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Volume 48(4); August 2014
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Original Articles
The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
Korean J Pathol. 2014;48(4):263-269.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.263
  • 6,731 View
  • 48 Download
  • 10 Citations
AbstractAbstract PDF
Background

Epithelial mesenchymal transition (EMT) has an important role in invasion and metastasis of tumor cells. The purpose of this study was to evaluate the roles of EMT-associated proteins on progression and metastasis as a prognostic/predictive factor in curatively-resected (R0) head and neck squamous cell carcinoma (HNSCC).

Methods

A total of 118 patients who received curative surgery for HNSCC at Inha University Hospital between January 1996 and December 2011 were included. We used protein immunohistochemistry to evaluate the expression of E-cadherin, vimentin, and EZH2 on tissue microarrays. Also, we reviewed all medical records and analyzed the relationship between the expression of EMT-associated proteins and prognosis.

Results

The E-cadherin-negative group showed more moderate/poor differentiation of cancer cell type than the higher E-cadherin-expressing group (p=.016) and high EZH2 expression was significantly correlated with nodal metastasis (p=.012). Our results demonstrate a significant association between high expression of EZH2 and vimentin and presence of distant progression (p=.026). However, expression of E-cadherin, vimentin, and EZH2 was not significantly associated with overall survival.

Conclusions

These findings suggest that an EMT-associated protein expression profile is correlated with aggressiveness of disease and prognosis, and could be a useful marker for determination of additional treatment in curatively-resected HNSCC patients.

Citations

Citations to this article as recorded by  
  • Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer
    Samar M. Abdel Raouf, Taiseer R. Ibrahim, Lobna A. Abdelaziz, Mohamed I. Farid, Salem Y Mohamed
    Journal of Gastrointestinal Cancer.2021; 52(1): 90.     CrossRef
  • HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin signaling axis
    Kyungmin Lee, Jae Won Chang, Chan Oh, Lihua Liu, Seung-Nam Jung, Ho-Ryun Won, Young Il Kim, Ki-Sang Rha, Bon Seok Koo
    European Journal of Surgical Oncology.2020; 46(6): 1066.     CrossRef
  • EZH2 overexpression in head and neck cancer is related to lymph node metastasis
    Julie C. Nienstedt, Cornelia Schroeder, Till Clauditz, Ronald Simon, Guido Sauter, Adrian Muenscher, Marco Blessmann, Henning Hanken, Christina Pflug
    Journal of Oral Pathology & Medicine.2018; 47(3): 240.     CrossRef
  • MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
    Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu, Xiaomeng Song
    Cancer Cell International.2018;[Epub]     CrossRef
  • HMGA2 is associated with the aggressiveness of tongue squamous cell carcinoma
    H Zhang, Z Tang, C Deng, Y He, F Wu, O Liu, C Hu
    Oral Diseases.2017; 23(2): 255.     CrossRef
  • miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin
    Lizandra Jimenez, Jihyeon Lim, Berta Burd, Thomas M. Harris, Thomas J. Ow, Nicole Kawachi, Thomas J. Belbin, Ruth Angeletti, Michael B. Prystowsky, Geoffrey Childs, Jeffrey E. Segall
    The American Journal of Pathology.2017; 187(7): 1523.     CrossRef
  • Functional and therapeutic significance of EZH2 in urological cancers
    Xiaobing Liu, Qingjian Wu, Longkun Li
    Oncotarget.2017; 8(23): 38044.     CrossRef
  • EZH2, an on–off valve in signal network of tumor cells
    Shanshan Sun, Feng Yu, Lun Zhang, Xuan Zhou
    Cellular Signalling.2016; 28(5): 481.     CrossRef
  • High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
    Si-Hyong Jang, Jong Eun Lee, Mee-Hye Oh, Ji-Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee
    Journal of Breast Cancer.2016; 19(1): 53.     CrossRef
  • EZH2 promotes invasion and metastasis of laryngeal squamous cells carcinoma via epithelial-mesenchymal transition through H3K27me3
    HuaNan Luo, Yuan Jiang, SiJing Ma, HuanHuan Chang, ChunXi Yi, Hui Cao, Ying Gao, HaiLi Guo, Jin Hou, Jing Yan, Ying Sheng, XiaoYong Ren
    Biochemical and Biophysical Research Communications.2016; 479(2): 253.     CrossRef
Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study
Hyun-Jin Son, Tae-Hwa Baek, Seung Yun Lee, Joo-Heon Kim, Dong-Wook Kang, Hye-Kyung Lee, Mee-Ja Park
Korean J Pathol. 2014;48(4):270-275.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.270
  • 6,205 View
  • 25 Download
  • 1 Citations
AbstractAbstract PDF
Background

Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.

Methods

We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.

Results

The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.

Conclusions

This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.

Citations

Citations to this article as recorded by  
  • Nodular fasciitis of the anterior chest wall mimicking myxofibrosarcoma: A case report and literature review
    Antonino Cattafi, Mariarosaria Galeano, Pietro Pitrone, Carmelo Sofia, Maria Adele Marino, Giorgio Ascenti, Maria Lentini, Antonio Ieni, Roberta Cardia, Alfio Luca Costa, Dario Familiari, Mario Barone, Francesco Monaco, Michele Rosario Colonna
    Radiology Case Reports.2021; 16(6): 1557.     CrossRef
Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status
Jung Ho Kim, Jeong Mo Bae, Kyung-Ju Kim, Ye-Young Rhee, Younghoon Kim, Nam-Yun Cho, Hye Seung Lee, Mee Soo Chang, Gyeong Hoon Kang
Korean J Pathol. 2014;48(4):276-282.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.276
  • 9,897 View
  • 57 Download
  • 14 Citations
AbstractAbstract PDF
Background

Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs.

Methods

Expression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight).

Results

Among 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004).

Conclusions

Loss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.

Citations

Citations to this article as recorded by  
  • Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
    S. Raghavan, Deepak Kumar Singh, J. Rohila, A. DeSouza, R. Engineer, A. Ramaswamy, V. Ostwal, A. Saklani
    Indian Journal of Surgical Oncology.2020; 11(4): 597.     CrossRef
  • Evaluation of the Role of Circulating Tumor Cells and Microsatellite Instability Status in Predicting Outcome of Advanced CRC Patients
    Ippokratis Messaritakis, Maria Sfakianaki, Konstantinos Vogiatzoglou, Asimina Koulouridi, Chara Koutoulaki, Dimitrios Mavroudis, Maria Tzardi, Nikolaos Gouvas, John Tsiaoussis, John Souglakos
    Journal of Personalized Medicine.2020; 10(4): 235.     CrossRef
  • Is Ep-CAM Expression a Diagnostic and Prognostic Biomarker for Colorectal Cancer? A Systematic Meta-Analysis
    Susu Han, Shaoqi Zong, Qi Shi, Hongjia Li, Shanshan Liu, Wei Yang, Wen Li, Fenggang Hou
    EBioMedicine.2017; 20: 61.     CrossRef
  • Prognostic factors in sporadic colon cancer with high-level microsatellite instability
    Bo Young Oh, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Ho-Kyung Chun
    Surgery.2016; 159(5): 1372.     CrossRef
  • Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status
    Ghilsuk Yoon, Hwayoung Lee, Jae-Hoon Kim, Keun Hur, An Na Seo
    Tumor Biology.2016; 37(8): 10209.     CrossRef
  • Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis
    Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan
    BMC Cancer.2016;[Epub]     CrossRef
  • BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis
    Soo Kyung Nam, Sumi Yun, Jiwon Koh, Yoonjin Kwak, An Na Seo, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Woo Ho Kim, Hye Seung Lee, Wayne A Phillips
    PLOS ONE.2016; 11(3): e0151865.     CrossRef
  • Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells
    Bo Young Oh, So-Young Kim, Yeo Song Lee, Hye Kyung Hong, Tae Won Kim, Seok Hyung Kim, Woo Yong Lee, Yong Beom Cho
    Oncotarget.2016; 7(35): 57066.     CrossRef
  • Clinicopathologic, molecular, and prognostic implications of the loss of EPCAM expression in colorectal carcinoma
    Jung Ho Kim, Jeong Mo Bae, Young Seok Song, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
    Oncotarget.2016; 7(12): 13372.     CrossRef
  • Pathologic Factors Associated with Prognosis after Adjuvant Chemotherapy in Stage II/III Microsatellite-Unstable Colorectal Cancers
    Jung Ho Kim, Jeong Mo Bae, Hyeon Jeong Oh, Hye Seung Lee, Gyeong Hoon Kang
    Journal of Pathology and Translational Medicine.2015; 49(2): 118.     CrossRef
  • HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value
    An Na Seo, Yoonjin Kwak, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Hye Seung Lee
    Virchows Archiv.2015; 466(6): 645.     CrossRef
  • Clinical and prognostic value of MET gene copy number gain and chromosome 7 polysomy in primary colorectal cancer patients
    An Na Seo, Kyoung Un Park, Gheeyoung Choe, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
    Tumor Biology.2015; 36(12): 9813.     CrossRef
  • c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer
    Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee, Andreas Krieg
    PLOS ONE.2015; 10(10): e0139727.     CrossRef
  • Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients
    Gunjan Srivastava, Jasmeet Assi, Lawrence Kashat, Ajay Matta, Martin Chang, Paul G Walfish, Ranju Ralhan
    BMC Cancer.2014;[Epub]     CrossRef
The Role of TWIST in Ovarian Epithelial Cancers
Kyungbin Kim, Eun Young Park, Man Soo Yoon, Dong Soo Suh, Ki Hyung Kim, Jeong Hee Lee, Dong Hoon Shin, Jee Yeon Kim, Mee Young Sol, Kyung Un Choi
Korean J Pathol. 2014;48(4):283-291.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.283
  • 6,424 View
  • 39 Download
  • 9 Citations
AbstractAbstract PDF
Background

Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.

Methods

We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters.

Results

The expression of TWIST, E-cadherin, HIF1α, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1α expression and reduced E-cadherin expression. The altered HIF1α/TWIST/E-cadherin pathway was associated with lower overall survival (OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS.

Conclusions

Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia-mediated EMT, which involves the HIF1α/TWIST/E-cadherin pathway may play an important role in the progression of OEC.

Citations

Citations to this article as recorded by  
  • Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer
    Danchen Wu, Asish Dasgupta, Austin D. Read, Rachel E.T. Bentley, Mehras Motamed, Kuang-Hueih Chen, Ruaa Al-Qazazi, Jeffrey D. Mewburn, Kimberly J. Dunham-Snary, Elahe Alizadeh, Lian Tian, Stephen L. Archer
    Free Radical Biology and Medicine.2021; 170: 150.     CrossRef
  • Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
    Shing Yau Tam, Vincent W. C. Wu, Helen K. W. Law
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Expression of selected epithelial–mesenchymal transition transcription factors in serous borderline ovarian tumors and type I ovarian cancers
    Pawel Sadlecki, Jakub Jóźwicki, Paulina Antosik, Marek Grabiec
    Tumor Biology.2018; 40(6): 101042831878480.     CrossRef
  • Expression and prognostic significance of epithelial-mesenchymal transition-related markers and phenotype in serous ovarian cancer
    In Hye Song, Kyu-Rae Kim, Sehun Lim, Seok-Hyung Kim, Chang Ohk Sung
    Pathology - Research and Practice.2018; 214(10): 1564.     CrossRef
  • Transcription factors controlling E-cadherin down-regulation in ovarian cancer
    Holly Russell, Md Zahidul Islam Pranjol
    Bioscience Horizons: The International Journal of Student Research.2018;[Epub]     CrossRef
  • Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF‐κB‐mediated IKKβ expression
    Yi‐Hui Wu, Yu‐Fang Huang, Tzu‐Hao Chang, Cheng‐Yang Chou
    International Journal of Cancer.2017; 141(11): 2305.     CrossRef
  • MicroRNA-219-5p inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells by targeting the Twist/Wnt/β-catenin signaling pathway
    Chunyan Wei, Xi Zhang, Sai He, Bianli Liu, Hongfang Han, Xuejun Sun
    Gene.2017; 637: 25.     CrossRef
  • Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism
    Zi Chen, Dongwen Xu, Tao Zhang
    International Journal of Oncology.2017; 51(3): 851.     CrossRef
  • Is overexpression of TWIST, a transcriptional factor, a prognostic biomarker of head and neck carcinoma? Evidence from fifteen studies
    Xianlu Zhuo, Huanli Luo, Aoshuang Chang, Dairong Li, Houyu Zhao, Qi Zhou
    Scientific Reports.2015;[Epub]     CrossRef
Case Studies
Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature
Aleem Ladak, Maria Bramley, Sami Titi
Korean J Pathol. 2014;48(4):292-296.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.292
  • 8,581 View
  • 72 Download
  • 3 Citations
AbstractAbstract PDF

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget's cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.

Citations

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  • Atypical cells on reflectance confocal microscopy may not represent melanoma: A case of axillary pigmented extramammary Paget disease
    Nadiya Chuchvara, Catherine Reilly, Attiya Haroon, Cindy Wassef, Amin Maghari, Babar Rao
    Journal of Cutaneous Pathology.2020; 47(12): 1170.     CrossRef
  • “Pigmented Extramammary Paget Disease”—A Potential Mimicker of Malignant Melanoma and a Pitfall in Diagnosis: A Case Report and Review of the Literature
    Katrin Kiavash, Steve Kim, Andrew D. Thompson
    The American Journal of Dermatopathology.2019; 41(1): 45.     CrossRef
  • Vulvar cancer: a review for dermatologists
    Anastasiya Atanasova Chokoeva, Georgi Tchernev, Elena Castelli, Elisabetta Orlando, Shyam B. Verma, Markus Grebe, Uwe Wollina
    Wiener Medizinische Wochenschrift.2015; 165(7-8): 164.     CrossRef
Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review
Byeong-Joo Noh, Ji-Youn Sung, Youn-Wha Kim, Yong-Koo Park
Korean J Pathol. 2014;48(4):297-301.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.297
  • 5,956 View
  • 42 Download
  • 1 Citations
AbstractAbstract PDF

Papillary thyroid carcinoma (PTC) in children under ten years old is very rare. To date, 18 cases of PTC in children under ten years old (including our two cases) have been reported in Korea. Here, we describe two cases of recurrent PTC with follicular variant and conventional type in an 8-year-old boy and a 7-year-old boy, respectively, and discuss clinicopathologic and molecular characteristics that differ in pediatric patients from adults.

Citations

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  • Extremely Well-Differentiated Papillary Thyroid Carcinoma Resembling Adenomatous Hyperplasia Can Metastasize to the Skull: A Case Report
    Ju Yeon Pyo, Jisup Kim, Sung-eun Choi, Eunah Shin, Seok-Woo Yang, Cheong Soo Park, Seok-Mo Kim, SoonWon Hong
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Brief Case Reports
Chordoid Meningioma in a Pediatric Patient with Tuberous Sclerosis Complex
Jiwon Lee, Hee Joon Yu, Jeehun Lee, Ji Hye Kim, Hyung Jin Shin, Yeon-Lim Suh, Munhyang Lee
Korean J Pathol. 2014;48(4):302-306.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.302
  • 6,531 View
  • 33 Download
  • 2 Citations
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Citations

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  • Innumerable Meningiomas Arising in a Patient With Tuberous Sclerosis Complex Decades After Radiation Therapy
    Ahmed Gilani, Julieann C Lee, BK Kleinschmidt-DeMasters
    Pediatric and Developmental Pathology.2021; 24(5): 471.     CrossRef
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    Winward Choy, Leonel Ampie, Jonathan B. Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T. Parsa, Orin Bloch
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Solitary Myofibroma of the Adult Mandible: A Case Report and Review of Literature
Yong-Moon Lee, Seung-Myoung Son, Kyoung Won Kim, Ok-Jun Lee
Korean J Pathol. 2014;48(4):307-310.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.307
  • 5,800 View
  • 49 Download
  • 8 Citations
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Citations

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    Scott Cannon, Yousef Hammad, Thomas Schlieve
    Oral and Maxillofacial Surgery Cases.2021; 7(4): 100234.     CrossRef
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    Irene Dixe de Oliveira Santo, Pedro V. Staziaki, Andrey Prilutskiy, Teviah E. Sachs, Akira M. Murakami
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    Alexandra Maby, Benoit Guay, François Thuot
    Journal of Otolaryngology - Head & Neck Surgery.2019;[Epub]     CrossRef
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    Jung-Hoon Yoon
    The Korean Journal of Oral and Maxillofacial Pathology.2018; 42(5): 125.     CrossRef
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    Molly Housley Smith, John D. Reith, Donald M. Cohen, Nadim M. Islam, Kimberly T. Sibille, Indraneel Bhattacharyya
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2017; 124(1): 62.     CrossRef
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    Natalia Murray, B. Hanna, Nicole Graf, He Fu, Veronneau Mylène, P.M. Campeau, Anne Ronan
    European Journal of Medical Genetics.2017; 60(7): 353.     CrossRef
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    Anita Dhupar, Karla Carvalho, Poonam Sawant, Anita Spadigam, Shaheen Syed
    Children.2017; 4(10): 91.     CrossRef
  • Surgical Management of Myofibroma of the Gengiva
    Paolo Garzino Demo, Matteo Savoini, Marco Marchetti, Francesca Maletta, Emanuele Zavattero, Guglielmo Ramieri
    Journal of Craniofacial Surgery.2016; 27(7): e646.     CrossRef
Undifferentiated Embryonal Sarcoma in Adult Liver
Won Ju Hong, Yu Na Kang, Koo Jeong Kang
Korean J Pathol. 2014;48(4):311-314.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.311
  • 6,452 View
  • 43 Download
  • 5 Citations
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Citations

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  • Undifferentiated embryonal sarcoma of the liver treated with associating liver partition and portal vein ligation for staged hepatectomy in a young adult: A case report
    Dmitri Schepelew, Tim Reese, Katja Horling, Christian Frenzel, Karl J. Oldhafer
    International Journal of Surgery Case Reports.2020; 66: 221.     CrossRef
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    Narendra Pandit, Kunal Bikram Deo, Lokesh Shekher Jaiswal, Anju Pradhan, Shailesh Adhikary
    Journal of Gastrointestinal Cancer.2019; 50(3): 689.     CrossRef
  • Unexpected Liver Embryonal Sarcoma in the Adult: Diagnosis and Treatment
    Maurizio Pinamonti, Federico Vittone, Francesco Ghiglione, Andrea Borasi, Stefano Silvestri, Sergio Coverlizza
    Case Reports in Surgery.2018; 2018: 1.     CrossRef
  • Undifferentiated embryonal sarcoma of the liver in adult patient: A report of two cases
    Germán Esteban Sánchez-Morales, Uriel Emilio Clemente-Gutiérrez, Francisco Emmanuel Alvarez-Bautista, Oscar Santes-Jasso, Paulina Carpinteyro-Espin, Miguel Angel Mercado
    Annals of Hepato-Biliary-Pancreatic Surgery.2018; 22(3): 269.     CrossRef
  • Undifferentiated Sarcoma of the Liver in an Adult Showing Early Recurrence after Hepatectomy and Rapid Growth Leading to Death
    Akira Yasuda, Keisuke Nonoyama, Shunsuke Hayakawa, Kaori Watanabe, Shiro Fujihata, Minoru Yamamoto, Hidehiko Kitagami, Yasunobu Shimizu, Tetsushi Hayakawa, Moritsugu Tanaka
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Signet-Ring Cell Carcinoma of the Distal Common Bile Duct: Report of a Case
Hyung Jun Kwon, Ghil-Suk Yoon, Yong Chul Kwon, Sang Geol Kim, Ji Yun Jeong
Korean J Pathol. 2014;48(4):315-318.   Published online August 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.315
  • 6,173 View
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  • 4 Citations
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Citations

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  • Rare histotypes of epithelial biliary tract tumors: A literature review
    Elena Sapuppo, Oronzo Brunetti, Dalila Tessitore, Giovanni Brandi, Nicola Di Giovanni, Guido Fadda, Claudio Luchini, Maurizio Martini, Davide Quaresmini, Antonio Russo, Mariacarmela Santarpia, Aldo Scarpa, Mario Scartozzi, Giovanni Tuccari, Tindara Franch
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