Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > Articles and issues > Previous issues
12 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 49(3); May 2015
Prev issue Next issue
Reviews
Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia
Nandor Gabor Than, Roberto Romero, Andrea Balogh, Eva Karpati, Salvatore Andrea Mastrolia, Orna Staretz-Chacham, Sinuhe Hahn, Offer Erez, Zoltan Papp, Chong Jai Kim
J Pathol Transl Med. 2015;49(3):181-208.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.02.25
  • 24,225 View
  • 261 Download
  • 42 Citations
AbstractAbstract PDF
Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

Citations

Citations to this article as recorded by  
  • Is human labor at term an inflammatory condition?
    Chandrashekara Kyathanahalli, Madeline Snedden, Emmet Hirsch
    Biology of Reproduction.2023; 108(1): 23.     CrossRef
  • Placental galectins regulate innate and adaptive immune responses in pregnancy
    Orsolya Oravecz, Roberto Romero, Eszter Tóth, Judit Kapitány, Máté Posta, Dahiana M. Gallo, Simona W. Rossi, Adi L. Tarca, Offer Erez, Zoltán Papp, János Matkó, Nándor Gábor Than, Andrea Balogh
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas
    Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Tha
    International Journal of Molecular Sciences.2022; 23(10): 5798.     CrossRef
  • Evolution of Placental Hormones: Implications for Animal Models
    Anthony M. Carter
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Possible important roles of galectins in the healing of human fetal membranes
    Jia-Le Chen, Yu Chen, De-Xiang Xu, Dao-Zhen Chen
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Melatonin-Primed MSCs Alleviate Intrauterine Adhesions by Affecting MSC-Expressed Galectin-3 on Macrophage Polarization
    Qi Jiang, Jingman Li, Yuchen Pan, Jiali Wang, Jingjing Yang, Sunan Shen, Yayi Hou
    Stem Cells.2022; 40(10): 919.     CrossRef
  • Galectin-1 and Galectin-9 Concentration in Maternal Serum: Implications in Pregnancies Complicated with Preterm Prelabor Rupture of Membranes
    Dorota Grażyna Boroń, Aleksy Świetlicki, Michał Potograbski, Grażyna Kurzawińska, Przemysław Wirstlein, Daniel Boroń, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
    Journal of Clinical Medicine.2022; 11(21): 6330.     CrossRef
  • Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia
    Ellen Menkhorst, Wei Zhou, Leilani Santos, Jian-Guo Zhang, Yves St-Pierre, Morag J. Young, Evdokia Dimitriadis
    Pregnancy Hypertension.2022; 30: 130.     CrossRef
  • Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance
    Xiao-Xiao Jin, Xiang Ying, Min-Yue Dong
    BMC Pregnancy and Childbirth.2021;[Epub]     CrossRef
  • Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation
    Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes
    Başak Kaya, Uğur Turhan, Salim Sezer, Serdar Kaya, İsmail Dağ, Ahmet Tayyar
    The Journal of Maternal-Fetal & Neonatal Medicine.2020; 33(5): 861.     CrossRef
  • Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice
    Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Hui-Hui Yang, Chen-Yu Zhang, Si-Yuan Tang
    Free Radical Biology and Medicine.2020; 146: 222.     CrossRef
  • Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood
    Masashi Mizuno, Kana Sakaguchi, Iwao Sakane
    Biomolecules.2020; 10(2): 258.     CrossRef
  • Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis
    Matyas Meggyes, Laszlo Szereday, Noemi Bohonyi, Miklos Koppan, Sarolta Szegedi, Anna Marics-Kutas, Mirjam Marton, Anett Totsimon, Beata Polgar
    International Journal of Molecular Sciences.2020; 21(7): 2343.     CrossRef
  • Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand
    Mirian Mendoza, Dongli Lu, Angela Ballesteros, Sandra M Blois, Kelsey Abernathy, Chiguang Feng, Charles J Dimitroff, Jonathan Zmuda, Maria Panico, Anne Dell, Gerardo R Vasta, Stuart M Haslam, Gabriela Dveksler
    Glycobiology.2020; 30(11): 895.     CrossRef
  • Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions
    Franziska Krautter, Carlota Recio, Mohammed T. Hussain, Danielle R. Lezama, Francesco Maione, Myriam Chimen, Asif J. Iqbal
    Biomedicine & Pharmacotherapy.2020; 130: 110595.     CrossRef
  • Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
    Sandra M. Blois, Stefan Verlohren, Gang Wu, Gary Clark, Anne Dell, Stuart M. Haslam, Gabriela Barrientos
    Seminars in Immunopathology.2020; 42(4): 469.     CrossRef
  • Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
    Ellen Menkhorst, Wei Zhou, Leilani L. Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J. Young, Kypros H. Nicolaides, Yves St-Pierre, Evdokia Dimitriadis
    Hypertension.2020; 76(4): 1185.     CrossRef
  • Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?
    Katalin Karaszi, Szilvia Szabo, Kata Juhasz, Peter Kiraly, Barbara Kocsis-Deak, Beata Hargitai, Tibor Krenacs, Petronella Hupuczi, Offer Erez, Zoltan Papp, Ilona Kovalszky, Nandor Gabor Than
    Placenta.2019; 76: 30.     CrossRef
  • Tacrolimus treatment for infertility related to maternal‐fetal immune interactions
    Koushi Yamaguchi
    American Journal of Reproductive Immunology.2019; 81(4): e13097.     CrossRef
  • Human trophoblast requires galectin-3 for cell migration and invasion
    Ž. Bojić-Trbojević, M. Jovanović Krivokuća, A. Vilotić, N. Kolundžić, I. Stefanoska, F. Zetterberg, U. J. Nilsson, H. Leffler, Lj. Vićovac
    Scientific Reports.2019;[Epub]     CrossRef
  • Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
    Sandra M. Blois, Gabriela Dveksler, Gerardo R. Vasta, Nancy Freitag, Véronique Blanchard, Gabriela Barrientos
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response
    Andrea Balogh, Eszter Toth, Roberto Romero, Katalin Parej, Diana Csala, Nikolett L. Szenasi, Istvan Hajdu, Kata Juhasz, Arpad F. Kovacs, Hamutal Meiri, Petronella Hupuczi, Adi L. Tarca, Sonia S. Hassan, Offer Erez, Peter Zavodszky, Janos Matko, Zoltan Pap
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy
    Marei Sammar, Tijana Drobnjak, Maurizio Mandala, Sveinbjörn Gizurarson, Berthold Huppertz, Hamutal Meiri
    International Journal of Molecular Sciences.2019; 20(13): 3192.     CrossRef
  • Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions
    Yongzhi Guo, Tom van Schaik, Naveed Jhamat, Adnan Niazi, Metasu Chanrot, Gilles Charpigny, Jean Francois Valarcher, Erik Bongcam-Rudloff, Göran Andersson, Patrice Humblot, Peter J. Hansen
    PLOS ONE.2019; 14(9): e0222081.     CrossRef
  • The Impact of Natural Selection on the Evolution and Function of Placentally Expressed Galectins
    Zackery A Ely, Jiyun M Moon, Gregory R Sliwoski, Amandeep K Sangha, Xing-Xing Shen, Abigail L Labella, Jens Meiler, John A Capra, Antonis Rokas, Soojin Yi
    Genome Biology and Evolution.2019; 11(9): 2574.     CrossRef
  • Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles
    Jennifer R. King, Melissa L. Wilson, Szabolcs Hetey, Peter Kiraly, Koji Matsuo, Antonio V. Castaneda, Eszter Toth, Tibor Krenacs, Petronella Hupuczi, Paulette Mhawech-Fauceglia, Andrea Balogh, Andras Szilagyi, Janos Matko, Zoltan Papp, Lynda D. Roman, Vic
    International Journal of Molecular Sciences.2019; 20(20): 4999.     CrossRef
  • The emerging role of galectins in high-fatality cancers
    Cherylane Dubé-Delarosbil, Yves St-Pierre
    Cellular and Molecular Life Sciences.2018; 75(7): 1215.     CrossRef
  • Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
    Yi-Chen Chan, Hsien-Ya Lin, Zhijay Tu, Yen-Hsi Kuo, Shang-Te Hsu, Chun-Hung Lin
    International Journal of Molecular Sciences.2018; 19(2): 392.     CrossRef
  • The link between immunity, autoimmunity and endometriosis: a literature update
    Tao Zhang, Caterina De Carolis, Gene Chi Wai Man, Chi Chiu Wang
    Autoimmunity Reviews.2018; 17(10): 945.     CrossRef
  • Systemic expression of galectin genes in periparturient goats
    Kingsley Ekwemalor, Sarah Adjei-Fremah, Emmanuel Asiamah, Egbogoye Eluka-Okoludoh, Bertha Osei, Mulumebet Worku
    Small Ruminant Research.2018; 168: 60.     CrossRef
  • Body Mass Index Impact and Predictability on Preeclamptic Toxemia
    AbdAllah Khaled M
    Journal of Gynecological Research and Obstetrics.2018; : 009.     CrossRef
  • The association between oxidative stress-induced galectins and differentiation of human promyelocytic HL-60 cells
    James R. Vinnai, Robert C. Cumming, Graham J. Thompson, Alexander V. Timoshenko
    Experimental Cell Research.2017; 355(2): 113.     CrossRef
  • Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition
    Haidy El-Azzamy, Andrea Balogh, Roberto Romero, Yi Xu, Christopher LaJeunesse, Olesya Plazyo, Zhonghui Xu, Theodore G. Price, Zhong Dong, Adi L. Tarca, Zoltan Papp, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Chong Jai Kim, Nardhy Gomez-Lopez, Nandor Gabor
    Journal of Pathology and Translational Medicine.2017; 51(3): 264.     CrossRef
  • Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function
    Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
    Computational and Structural Biotechnology Journal.2017; 15: 433.     CrossRef
  • Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7
    Nathalie Bibens-Laulan, Yves St-Pierre, Ivan R Nabi
    PLOS ONE.2017; 12(11): e0187194.     CrossRef
  • Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders
    Reka Brubel, Attila Bokor, Akos Pohl, Gabriella Krisztina Schilli, Laszlo Szereday, Reka Bacher-Szamuel, Janos Rigo, Beata Polgar
    Fertility and Sterility.2017; 108(6): 1016.     CrossRef
  • The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis
    Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
    Oncology Letters.2017;[Epub]     CrossRef
  • Development and Applications of Lectins as Biological Tools in Biomedical Research
    Xiuli Dan, Wenlong Liu, Tzi Bun Ng
    Medicinal Research Reviews.2016; 36(2): 221.     CrossRef
  • The human fetoembryonic defense system hypothesis: Twenty years on
    Poh-Choo Pang, Stuart M. Haslam, Anne Dell, Gary F. Clark
    Molecular Aspects of Medicine.2016; 51: 71.     CrossRef
  • A Human Lectin Microarray for Sperm Surface Glycosylation Analysis
    Yangyang Sun, Li Cheng, Yihua Gu, Aijie Xin, Bin Wu, Shumin Zhou, Shujuan Guo, Yin Liu, Hua Diao, Huijuan Shi, Guangyu Wang, Sheng-ce Tao
    Molecular & Cellular Proteomics.2016; 15(9): 2839.     CrossRef
  • Fetal gender specific expression of tandem-repeat galectins in placental tissue from normally progressed human pregnancies and intrauterine growth restriction (IUGR)
    Stefan Hutter, Julia Knabl, Ulrich Andergassen, Doris Mayr, Simone Hofmann, Christina Kuhn, Sven Mahner, Petra Arck, Udo Jeschke
    Placenta.2015; 36(12): 1352.     CrossRef
Advances in the Endoscopic Assessment of Inflammatory Bowel Diseases: Cooperation between Endoscopic and Pathologic Evaluations
Jae Hee Cheon
J Pathol Transl Med. 2015;49(3):209-217.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.09
  • 10,996 View
  • 89 Download
  • 4 Citations
AbstractAbstract PDF
Endoscopic assessment has a crucial role in the management of inflammatory bowel disease (IBD). It is particularly useful for the assessment of IBD disease extension, severity, and neoplasia surveillance. Recent advances in endoscopic imaging techniques have been revolutionized over the past decades, progressing from conventional white light endoscopy to novel endoscopic techniques using molecular probes or electronic filter technologies. These new technologies allow for visualization of the mucosa in detail and monitor for inflammation/dysplasia at the cellular or sub-cellular level. These techniques may enable us to alter the IBD surveillance paradigm from four quadrant random biopsy to targeted biopsy and diagnosis. High definition endoscopy and dye-based chromoendoscopy can improve the detection rate of dysplasia and evaluate inflammatory changes with better visualization. Dye-less chromoendoscopy, including narrow band imaging, iScan, and autofluorescence imaging can also enhance surveillance in comparison to white light endoscopy with optical or electronic filter technologies. Moreover, confocal laser endomicroscopy or endocytoscopy have can achieve real-time histology evaluation in vivo and have greater accuracy in comparison with histology. These new technologies could be combined with standard endoscopy or further histologic confirmation in patients with IBD. This review offers an evidence-based overview of new endoscopic techniques in patients with IBD.

Citations

Citations to this article as recorded by  
  • Colorectal cancer in inflammatory bowel disease: review of the evidence
    D. S. Keller, A. Windsor, R. Cohen, M. Chand
    Techniques in Coloproctology.2019; 23(1): 3.     CrossRef
  • Probe-based confocal laser endomicroscopy in the differential diagnosis of inflammatory bowel diseases: a case series
    Jung Won Park, Tae Il Kim, Jae Hee Cheon
    Intestinal Research.2018; 16(4): 641.     CrossRef
  • How to Assess and Document Endoscopies in IBD Patients by Including Standard Scoring Systems
    Anna M. Buchner, Gary R. Lichtenstein
    Inflammatory Bowel Diseases.2016; 22(4): 1010.     CrossRef
  • Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
    Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini
    World Journal of Gastroenterology.2016; 22(46): 10198.     CrossRef
Pathology-MRI Correlation of Hepatocarcinogenesis: Recent Update
Jimi Huh, Kyung Won Kim, Jihun Kim, Eunsil Yu
J Pathol Transl Med. 2015;49(3):218-229.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.15
  • 21,609 View
  • 272 Download
  • 6 Citations
AbstractAbstract PDF
Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma. Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

Citations

Citations to this article as recorded by  
  • Risk Factors for Hypervascularization in Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement: A Systematic Review and Meta-analysis
    Tae-Hyung Kim, Sungmin Woo, Sangwon Han, Chong Hyun Suh, Richard Kinh Gian Do, Jeong Min Lee
    Academic Radiology.2022; 29(2): 198.     CrossRef
  • Hepatocarcinogenesis
    Alice Fung, Krishna P. Shanbhogue, Myles T. Taffel, Brian T. Brinkerhoff, Neil D. Theise
    Magnetic Resonance Imaging Clinics of North America.2021; 29(3): 359.     CrossRef
  • Pathologic, Molecular, and Prognostic Radiologic Features of Hepatocellular Carcinoma
    Kathryn J. Fowler, Adam Burgoyne, Tyler J. Fraum, Mojgan Hosseini, Shintaro Ichikawa, Sooah Kim, Azusa Kitao, Jeong Min Lee, Valérie Paradis, Bachir Taouli, Neil D. Theise, Valérie Vilgrain, Jin Wang, Claude B. Sirlin, Victoria Chernyak
    RadioGraphics.2021; 41(6): 1611.     CrossRef
  • Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
    Nese Karadag Soylu
    Journal of Gastrointestinal Cancer.2020; 51(4): 1176.     CrossRef
  • Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials
    Jimi Huh, Su Jung Ham, Young Chul Cho, Bumwoo Park, Bohyun Kim, Chul-Woong Woo, Yoonseok Choi, Dong-Cheol Woo, Kyung Won Kim
    BMC Medical Imaging.2019;[Epub]     CrossRef
  • Non-Hypervascular Hypointense Nodules at Gadoxetic Acid MRI: Hepatocellular Carcinoma Risk Assessment with Emphasis on the Role of Diffusion-Weighted Imaging
    Chiara Briani, Marco Di Pietropaolo, Massimo Marignani, Francesco Carbonetti, Paola Begini, Vincenzo David, Elsa Iannicelli
    Journal of Gastrointestinal Cancer.2018; 49(3): 302.     CrossRef
Effectiveness and Limitations of Core Needle Biopsy in the Diagnosis of Thyroid Nodules: Review of Current Literature
Jung Hyun Yoon, Eun-Kyung Kim, Jin Young Kwak, Hee Jung Moon
J Pathol Transl Med. 2015;49(3):230-235.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.21
  • 9,650 View
  • 90 Download
  • 42 Citations
AbstractAbstract PDF
Fine needle aspiration (FNA) is currently accepted as an easy, safe, and reliable tool for the diagnosis of thyroid nodules. Nonetheless, a proportion of FNA samples are categorized into non-diagnostic or indeterminate cytology, which frustrates both the clinician and patient. To overcome this limitation of FNA, core needle biopsy (CNB) of the thyroid has been proposed as an additional diagnostic method for more accurate and decisive diagnosis for thyroid nodules of concern. In this review, we focus on the effectiveness and limitations of CNB, and what factors should be considered when CNB is utilized in the diagnosis of thyroid nodules.

Citations

Citations to this article as recorded by  
  • Ultrasound Elastography: Basic Principles and Examples of Clinical Applications with Artificial Intelligence—A Review
    Maurizio Cè, Natascha Claudia D'Amico, Giulia Maria Danesini, Chiara Foschini, Giancarlo Oliva, Carlo Martinenghi, Michaela Cellina
    BioMedInformatics.2023; 3(1): 17.     CrossRef
  • Core needle biopsy and ultrasonography are superior to fine needle aspiration in the management of follicular variant papillary thyroid carcinomas
    Ji-Ye Kim, Sunhee Chang, Ah-Young Kwon, Eun Young Park, Tae Hyuk Kim, Sangjoon Choi, Minju Lee, Young Lyun Oh
    Endocrine.2022; 75(2): 437.     CrossRef
  • Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen
    Hyuk Kwon, Jandee Lee, Soon Won Hong, Hyeong Ju Kwon, Jin Young Kwak, Jung Hyun Yoon
    Journal of the Korean Society of Radiology.2022; 83(3): 645.     CrossRef
  • Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management
    Marie Nguyen, George He, Alfred King-Yin Lam
    International Journal of Molecular Sciences.2022; 23(6): 3242.     CrossRef
  • Ultrasound Features of Thyroid Metastatic Tumors from the Digestive System: A Report of 2 Case
    Zhang,BS Chao, Li,MD Yingying, Zhang,MD Mingbo
    ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY.2022; 6(4): 217.     CrossRef
  • Unsupervised Convolutional Neural Network for Motion Estimation in Ultrasound Elastography
    Xingyue Wei, Yuanyuan Wang, Lin Ge, Bo Peng, Qiong He, Rui Wang, Lijie Huang, Yan Xu, Jianwen Luo
    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.2022; 69(7): 2236.     CrossRef
  • The Value of Ultrasonography Using Thyroid Imaging Reporting and Data Systems (TIRADS) in the Diagnosis of Thyroid Cancer Among the Population of Ha'il, Saudi Arabia
    Ashraf Elaggan, Amr Mostafa, Raghad Albdair, Rema Almarshedi, Anas Aljohani, Zaid Alshammari
    Cureus.2022;[Epub]     CrossRef
  • NKD2 is correlated with the occurrence, progression and prognosis of thyroid carcinoma
    Yu Gao, Yiwei Wang, Rende Guo
    European Journal of Medical Research.2022;[Epub]     CrossRef
  • Update on the Evaluation of Thyroid Nodules
    Victor J. Bernet, Ana-Maria Chindris
    Journal of Nuclear Medicine.2021; 62(Supplement): 13S.     CrossRef
  • Core-Needle Biopsy Does Not Show Superior Diagnostic Performance to Fine-Needle Aspiration for Diagnosing Thyroid Nodules
    Ilah Shin, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Si Eun Lee, Hye Sun Lee, Jin Young Kwak
    Yonsei Medical Journal.2020; 61(2): 161.     CrossRef
  • Comparison Between Fine Needle Aspiration and Core Needle Biopsy for the Diagnosis of Thyroid Nodules: Effective Indications According to US Findings
    Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park, Yaeji Lim
    Scientific Reports.2020;[Epub]     CrossRef
  • Plasma-Derived miRNA-222 as a Candidate Marker for Papillary Thyroid Cancer
    Aistė Kondrotienė, Albertas Daukša, Daina Pamedytytė, Mintautė Kazokaitė, Aurelija Žvirblienė, Dalia Daukšienė, Vaida Simanavičienė, Raimonda Klimaitė, Ieva Golubickaitė, Rytis Stakaitis, Valdas Šarauskas, Rasa Verkauskienė, Birutė Žilaitienė
    International Journal of Molecular Sciences.2020; 21(17): 6445.     CrossRef
  • Ultrasound‐guided needle biopsy of large thyroid nodules: Core needle biopsy yields more reliable results than fine needle aspiration
    Hyeon Jin Lee, Young Joong Kim, Hye Yeon Han, Jae Young Seo, Cheol Mog Hwang, KeumWon Kim
    Journal of Clinical Ultrasound.2019; 47(5): 255.     CrossRef
  • Degenerating Thyroid Nodules: Ultrasound Diagnosis, Clinical Significance, and Management
    Jie Ren, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Chan Kwon Jung, Jeong Hyun Lee
    Korean Journal of Radiology.2019; 20(6): 947.     CrossRef
  • Thyroid core needle biopsy: patients’ pain and satisfaction compared to fine needle aspiration
    Hyo Jin Kim, Yeo Koon Kim, Jae Hoon Moon, June Young Choi, Sang Il Choi
    Endocrine.2019; 65(2): 365.     CrossRef
  • Ultrasonography-Guided Core Needle Biopsy Did Not Reduce Diagnostic Lobectomy for Thyroid Nodules Diagnosed as Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance
    Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon, Eun-Kyung Kim
    Ultrasound Quarterly.2019; 35(3): 253.     CrossRef
  • Diagnostic value of fine-needle aspiration combined with ultrasound for thyroid cancer
    Juan Li, Qian Wang, Liangliang Wang, Jing Wang, Dongxiao Wang, Zhaoqin Xin, Yilin Liu, Qinghua Zhao
    Oncology Letters.2019;[Epub]     CrossRef
  • Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases
    Ji-Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
    Clinical Endocrinology.2018; 88(1): 96.     CrossRef
  • Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
    Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
    Annals of Diagnostic Pathology.2018; 32: 35.     CrossRef
  • Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
    Christoph F. Dietrich, Thomas Müller, Jörg Bojunga, Yi Dong, Giovanni Mauri, Maija Radzina, Manjiri Dighe, Xin-Wu Cui, Frank Grünwald, Andreas Schuler, Andre Ignee, Huedayi Korkusuz
    Ultrasound in Medicine & Biology.2018; 44(1): 14.     CrossRef
  • Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
    Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
    Acta Radiologica.2018; 59(8): 924.     CrossRef
  • A spectral X-ray CT simulation study for quantitative determination of iron
    Ting Su, Valérie Kaftandjian, Philippe Duvauchelle, Yuemin Zhu
    Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment.2018; 894: 39.     CrossRef
  • Comparison of the Diagnostic Efficacy of Ultrasound-Guided Core Needle Biopsy With 18- Versus 20-Gauge Needles for Thyroid Nodules
    Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
    Journal of Ultrasound in Medicine.2018; 37(11): 2565.     CrossRef
  • Evaluation of Modified Core-Needle Biopsy in the Diagnosis of Thyroid Nodules
    Soomin Ahn, Sejin Jung, Ji-Ye Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh
    Korean Journal of Radiology.2018; 19(4): 656.     CrossRef
  • Model-based quantitative optical biopsy in multilayer in vitro soft tissue models for whole field assessment of nonmelanoma skin cancer
    Bala Nivetha Kanakaraj
    Journal of Medical Imaging.2018; 5(01): 1.     CrossRef
  • Decreased apolipoprotein A4 and increased complement component 3 as potential markers for papillary thyroid carcinoma: A proteomic study
    Reyhaneh Farrokhi Yekta, Afsaneh Arefi Oskouie, Mostafa Rezaei Tavirani, Mohammad R. Mohajeri-Tehrani, Ahmad R. Soroush
    The International Journal of Biological Markers.2018; 33(4): 455.     CrossRef
  • Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt’s lymphoma: a case report and review of the literature
    Stella Bernardi, Andrea Michelli, Deborah Bonazza, Veronica Calabrò, Fabrizio Zanconati, Gabriele Pozzato, Bruno Fabris
    BMC Endocrine Disorders.2018;[Epub]     CrossRef
  • Risk of malignancy according to sub-classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology
    S. J. Kim, J. Roh, J. H. Baek, S. J. Hong, Y. K. Shong, W. B. Kim, D. E. Song
    Cytopathology.2017; 28(1): 65.     CrossRef
  • Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study
    Soo-Yeon Kim, Hye Sun Lee, Jieun Moon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
    European Radiology.2017; 27(2): 801.     CrossRef
  • Core-needle biopsy versus repeat fine-needle aspiration for thyroid nodules initially read as atypia/follicular lesion of undetermined significance
    Young Jun Choi, Jung Hwan Baek, Chong Hyun Suh, Woo Hyun Shim, Boseul Jeong, Jae Kyun Kim, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
    Head & Neck.2017; 39(2): 361.     CrossRef
  • Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
    Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
    Korean Journal of Radiology.2017; 18(1): 217.     CrossRef
  • Ultrasound-Pathology Discordant Nodules on Core-Needle Biopsy: Malignancy Risk and Management Strategy
    Sae Rom Chung, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Thyroid.2017; 27(5): 707.     CrossRef
  • Ultrasound-guided fine needle aspiration versus core needle biopsy: comparison of post-biopsy hematoma rates and risk factors
    In Hye Chae, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y. Park, Jin Young Kwak
    Endocrine.2017; 57(1): 108.     CrossRef
  • Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
    Wojciech Wojtowicz, Adam Zabek, Stanislaw Deja, Tomasz Dawiskiba, Dorota Pawelka, Mateusz Glod, Waldemar Balcerzak, Piotr Mlynarz
    Scientific Reports.2017;[Epub]     CrossRef
  • Comparison of Core-Needle Biopsy and Fine-Needle Aspiration for Evaluating Thyroid Incidentalomas Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Propensity Score Analysis
    Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
    Thyroid.2017; 27(10): 1258.     CrossRef
  • Identification of novel diagnostic biomarkers for thyroid carcinoma
    Xiliang Wang, Qing Zhang, Zhiming Cai, Yifan Dai, Lisha Mou
    Oncotarget.2017; 8(67): 111551.     CrossRef
  • Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
    Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
    Pathology - Research and Practice.2016; 212(1): 44.     CrossRef
  • Non-Coding RNAs in Thyroid Cancer
    Ranran Zhang, Heather Hardin, Jidong Chen, Zhenying Guo, Ricardo V. Lloyd
    Endocrine Pathology.2016; 27(1): 12.     CrossRef
  • Fine-needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
    Paul A. VanderLaan
    Cancer Cytopathology.2016; 124(12): 862.     CrossRef
  • Core Needle Biopsy Is a More Conclusive Follow-up Method Than Repeat Fine Needle Aspiration for Thyroid Nodules with Initially Inconclusive Results: A Systematic Review and Meta-Analysis
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
    Journal of Pathology and Translational Medicine.2016; 50(3): 217.     CrossRef
  • The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis
    Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Kyung Won Kim, Jayoun Lee, Ki-Wook Chung, Young Kee Shong
    Endocrine.2016; 54(2): 315.     CrossRef
  • Fine-needle aspiration versus core needle biopsy: Reconsidering the evidence of superiority
    Annemieke van Zante, Britt-Marie Ljung
    Cancer Cytopathology.2016; 124(12): 853.     CrossRef
Original Articles
Proposal of an Appropriate Decalcification Method of Bone Marrow Biopsy Specimens in the Era of Expanding Genetic Molecular Study
Sung-Eun Choi, Soon Won Hong, Sun Och Yoon
J Pathol Transl Med. 2015;49(3):236-242.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.16
  • 11,356 View
  • 246 Download
  • 39 Citations
AbstractAbstract PDF
Background
The conventional method for decalcification of bone specimens uses hydrochloric acid (HCl) and is notorious for damaging cellular RNA, DNA, and proteins, thus complicating molecular and immunohistochemical analyses. A method that can effectively decalcify while preserving genetic material is necessary. Methods: Pairs of bilateral bone marrow biopsies sampled from 53 patients were decalcified according to protocols of two comparison groups: EDTA versus HCl and RDO GOLD (RDO) versus HCl. Pairs of right and left bone marrow biopsy samples harvested from 28 cases were allocated into the EDTA versus HCl comparison group, and 25 cases to the RDO versus HCl comparison group. The decalcification protocols were compared with regards to histomorphology, immunohistochemistry, and molecular analysis. For molecular analysis, we randomly selected 5 cases from the EDTA versus HCl and RDO versus HCl groups. Results: The decalcification time for appropriate histomorphologic analysis was the longest in the EDTA method and the shortest in the RDO method. EDTA was superior to RDO or HCl in DNA yield and integrity, assessed via DNA extraction, polymerase chain reaction, and silver in situ hybridization using DNA probes. The EDTA method maintained intact nuclear protein staining on immunohistochemistry, while the HCl method produced poor quality images. Staining after the RDO method had equivocal results. RNA in situ hybridization using kappa and lambda RNA probes measured RNA integrity; the EDTA and RDO method had the best quality, followed by HCl. Conclusions: The EDTA protocol would be the best in preserving genetic material. RDO may be an acceptable alternative when rapid decalcification is necessary.

Citations

Citations to this article as recorded by  
  • Epithelioid haemangioendothelioma of the mandible – A case report and review of the literature
    Ali Rizvi, Tim K. Blackburn, Guy N. J. Betts
    Oral Surgery.2022; 15(3): 387.     CrossRef
  • Evaluation of EDTA and nitric acid solutions for decalcification of joints in AG/WT, BALB/c, C57, DBA1/J mice, and in Wistar rats
    Eduarda Correa Freitas, Suelen Pizzolatto Dalmolin, Mateus Müller da Silva, Francine Hehn de Oliveira, Emily Ferreira Salles Pilar
    Biotechnic & Histochemistry.2022; 97(5): 372.     CrossRef
  • Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations
    Na Sun, Benjamin V. Tran, Zishan Peng, Jing Wang, Ceng Zhang, Peng Yang, Tiffany X. Zhang, Josephine Widjaja, Ryan Y. Zhang, Wenxi Xia, Alexandra Keir, Jia‐Wei She, Hsiao‐hua Yu, Jing‐Jong Shyue, Hongguang Zhu, Vatche G. Agopian, Renjun Pei, James S. Toml
    Advanced Science.2022; 9(14): 2105853.     CrossRef
  • The Expressions of CD30 and CD123 of Mastocytosis in Taiwan
    Ching-Fen Yang, Chih-Yi Hsu
    Applied Immunohistochemistry & Molecular Morphology.2022; 30(4): 278.     CrossRef
  • Unusual Patterns of HER2 Expression in Breast Cancer: Insights and Perspectives
    Dora Grassini, Eliano Cascardi, Ivana Sarotto, Laura Annaratone, Anna Sapino, Enrico Berrino, Caterina Marchiò
    Pathobiology.2022; 89(5): 278.     CrossRef
  • Expert opinion on NSCLC small specimen biomarker testing — Part 1: Tissue collection and management
    Frédérique Penault-Llorca, Keith M. Kerr, Pilar Garrido, Erik Thunnissen, Elisabeth Dequeker, Nicola Normanno, Simon J. Patton, Jenni Fairley, Joshua Kapp, Daniëlle de Ridder, Aleš Ryška, Holger Moch
    Virchows Archiv.2022; 481(3): 335.     CrossRef
  • To Freeze or Not to Freeze? Recommendations for Intraoperative Examination and Gross Prosection of Thyroid Glands
    Fouad R. Zakka, Nicole A. Cipriani
    Surgical Pathology Clinics.2022;[Epub]     CrossRef
  • Comparison of bone demineralisation procedures for DNA recovery from burned remains
    Meghan Mckinnon, Denice Higgins
    Forensic Science International: Genetics.2021; 51: 102448.     CrossRef
  • A review of the current understanding of burned bone as a source of DNA for human identification
    Meghan Mckinnon, Maciej Henneberg, Denice Higgins
    Science & Justice.2021; 61(4): 332.     CrossRef
  • Time is bone — Quantitative comparison of decalcification solvents in human femur samples using dual-X-ray-absorptiometry and computed tomography
    Joshua Gawlitza, Jakob Steinhäuser, Arno Bücker, Gabriela Krasteva-Christ, Thomas Tschernig
    Annals of Anatomy - Anatomischer Anzeiger.2021; 235: 151696.     CrossRef
  • Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
    Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
    Journal of Pathology and Translational Medicine.2021; 55(3): 181.     CrossRef
  • Effect of EDTA decalcification on estrogen receptor and progesterone receptor immunohistochemistry and HER2/neu fluorescence in situ hybridization in breast carcinoma
    Erik Washburn, Xiaoyu Tang, Carla Caruso, Michelle Walls, Bing Han
    Human Pathology.2021; 117: 108.     CrossRef
  • Performances of single tube nested polymerase chain reaction and GeneXpert ultra on Formalin fixed paraffin embedded tissues in the diagnosis of tuberculous spondylodiscitis
    Emna Romdhane, Soumaya Rammeh, Chelli Mouna Bouaziz, Hend Riahi, Meriam Rekaya Ben, Meriam Ksentini, Yosra Chebbi, Wafa Achour, Asma Ferjani, Ben Boubaker Ilhem Boutiba, Leila Slim-Saidi, Mohamed Fethi Ladeb
    Clinical Rheumatology.2021; 40(10): 4317.     CrossRef
  • Molecular Characterization of Prostate Cancers in the Precision Medicine Era
    Emilio Francesco Giunta, Laura Annaratone, Enrico Bollito, Francesco Porpiglia, Matteo Cereda, Giuseppe Luigi Banna, Alessandra Mosca, Caterina Marchiò, Pasquale Rescigno
    Cancers.2021; 13(19): 4771.     CrossRef
  • Increased NF-κB Activity in Osteoprogenitor-Lineage Cells Impairs the Balance of Bone Versus Fat in the Marrow of Skeletally Mature Mice
    Tzuhua Lin, Jukka Pajarinen, Yusuke Kohno, Akira Nabeshima, Laura Lu, Karthik Nathan, Zhenyu Yao, Joy Y. Wu, Stuart Goodman
    Regenerative Engineering and Translational Medicine.2020; 6(1): 69.     CrossRef
  • Percutaneous CT-guided biopsy of lytic bone lesions in patients clinically suspected of lung cancer: Diagnostic performances for pathological diagnosis and molecular testing
    Anne-Claire Toffart, Stéphane Asfari, Anne Mc Leer, Emilie Reymond, Adrien Jankowski, Denis Moro-Sibilot, Olivier Stephanov, Julien Ghelfi, Sylvie Lantuejoul, Gilbert R. Ferretti
    Lung Cancer.2020; 140: 93.     CrossRef
  • Effect of decalcification protocols on immunohistochemistry and molecular analyses of bone samples
    Elodie Miquelestorena-Standley, Marie-Lise Jourdan, Christine Collin, Corinne Bouvier, Frédérique Larousserie, Sébastien Aubert, Anne Gomez-Brouchet, Jean-Marc Guinebretière, Matthias Tallegas, Bénédicte Brulin, Louis-Romée Le Nail, Anne Tallet, François
    Modern Pathology.2020; 33(8): 1505.     CrossRef
  • Identifying Opportunities and Challenges for Patients With Sarcoma as a Result of Comprehensive Genomic Profiling of Sarcoma Specimens
    Margaret A. Hay, Eric A. Severson, Vincent A. Miller, David A. Liebner, Jo-Anne Vergilio, Sherri Z. Millis, James L. Chen
    JCO Precision Oncology.2020; (4): 176.     CrossRef
  • Comparison of Methods for the Histological Evaluation of Odontocete Spiral Ganglion Cells
    Tania Ramírez, Simona Sacchini, Yania Paz, Rubén S. Rosales, Nakita Câmara, Marisa Andrada, Manuel Arbelo, Antonio Fernández
    Animals.2020; 10(4): 683.     CrossRef
  • Molecular Pathology of Primary Non-small Cell Lung Cancer
    David Ilan Suster, Mari Mino-Kenudson
    Archives of Medical Research.2020; 51(8): 784.     CrossRef
  • Comparison of ethylenediaminetetraacetic acid and rapid decalcificier solution for studying human temporal bones by immunofluorescence
    Sumana Ghosh, Mark B. Lewis, Bradley J. Walters
    Laryngoscope Investigative Otolaryngology.2020; 5(5): 919.     CrossRef
  • A novel cryo-embedding method for in-depth analysis of craniofacial mini pig bone specimens
    Pavla Ticha, Igor Pilawski, Xue Yuan, Jie Pan, Ustun S. Tulu, Benjamin R. Coyac, Waldemar Hoffmann, Jill A. Helms
    Scientific Reports.2020;[Epub]     CrossRef
  • Accelerating precision medicine in metastatic prostate cancer
    Joaquin Mateo, Rana McKay, Wassim Abida, Rahul Aggarwal, Joshi Alumkal, Ajjai Alva, Felix Feng, Xin Gao, Julie Graff, Maha Hussain, Fatima Karzai, Bruce Montgomery, William Oh, Vaibhav Patel, Dana Rathkopf, Matthew Rettig, Nikolaus Schultz, Matthew Smith,
    Nature Cancer.2020; 1(11): 1041.     CrossRef
  • Tissue Morphology and Antigenicity in Mouse and Rat Tibia: Comparing 12 Different Decalcification Conditions
    Kristofor Bogoevski, Anna Woloszyk, Keith Blackwood, Maria A. Woodruff, Vaida Glatt
    Journal of Histochemistry & Cytochemistry.2019; 67(8): 545.     CrossRef
  • Cellular and collagen reference values of gingival and periodontal ligament tissues in rats: a pilot study
    Antoine Alves, Nina Attik, Carine Wirth, Yves Bayon, Alexis Piat, Brigitte Grosgogeat, Kerstin Gritsch
    Histochemistry and Cell Biology.2019; 152(2): 145.     CrossRef
  • Implementing Precision Medicine Programs and Clinical Trials in the Community-Based Oncology Practice: Barriers and Best Practices
    Jennifer L. Ersek, Lora J. Black, Michael A. Thompson, Edward S. Kim
    American Society of Clinical Oncology Educational Book.2018; (38): 188.     CrossRef
  • Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL
    Zandra C Deans, Jose Luis Costa, Ian Cree, Els Dequeker, Anders Edsjö, Shirley Henderson, Michael Hummel, Marjolijn JL Ligtenberg, Marco Loddo, Jose Carlos Machado, Antonio Marchetti, Katherine Marquis, Joanne Mason, Nicola Normanno, Etienne Rouleau, Ed S
    Virchows Archiv.2017; 470(1): 5.     CrossRef
  • Protocolo para el estudio de muestras y estandarización del informe patológico de tumores óseos
    Isidro Machado, José Juan Pozo, David Marcilla, Julia Cruz, Juan C. Tardío, Aurora Astudillo, Sílvia Bagué
    Revista Española de Patología.2017; 50(1): 34.     CrossRef
  • Extremely Well-Differentiated Papillary Thyroid Carcinoma Resembling Adenomatous Hyperplasia Can Metastasize to the Skull: A Case Report
    Ju Yeon Pyo, Jisup Kim, Sung-eun Choi, Eunah Shin, Seok-Woo Yang, Cheong Soo Park, Seok-Mo Kim, SoonWon Hong
    Yonsei Medical Journal.2017; 58(1): 255.     CrossRef
  • Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species
    Guoying Deng, Kerun Niu, Feng Zhou, Buxiao Li, Yingjie Kang, Xijian Liu, Junqing Hu, Bo Li, Qiugen Wang, Chengqing Yi, Qian Wang
    Scientific Reports.2017;[Epub]     CrossRef
  • Precision Medicine Starts With Preanalytics: Real-Time Assessment of Tissue Fixation Quality by Ultrasound Time-of-Flight Analysis
    Melissa L. Lerch, Daniel R. Bauer, David Chafin, Abbey Theiss, Michael Otter, Geoffrey S. Baird
    Applied Immunohistochemistry & Molecular Morphology.2017; 25(3): 160.     CrossRef
  • Good Laboratory Standards for Clinical Next-Generation Sequencing Cancer Panel Tests
    Jihun Kim, Woong-Yang Park, Nayoung K. D. Kim, Se Jin Jang, Sung-Min Chun, Chang-Ohk Sung, Jene Choi, Young-Hyeh Ko, Yoon-La Choi, Hyo Sup Shim, Jae-Kyung Won
    Journal of Pathology and Translational Medicine.2017; 51(3): 191.     CrossRef
  • An international survey about nail histology processing techniques
    Christina Wlodek, Pauline Lecerf, Josette Andre, Beth S. Ruben, David de Berker
    Journal of Cutaneous Pathology.2017; 44(9): 749.     CrossRef
  • pSTAT5 and ERK exhibit different expression in myeloproliferative neoplasms
    Ewa Wiśniewska-Chudy, Łukasz Szylberg, Grzegorz Dworacki, Ewa Mizera-Nyczak, Andrzej Marszałek
    Oncology Reports.2017; 37(4): 2295.     CrossRef
  • How we do: optimizing bone marrow biopsy logistics for sign-out within 2 days
    I. de Laak–de Vries, A. G. Siebers, L. Burgers, C. Diepenbroek, M. Link, P. Groenen, J. H. J. M. van Krieken, K. M. Hebeda
    Journal of Hematopathology.2016; 9(2): 67.     CrossRef
  • Do More With Less: Tips and Techniques for Maximizing Small Biopsy and Cytology Specimens for Molecular and Ancillary Testing: The University of Colorado Experience
    Dara L. Aisner, Mathew D. Rumery, Daniel T. Merrick, Kimi L. Kondo, Hala Nijmeh, Derek J. Linderman, Robert C. Doebele, Natalie Thomas, Patrick C. Chesnut, Marileila Varella-Garcia, Wilbur A. Franklin, D. Ross Camidge
    Archives of Pathology & Laboratory Medicine.2016; 140(11): 1206.     CrossRef
  • Analysis of the Effects of Bone Marrow Biopsy Decalcification Methods on Histopathological Examination
    Ji Young Park, Kyung Hee Han
    The Korean Journal of Clinical Laboratory Science.2016; 48(4): 371.     CrossRef
  • Distinguishing between Microbial Habitats Unravels Ecological Complexity in Coral Microbiomes
    Amy Apprill, Laura G. Weber, Alyson E. Santoro, Nicole S. Webster
    mSystems.2016;[Epub]     CrossRef
  • Optimal Fixation and Decalcification Methods for Bone Marrow Biopsy
    Myung-Sub Choi, Hyunsup Lee, Hyuk-Chul Kwon, Moon-Hwan Bae, Young-Hye Ko, Hee-Jin Kim, Beom-Se Lee, Bon-Kyung Koo
    Korean Journal of Clinical Laboratory Science.2015; 47(4): 243.     CrossRef
Smad1 Expression in Follicular Lymphoma
Jai Hyang Go
J Pathol Transl Med. 2015;49(3):243-248.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.30
  • 6,625 View
  • 43 Download
AbstractAbstract PDF
Background
Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue. Methods: In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1’s usefulness in the diagnosis of follicular lymphoma. Results: In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns. Conclusions: These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma.
MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis
Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang, Dong-Hoon Kim, Kyungeun Kim, In-Gu Do, Dong Hyun Kim
J Pathol Transl Med. 2015;49(3):249-256.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.27
  • 6,800 View
  • 62 Download
  • 4 Citations
AbstractAbstract PDF
Background
While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinico-pathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC). Methods: The present study investigated the correlation between MUC2 expression and clinico-pathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs. Results: MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren’s classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren’s classification, pN stage, or pTNM stage. Conclusions: MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.

Citations

Citations to this article as recorded by  
  • Gastric epithelial histology and precancerous conditions
    Hang Yang, Wen-Juan Yang, Bing Hu
    World Journal of Gastrointestinal Oncology.2022; 14(2): 396.     CrossRef
  • COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells
    Shen Jiangang, Kang Nayoung, Wang Hongfang, Li Junda, Chen Li, Bai Xuefeng, Li Mingsong
    BMC Molecular and Cell Biology.2022;[Epub]     CrossRef
  • Comparative genomic analysis of primary tumors and paired brain metastases in lung cancer patients by whole exome sequencing: a pilot study
    Pascale Tomasini, Fabrice Barlesi, Sophie Gilles, Isabelle Nanni-Metellus, Riccardo Soffietti, Emilie Denicolai, Eric Pellegrino, Emilie Bialecki, L’Houcine Ouafik, Philippe Metellus
    Oncotarget.2020; 11(50): 4648.     CrossRef
  • A High Ki67/BCL2 Index Could Predict Lower Disease-Free and Overall Survival in Intestinal-Type Gastric Cancer
    Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Dong Hyun Kim, Eun-Kyung Kim, Jinwon Seo, Sang Bong Ahn, Yun Ju Jo, Young Sook Park, Junghoon Ha
    European Surgical Research.2017; 58(3-4): 158.     CrossRef
IDH Mutation Analysis in Ewing Sarcoma Family Tumors
Ki Yong Na, Byeong-Joo Noh, Ji-Youn Sung, Youn Wha Kim, Eduardo Santini Araujo, Yong-Koo Park
J Pathol Transl Med. 2015;49(3):257-261.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.14
  • 8,702 View
  • 70 Download
  • 5 Citations
AbstractAbstract PDF
Background
Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. This results in increased oxidative damage and stabilization of hypoxia-inducible factor α, causing cells to be prone to tumorigenesis. Methods: This study investigated IDH mutations in 61 Ewing sarcoma family tumors (ESFTs), using a pentose nucleic acid clamping method and direct sequencing. Results: We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. Clinicopathologic analysis according to IDH mutation status did not reveal significant results. Conclusions: This study is the first to report IDH mutations in ESFTs. The results indicate that ESFTs can harbor IDH mutations in previously known hot-spot regions, although their incidence is rare. Further validation with a larger case-based study would establish more reliable and significant data on prevalence rate and the biological significance of IDH mutations in ESFTs.

Citations

Citations to this article as recorded by  
  • Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
    Ingvild Comfort Hvinden, Tom Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
    Cell Reports Medicine.2021; 2(12): 100469.     CrossRef
  • Isocitrate dehydrogenase gene variants in cancer and their clinical significance
    Thomas Cadoux-Hudson, Christopher J. Schofield, James S.O. McCullagh
    Biochemical Society Transactions.2021; 49(6): 2561.     CrossRef
  • Advances in sarcoma gene mutations and therapeutic targets
    Peng Gao, Nicole A. Seebacher, Francis Hornicek, Zheng Guo, Zhenfeng Duan
    Cancer Treatment Reviews.2018; 62: 98.     CrossRef
  • Clinicopathologic Features of the Non-CNS Primary Ewing Sarcoma Family of Tumors in the Head and Neck Region
    Chang Gok Woo, Bora Lee, Joon Seon Song, Kyung-Ja Cho
    Applied Immunohistochemistry & Molecular Morphology.2018; 26(9): 632.     CrossRef
  • EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
    Jason M. Tanner, Claire Bensard, Peng Wei, Nathan M. Krah, John C. Schell, Jamie Gardiner, Joshua Schiffman, Stephen L. Lessnick, Jared Rutter
    Molecular Cancer Research.2017; 15(11): 1517.     CrossRef
Case Study
Follicular Proliferative Lesion Arising in Struma Ovarii
Min Jee Park, Min A Kim, Mi Kyung Shin, Hye Sook Min
J Pathol Transl Med. 2015;49(3):262-266.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.26
  • 7,484 View
  • 118 Download
  • 5 Citations
AbstractAbstract PDF
Malignant struma ovarii is extremely rare and difficult to diagnose histologically, particularly in cases of follicular carcinoma. This case study is intended to describe three cases of follicular proliferative lesion arising in struma ovarii that we experienced. The first case was clearly malignant given the clinical picture of multiple recurrences, but there was little histological evidence of malignancy. Our second case featured architectural and cellular atypia and necrosis and was diagnosed as malignant despite the absence of vascular and stromal invasion. Our third case exhibit-ed solid microfollicular proliferation without any definite evidence of malignancy (even the molecular data was negative); however, we could not completely exclude malignant potential after conducting a literature review. In cases such as our third case, it has been previously suggested that a diagnostic term recognizing the low-grade malignant potential, such as “proliferative stromal ovarii” or “follicular proliferative lesion arising in the stromal ovarii” would be appropriate.

Citations

Citations to this article as recorded by  
  • Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations
    Roberta Poli, Maria Scatolini, Enrico Grosso, Francesca Maletta, Marco Gallo, Daniele Liscia, Anna Nelva, Flora Cesario, Giuseppe Forte, Jasna Metovic, Marco Volante, Emanuela Arvat, Mauro Papotti
    Endocrine.2021; 71(1): 216.     CrossRef
  • Proliferative struma ovarii: A rare case report
    Shankhanila Mazumdar, GaganKumar Rangari, Neeraj Dhameja, NishaRani Agrawal
    International Journal of Clinicopathological Correlation.2021; 5(2): 85.     CrossRef
  • Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis
    Takafumi Tsukada, Hiroshi Yoshida, Mitsuya Ishikawa, Yuka Asami, Kouya Shiraishi, Tomoyasu Kato
    Gynecologic Oncology Reports.2019; 30: 100498.     CrossRef
  • A Rare Case: Struma Ovarii in a 14-Year-Old Girl
    Elif Iltar, Isin Ureyen, Tayfun Toptas, Melike Savas, Sema Çekiç, Aysel Uysal
    Journal of Adolescent and Young Adult Oncology.2018; 7(1): 134.     CrossRef
  • Proliferative Highly Differentiated Follicular Carcinoma Of Ovarian Origin (Hdfco) Presenting Long After Bilateral Oophorectomy
    Natalie M. Liu, Neda Moatamed, Racquel S. Bueno, Wendy L. Sacks
    AACE Clinical Case Reports.2017; 3(3): e264.     CrossRef
Brief Case Reports
Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor
Dong Hyun Kim, Kyueng-Whan Min, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn, Jung-Soo Pyo, Sung-Im Do, Kyungeun Kim, Hyun Joo Lee
J Pathol Transl Med. 2015;49(3):267-269.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.20
  • 6,656 View
  • 45 Download
  • 1 Citations
PDF

Citations

Citations to this article as recorded by  
  • Calcifying Fibrous Tumor
    Angeliki Chorti, Theodossis S. Papavramidis, Antonios Michalopoulos
    Medicine.2016; 95(20): e3690.     CrossRef
Cytomegalovirus-Associated Intussusception with Florid Vascular Proliferation in an Infant
Heejung Park, Sanghui Park, Young Ju Hong, Sun Wha Lee, Min-Sun Cho
J Pathol Transl Med. 2015;49(3):270-273.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.01
  • 6,276 View
  • 40 Download
  • 3 Citations
PDF

Citations

Citations to this article as recorded by  
  • Severe Postnatal Cytomegalovirus Enterocolitis in Immunocompetent Term Infants Requiring Total Parenteral Nutrition
    Annaleise R. Howard-Jones, Giancarlo H. Cristerna-Tarrasa, Rabia Khan, Michael Stormon, Susan Arbuckle, Philip N. Britton
    JPGN Reports.2021; 2(3): e110.     CrossRef
  • Retrospective multicenter matched case–control study on the risk factors for intussusception in infants less than 1 year of age with a special focus on rotavirus vaccines – the German Intussusception Study
    Doris Oberle, Marcus Hoffelner, Jutta Pavel, Dirk Mentzer, Immanuel Barth, Ursula Drechsel-Bäuerle, Brigitte Keller-Stanislawski
    Human Vaccines & Immunotherapeutics.2020; 16(10): 2481.     CrossRef
  • Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates
    Ronald Reisler, Xiankun Zeng, Christopher Schellhase, Jeremy Bearss, Travis Warren, John Trefry, George Christopher, Mark Kortepeter, Sina Bavari, Anthony Cardile
    Viruses.2018; 10(10): 513.     CrossRef
A Case of Primary Subpleural Pulmonary Microcystic Myxoma Coincidentally Occurred with Pulmonary Adenocarcinoma
Jungsuk Ahn, Na Rae Kim, Seung Yeon Ha, Keun-Woo Kim, Kook Yang Park, Yon Mi Sung
J Pathol Transl Med. 2015;49(3):274-278.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.12
  • 6,415 View
  • 49 Download
  • 1 Citations
PDF

Citations

Citations to this article as recorded by  
  • Endobronchial Myxoma
    Arindam Mukherjee, Ritesh Agarwal, Sahajal Dhooria, Pawan Singh, Amanjit Bal, Harkant Singh, Inderpaul S. Sehgal
    Journal of Bronchology & Interventional Pulmonology.2018; 25(4): 335.     CrossRef

JPTM : Journal of Pathology and Translational Medicine