Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
8 "Jae Jun Lee"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Articles
Extrapulmonary Lymphangioleiomyoma: Clinicopathological Analysis of 4 Cases
Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Kee-Taek Jang, Sang Yong Song, Chin A Yi, Joungho Han
Korean J Pathol. 2014;48(3):188-192.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.188
  • 7,161 View
  • 54 Download
  • 8 Citations
AbstractAbstract PDF
Background

Lymphangioleiomyomatosis (LAM) is a slowly progressive neoplastic disease that predominantly affects females. Usually, LAM affects the lung; it can also affect extrapulmonary sites, such as the mediastinum, the retroperitoneum, or the lymph nodes, although these locations are rare. A localized form of LAM can manifest as extrapulmonary lesions; this form is referred to as extrapulmonary lymphangioleiomyoma (E-LAM). Due to the rare occurrence of E-LAM and its variable, atypical location, E-LAM is often difficult to diagnose. Herein, we report the clinicopathological information from four E-LAM cases, and also review previous articles investigating this disease.

Methods

Four patients with E-LAM were identified at the Samsung Medical Center (Seoul, Korea) from 1995 to 2012. All E-LAM lesions underwent surgical excision.

Results

All patients were females within the age range of 43 to 47 years. Two patients had para-aortic retroperitoneal masses, while the other two patients had pelvic lesions; two out of the four patients also had accompanying pulmonary LAM. In addition, no patient displayed any evidence of tuberous sclerosis. Histologically, two patients exhibited nuclear atypism with cytologic degeneration.

Conclusions

E-LAM should be considered in the differential diagnosis of patients presenting with pelvic or para-aortic masses. We also conclude that further clinical and pathological evaluation is needed in patients with E-LAM and nuclear atypism.

Citations

Citations to this article as recorded by  
  • A case of lymphangioleiomyomatosis with endometrial cancer diagnosed by retroperitoneoscopic para-aortic lymph node dissection
    Aiko Ogasawara, Shogo Yamaguchi, Hiroaki Inui, Mieko Hanaoka, Daisuke Shintani, Sho Sato, Masanori Yasuda, Akira Yabuno
    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY.2022; 38(1): 158.     CrossRef
  • Primary retroperitoneal PEComa: an incidental finding
    Bárbara Monteiro Marinho, António Gâmboa Canha, Donzília Sousa Silva, José Davide Pinto Silva
    BMJ Case Reports.2022; 15(11): e250466.     CrossRef
  • Imaging Findings of Thoracic Lymphatic Abnormalities
    Jingshuo (Derek) Sun, Thomas Shum, Fardad Behzadi, Mark M. Hammer
    RadioGraphics.2022; 42(5): 1265.     CrossRef
  • Extrapulmonary uterine lymphangioleiomyomatosis (LAM) and dysfunctional uterine bleeding: the first presentation of LAM in a tuberous sclerosis complex patient
    Lucy Grant, Saliya Chipwete, San Soo Hoo, Anjali Bhatnagar
    BMJ Case Reports.2019; 12(2): e226358.     CrossRef
  • Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia
    Takashi Ogura, Nagio Takigawa, Keisuke Tomii, Kazuma Kishi, Yoshikazu Inoue, Eiki Ichihara, Sakae Homma, Kazuhisa Takahashi, Hiroaki Akamatsu, Satoshi Ikeda, Naohiko Inase, Tae Iwasawa, Yuichiro Ohe, Hiromitsu Ohta, Hiroshi Onishi, Isamu Okamoto, Kazumasa
    Respiratory Investigation.2019; 57(6): 512.     CrossRef
  • Incidental lymphangioleiomyomatosis in the lymph nodes of gynecologic surgical specimens
    Ikumi Kuno, Hiroshi Yoshida, Hanako Shimizu, Takashi Uehara, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2018; 231: 93.     CrossRef
  • Solitary extrapulmonary lymphangioleiomyomatosis of the liver: A case report and literature review
    Weiwei Fu, Yujun Li, Hong Li, Ping Yang, Xiaoming Xing
    Experimental and Therapeutic Medicine.2016; 12(3): 1499.     CrossRef
  • Incidental Pelvic and Para-aortic Lymph Node Lymphangioleiomyomatosis Detected During Surgical Staging of Pelvic Cancer in Women Without Symptomatic Pulmonary Lymphangioleiomyomatosis or Tuberous Sclerosis Complex
    Joseph T. Rabban, Brandie Firetag, Ankur R. Sangoi, Miriam D. Post, Charles J. Zaloudek
    American Journal of Surgical Pathology.2015; 39(8): 1015.     CrossRef
Usual Interstitial Pneumonia with Lung Cancer: Clinicopathological Analysis of 43 Cases
Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Kyeongman Jeon, Man Pyo Chung, Jhingook Kim, Joungho Han
Korean J Pathol. 2014;48(1):10-16.   Published online February 25, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.10
  • 8,233 View
  • 67 Download
  • 14 Citations
AbstractAbstract PDF
Background

Previous studies have suggested an association between usual interstitial pneumonia (UIP) and lung cancer (Ca). However, clinical and histological information is not enough to determine such an association, due to the low incidence and short survival time of patients with both conditions.

Methods

We retrospectively reviewed the clinical and histological records of Ca patients with UIP between January 1999 and August 2013 at the Samsung Medical Center, Seoul, Korea. We found 43 patients who had Ca with UIP (UIP-Ca). Previously reported data of eighty-four patients with UIP-only were included as a comparison group.

Results

Smoking is related to poor prognosis in patients with UIP-Ca, and the number of patients with a high smoking index of more than 30 pack-years significantly increased in UIP-Ca patients compared with UIP-only patients. There is no significant prognostic differentiation between UIP-Ca patients and UIP-only patients. Microscopically, UIP-Ca patients showed characteristically heterogeneous histological patterns and degrees of differentiation. There were many foci of squamous metaplasia or dysplasia at the peripheral area of squamous cell carcinomas.

Conclusions

We report 43 cases of UIP-Ca. Our results suggest that smoking is related to cancer occurrence in UIP patients and poor prognosis in UIP-Ca patients.

Citations

Citations to this article as recorded by  
  • Prognosis of idiopathic pulmonary fibrosis without anti-fibrotic therapy: a systematic review
    Yet H. Khor, Yvonne Ng, Hayley Barnes, Nicole S.L. Goh, Christine F. McDonald, Anne E. Holland
    European Respiratory Review.2020; 29(157): 190158.     CrossRef
  • Linfoma difuso de células B grandes pulmonar en paciente con neumonía intersticial no específica
    Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
    Reumatología Clínica.2019; 15(6): e151.     CrossRef
  • Diffuse Large B-cell Lymphoma of the Lung in a Patient With Nonspecific Interstitial Pneumonia
    Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
    Reumatología Clínica (English Edition).2019; 15(6): e151.     CrossRef
  • Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
    Joo Heung Yoon, Mehdi Nouraie, Xiaoping Chen, Richard H Zou, Jacobo Sellares, Kristen L Veraldi, Jared Chiarchiaro, Kathleen Lindell, David O Wilson, Naftali Kaminski, Timothy Burns, Humberto Trejo Bittar, Samuel Yousem, Kevin Gibson, Daniel J Kass
    Respiratory Research.2018;[Epub]     CrossRef
  • Genomic profiles of lung cancer associated with idiopathic pulmonary fibrosis
    Ji An Hwang, Deokhoon Kim, Sung-Min Chun, SooHyun Bae, Joon Seon Song, Mi Young Kim, Hyun Jung Koo, Jin Woo Song, Woo Sung Kim, Jae Cheol Lee, Hyeong Ryul Kim, Chang-Min Choi, Se Jin Jang
    The Journal of Pathology.2018; 244(1): 25.     CrossRef
  • Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study
    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida
    BMC Pulmonary Medicine.2018;[Epub]     CrossRef
  • Alveolar Squamous Cell Metaplasia: Preneoplastic Lesion?
    Adriana Handra-Luca
    Journal of Pathology and Translational Medicine.2018; 52(6): 355.     CrossRef
  • Low expression of long noncoding RNA CDKN2B-AS1 in patients with idiopathic pulmonary fibrosis predicts lung cancer by regulating the p53-signaling pathway
    Yufeng Du, Xiaoyan Hao, Xuejun Liu
    Oncology Letters.2018;[Epub]     CrossRef
  • A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia
    Yasutaka Watanabe, Yoshinori Kawabata, Nobuyuki Koyama, Tomohiko Ikeya, Eishin Hoshi, Noboru Takayanagi, Shinichiro Koyama
    Respiratory Medicine.2017; 129: 158.     CrossRef
  • Risk of the preoperative underestimation of tumour size of lung cancer in patients with idiopathic interstitial pneumonias
    Mariko Fukui, Kazuya Takamochi, Takeshi Matsunaga, Shiaki Oh, Katsutoshi Ando, Kazuhiro Suzuki, Atsushi Arakawa, Toshimasa Uekusa, Kenji Suzuki
    European Journal of Cardio-Thoracic Surgery.2016; 50(3): 428.     CrossRef
  • The Idiopathic Interstitial Pneumonias: Histology and Imaging
    Diane C. Strollo, Teri J. Franks, Jeffrey R. Galvin
    Seminars in Roentgenology.2015; 50(1): 8.     CrossRef
  • Do Chest Expansion Exercises Aid Re-shaping the Diaphragm Within the First 72 Hours Following Lung Transplantation in a Usual Interstitial Pneumonia Patient?
    Massimiliano Polastri, Erika Venturini, Saverio Pastore, Andrea Dell'Amore
    Physiotherapy Research International.2015; 20(3): 191.     CrossRef
  • Scrotal wall metastasis from a primary lung adenocarcinoma
    Marie-Louise M. Coussa-Koniski, Pia A. Maalouf, Nehme E. Raad, Noha A. Bejjani
    Respiratory Medicine Case Reports.2015; 15: 77.     CrossRef
  • The Ratio KL-6 to SLX in Serum for Prediction of the Occurrence of Drug-Induced Interstitial Lung Disease in Lung Cancer Patients with Idiopathic Interstitial Pneumonias Receiving Chemotherapy
    Kosuke Kashiwabara, Hiroshi Semba, Shinji Fujii, Shinsuke Tsumura, Ryota Aoki
    Cancer Investigation.2015; 33(10): 516.     CrossRef
Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
Seung Yeon Ha, Jungsuk Ahn, Mee Sook Roh, Joungho Han, Jae Jun Lee, Boin Lee, Jun Yim
Korean J Pathol. 2013;47(3):252-257.   Published online June 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.252
  • 6,404 View
  • 28 Download
  • 9 Citations
AbstractAbstract PDF
Background

The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma.

Methods

We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma.

Results

Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus.

Conclusions

The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).

Citations

Citations to this article as recorded by  
  • Machine learning‐based gene alteration prediction model for primary lung cancer using cytologic images
    Shuhei Ishii, Manabu Takamatsu, Hironori Ninomiya, Kentaro Inamura, Takeshi Horai, Akira Iyoda, Naoko Honma, Rira Hoshi, Yuko Sugiyama, Noriko Yanagitani, Mingyon Mun, Hitoshi Abe, Tetuo Mikami, Kengo Takeuchi
    Cancer Cytopathology.2022; 130(10): 812.     CrossRef
  • Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift
    Pranab Dey, Ratan Kumar Ghosh
    Diagnostic Cytopathology.2019; 47(4): 351.     CrossRef
  • Qualitative and quantitative cytomorphological features of primary anaplastic lymphoma kinase‐positive lung cancer
    Ryuko Tsukamoto, Hiroyuki Ohsaki, Sho Hosokawa, Yasunori Tokuhara, Shingo Kamoshida, Toshiko Sakuma, Tomoo Itoh, Chiho Ohbayashi
    Cytopathology.2019; 30(3): 295.     CrossRef
  • Primary signet-ring adenocarcinoma of the lung: A rare lung tumor
    Varun Rajpal, Rahul Kumar Sharma, Charul Dabral, Deepak Talwar
    South Asian Journal of Cancer.2019; 08(04): 257.     CrossRef
  • Cytological features in eight patients with ALK -rearranged lung cancer
    Naoto Kuroda, Masahiko Ohara, Yukari Wada, Kaori Yasuoka, Keiko Mizuno, Kenji Yorita, Chiho Obayashi, Kengo Takeuchi
    Diagnostic Cytopathology.2018; 46(6): 516.     CrossRef
  • Cytological markers for predicting ALK -positive pulmonary adenocarcinoma
    K. Miyata, S. Morita, H. Dejima, N. Seki, N. Matsutani, M. Mieno, F. Kondo, Y. Soejima, F. Tanaka, M. Sawabe
    Diagnostic Cytopathology.2017; 45(11): 963.     CrossRef
  • ALK-rearranged adenocarcinoma with extensive mucin production can mimic mucinous adenocarcinoma: clinicopathological analysis and comprehensive histological comparison with KRAS-mutated mucinous adenocarcinoma
    Yoon Jin Cha, Joungho Han, Soo Hyun Hwang, Tae Bum Lee, Hojoong Kim, Jea Ill Zo
    Pathology.2016; 48(4): 325.     CrossRef
  • Cytomorphological identification of advanced pulmonary adenocarcinoma harboring KRAS mutation in lymph node fine-needle aspiration specimens: Comparative investigation of adenocarcinoma with KRAS and EGFR mutations
    Dae Hyun Song, Boram Lee, Yooju Shin, In Ho Choi, Sang Yun Ha, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Joungho Han, Sang-Won Um
    Diagnostic Cytopathology.2015; 43(7): 539.     CrossRef
  • Comprehensive analysis of RET and ROS1 rearrangement in lung adenocarcinoma
    Seung Eun Lee, Boram Lee, Mineui Hong, Ji-Young Song, Kyungsoo Jung, Maruja E Lira, Mao Mao, Joungho Han, Jhingook Kim, Yoon-La Choi
    Modern Pathology.2015; 28(4): 468.     CrossRef
Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
Jiyeon Hyeon, Soomin Ahn, Jae Jun Lee, Dae Hyun Song, Cheol-Keun Park
Korean J Pathol. 2013;47(2):130-136.   Published online April 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.130
  • 6,763 View
  • 51 Download
  • 17 Citations
AbstractAbstract PDF
Background

BCL9 enhances β-catenin-mediated transcriptional activity regardless of the mutational status of the Wnt signaling components and increases the cell proliferation, migration, invasion, and metastatic potential of tumor cells. The goal of this study was to elucidate the prognostic significance of BCL9 protein expression in hepatocellular carcinoma (HCC) patients.

Methods

We evaluated BCL9 protein expression by immunohistochemistry in tumor tissue from 288 primary HCC patients who underwent curative hepatectomy. The impact of BCL9 expression on the survival of the patients was analyzed. The median follow-up period was 97.1 months.

Results

Nuclear BCL9 protein expression was observed in 74 (25.7%) of the 288 HCCs. BCL9 expression was significantly associated with younger age (p=0.038), higher Edmondson grade (p=0.001), microvascular invasion (p=0.013), and intrahepatic metastasis (p=0.017). Based on univariate analyses, BCL9 expression showed an unfavorable influence on both disease-free survival (DFS, p=0.012) and disease-specific survival (DSS, p=0.032). Multivariate analyses revealed that higher Barcelona Clinic Liver Cancer stage was an independent predictor of both shorter DFS (p<0.001) and shorter DSS (p<0.001). BCL9 expression tended to be an independent predictor of shorter DFS (p=0.078).

Conclusions

BCL9 protein expression might be a marker of shorter DFS in HCC patients after curative hepatectomy.

Citations

Citations to this article as recorded by  
  • The role of BCL9 genetic variation as a biomarker for hepatitis C-related hepatocellular carcinoma in Egyptian patients
    Eman Abd El Razek Abbas, Ahmed Barakat Barakat, Mohamed Hassany, Samar Samir Youssef
    Journal of Genetic Engineering and Biotechnology.2022;[Epub]     CrossRef
  • Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma
    Kwang-Hoon Chun
    Pharmaceutics.2022; 14(7): 1380.     CrossRef
  • Wnt/β-Catenin Signalling and Its Cofactor BCL9L Have an Oncogenic Effect in Bladder Cancer Cells
    Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
    International Journal of Molecular Sciences.2022; 23(10): 5319.     CrossRef
  • Bcl9 Depletion Modulates Endothelial Cell in Tumor Immune Microenvironment in Colorectal Cancer Tumor
    Zhuang Wei, Mei Feng, Zhongen Wu, Shuru Shen, Di Zhu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Wnt Signaling Pathway Is among the Drivers of Liver Metastasis
    Ivana Samaržija
    Livers.2021; 1(4): 180.     CrossRef
  • Nuclear Expression of Pygo2 Correlates with Poorly Differentiated State Involving c-Myc, PCNA and Bcl9 in Myanmar Hepatocellular Carcinoma
    Myo Win Htun, Yasuaki Shibata, Kyaw Soe, Takehiko Koji
    ACTA HISTOCHEMICA ET CYTOCHEMICA.2021; 54(6): 195.     CrossRef
  • Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma
    Nicole Huge, Maria Sandbothe, Anna K. Schröder, Amelie Stalke, Marlies Eilers, Vera Schäffer, Brigitte Schlegelberger, Thomas Illig, Beate Vajen, Britta Skawran
    Hepatology International.2020; 14(3): 373.     CrossRef
  • Structure and function of Pygo in organ development dependent and independent Wnt signalling
    Yan Shi, Xiushan Wu, Shuoji Zhu, Huanlei Huang, Jian Zhuang, Haiyun Yuan, Wuzhou Yuan, Ping Zhu
    Biochemical Society Transactions.2020; 48(4): 1781.     CrossRef
  • BCL9/BCL9L in hepatocellular carcinoma: will it or Wnt it be the next therapeutic target?
    Akshata Moghe, Satdarshan P. Monga
    Hepatology International.2020; 14(4): 460.     CrossRef
  • Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
    David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
    Nature Communications.2019;[Epub]     CrossRef
  • Immunohistochemical Mapping of Bcl9 Using Two Antibodies that Recognize Different Epitopes Is Useful to Characterize Juvenile Development of Hepatocellular Carcinoma in Myanmar
    Myat Thu Soe, Yasuaki Shibata, Myo Win Htun, Kuniko Abe, Kyaw Soe, Nay Win Than, Thann Lwin, Myat Phone Kyaw, Takehiko Koji
    ACTA HISTOCHEMICA ET CYTOCHEMICA.2019; 52(1): 9.     CrossRef
  • Low BCL9 expression inhibited ovarian epithelial malignant tumor progression by decreasing proliferation, migration, and increasing apoptosis to cancer cells
    Jing Wang, Mingjun Zheng, Liancheng Zhu, Lu Deng, Xiao Li, Linging Gao, Caixia Wang, Huimin Wang, Juanjuan Liu, Bei Lin
    Cancer Cell International.2019;[Epub]     CrossRef
  • SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction
    Rong Fan, HaiYan He, Wang Yao, YanFeng Zhu, XunJie Zhou, MingTai Gui, Jing Lu, Hao Xi, ZhongLong Deng, Min Fan
    DNA and Cell Biology.2018; 37(2): 126.     CrossRef
  • Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma
    Wei Xu, Wang Zhou, Mo Cheng, Jing Wang, Zhian Liu, Shaohui He, Xiangji Luo, Wending Huang, Tianrui Chen, Wangjun Yan, Jianru Xiao
    Scientific Reports.2017;[Epub]     CrossRef
  • Hepatocellular carcinoma biology predicts survival outcome after liver transplantation in the USA
    Mohamed Abd El-Fattah
    Indian Journal of Gastroenterology.2017; 36(2): 117.     CrossRef
  • miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models
    Xuan Liu, Qing Ji, Chengcheng Zhang, Xiaowei Liu, Yanna Liu, Ningning Liu, Hua Sui, Lihong Zhou, Songpo Wang, Qi Li
    Scientific Reports.2017;[Epub]     CrossRef
  • BCL9, a coactivator for Wnt/β-catenin transcription, is targeted by miR-30c and is associated with prostate cancer progression
    XIAO-HUI LING, ZHI-YUN CHEN, HONG-WEI LUO, ZE-ZHEN LIU, YING-KE LIANG, GUAN-XING CHEN, FU-NENG JIANG, WEI-DE ZHONG
    Oncology Letters.2016; 11(3): 2001.     CrossRef
Methylation and Immunoexpression of p16INK4a Tumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitative p16INK4a Hypermethylation in Plasma by Real-Time PCR
Jae Jun Lee, Eunkyung Ko, Junhun Cho, Ha Young Park, Jeong Eon Lee, Seok Jin Nam, Duk-Hwan Kim, Eun Yoon Cho
Korean J Pathol. 2012;46(6):554-561.   Published online December 26, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.554
  • 6,263 View
  • 46 Download
  • 16 Citations
AbstractAbstract PDF
Background

The p16INK4a gene methylation has been reported to be a major tumorigenic mechanism.

Methods

We evaluated the methylation status of the p16INK4a genes in 231 invasive breast cancer and 90 intraductal carcinoma specimens using a methylation-specific polymerase chain reaction and p16 protein expression using immunohistochemistry. The quantity of cell-free methylated p16INK4a DNA in the plasma samples of 200 patients with invasive breast cancer was also examined using a fluorescence-based real-time polymerase chain reaction assay.

Results

The frequencies of p16INK4a methylation in invasive and intraductal tumors were 52.8% (122/231) and 57.8% (52/90), respectively. The p16 protein was overexpressed in 145 of the 231 invasive carcinomas (62.8%) and 63 of the 90 intraductal carcinomas (70%). High p16 expression in invasive carcinomas correlated significantly with a high histologic grade, a negative estrogen receptor and progesterone receptor status, p53 immunoreactivity and high Ki-67 expression with immunohistochemistry. In addition, the methylation index of p16INK4a was significantly higher in the cancer patients than the normal controls (p<0.001).

Conclusions

High p16 immunoreactivity correlated with a loss of differentiation in breast carcinomas and high frequency of p16INK4a promoter methylation in both invasive and intraductal carcinomas, suggesting it may be involved in the pathogenesis of breast cancer.

Citations

Citations to this article as recorded by  
  • Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
    Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
    Cancers.2021; 13(12): 2978.     CrossRef
  • Mechanisms of resistance to estrogen receptor modulators in ER+/HER2− advanced breast cancer
    Jin Zhang, Qianying Wang, Qing Wang, Jiangran Cao, Jiafu Sun, Zhengmao Zhu
    Cellular and Molecular Life Sciences.2020; 77(4): 559.     CrossRef
  • Aberrantly Methylated cfDNA in Body Fluids as a Promising Diagnostic Tool for Early Detection of Breast Cancer
    Igor Stastny, Pavol Zubor, Karol Kajo, Peter Kubatka, Olga Golubnitschaja, Zuzana Dankova
    Clinical Breast Cancer.2020; 20(6): e711.     CrossRef
  • Epigenetic modulation of BRCA‐1 and MGMT genes, and histones H4 and H3 are associated with breast tumors
    Parisa Paydar, Gholamreza Asadikaram, Hamid Zeynali Nejad, Hamed Akbari, Moslem Abolhassani, Vahid Moazed, Mohammad Hadi Nematollahi, Ghasem Ebrahimi, Hossein Fallah
    Journal of Cellular Biochemistry.2019; 120(8): 13726.     CrossRef
  • The 9p21 locus: A potential therapeutic target and prognostic marker in breast cancer
    Mahdi Rivandi, Mohammad‐Sadegh Khorrami, Hamid Fiuji, Soodabeh Shahidsales, Malihe Hasanzadeh, Mir Hadi Jazayeri, Seyed Mahdi Hassanian, Gordon A. Ferns, Nafiseh Saghafi, Amir Avan
    Journal of Cellular Physiology.2018; 233(7): 5170.     CrossRef
  • p16INK4a overexpression as a predictor of survival in ocular surface squamous neoplasia
    Sheetal Chauhan, Seema Sen, Anjana Sharma, Seema Kashyap, Radhika Tandon, Mandeep S Bajaj, Neelam Pushker, Murugesan Vanathi, Shyam S Chauhan
    British Journal of Ophthalmology.2018; 102(6): 840.     CrossRef
  • Liquid biopsy prediction of axillary lymph node metastasis, cancer recurrence, and patient survival in breast cancer
    Ju-Han Lee, Hoiseon Jeong, Jung-Woo Choi, Hwa Eun Oh, Young-Sik Kim
    Medicine.2018; 97(42): e12862.     CrossRef
  • EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation
    Si Chen, Fan Yao, Qinghuan Xiao, Qiannan Liu, Yikun Yang, Xuejuan Li, Guanglie Jiang, Takayoshi Kuno, Yue Fang
    Molecular Medicine Reports.2017;[Epub]     CrossRef
  • Aberrant promoter methylation of cancer-related genes in human breast cancer
    Liang Wu, Ye Shen, Xianzhen Peng, Simin Zhang, Ming Wang, Guisheng Xu, Xianzhi Zheng, Jianming Wang, Cheng Lu
    Oncology Letters.2016; 12(6): 5145.     CrossRef
  • Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress
    Daniel Domínguez, Purificación Feijoo, Aina Bernal, Amaia Ercilla, Neus Agell, Anna Genescà, Laura Tusell
    Oncotarget.2015; 6(29): 28238.     CrossRef
  • Relationships Betweenp16Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies
    Yan-Zhi Chen, Dan Liu, Yu-Xia Zhao, He-Tong Wang, Ya Gao, Ying Chen
    DNA and Cell Biology.2014; 33(10): 729.     CrossRef
  • Endocrine disruption of the epigenome: a breast cancer link
    Kevin C Knower, Sarah Q To, Yuet-Kin Leung, Shuk-Mei Ho, Colin D Clyne
    Endocrine-Related Cancer.2014; 21(2): T33.     CrossRef
  • Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma
    Mutsuko Omatsu, Toshiaki Kunimura, Tetsuya Mikogami, Akira Shiokawa, Atsuko Masunaga, Tomoko Nagai, Akihiko Kitami, Takashi Suzuki, Mitsutaka Kadokura
    General Thoracic and Cardiovascular Surgery.2014; 62(11): 678.     CrossRef
  • Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation
    Mounira Krifa, Mahmoud Alhosin, Christian D Muller, Jean-Pierre Gies, Leila Chekir-Ghedira, Kamel Ghedira, Yves Mély, Christian Bronner, Marc Mousli
    Journal of Experimental & Clinical Cancer Research.2013;[Epub]     CrossRef
  • Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients
    Diego M Marzese, Hajime Hirose, Dave S B Hoon
    Expert Review of Molecular Diagnostics.2013; 13(8): 827.     CrossRef
  • Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a
    DAN-SEN WU, JIAN-ZHEN SHEN, AI-FANG YU, HAI-YING FU, HUA-RONG ZHOU, SONG-FEI SHEN
    Oncology Reports.2013; 30(6): 2969.     CrossRef
Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors
Soomin Ahn, Jae Jun Lee, Sang Yun Ha, Chang Ohk Sung, Jhingook Kim, Joungho Han
Korean J Pathol. 2012;46(3):221-225.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.221
  • 7,705 View
  • 72 Download
  • 26 Citations
AbstractAbstract PDF
Background

Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.

Methods

We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.

Results

It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.

Conclusions

In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

Citations

Citations to this article as recorded by  
  • Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)
    Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen
    Seminars in Cancer Biology.2022; 79: 141.     CrossRef
  • Multiple electrolyte disturbances as the presenting feature of multiple endocrine neoplasia type 1 (MEN-1)
    Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E Drakou, Royce P Vincent, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
    Endocrinology, Diabetes & Metabolism Case Reports.2022;[Epub]     CrossRef
  • Metastatic Thymic Carcinoid: Does Surgeon Have a Primary Role?
    Kumud Gupta, Ravindra K. Dewan, Vinitha Viswambharan Nair, Rajat Saxena, Shaleen Prasad
    The Indian Journal of Chest Diseases and Allied Sciences.2022; 56(4): 255.     CrossRef
  • A resected case of large cell neuroendocrine carcinoma of the thymus
    Masashi Umeda, Takahiko Misao, Tomoya Senoh, Yoshinobu Shikatani, Motoi Aoe
    The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 766.     CrossRef
  • Thymic neuroendocrine tumours
    Jan von der Thüsen
    Diagnostic Histopathology.2022;[Epub]     CrossRef
  • Treatment strategy and prognostic analysis of spinal metastases from thymomas: A retrospective study from a single center
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, Siyuan Yao, Yipeng Wang, Yong Liu
    Clinical Neurology and Neurosurgery.2020; 196: 106056.     CrossRef
  • Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy
    Takeaki Hidaka, Saki Okuzumi, Ako Matsuhashi, Hidenori Takahashi, Kazunori Hata, Seiichiro Shimizu, Yoshinobu Iwasaki
    Internal Medicine.2019; 58(4): 563.     CrossRef
  • Surgical management of spinal metastases of thymic carcinoma
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2019; 98(3): e14198.     CrossRef
  • Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature
    Shogo Ogata, Ryo Maeda, Masaki Tomita, Yuichiro Sato, Takanori Ayabe, Kunihide Nakamura
    International Journal of Surgery Case Reports.2019; 60: 53.     CrossRef
  • Metastatic or locally advanced mediastinal neuroendocrine tumours
    Aadil Adnan, Shreyas Kudachi, Sudha Ramesh, Kumar Prabhash, Sandip Basu
    Nuclear Medicine Communications.2019; 40(9): 947.     CrossRef
  • Results of treatment for thymic neuroendocrine tumours: multicentre clinicopathological study†
    Naoko Ose, Hajime Maeda, Masayoshi Inoue, Eiichi Morii, Yasushi Shintani, Hiroshi Matsui, Hirohito Tada, Tositeru Tokunaga, Kenji Kimura, Yasushi Sakamaki, Yukiyasu Takeuchi, Kenjiro Fukuhara, Hiroshi Katsura, Teruo Iwasaki, Meinoshin Okumura
    Interactive CardioVascular and Thoracic Surgery.2018; 26(1): 18.     CrossRef
  • Patterns of Failure Following Postoperative Radiation Therapy Based on “Tumor Bed With Margin” for Stage II to IV Type C Thymic Epithelial Tumor
    Kyung Hwa Lee, Jae Myoung Noh, Yong Chan Ahn, Dongryul Oh, Jhingook Kim, Young Mog Shim, Jung-ho Han
    International Journal of Radiation Oncology*Biology*Physics.2018; 102(5): 1505.     CrossRef
  • Resected thymic large cell neuroendocrine carcinoma: report of a case
    Hiromitsu Domen, Yasuhiro Hida, Masaaki Sato, Haruka Takahashi, Tatsuru Ishikawa, Yosuke Shionoya, Midori Hashimoto, Kaoru Nishiyama, Yuma Aoki, Kazuho Inoko, Syotaro Furukawa, Kazuomi Ichinokawa, Hidehisa Yamada
    Surgical Case Reports.2018;[Epub]     CrossRef
  • Successful treatment of malignant thymoma with sacrum metastases
    Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
    Medicine.2018; 97(51): e13796.     CrossRef
  • Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report
    Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
    Journal of Medical Case Reports.2017;[Epub]     CrossRef
  • Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift
    Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Paolo Bidoli, Stefania Canova, Diego Cortinovis, Maria Ida Abbate, Fiorella Calabrese, Nazarena Nannini, Francesca Lunardi, Giulio Rossi, Stefano La Rosa, Carlo Capella, Elena Tamborini, Federica Perrone,
    Virchows Archiv.2017; 471(1): 31.     CrossRef
  • Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report
    Efared Boubacar, Gabrielle Atsame-Ebang, Sani Rabiou, Ammor Fatimazahra, Asmae Mazti, Ibrahim S. Sidibé, Layla Tahiri, Nawal Hammas, Ouadnouni Yassine, Smahi Mohamed, Chbani Laila, El Fatemi Hinde
    Journal of Medical Case Reports.2017;[Epub]     CrossRef
  • Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver
    Yoriko Nomura, Osamu Nakashima, Jun Akiba, Sachiko Ogasawara, Shogo Fukutomi, Rin Yamaguchi, Hironori Kusano, Masayoshi Kage, Koji Okuda, Hirohisa Yano
    Journal of Clinical Pathology.2017; 70(7): 563.     CrossRef
  • Retrosternal goiter and thymic carcinoid: A rare co-existence
    Abdulsalam Yaseen Taha, Nezar A. Almahfooz, Hassanain H. Khudair
    Journal of the Egyptian Society of Cardio-Thoracic Surgery.2017; 25(4): 369.     CrossRef
  • A case of large-cell neuroendocrine carcinoma of the thymus involving a patient with long-term survival after surgery
    Qiuming Kan, Kohei Tagawa, Teruaki Ishida, Mitsuyo Nishimura, Katsuhiko Aoyama
    The Journal of the Japanese Association for Chest Surgery.2017; 31(7): 927.     CrossRef
  • Neuroendokrine Neoplasien des Mediastinums
    L. Brcic, M. Heidinger, H. Popper
    Der Pathologe.2016; 37(5): 434.     CrossRef
  • Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
    Pier Luigi Filosso, Xiaopan Yao, Usman Ahmad, Yilei Zhan, James Huang, Enrico Ruffini, William Travis, Marco Lucchi, Andreas Rimner, Alberto Antonicelli, Francesco Guerrera, Frank Detterbeck
    The Journal of Thoracic and Cardiovascular Surgery.2015; 149(1): 103.     CrossRef
  • Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
    Young Bae Choi, Go Eun Bae, Na Hee Lee, Jung-Sun Kim, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
    Journal of Korean Medical Science.2015; 30(8): 1062.     CrossRef
  • Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi-institutional clinicopathologic study
    Philipp Ströbel, Andreas Zettl, Konstantin Shilo, Wen-Yu Chuang, Andrew G. Nicholson, Yoshihiro Matsuno, Anthony Gal, Rolf Hubert Laeng, Peter Engel, Carlo Capella, Mirella Marino, John Kwok-Cheung Chan, Andreas Rosenwald, William Travis, Teri J. Franks,
    Genes, Chromosomes and Cancer.2014; 53(9): 738.     CrossRef
  • Disseminated large cell neuroendocrine carcinoma associated with ectopic adrenocorticotropic hormone secretion
    A Van der Walt, K Huddle, S Pather, A Korb
    Journal of Endocrinology, Metabolism and Diabetes of South Africa.2014; 19(1): 40.     CrossRef
  • Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
    Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
    Korean Journal of Pathology.2013; 47(5): 433.     CrossRef
Case Report
Localized Primary Thymic Amyloidosis Presenting as a Mediastinal Mass: A Case Report.
Sang Yun Ha, Jae Jun Lee, Heejung Park, Joungho Han, Hong Kwan Kim, Kyung Soo Lee
Korean J Pathol. 2011;45:S41-S44.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S41
  • 3,125 View
  • 30 Download
  • 3 Citations
AbstractAbstract PDF
We herein describe a case of a 55-year-old healthy woman with localized primary thymic amyloidosis presented as a mediastinal mass, found incidentally by chest radiography. Computed tomography revealed a 4.1 cm soft tissue lesion with nodular calcification in the left anterior mediastinum. The resected specimen was a well-defined lobulating mass with calcification. Microscopically, the mass was consisted of amorphous eosinophilc hyalinized substances involving the thymus and intrathymic lymph nodes. These eosinophilic substances showed apple-green bi-refringence under polarized light after staining with Congo red. In immunohistochemical study, they were positive for kappa and lambda light chains and negative for amyloid A. There was no evidence of systemic amyloidosis in clinical investigations. A final diagnosis of localized primary thymic amyloidosis was made.

Citations

Citations to this article as recorded by  
  • EBUS-TBNA diagnosis of localised amyloidosis presenting as mediastinal lymphadenopathy
    Avnee Kumar, Barathi Sivasailam, Ellen Marciniak, Janaki Deepak
    BMJ Case Reports.2018; 11(1): e226619.     CrossRef
  • Ocular Myasthenia Gravis Associated With Thymic Amyloidosis
    Kristin O. Chapman, Debra M. Beneck, Marc J. Dinkin
    Journal of Neuro-Ophthalmology.2016; 36(1): 50.     CrossRef
  • Localized Thymic Amyloidosis Presenting with Myasthenia Gravis: Case Report
    Seung-Myoung Son, Yong-Moon Lee, Si Wook Kim, Ok-Jun Lee
    Journal of Korean Medical Science.2014; 29(1): 145.     CrossRef
Original Article
Mucoepidermoid Carcinoma of Tracheobronchial Tree: Clinicopathological Study of 31 Cases.
Sang Yun Ha, Joungho Han, Jae Jun Lee, Young Eun Kim, Yoon La Choi, Hong Kwan Kim
Korean J Pathol. 2011;45(2):175-181.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.175
  • 3,567 View
  • 20 Download
  • 8 Citations
AbstractAbstract PDF
BACKGROUND
All aspects of mucoepidermoid carcinoma (MEC) of the lung including histologic grading, clinical behavior and its differentiation from adenosquamous cell carcinoma are still not fully understood.
METHODS
We reviewed the hematoxylin-eosin stained slides and medical records of 31 cases of MEC of the lungs. The cases were classified as low and high grade according to the quantitative grading system formulated for MEC. High grade tumors were tested for an epidermal growth factor receptor (EGFR) mutation.
RESULTS
Twenty eight cases were classified as low grade and 3 cases as high grade. Histologically, lower glandular component, cellular atypia, necrosis, mitoses >4/10 high power fields, and endolymphatic tumor emboli were typical characteristics of a high grade tumor. Although some tumors showed histologic features mimicking high grade tumors, they were classified as low grade tumors according to this quantitative grading system. Low grade tumors showed no recurrence or metastasis. However, among three patients with a high grade tumor, two had distant metastases and one died of disease. Additionally, an EGFR mutation was not detected.
CONCLUSIONS
A high grade MEC was consistently different from a low grade tumor with regard to malignant histologic features and poor prognosis. Therefore, correct histologic grading is important in predicting the prognosis to avoid unnecessary treatment.

Citations

Citations to this article as recorded by  
  • A rare case of endobronchial mucoepidermoid carcinoma of the lung presenting as non-resolving pneumonia
    Toolsie Omesh, Ranjan Gupta, Anjali Saqi, Joshua Burack, Misbahuddin Khaja
    Respiratory Medicine Case Reports.2018; 25: 154.     CrossRef
  • Cutaneous Involvement by Nasal Mucoepidermoid Carcinoma: The Tip of the Iceberg Phenomenon
    Ge Zhao, Oliver Chang, John Streidl, Amit Bhrany, Kyle Garton, Timothy H. McCalmont, Paul E. Swanson, Zsolt Argenyi, Michi M. Shinohara
    Journal of Cutaneous Pathology.2017; 44(2): 113.     CrossRef
  • Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases
    Chih-Cheng Hsieh, Yung-Han Sun, Shih-Wei Lin, Yi-Chen Yeh, Mei-Lin Chan, Pei-Yi Chu
    PLOS ONE.2017; 12(5): e0176918.     CrossRef
  • Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers
    Boram Lee, Taebum Lee, Se-Hoon Lee, Yoon-La Choi, Joungho Han
    Oncotarget.2016; 7(17): 23874.     CrossRef
  • Metastatic Pulmonary Mucoepidermoid Carcinoma with Fulminant Clinical Course
    Yong Won Park, Seon Bin Yoon, Mi Ju Cheon, Young Min Koh, Hyeon Sik Oh, Se Joong Kim, Seung Hyeun Lee
    The Ewha Medical Journal.2015; 38(2): 85.     CrossRef
  • Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR
    Sang Yun Ha, So-Jung Choi, Jong Ho Cho, Hye Joo Choi, Jinseon Lee, Kyungsoo Jung, Darry Irwin, Xiao Liu, Maruja E. Lira, Mao Mao, Hong Kwan Kim, Yong Soo Choi, Young Mog Shim, Woong Yang Park, Yoon-La Choi, Jhingook Kim
    Oncotarget.2015; 6(7): 5465.     CrossRef
  • Bronchoscopic Resection of an Exophytic Endoluminal Tracheal Mass
    Russell J. Miller, Septimiu D. Murgu
    Annals of the American Thoracic Society.2013; 10(6): 697.     CrossRef
  • EGFR mutations and mucoepidermoid carcinoma: Putative significance in differing populations
    Iain D. O’Neill
    Lung Cancer.2012; 78(1): 125.     CrossRef

JPTM : Journal of Pathology and Translational Medicine