TIANMIN XU, SHUYING WU, RULIN YANG, LIPING ZHAO, MINGXING SUI, MANHUA CUI, WEIQIN CHANG
    Oncology Letters.2016; 11(4): 2865.     CrossRef
  • COTYLEDONOID DISSECTING LEIOMYOMA (CDL) OF UTERUS MIMICKING MALIGNANCY: A CLINICAL DILEMMA
    Roma Isaacs, Rupinder Kaur, Sunita Goyal
    Journal of Evolution of Medical and Dental Sciences.2016; 5(57): 3973.     CrossRef
Fine-Needle Aspiration Cytology of Low-Grade Cribriform Cystadenocarcinoma with Many Psammoma Bodies of the Salivary Gland
Ji Yun Jeong, Dongbin Ahn, Ji Young Park
Korean J Pathol. 2013;47(5):481-485.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.481
  • 5,808 View
  • 36 Download
  • 11 Citations
AbstractAbstract PDF

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare salivary gland tumor that was recently defined as a variant of cystadenocarcinoma by the 2005 World Health Orgazniation (WHO) classification system. We report cytologic findings of an unusual case of LGCCC with many psammoma bodies. A 90-year-old man presented a palpable mass on his left parotid gland. Fine-needle aspiration (FNA) cytology showed tumor cells that were arranged in clusters and dispersed individually. The tumor cells showed mild atypia and had clear or dense cytoplasm with some vacuoles. Numerous psammoma bodies were noted. After surgical resection, the histologic examination revealed a mixed solid and cystic mass showing intraductal growth with focal stromal invasion. The S-100 protein expressed in the tumor cells, but smooth muscle actin and p63 were positive only in myoepithelial cells. Although LGCCCs resemble other salivary gland tumors, differentiating LGCCC during preoperative FNA is important to avoid unnecessary overtreatment.

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  • Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification
    Lester D. R. Thompson, Justin A. Bishop
    Advances in Anatomic Pathology.2022;[Epub]     CrossRef
  • Intraductal carcinoma of the parotid gland
    Yukiya HIRATA, Kayoko HIGUCHI, Toshitaka NAGAO, Yoko ZUKERAN, Takao KINJO, Naoki WADA
    The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 431.     CrossRef
  • Intraductal carcinoma of the retromolar trigone found with elevated serum CEA and CA19-9 levels: a case report
    Mao KAWAKAMI, Nobuhiro UEDA, Yuka TAKAHASHI, Sho ARIKAWA, Nobuhiro YAMAKAWA, Tadaaki KIRITA
    Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(5): 292.     CrossRef
  • Endoscopic trans‐pterygoid resection of a low‐grade cribriform cystadenocarcinoma of the infratemporal fossa
    Vikram G. Ramjee, Landon J. Massoth, John P. Richards, Kibwei A. McKinney
    World Journal of Otorhinolaryngology - Head and Neck Surgery.2020; 6(2): 115.     CrossRef
  • Psammoma Bodies in a Large Myoepithelioma
    Marcela Pessoa de Melo, Diego Filipe Bezerra Silva, Rodrigo Alves Ribeiro, Tony Santos Peixoto, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Bárbara Vanessa de Brito Monteiro
    Journal of Craniofacial Surgery.2020; 31(4): e326.     CrossRef
  • Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity
    Francesco Giovacchini, Caterina Bensi, Stefano Belli, Maria Elena Laurenti, Martina Mandarano, Daniele Paradiso, Michele Giansanti, Antonio Tullio
    Journal of Oral Biology and Craniofacial Research.2019; 9(1): 96.     CrossRef
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    Julie Allen, Ashley M. Talley, Carol B. Grindem, Jennifer A. Neel
    Veterinary Clinical Pathology.2018; 47(4): 676.     CrossRef
  • Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature
    Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
    Pathology - Research and Practice.2017; 213(4): 405.     CrossRef
  • Cytology of low-grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms
    Yoshiki Ohta, Yuko Hirota, Yohko Kohno, Koji Kishimoto, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Akira Shiokawa, Hidekazu Ota
    Diagnostic Cytopathology.2016; 44(3): 241.     CrossRef
  • Low-grade cribriform cystadenocarcinoma arising from a minor salivary gland: a case report
    Masashi Kimura, Shinji Mii, Shinichi Sugimoto, Kosuke Saida, Shojiroh Morinaga, Masahiro Umemura
    Journal of Oral Science.2016; 58(1): 145.     CrossRef
  • A Case of Cystadenocarcinoma Arising from Parotid Gland
    Jong Chul Hong, Tae Kyoung Koh, Min Gyoung Pak, Heon Soo Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2016; 59(4): 300.     CrossRef
Brief Case Reports
A Primary Malignant Rhabdoid Tumor in Adult Liver
Yu Na Kang, Sang Pyo Kim, Byoung Kuk Jang
Korean J Pathol. 2013;47(5):486-488.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.486
  • 5,907 View
  • 38 Download
  • 4 Citations
PDF

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  • Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review
    Haikun Ye, Zirong Liu, Yamin Zhang
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Primary Malignant Rhabdoid Tumour of the Liver in Adult Male: a Diagnostic and Therapeutic Challenge
    Sunil Pasricha, Garima Durga, Gurudutt Gupta, Ankush Jajodia, Venkata Pradeep Babu Koyyala, Anila Sharma, Meenakshi Kamboj, Manoj Gupta, Anurag Mehta
    Journal of Gastrointestinal Cancer.2021; 52(2): 738.     CrossRef
  • Embryonic signature distinguishes pediatric and adult rhabdoid tumors from other SMARCB1-deficient cancers
    Wilfrid Richer, Julien Masliah-Planchon, Nathalie Clement, Irene Jimenez, Laetitia Maillot, David Gentien, Benoît Albaud, Walid Chemlali, Christine Galant, Frederique Larousserie, Pascaline Boudou-Rouquette, Amaury Leruste, Celine Chauvin, Zhi Yan Han, Je
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    Varsha Podduturi, Molly M. Campa-Thompson, Xin J. Zhou, Joseph M. Guileyardo
    Baylor University Medical Center Proceedings.2014; 27(3): 239.     CrossRef
Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus
Ji Eun Choi, Sang Jae Noh, Jong Jin Sung, Woo Sung Moon
Korean J Pathol. 2013;47(5):489-491.   Published online October 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.489
  • 6,659 View
  • 60 Download
  • 8 Citations
PDF

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    Minerva K. Fahmy, Hayam G. Sayyed, Eman A. Abd Elrahim, Rana T.A. Farag
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    Keijiro Ueda, Ken Kawabe, Lingaku Lee, Yuichi Tachibana, Nao Fujimori, Hisato Igarashi, Yoshinao Oda, Robert T. Jensen, Ryoichi Takayanagi, Tetsuhide Ito
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    A. G. Kriger, A. V. Smirnov, D. V. Kalinin, A. V. Glotov, S. V. Berelavichus, G. I. Konyaeva, A. N. Lebedeva, N. A. Karel’skaya, V. N. Tsygankov
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JPTM : Journal of Pathology and Translational Medicine