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Volume 49(5); September 2015
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Reviews
Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer
Sung Gwe Ahn, Joon Jeong, SoonWon Hong, Woo Hee Jung
J Pathol Transl Med. 2015;49(5):355-363.   Published online August 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.29
  • 11,724 View
  • 219 Download
  • 28 Citations
AbstractAbstract PDF
With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly considered in research or practice, tumor-infiltrating lymphocytes (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studies have provided evidence that the level of TILs has prognostic value and the potential for predictive value, particularly in triple-negative and human epidermal growth factor receptor 2–positive breast cancer. Moreover, the level of TILs has been associated with treatment outcome in patients undergoing neoadjuvant chemotherapy. To date, no standardized methodology for measuring TILs has been established. In this article, we review current issues and clinical evidence for the use of TILs in breast cancer.

Citations

Citations to this article as recorded by  
  • Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes in Patients with Advanced Breast Cancer Treated with Primary Systemic Therapy
    Gaurav Agarwal, K. M. M. Vishvak Chanthar, Shweta Katiyar, Niraj Kumari, Narendra Krishnani, M. Sabaretnam, Gyan Chand, Anjali Mishra, Punita Lal
    World Journal of Surgery.2023;[Epub]     CrossRef
  • Using Self-Assembling ADDomer Platform to Display B and T Epitopes of Type O Foot-and-Mouth Disease Virus
    Chaowei Luo, Quanhui Yan, Juncong Huang, Jiameng Liu, Yuwan Li, Keke Wu, Bingke Li, Mingqiu Zhao, Shuangqi Fan, Hongxing Ding, Jinding Chen
    Viruses.2022; 14(8): 1810.     CrossRef
  • Modification of the Tumor Microenvironment Enhances Anti-PD-1 Immunotherapy in Metastatic Melanoma
    Guilan Shi, Megan Scott, Cathryn G. Mangiamele, Richard Heller
    Pharmaceutics.2022; 14(11): 2429.     CrossRef
  • Assessment of Immune Status in Dynamics for Patients with Cancer Undergoing Immunotherapy
    Bacinschi Xenia Elena, Laurentia Nicoleta Gales, Anca Florina Zgura, Laura Iliescu, Rodica Maricela Anghel, Bogdan Haineala, Xiaosheng Wang
    Journal of Oncology.2021; 2021: 1.     CrossRef
  • Differences in immune-related gene expressions and tumor-infiltrating lymphocytes according to chemotherapeutic response in ovarian high-grade serous carcinoma
    Kyung Un Choi, Ahrong Kim, Jee Yeon Kim, Ki Hyung Kim, Chungsu Hwang, So Jung Lee, Won Young Park, Sejin Jung, Hye Jeong Choi, Kyungbin Kim
    Journal of Ovarian Research.2020;[Epub]     CrossRef
  • Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer: A Review


    Weilin Xu, Xiu Chen, Fei Deng, Jian Zhang, Wei Zhang, Jinhai Tang
    OncoTargets and Therapy.2020; Volume 13: 5887.     CrossRef
  • Immune phenotype of patients with stage IV metastatic inflammatory breast cancer
    Sandra V. Fernandez, Alexander W. MacFarlane, Mowafaq Jillab, Maria F. Arisi, Jennifer Yearley, Lakshmanan Annamalai, Yulan Gong, Kathy Q. Cai, R. Katherine Alpaugh, Massimo Cristofanilli, Kerry S. Campbell
    Breast Cancer Research.2020;[Epub]     CrossRef
  • Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression
    C. Van Berckelaer, C. Rypens, P. van Dam, L. Pouillon, M. Parizel, K. A. Schats, M. Kockx, W. A. A. Tjalma, P. Vermeulen, S. van Laere, F. Bertucci, C. Colpaert, L. Dirix
    Breast Cancer Research.2019;[Epub]     CrossRef
  • The composition of T cell infiltrates varies in primary invasive breast cancer of different molecular subtypes as well as according to tumor size and nodal status
    Anna Glajcar, Joanna Szpor, Diana Hodorowicz-Zaniewska, Katarzyna Ewa Tyrak, Krzysztof Okoń
    Virchows Archiv.2019; 475(1): 13.     CrossRef
  • Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models
    Ana S. Leal, Kayla Zydeck, Sarah Carapellucci, Lyndsey A. Reich, Di Zhang, Jessica A. Moerland, Michael B. Sporn, Karen T. Liby
    npj Breast Cancer.2019;[Epub]     CrossRef
  • Stromal tumor‑infiltrating lymphocytes evaluated on H&E‑stained slides are an independent prognostic factor in epithelial ovarian cancer and ovarian serous carcinoma
    Chungsu Hwang, So Lee, Jung Lee, Ki Kim, Dong Suh, Byung‑Su Kwon, Kyung Choi
    Oncology Letters.2019;[Epub]     CrossRef
  • The therapeutic candidate for immune checkpoint inhibitors elucidated by the status of tumor-infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) expression in triple negative breast cancer (TNBC)
    Nobumoto Tomioka, Manabu Azuma, Mayuko Ikarashi, Mitsugu Yamamoto, Masako Sato, Ken-ichi Watanabe, Katsushige Yamashiro, Masato Takahashi
    Breast Cancer.2018; 25(1): 34.     CrossRef
  • Triple negative breast cancer – prognostic role of immune-related factors: a systematic review
    Elisabeth Specht Stovgaard, Dorte Nielsen, Estrid Hogdall, Eva Balslev
    Acta Oncologica.2018; 57(1): 74.     CrossRef
  • Lack of effective translational regulation of PLD expression and exosome biogenesis in triple-negative breast cancer cells
    Julian Gomez-Cambronero
    Cancer and Metastasis Reviews.2018; 37(2-3): 491.     CrossRef
  • Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)–Positive Breast Cancers
    So Jeong Lee, Cheong-Soo Hwang, Young-Keum Kim, Hyun Jung Lee, Sang-Jeong Ahn, Nari Shin, Jung Hee Lee, Dong Hoon Shin, Kyung Un Choi, Do Youn Park, Chang Hun Lee, Gi Young Huh, Mi Young Sol, Hee Jin Lee, Gyungyub Gong, Jee Yeon Kim, Ahrong Kim
    Cancer Research and Treatment.2017; 49(2): 313.     CrossRef
  • Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes
    Joo Young Kim, Sun-Hee Heo, Seul Ki Choi, In Hye Song, In Ah Park, Young-Ae Kim, Hye Seon Park, Suk Young Park, Won Seon Bang, Gyungyub Gong, Hee Jin Lee
    Virchows Archiv.2017; 470(4): 381.     CrossRef
  • Whole Slide Imaging for Analytical Anatomic Pathology and Telepathology: Practical Applications Today, Promises, and Perils
    Alton Brad Farris, Cynthia Cohen, Thomas E. Rogers, Geoffrey H. Smith
    Archives of Pathology & Laboratory Medicine.2017; 141(4): 542.     CrossRef
  • Tumor-infiltrating lymphocytes and breast cancer: Beyond the prognostic and predictive utility
    Andrea Ravelli, Giandomenico Roviello, Daniele Cretella, Andrea Cavazzoni, Alessandra Biondi, Maria Rosa Cappelletti, Laura Zanotti, Giuseppina Ferrero, Marco Ungari, Fabrizio Zanconati, Alberto Bottini, Roberta Alfieri, Pier Giorgio Petronini, Daniele Ge
    Tumor Biology.2017; 39(4): 101042831769502.     CrossRef
  • Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer
    In Hye Song, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, In Ah Park, Young-Ae Kim, Suk Young Park, Jin Roh, Gyungyub Gong, Hee Jin Lee
    Cancer Research and Treatment.2017; 49(2): 399.     CrossRef
  • Lymphocyte count or percentage: which can better predict the prognosis of advanced cancer patients following palliative care?
    Weiwei Zhao, Peng Wang, Huixun Jia, Menglei Chen, Xiaoli Gu, Minghui Liu, Zhe Zhang, Wenwu Cheng, Zhenyu Wu
    BMC Cancer.2017;[Epub]     CrossRef
  • Programmed death-ligand 1 (PD-L1) expression in tumour cell and tumour infiltrating lymphocytes of HER2-positive breast cancer and its prognostic value
    Ahrong Kim, So Jeong Lee, Young Keum Kim, Won Young Park, Do Youn Park, Jee Yeon Kim, Chang Hun Lee, Gyungyub Gong, Gi Yeong Huh, Kyung Un Choi
    Scientific Reports.2017;[Epub]     CrossRef
  • Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer
    Kyueng-Whan Min, Dong-Hoon Kim, Sung-Im Do, Seoung Wan Chae, Kyungeun Kim, Jin Hee Sohn, Jung-Soo Pyo, Hyun Joo Lee, Dong Hyun Kim, Sukjoong Oh, Seon Hyeong Choi, Yong Lai Park, Chan Heun Park, Eun-Kyung Kim, Mi Jung Kwon, Jinwon Seo, Kyoung Min Moon
    Virchows Archiv.2016; 468(4): 409.     CrossRef
  • Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer
    Hee Jin Lee, Ahrong Kim, In Hye Song, In Ah Park, Jong Han Yu, Jin Hee Ahn, Gyungyub Gong
    Pathology International.2016; 66(4): 202.     CrossRef
  • Clinical pharmacologic aspects of immune checkpoint inhibitors in cancer therapy
    Kyu-pyo Kim, Hun Jung
    Translational and Clinical Pharmacology.2016; 24(1): 7.     CrossRef
  • The next level of 3D tumour models: immunocompetence
    Agata Nyga, Joana Neves, Katerina Stamati, Marilena Loizidou, Mark Emberton, Umber Cheema
    Drug Discovery Today.2016; 21(9): 1421.     CrossRef
  • An Examination of the Local Cellular Immune Response to Examples of Both Ductal Carcinoma In Situ (DCIS) of the Breast and DCIS With Microinvasion, With Emphasis on Tertiary Lymphoid Structures and Tumor Infiltrating Lymphoctytes
    Ahrong Kim, Sun-Hee Heo, Young-Ae Kim, Gyungyub Gong, Hee Jin Lee
    American Journal of Clinical Pathology.2016; 146(1): 137.     CrossRef
  • High Ki67/BCL2 index is associated with worse outcome in early stage breast cancer
    Kyueng-Whan Min, Dong-Hoon Kim, Sung-Im Do, Jung-Soo Pyo, Seoung Wan Chae, Jin Hee Sohn, Kyungeun Kim, Hyun Joo Lee, Dong Hyun Kim, Sukjoong Oh, Seon Hyeong Choi, Yong Lai Park, Chan Heun Park, Mi Jung Kwon, Kyoung Min Moon
    Postgraduate Medical Journal.2016; 92(1094): 707.     CrossRef
  • Expression of T-Lymphocyte Markers in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
    Changro Lee, Seho Park, Joo Heung Kim, Sung Mook Lim, Hyung Seok Park, Seung Il Kim, Byeong-Woo Park
    Journal of Breast Cancer.2016; 19(4): 385.     CrossRef
Cytology Specimen Management, Triage and Standardized Reporting of Fine Needle Aspiration Biopsies of the Pancreas
Won Jae Yoon, Martha Bishop Pitman
J Pathol Transl Med. 2015;49(5):364-372.   Published online August 10, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.19
  • 11,087 View
  • 125 Download
  • 6 Citations
AbstractAbstract PDF
The recent advances in pancreas cytology specimen sampling methods have enabled a specific cytologic diagnosis in most cases. Proper triage and processing of the cytologic specimen is pivotal in making a diagnosis due to the need for ancillary testing in addition to cytological evaluation, which is especially true in the diagnosis of pancreatic cysts. Newly proposed terminology for pancreaticobiliary cytology offers a standardized language for reporting that aims to improve communication among patient caregivers and provide for increased flexibility in patient management. This review focuses on these updates in pancreas cytology for the optimal evaluation of solid and cystic lesions of the pancreas.

Citations

Citations to this article as recorded by  
  • Role of fluorescence confocal microscopy for rapid evaluation of EUS fine-needle biopsy sampling in pancreatic solid lesions
    Serena Stigliano, Anna Crescenzi, Chiara Taffon, Francesco Covotta, Cesare Hassan, Giulio Antonelli, Martina Verri, Dario Biasutto, Roberto Mario Scarpa, Francesco Maria Di Matteo
    Gastrointestinal Endoscopy.2021; 94(3): 562.     CrossRef
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    Gut.2019; 68(10): 1906.     CrossRef
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    Pancreatology.2018; 18(8): 977.     CrossRef
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    Ted Gansler, Stacey A. Fedewa, Chun Chieh Lin, Ahmedin Jemal, Elizabeth M. Ward
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Original Articles
SALL4 Expression in Hepatocellular Carcinomas Is Associated with EpCAM-Positivity and a Poor Prognosis
Hyunjin Park, Hyejung Lee, An Na Seo, Jai Young Cho, Young Rok Choi, Yoo-Seok Yoon, Ho-Seong Han, Young Nyun Park, Haeryoung Kim
J Pathol Transl Med. 2015;49(5):373-381.   Published online August 10, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.09
  • 8,977 View
  • 71 Download
  • 19 Citations
AbstractAbstract PDF
Background
There is increasing interest in hepatocellular carcinomas (HCC) expressing “stemness”-related markers, as they have been associated with aggressive behavior and poor prognosis. In this study, we investigated the usefulness of Sal-like protein 4 (SALL4), a recently proposed candidate marker of “stemness.” Methods: Immunohistochemical stains were performed for SALL4, K19, and epithelial cellular adhesion molecule (EpCAM) on tissue microarrays constructed from 190 surgically resected HCCs, and the results were correlated with the clinicopathological features and patient survival data. Results: Nuclear SALL4 expression was observed in 39/190 HCCs (20.5%), while K19 and EpCAM were expressed in 30 (15.9%) and 92 (48.7%) HCCs, respectively. The nuclear expression was generally weak, punctate or clumped. SALL4 expression was significantly associated with a poor overall survival compared to SALL4-negative HCCs (p = .014) compared to SALL4-negative HCCs. On multivariate analysis adjusted for tumor size, multiplicity, vascular invasion, and pathological tumor stage, SALL4 remained as a significant independent predictor of decreased overall survival (p= .004). SALL4 expression was positively correlated with EpCAM expression (p = .013) but not with K19 expression. HCCs that expressed both SALL4 and EpCAM were associated with significantly decreased overall survival, compared to those cases which were negative for both of these markers (p = .031). Conclusions: Although SALL4 expression was not significantly correlated with other clinicopathological parameters suggestive of tumor aggressiveness, SALL4 expression was an independent predictor of poor overall survival in human HCCs, and was also positively correlated with EpCAM expression.

Citations

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    Long Zhao, Changjiang Yang, Yilin Lin, Shan Wang, Yingjiang Ye, Zhanlong Shen
    Foregut Surgery.2022; 2(1): 29.     CrossRef
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    Jun Liu, Madeline A. Sauer, Shaza G. Hussein, Junyu Yang, Daniel G. Tenen, Li Chai
    Genes.2021; 12(9): 1301.     CrossRef
  • Hepatoid Teratoma, Hepatoid Yolk Sac Tumor, and Hepatocellular Carcinoma
    Khaleel I. Al-Obaidy, Sean R. Williamson, Nathan Shelman, Muhammad T. Idrees, Thomas M. Ulbright
    American Journal of Surgical Pathology.2021; 45(1): 127.     CrossRef
  • Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy
    Junyu Yang, Chong Gao, Miao Liu, Yao-Chung Liu, Junsu Kwon, Jun Qi, Xi Tian, Alicia Stein, Yanjing V. Liu, Nikki R. Kong, Yue Wu, Shenyi Yin, Jianzhong Xi, Zhiyuan Chen, Kalpana Kumari, Hannan Wong, Hongbo Luo, Leslie E. Silberstein, Julie A.I. Thoms, Ash
    Cancer Research.2021; 81(23): 6018.     CrossRef
  • Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden
    William Cruz, Huang Huang, Brian Barber, Elisa Pasini, Lili Ding, Gang Zheng, Juan Chen, Mamatha Bhat
    Hepatology Communications.2020; 4(5): 769.     CrossRef
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    Gastric Cancer.2019; 22(6): 1183.     CrossRef
  • Gynecologic Serous Carcinoma: An Immunohistochemical Analysis of Malignant Body Fluid Specimens
    Shuyue Ren, William Klump
    Archives of Pathology & Laboratory Medicine.2019; 143(6): 677.     CrossRef
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    Ioannis A Voutsadakis
    Biomarkers in Medicine.2018; 12(6): 653.     CrossRef
  • Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies
    Nuozhou Wang, Shanshan Wang, Ming-Yue Li, Bao-guang Hu, Li-ping Liu, Sheng-li Yang, Shucai Yang, Zhongqin Gong, Paul B. S. Lai, George G. Chen
    Therapeutic Advances in Medical Oncology.2018; 10: 175883591881628.     CrossRef
  • DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection
    H Fan, Z Cui, H Zhang, S K Mani, A Diab, L Lefrancois, N Fares, P Merle, O Andrisani
    Oncogene.2017; 36(17): 2435.     CrossRef
  • Higher expression of SALL4 predicts poor cancer prognosis: A meta-analysis
    Hongyu Shen, Liangpeng Li, Dandan Wang, Sujin Yang, Xiu Chen, Siying Zhou, Shanliang Zhong, Jianhua Zhao, Jinhai Tang
    Cancer Biomarkers.2017; 19(4): 365.     CrossRef
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    Chuanjin Liu, Haibin Wu, Yanyan Li, Liang Shen, Renchun Yu, Hongwei Yin, Ting Sun, Chunming Sun, Youxin Zhou, Ziwei Du
    Journal of Neuro-Oncology.2017; 135(2): 263.     CrossRef
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    Lorenzo Nicolè, Tiziana Sanavia, Nicola Veronese, Rocco Cappellesso, Claudio Luchini, Paolo Dabrilli, Ambrogio Fassina
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  • MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression
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Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma
Eunhyang Park, Soo Young Park, Hyojin Kim, Ping-Li Sun, Yan Jin, Suk Ki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
J Pathol Transl Med. 2015;49(5):382-388.   Published online August 4, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.10
  • 7,072 View
  • 71 Download
  • 14 Citations
AbstractAbstract PDF
Background
Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC. Methods: IGF1R protein expression was evaluated using immunohistochemistry in 372 patients with NSCLC who underwent curative surgical resection (146 squamous cell carcinomas [SqCCs] and 226 adenocarcinomas [ADCs]). We then analyzed correlations between expression of IGF1R and clinicopathological and molecular features and prognostic significance. Results: Membranous and cytoplasmic IGF1R expression were significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGF1R expression was associated with absence of vascular, lymphatic, and perineural invasion; lower stage; and better progression-free survival (PFS) (hazard ratio [HR], 0.586; p = .040). In patients with ADC, IGF1R expression did not have a significant prognostic value; however, in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with lymphatic and perineural invasion, solid predominant histology, and higher cancer stage and was significantly associated with worse PFS (HR, 2.582; p = .009). Conclusions: Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.

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Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters
Serap Karaarslan, Banu Yaman, Hakan Ozturk, Banu Sarsik Kumbaraci
J Pathol Transl Med. 2015;49(5):389-395.   Published online September 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.08.10
  • 6,527 View
  • 43 Download
  • 5 Citations
AbstractAbstract PDF
Background
Parafibromin is a recently defined tumor suppressor gene. The aim of our study was to determine the relationships of parafibromin expression in urothelial carcinomas (UCs) with prognostic parameters and to evaluate the use of parafibromin as a potential marker of UC. Methods: Parafibromin expression was assessed in 49 UC specimens using immunohistochemistry. The correlations between parafibromin expression and clinical and pathologic parameters were investigated. Results: Of the patients, 42 (85.7%) were male, and the mean age was 69.6 ± 8.2 years (range, 54 to 88 years). Morphologically, the UCs were divided into two groups: papillary (n = 27) and non-papillary (n = 22). There were seven low-grade (14.3%) and 42 high-grade (85.7%) tumors. Parafibromin was negative in 13 tumors (26.5%), partially positive in 19 tumors (38.8%), and positive in 17 tumors (34.7%). Parafibromin expression was more negative in UCs from upper urinary locations (n=17) and with muscularis propria invasion (n=28), which was statistically significant (p = .009 and p = .007, respectively). There was no statistically significant relationship between parafibromin expression and gender, age, tumor grade, survival, or disease-free survival. Conclusions: We found that UC cases with parafibromin positivity had less of a tendency to show muscularis propria invasion and were more commonly located in the lower urinary system. These results need to be confirmed with studies based on larger case series.

Citations

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  • The roles of the tumor suppressor parafibromin in cancer
    Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Prognostic role of parafibromin staining and CDC73 mutation in patients with parathyroid carcinoma: A systematic review and meta‐analysis based on individual patient data
    Ruizhe Zhu, Zixing Wang, Ya Hu
    Clinical Endocrinology.2020; 92(4): 295.     CrossRef
  • The in vitro and in vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target
    Hua-chuan Zheng, Jia-jie Liu, Jing Li, Ji-cheng Wu, Lei Yang, Gui-feng Zhao, Xin Zhao, Hua-mao Jiang, Ke-qiang Huang, Zhi-jie Li
    Oncotarget.2017; 8(14): 23603.     CrossRef
  • The clinicopathological and prognostic significances of CDC73 expression in cancers: a bioinformatics analysis
    Hua-Chuan Zheng, Bao-Cheng Gong, Shuang Zhao
    Oncotarget.2017; 8(56): 95270.     CrossRef
  • Significance of Parafibromin Expression in Laryngeal Squamous Cell Carcinomas
    Inju Cho, Mija Lee, Sharon Lim, Ran Hong
    Journal of Pathology and Translational Medicine.2016; 50(4): 264.     CrossRef
Comparison of Cytologic Characteristics between Adenoid Cystic Carcinoma and Adenoid Basal Carcinoma in the Uterine Cervix
Juhyeon Jeong, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Jungsuk An
J Pathol Transl Med. 2015;49(5):396-402.   Published online August 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.08
  • 7,641 View
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  • 1 Citations
AbstractAbstract PDF
Background
Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are rare in the uterine cervix. ACC is more aggressive than ABC, thus accurate differential diagnosis is important. In this study, we identified cytologic features useful in distinguishing these two tumors for diagnosis. Methods: Three cases of ACC and five cases of ABC were selected for this study. Cervicovaginal smear slides were reviewed retrospectively, and the area, circumference, major axis, and minor axis of nuclei were measured using an image analyzer. Results: ACC displayed three-dimensional clusters with a small acini pattern. ABC displayed peripheral palisading without an acini pattern. The nuclei of ACC were more irregular and angulated than those of ABC, and the former showed a coarsely granular chromatin pattern. The nucleic area, circumference, major axis, and minor axis were 18.556±8.665 µm2, 23.320±11.412 µm, 5.664±1.537 µm, and 4.127±1.107 µm in ACC and 11.017±4.440 µm2, 15.920±5.664 µm, 4.612±1.025 µm, and 3.088±0.762 µm in the cases of ABC. All measured values showed statistically significant difference (p < .001). Conclusions: Although the nuclei of both of these tumor types were oval shaped, inferred from the ratio of minor axis to major axis (0.728 in ACC and 0.669 in ABC), the area of nuclei was approximately 1.7 times larger in ACC than in ABC. Distinguishing nucleic features, including area, morphology, and chromatin pattern, may be helpful in making a correct diagnosis.

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  • Adenoid Basal Carcinoma of the Uterine Cervix: A Case Report
    Tatsuya Kanuma, Keiko Kigure, Tosio Nishimura, Yuji Ibuki, Shigeru Tsuchida, Harumi Kamiyama, Misa Iijima, Kazuto Nakamura
    The KITAKANTO Medical Journal.2016; 66(1): 11.     CrossRef
Case Studies
Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features
Miguel Fdo. Salazar, María del Rocío Estrada Hernández, Erick Gómez Apo, Laura G. Chávez Macías, Carlos Alfonso Rodríguez Álvarez
J Pathol Transl Med. 2015;49(5):403-408.   Published online June 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.05.28
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  • 1 Citations
AbstractAbstract PDF
We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described.

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  • Reticulohistiocytoses: a revision of the full spectrum
    A. Bonometti, E. Berti
    Journal of the European Academy of Dermatology and Venereology.2020; 34(8): 1684.     CrossRef
Human Herpesvirus 8-Negative and Epstein-Barr Virus-Positive Effusion-Based Lymphoma in a Patient with Human Immunodeficiency Virus
Jung-Woo Choi, Younghye Kim, Ju-Han Lee, Young-Sik Kim
J Pathol Transl Med. 2015;49(5):409-412.   Published online June 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.06.03
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  • 3 Citations
AbstractAbstract PDF
A 39-year-old man infected with human immunodeficiency virus (HIV) was admitted to our hospital because of sudden onset of chest pain. Chest radiography revealed pneumothorax of the right lung. Computed tomographic scans disclosed a 5.8-cm-sized emphysematous bulla in the right middle lobe of the lung. Histologically, the wedge-resected lung showed medium to large atypical cells within the bullous cavity of the Pneumocystis jirovecii pneumonia, without solid mass formation. These atypical cells were confirmed to be large B-cell lymphoma, Epstein-Barr virus–positive and human herpesvirus 8–negative. Therefore, this case was not diagnosed as primary effusion lymphoma, but effusion-based lymphoma arising in an emphysematous cavity of an HIV-infected patient. This type of effusion-based lymphoma has never been reported, and, although rare, it should be noted in order to clinically diagnose this lymphoma.

Citations

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  • Primary Effusion Lymphoma: A Timely Review on the Association with HIV, HHV8, and EBV
    Chih-Yi Liu, Bo-Jung Chen, Shih-Sung Chuang
    Diagnostics.2022; 12(3): 713.     CrossRef
  • Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics
    Savanah D. Gisriel, Ji Yuan, Ryan C. Braunberger, Danielle L.V. Maracaja, Xueyan Chen, Xiaojun Wu, Jenna McCracken, Mingyi Chen, Yi Xie, Laura E. Brown, Peng Li, Yi Zhou, Tarsheen Sethi, Austin McHenry, Ronald G. Hauser, Nathan Paulson, Haiming Tang, Eric
    Modern Pathology.2022; 35(10): 1411.     CrossRef
  • Age and CD20 Expression Are Significant Prognostic Factors in Human Herpes Virus-8-negative Effusion-based Lymphoma
    Tomomi Kubota, Yosuke Sasaki, Eisuke Shiozawa, Masafumi Takimoto, Tsunekazu Hishima, Ja-Mun Chong
    American Journal of Surgical Pathology.2018; 42(12): 1607.     CrossRef
Oncocytic Renal Cell Carcinoma with Tubulopapillary Growth Having a Fat Component
Na Rae Kim, Hyun Yee Cho
J Pathol Transl Med. 2015;49(5):413-417.   Published online July 30, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.01
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AbstractAbstract PDF
We report a rare case of oncocytic renal cell carcinoma (RCC) with tubulopapillary growth in the background of tuberculous end-stage kidney disease. Histology of the renal mass consisted of oncocytic cells forming solid, thin tubules and rare papillae. The tumor had abundant eosinophilic oncocytic cells containing occasional cytoplasmic Mallory body–like hyaline globules and a tiny focus of clear cells with intervening mature fat. Both the oncocytic cells and clear cells were immunoreactive for a-methylacyl-CoA racemase, vimentin, pancytokeratin, and CD10, and negative for transcription factor E3, CD15, human melanoma black 45, and c-kit. Mallory body–like hyaline globules were positive for CAM 5.2 and periodic acid–Schiff with or without diastase. Ultrastructurally, the tumor cells had abundant cytoplasmic mitochondria. The present case is a rare case of oncocytic RCC with tubulopapillary growth pattern. The case is unique in that the tumor was mixed with fat component, which is not common in RCC and thus can lead to misdiagnosis.
Brief Case Reports
Multifocal Polypoid Endometriosis Mimicking Malignancy in a Young Woman with a History of Hormonal Treatment
Ji-Young Kim, Tae-Jong Song, Hye-Kyung Choi, Jeong Yun Shim
J Pathol Transl Med. 2015;49(5):418-420.   Published online June 9, 2015
DOI: https://doi.org/10.4132/jptm.2015.05.12
  • 7,363 View
  • 57 Download
  • 3 Citations
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  • Fertility preservation of polypoid endometriosis: Case series and literature review
    Sayuri Miyoshi, Ken Yamaguchi, Yoshitsugu Chigusa, Masumi Sunada, Koji Yamanoi, Akihito Horie, Junzo Hamanishi, Eiji Kondoh, Masaki Mandai
    Journal of Obstetrics and Gynaecology Research.2022; 48(2): 502.     CrossRef
  • A case of polypoid endometriosis mimicking advanced ovarian carcinoma with rapid growth, invasion, and dissemination
    Hiroyuki Yazawa, Riho Yazawa, Kaoru Fukuda, Miki Ohara
    FUKUSHIMA JOURNAL OF MEDICAL SCIENCE.2022; 68(3): 183.     CrossRef
  • Polypoid endometriosis: a mimic of malignancy
    Soleen Ghafoor, Yulia Lakhman, Kay J. Park, Iva Petkovska
    Abdominal Radiology.2020; 45(6): 1776.     CrossRef
Gastric Langerhans Cell Histiocytosis: Case Report and Review of the Literature
So Jung Lee, Chung Su Hwang, Gi Young Huh, Chang Hun Lee, Do Youn Park
J Pathol Transl Med. 2015;49(5):421-423.   Published online June 9, 2015
DOI: https://doi.org/10.4132/jptm.2015.05.19
  • 8,357 View
  • 56 Download
  • 5 Citations
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Citations

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  • Unifocal Gastric Langerhans Cell Histiocytosis in a Child—A Unique Case to Remember
    Bhaswati C. Acharyya, Mandira Roy, Hema Chakraborty
    JPGN Reports.2022; 3(2): e192.     CrossRef
  • Langerhans Cell Histiocytosis with the Synchronous Invasion of Stomach and Colon in an Adult Patient: A Case Report
    Seong Je Kim, Se In Hah, Ji Yoon Kwak, Jung Woo Choi, Hyun Chin Cho, Chang Yoon Ha, Woon Tae Jung, Ok Jae Lee, Chang Min Lee
    The Korean Journal of Gastroenterology.2022; 80(3): 149.     CrossRef
  • Gastrointestinal Langerhans cell histiocytosis with unifocal, single‐system involvement in adults: Cases report and literature review
    Li Wang, Fang Yang, Yong Ding, Lixia Lu, Haili Li, Yangyang Cui, Lu Lu, Xiaohan Shen, Rong Ge
    Journal of Clinical Laboratory Analysis.2022;[Epub]     CrossRef
  • Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review
    Yui Matsuoka, Yoshiki Iemura, Masakazu Fujimoto, Shinsuke Shibuya, Atsushi Yamada, Shigehiko Fujii, Toshihiro Kusaka, Takero Shindo, Sachiko Minamiguchi, Hironori Haga
    International Journal of Surgical Pathology.2021; 29(5): 550.     CrossRef
  • Langerhans cell histiocytosis of the gastrointestinal tract
    Aoife J. McCarthy, Madiha Emran Soofi, Imaad Mujeeb, Runjan Chetty
    Diagnostic Histopathology.2018; 24(4): 154.     CrossRef

JPTM : Journal of Pathology and Translational Medicine