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Original Article
Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng
J Pathol Transl Med. 2017;51(1):32-39.   Published online December 25, 2016
DOI: https://doi.org/10.4132/jptm.2016.10.17
  • 7,493 View
  • 175 Download
  • 19 Citations
AbstractAbstract PDF
Background
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.
Methods
AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.
Results
AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).
Conclusions
AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients.

Citations

Citations to this article as recorded by  
  • Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer
    Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
    Cellular and Molecular Gastroenterology and Hepatology.2022; 13(2): 517.     CrossRef
  • Colorectal cancer on a dish: exploring the 3D-sphere culture of primary colorectal cancer cells from an Indonesian perspective
    Murdani Abdullah, DR Noor, Amanda Pitarini Utari, Virly Nanda Muzellina, Nur Rahadiani, Radiana Dhewayani Antarianto
    F1000Research.2022; 11: 182.     CrossRef
  • Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
    Chang-Hyeon Kim, Da-Eun Kim, Dae-Hoon Kim, Ga-Hong Min, Jung-Won Park, Yeo-Bin Kim, Chang K. Sung, Hyungshin Yim
    Experimental & Molecular Medicine.2022; 54(4): 414.     CrossRef
  • AURKA is a prognostic biomarker for good overall survival in stage II colorectal cancer patients
    Peter Jung, David Horst, Thomas Kirchner, Frederick Klauschen, Jens Neumann
    Pathology - Research and Practice.2022; 235: 153936.     CrossRef
  • Therapeutic Potential of Mitotic Kinases’ Inhibitors in Cancers of the Gastrointestinal System
    Aadil Javed, Gianluca Malagraba, Mahdieh Yarmohammadi, Catalina M. Perelló-Reus, Carles Barceló, Teresa Rubio-Tomás
    Future Pharmacology.2022; 2(3): 214.     CrossRef
  • Bioinformatics Analysis of RNA-seq Data Reveals Genes Related to Cancer Stem Cells in Colorectal Cancerogenesis
    Kristian Urh, Nina Zidar, Emanuela Boštjančič
    International Journal of Molecular Sciences.2022; 23(21): 13252.     CrossRef
  • Unweaving the mitotic spindle: A focus on Aurora kinase inhibitors in lung cancer
    Alessio Stefani, Geny Piro, Francesco Schietroma, Alessandro Strusi, Emanuele Vita, Simone Fiorani, Diletta Barone, Federico Monaca, Ileana Sparagna, Giustina Valente, Miriam Grazia Ferrara, Ettore D’Argento, Mariantonietta Di Salvatore, Carmine Carbone,
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer
    Jiyoon Jung, Hoiseon Jeong, Jung-Woo Choi, Hye-Sun Kim, Hwa Eun Oh, Eung Seok Lee, Young-Sik Kim, Ju-Han Lee
    Pathology - Research and Practice.2021; 224: 153524.     CrossRef
  • SALL Proteins; Common and Antagonistic Roles in Cancer
    Claudia Álvarez, Aracelly Quiroz, Diego Benítez-Riquelme, Elizabeth Riffo, Ariel F. Castro, Roxana Pincheira
    Cancers.2021; 13(24): 6292.     CrossRef
  • AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children
    Yong-Ping Chen, Li Yuan, Hui-Ran Lin, Xiao-Kai Huang, Ji-Chen Ruan, Zhen-Jian Zhuo
    Discover Oncology.2021;[Epub]     CrossRef
  • Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA
    Xiaojiang Liu, Yaru Zhang, Siqi Wu, Minmin Xu, Youfeng Shen, Min Yu, Jinhua Fan, Sijia Wei, Chaohang Xu, Lu Huang, Han Zhao, Xuegang Li, Xiaoli Ye
    Biochemical Pharmacology.2020; 175: 113933.     CrossRef
  • New landscapes and horizons in hepatocellular carcinoma therapy
    Melchiorre Cervello, Maria R. Emma, Giuseppa Augello, Antonella Cusimano, Lydia Giannitrapani, Maurizio Soresi, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Alessandro Gulino, Beatrice Belmonte, Giuseppe Montalto, James A. McCubrey
    Aging.2020; 12(3): 3053.     CrossRef
  • The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes
    Anna Maria Grimaldi, Federica Conte, Katia Pane, Giulia Fiscon, Peppino Mirabelli, Simona Baselice, Rosa Giannatiempo, Francesco Messina, Monica Franzese, Marco Salvatore, Paola Paci, Mariarosaria Incoronato
    International Journal of Molecular Sciences.2020; 21(18): 6690.     CrossRef
  • The GTEx Consortium atlas of genetic regulatory effects across human tissues
    François Aguet, Shankara Anand, Kristin G. Ardlie, Stacey Gabriel, Gad A. Getz, Aaron Graubert, Kane Hadley, Robert E. Handsaker, Katherine H. Huang, Seva Kashin, Xiao Li, Daniel G. MacArthur, Samuel R. Meier, Jared L. Nedzel, Duyen T. Nguyen, Ayellet V.
    Science.2020; 369(6509): 1318.     CrossRef
  • Upregulation of aurora kinase A promotes vascular smooth muscle cell proliferation and migration by activating the GSK-3β/β-catenin pathway in aortic-dissecting aneurysms
    Jia Meng, He-Liang Liu, Dong Ma, Hong-Yan Wang, Yue Peng, Hong-Li Wang
    Life Sciences.2020; 262: 118491.     CrossRef
  • Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1
    Lihong Wang-Bishop, Zheng Chen, Ahmed Gomaa, Albert Craig Lockhart, Safia Salaria, Jialiang Wang, Keeli B. Lewis, Jeffrey Ecsedy, Kay Washington, Robert Daniel Beauchamp, Wael El-Rifai
    Gastroenterology.2019; 156(3): 662.     CrossRef
  • Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer
    Kulbe, Otto, Darb-Esfahani, Lammert, Abobaker, Welsch, Chekerov, Schäfer, Dragun, Hummel, Leser, Sehouli, Braicu
    Cells.2019; 8(7): 713.     CrossRef
  • Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
    Ahmed Gomaa, Dunfa Peng, Zheng Chen, Mohammed Soutto, Khaled Abouelezz, Alejandro Corvalan, Wael El-Rifai
    Scientific Reports.2019;[Epub]     CrossRef
  • The functional diversity of Aurora kinases: a comprehensive review
    Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister
    Cell Division.2018;[Epub]     CrossRef
Brief Case Report
A Rare Case of Nodular Mucinosis of the Breast
Hyun Min Koh, Young Hee Maeng, Bo Geun Jang, Jae Hyuk Choi, Chang lim Hyun
J Pathol Transl Med. 2017;51(3):332-334.   Published online December 5, 2016
DOI: https://doi.org/10.4132/jptm.2016.07.26
  • 6,340 View
  • 119 Download
  • 6 Citations
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Citations

Citations to this article as recorded by  
  • New and emerging conditions of acquired cutaneous mucinoses in adults
    F. Rongioletti
    Journal of the European Academy of Dermatology and Venereology.2022; 36(7): 1016.     CrossRef
  • Altered presence of extra cellular matrix components in murine skin cancer: Modulation by Azadirachta indica leaf extract
    N.A. Chugh, A. Koul
    Journal of Traditional and Complementary Medicine.2021; 11(3): 197.     CrossRef
  • Mucinosis nodular de la mama
    Bernardo Weil Lara, Daniela Pérez Martínez, Beatriz Romero Madrid
    Revista Española de Patología.2020; 53(1): 42.     CrossRef
  • Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice
    Ashwani Koul, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, Neha Arora Chugh
    International Journal for Vitamin and Nutrition Research.2020; 90(5-6): 493.     CrossRef
  • A review of mucinous lesions of the breast
    Paula S. Ginter, Xiaoyu Tang, Sandra J. Shin
    The Breast Journal.2020; 26(6): 1168.     CrossRef
  • Mesenchymal Lesions of the Breast: What Radiologists Need to Know
    Debra S. Whorms, Michael D. C. Fishman, Priscilla J. Slanetz
    American Journal of Roentgenology.2018; 211(1): 224.     CrossRef
Case Report
Undifferentiated Carcinoma Arising in a Choledochal Cyst: A Case Report.
Hee Eun Lee, Chang Lim Hyun, You Jeong Lee, Hye Sil Seol, Ja June Jang
Korean J Pathol. 2006;40(6):461-465.
  • 1,389 View
  • 14 Download
AbstractAbstract PDF
An association between choledochal cyst and carcinoma is well established. Here, we report an extremely rare case of undifferentiated carcinoma exhibiting extensive sarcomatous features arising in a choledochal cyst. The patient in our case had a radiologically confirmed choledochal cyst and anomalous pancreaticobiliary ductal union, and mild wall thickening in the cyst was observed on endoscopic retrograde cholangiopancreatography. The patient underwent common bile duct excision and cholecystectomy. In the choledochal cyst, a nodule measuring 1.5x1 cm was detected. The lesion was composed of atypical, spindle-shaped and large, round pleomorphic tumor cells simulating sarcoma. Neither glandular nor squamous differentiation was observed. These cells were immunoreactive for both vimentin and cytokeratin by immunohistochemistry. These histologic and immunohistochemical findings were consistent with undifferentiated carcinoma, spindle and giant cell type, according to the WHO classification.
Original Article
Pathological Analysis of 1,000 Cases of Transrectal Ultrasoundguided Systematic Prostate Biopsy: Establishment of New Sample Processing Method and Diagnostic Utility of Immunohistochemistry.
Chang Lim Hyun, Hee Eun Lee, Haeryung Kim, Hye Seung Lee, So Yeon Park, Jin Haeng Chung, Gheeyoung Choe
Korean J Pathol. 2006;40(6):406-419.
  • 1,558 View
  • 28 Download
AbstractAbstract PDF
BACKGROUND
We developed a new processing method for extended prostate needle biopsy, and evaluated diagnostic utility of routine immunohistochemistry in 1,000 consecutive unselected cases of transrectal ultrasound-guided systematic prostate biopsy.
METHODS
Four to five biopsy cores were embedded in one paraffin block. All the biopsy cores were immunohistochemically stained with basal cell markers.
RESULTS
The new sample processing method was technically perfect for making a diagnosis from extended prostate needle biopsy. Among 1,000 cases, there were 323 cases (32.3%) of adenocarcinoma, 5 cases of other malignant tumors, 9 cases of high-grade prostatic intraepithelial neoplasia without a carcinoma, and only 8 cases of atypical small acinar proliferation. Among the 323 cases of adenocarcinoma, there were 38 cases (11.8%) of microcarcinomas <0.1 cm and 101 cases (31.3%) of small adenocarcinomas <0.3 cm in length. In the needle biopsy specimens, 59 cases (18.3%) were classified as clinically insignificant carcinomas. Among them, 37 cases underwent radical prostatectomy, which turned out to be clinically significant carcinomas in 24 cases (64.9%).
CONCLUSIONS
Routinely performed immunohistochemistry combined with the new sample processing method is very effective for detecting microscopic carcinoma foci as well as differentiating carcinoma from benign conditions mimicking cancer.

JPTM : Journal of Pathology and Translational Medicine