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8 "Jhingook Kim"
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Original Articles
Pleural Mesothelioma: An Institutional Experience of 66 Cases
Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn
Korean J Pathol. 2014;48(2):91-99.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.91
  • 7,229 View
  • 62 Download
  • 2 Citations
AbstractAbstract PDF
Background

Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers.

Methods

During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and immunohistochemical slides of pleural mesothelioma and evaluated their pathological and clinical features.

Results

The male-to-female ratio was 1.75:1, and age of patients ranged from 28 to 80 years with an average age of 56.84 years. Twenty-two out of 66 patients underwent curative pneumonectomy. Follow-up data was available in 60 patients (90.9%), and 50 of them (83.3%) died from the disease. The average overall survival was 15.39 months. Histologically, the epithelioid type was the most common, followed by the sarcomatoid and the biphasic types. Epidemiologic information was not available in most cases, and only one patient was confirmed to have a history of asbestos exposure.

Conclusions

Malignant mesothelioma of the pleura is a fatal tumor, and the therapeutic benefit of pneumonectomy remains unproven. The combination of calretinin, Wilms tumor 1, HMBE-1, and thyroid transcription factor-1 may provide high diagnostic accuracy in diagnosing mesothelioma.

Citations

Citations to this article as recorded by  
  • Expression of V-set immunoregulatory receptor in malignant mesothelioma
    Yeon Seung Chung, Moonsik Kim, Yoon Jin Cha, Kyung A Kim, Hyo Sup Shim
    Modern Pathology.2020; 33(2): 263.     CrossRef
  • Is the pathology related to the amount of pleural thickening measured by thorax CT?
    özgür katrancıoğlu, Tuba Sahinoglu, Kayhan Karakus, Ozan Kandemir, Semiha Urvay, Esra Aydın Karakaya, Nurkay Katrancioglu
    Cumhuriyet Medical Journal.2018; 40(2): 157.     CrossRef
Usual Interstitial Pneumonia with Lung Cancer: Clinicopathological Analysis of 43 Cases
Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Kyeongman Jeon, Man Pyo Chung, Jhingook Kim, Joungho Han
Korean J Pathol. 2014;48(1):10-16.   Published online February 25, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.10
  • 8,233 View
  • 67 Download
  • 14 Citations
AbstractAbstract PDF
Background

Previous studies have suggested an association between usual interstitial pneumonia (UIP) and lung cancer (Ca). However, clinical and histological information is not enough to determine such an association, due to the low incidence and short survival time of patients with both conditions.

Methods

We retrospectively reviewed the clinical and histological records of Ca patients with UIP between January 1999 and August 2013 at the Samsung Medical Center, Seoul, Korea. We found 43 patients who had Ca with UIP (UIP-Ca). Previously reported data of eighty-four patients with UIP-only were included as a comparison group.

Results

Smoking is related to poor prognosis in patients with UIP-Ca, and the number of patients with a high smoking index of more than 30 pack-years significantly increased in UIP-Ca patients compared with UIP-only patients. There is no significant prognostic differentiation between UIP-Ca patients and UIP-only patients. Microscopically, UIP-Ca patients showed characteristically heterogeneous histological patterns and degrees of differentiation. There were many foci of squamous metaplasia or dysplasia at the peripheral area of squamous cell carcinomas.

Conclusions

We report 43 cases of UIP-Ca. Our results suggest that smoking is related to cancer occurrence in UIP patients and poor prognosis in UIP-Ca patients.

Citations

Citations to this article as recorded by  
  • Prognosis of idiopathic pulmonary fibrosis without anti-fibrotic therapy: a systematic review
    Yet H. Khor, Yvonne Ng, Hayley Barnes, Nicole S.L. Goh, Christine F. McDonald, Anne E. Holland
    European Respiratory Review.2020; 29(157): 190158.     CrossRef
  • Linfoma difuso de células B grandes pulmonar en paciente con neumonía intersticial no específica
    Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
    Reumatología Clínica.2019; 15(6): e151.     CrossRef
  • Diffuse Large B-cell Lymphoma of the Lung in a Patient With Nonspecific Interstitial Pneumonia
    Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
    Reumatología Clínica (English Edition).2019; 15(6): e151.     CrossRef
  • Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
    Joo Heung Yoon, Mehdi Nouraie, Xiaoping Chen, Richard H Zou, Jacobo Sellares, Kristen L Veraldi, Jared Chiarchiaro, Kathleen Lindell, David O Wilson, Naftali Kaminski, Timothy Burns, Humberto Trejo Bittar, Samuel Yousem, Kevin Gibson, Daniel J Kass
    Respiratory Research.2018;[Epub]     CrossRef
  • Genomic profiles of lung cancer associated with idiopathic pulmonary fibrosis
    Ji An Hwang, Deokhoon Kim, Sung-Min Chun, SooHyun Bae, Joon Seon Song, Mi Young Kim, Hyun Jung Koo, Jin Woo Song, Woo Sung Kim, Jae Cheol Lee, Hyeong Ryul Kim, Chang-Min Choi, Se Jin Jang
    The Journal of Pathology.2018; 244(1): 25.     CrossRef
  • Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study
    Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida
    BMC Pulmonary Medicine.2018;[Epub]     CrossRef
  • Alveolar Squamous Cell Metaplasia: Preneoplastic Lesion?
    Adriana Handra-Luca
    Journal of Pathology and Translational Medicine.2018; 52(6): 355.     CrossRef
  • Low expression of long noncoding RNA CDKN2B-AS1 in patients with idiopathic pulmonary fibrosis predicts lung cancer by regulating the p53-signaling pathway
    Yufeng Du, Xiaoyan Hao, Xuejun Liu
    Oncology Letters.2018;[Epub]     CrossRef
  • A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia
    Yasutaka Watanabe, Yoshinori Kawabata, Nobuyuki Koyama, Tomohiko Ikeya, Eishin Hoshi, Noboru Takayanagi, Shinichiro Koyama
    Respiratory Medicine.2017; 129: 158.     CrossRef
  • Risk of the preoperative underestimation of tumour size of lung cancer in patients with idiopathic interstitial pneumonias
    Mariko Fukui, Kazuya Takamochi, Takeshi Matsunaga, Shiaki Oh, Katsutoshi Ando, Kazuhiro Suzuki, Atsushi Arakawa, Toshimasa Uekusa, Kenji Suzuki
    European Journal of Cardio-Thoracic Surgery.2016; 50(3): 428.     CrossRef
  • The Idiopathic Interstitial Pneumonias: Histology and Imaging
    Diane C. Strollo, Teri J. Franks, Jeffrey R. Galvin
    Seminars in Roentgenology.2015; 50(1): 8.     CrossRef
  • Do Chest Expansion Exercises Aid Re-shaping the Diaphragm Within the First 72 Hours Following Lung Transplantation in a Usual Interstitial Pneumonia Patient?
    Massimiliano Polastri, Erika Venturini, Saverio Pastore, Andrea Dell'Amore
    Physiotherapy Research International.2015; 20(3): 191.     CrossRef
  • Scrotal wall metastasis from a primary lung adenocarcinoma
    Marie-Louise M. Coussa-Koniski, Pia A. Maalouf, Nehme E. Raad, Noha A. Bejjani
    Respiratory Medicine Case Reports.2015; 15: 77.     CrossRef
  • The Ratio KL-6 to SLX in Serum for Prediction of the Occurrence of Drug-Induced Interstitial Lung Disease in Lung Cancer Patients with Idiopathic Interstitial Pneumonias Receiving Chemotherapy
    Kosuke Kashiwabara, Hiroshi Semba, Shinji Fujii, Shinsuke Tsumura, Ryota Aoki
    Cancer Investigation.2015; 33(10): 516.     CrossRef
Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases
Yoon Yang Jung, Min Eui Hong, Joungho Han, Tae Sung Kim, Jhingook Kim, Young-Mog Shim, Hojoong Kim
Korean J Pathol. 2013;47(4):326-331.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.326
  • 6,614 View
  • 57 Download
  • 13 Citations
AbstractAbstract PDF
Background

It has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic.

Methods

We reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features.

Results

The present study included five female and two male patients, with ages ranging from 16 to 81 years (mean age, 44.9 years). The clinical presentation varied according to tumor size and location. Patients with more centrally (trachea or main bronchus) located tumors experienced respiratory symptoms (80%) more often than patients with more peripherally (lobar or segmental bronchus) located tumors (0%). Histologically, the tumors were composed of spindle cells that stained with S100 protein. Some of the tumors showed typical Antoni A areas with Verocay body formation. Five of six patients (83.3%) underwent complete tumor removal by rigid bronchoscopy.

Conclusions

Pathologists should consider endobronchial schwannoma in the differential diagnosis of a spindle cell tumor involving the bronchus. Additionally, our results showed that rigid bronchoscopy is an effective tool for tumor removal in endobronchial schwannoma patients.

Citations

Citations to this article as recorded by  
  • Treatment of primary tracheal schwannoma with endoscopic resection: A case report
    Yong-Shuai Shen, Xiang-Dong Tian, Yi Pan, Hua Li
    World Journal of Clinical Cases.2022; 10(28): 10279.     CrossRef
  • Primary bronchial schwannoma: A case report
    Yosuke Aoyama, Atsushi Miyamoto, Takeshi Fujii, Sakashi Fujimori, Meiyo Tamaoka, Daiya Takai
    Medicine.2022; 101(40): e31062.     CrossRef
  • Endobronchial schwannoma in adult: A case report
    Touil Imen, Boudaya Mohamed Sadok, Aloui Raoudha, Souhir Ksissa, Brahem Yosra, Ben Attig Yosr, Ksontini Meriem, Bouchareb Soumaya, Keskes Boudawara Nadia, Boussoffara Leila, Knani Jalel
    Respiratory Medicine Case Reports.2021; 33: 101396.     CrossRef
  • Primary intratracheal schwannoma misdiagnosed as severe asthma in an adolescent: A case report
    Hui-Rong Huang, Pei-Qiang Li, Yi-Xin Wan
    World Journal of Clinical Cases.2021; 9(17): 4388.     CrossRef
  • PD ‐1/ PD‐L1 negative schwannoma mimicking obstructive bronchial malignancy: A case report
    Daibing Zhou, Xiaoyan Xing, Jie Fan, Youzhi Zhang, Jie Liu, Yi Gong
    Thoracic Cancer.2020; 11(8): 2335.     CrossRef
  • Case report: A tracheobronchial schwannoma in a child
    Li Zhang, Wen Tang, Qing-Shan Hong, Pei-feng Lv, Kui-Ming Jiang, Rui Du
    Respiratory Medicine Case Reports.2020; 30: 101047.     CrossRef
  • Recurrent transmural tracheal schwannoma resected by video-assisted thoracoscopic window resection
    Huiguo Chen, Kai Zhang, Mingjun Bai, Haifeng Li, Jian Zhang, Lijia Gu, Weibin Wu
    Medicine.2019; 98(51): e18180.     CrossRef
  • Primary intratracheal schwannoma resected during bronchoscopy using argon plasma coagulation
    Purva V Sharma, Yash B Jobanputra, Tatiana Perdomo Miquel, J Ryan Schroeder, Adam Wellikoff
    BMJ Case Reports.2018; : bcr-2018-225140.     CrossRef
  • Dumbbell posterior mediastinal schwannoma invading trachea: Multidisciplinary management – weight off the chest
    Abhijeet Singh, VallandramamR Pattabhiraman, Arjun Srinivasan, Sivaramakrishnan Mahadevan
    Lung India.2018; 35(3): 269.     CrossRef
  • Primary tracheal schwannoma a review of a rare entity: current understanding of management and followup
    Shadi Hamouri, Nathan M. Novotny
    Journal of Cardiothoracic Surgery.2017;[Epub]     CrossRef
  • A Case of Primary Tracheal Schwannoma
    Sung Min Choi, Ji Hong You, Sang Bae Lee, Seong Han Kim, Yon Soo Kim
    Kosin Medical Journal.2017; 32(2): 258.     CrossRef
  • Endobronchial Neurilemmoma Mimicking a Bronchial Polyp
    Ryoung Eun Ko, Seung Yong Park, Yeong Hun Choe, So Ri Kim, Heung Bum Lee, Yong Chul Lee, Seoung Ju Park
    Soonchunhyang Medical Science.2015; 21(2): 176.     CrossRef
  • Optimal treatment for primary benign intratracheal schwannoma: A case report and review of the literature
    XIAHUI GE, FENGFENG HAN, WENBIN GUAN, JINYUAN SUN, XUEJUN GUO
    Oncology Letters.2015; 10(4): 2273.     CrossRef
Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors
Soomin Ahn, Jae Jun Lee, Sang Yun Ha, Chang Ohk Sung, Jhingook Kim, Joungho Han
Korean J Pathol. 2012;46(3):221-225.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.221
  • 7,705 View
  • 72 Download
  • 26 Citations
AbstractAbstract PDF
Background

Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.

Methods

We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.

Results

It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.

Conclusions

In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

Citations

Citations to this article as recorded by  
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    Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen
    Seminars in Cancer Biology.2022; 79: 141.     CrossRef
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    Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E Drakou, Royce P Vincent, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
    Endocrinology, Diabetes & Metabolism Case Reports.2022;[Epub]     CrossRef
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    The Indian Journal of Chest Diseases and Allied Sciences.2022; 56(4): 255.     CrossRef
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    The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 766.     CrossRef
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    Diagnostic Histopathology.2022;[Epub]     CrossRef
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Pulmonary Vascular Sarcomas: Clinicopathologic Analysis of 14 Cases.
Na Rae Kim, Jhingook Kim, Seung Yeon Ha, Joungho Han
Korean J Pathol. 2011;45(2):132-138.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.132
  • 3,353 View
  • 21 Download
  • 3 Citations
AbstractAbstract PDF
BACKGROUND
Pulmonary vessel sarcomas are rare, and their pathogenesis is still unclear.
METHODS
We focus on the pathologic findings of fourteen pulmonary artery and/or vein sarcomas along with clinical prognosis.
RESULTS
Nine patients were male and five were female, and they ranged in age from 26 to 72 years (mean, 47 years). There were ten cases of pulmonary artery sarcoma, three cases of pulmonary artery and vein sarcoma, and one case of pure pulmonary vein sarcoma. Ten out of the fourteen cases were associated with pulmonary thromboembolism. Microscopically, all the tumors showed an undifferentiated sarcomatous portion. There were leiomyosarcoma portions in 8 cases, malignant fibrous histiocytomatous portions in 7 cases, angiosarcomatous differentiation in 3 cases, and osteosarcomatous portion in 1 case. All but two patients died during the follow up period (range, 1 to 78 months). The mean survival time of the patients who died was 14 months and the longest survival time was 78 months after surgical resection.
CONCLUSIONS
The current study is one of the largest single institutional reviews of pulmonary artery and/or vein sarcoma. Regardless of the histological components and macroscopic growth patterns, these rare tumors have a grave prognosis.

Citations

Citations to this article as recorded by  
  • Intimal Sarcoma of the Great Vessels
    Alan M. Ropp, Allen P. Burke, Seth J. Kligerman, Jay S. Leb, Aletta A. Frazier
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Alveolar Soft Part Sarcoma of the Lung: A Report of Six Cases and Clinicopathological Analysis.
Na Rae Kim, Mi Sook Lee, Young Cheol Yoon, Dae Su Kim, Kyong Soo Lee, Gee Young Suh, Jhingook Kim, Joung Ho Han
Korean J Pathol. 2003;37(2):87-92.
  • 1,553 View
  • 25 Download
AbstractAbstract PDF
BACKGROUND
Alveolar soft part sarcoma (ASPS) accounts for 0.5-1% of soft tissue sarcomas, and often metastasizes to the lung. Cases of pulmonary ASPS of unknown primary site have rarely been reported in literature.
METHODS
Here, we report three cases of metastatic pulmonary ASPS and three cases of presumably primary ASPS using immunohistochemistry and clinicoradiologic findings.
RESULTS
All of the cases occurred in young females. Two of the cases had metastasized from soft tissue ASPS of the lower extremities, and one case had metastasized from one of the patient? femur bones. Immunohistochemical stains were applied to four cases that had available paraffin blocks. The tumor cells of all cases on which immunohistochemical stains were done were positive for vimentin (4/4, 100%). None of the tumors were positive for myoglobin, desmin, smooth muscle actin, progesterone receptor, estrogen receptor, thyroid transcription factor-1, S-100 protein, pancytokeratin, and HMB-45 antibodies.
CONCLUSION
The present study revealed that the rare pulmonary ASPS has nonspecific clinicoradiologic findings. In the immunohistochemical results, no differences existed between the presumably primary ASPS and the metastatic ASPS except for a higher Ki-67 labeling index in the latter (less than 0.1% vs. 30%). The higher index was not dissimilar to those of the extrapulmonary ASPS which showed a tumor with a low proliferation index, signifying a better prognosis and have a low potential to metastasize.
Case Reports
Solitary Pulmonary Mixed Squamous Cell and Glandular Papilloma: A Brief Case Report.
Chan Ohk Sung, Jhingook Kim, In Gu Do, Joungho Han
Korean J Pathol. 2008;42(6):393-395.
  • 1,535 View
  • 10 Download
AbstractAbstract
Pulmonary mixed squamous cell and glandular papillomas are extremely rare-only a few cases have been reported worldwide. We report a case of mixed squamous cell and glandular papilloma that presented as a solitary pulmonary nodule in a 53-year-old man. The tumor was located in the peripheral small bronchus of the posterobasal segment of the right lower lobe. Microscopically, the tumor was composed of papillary structures lined by squamous and glandular epithelium with mucous material. The fibrovascular cores showed lymphoplasmacytic infiltrates.
Placental Transmogrification of the Lung: A Brief Case Report.
Eun Su Park, Joungho Han, Won Jung Koh, Kyung Soo Lee, Jhingook Kim, Jinwon Seo, Jiyoung Kim
Korean J Pathol. 2008;42(5):308-310.
  • 1,673 View
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AbstractAbstract PDF
Placental transmogrification (PT) is an unusual condition in which the alveoli develop a peculiar villous configuration that resembles the placental villi. We report a rare case of pulmonary PT in a 46-year-old man who presented with multiple cystic lesions and nodules on radiography. The patient was treated with a surgical excision. The cut surface of the lung lesion had a villous spongiform manifestation with a partly yellow granular appearance. Microscopically, multiple papillary cores mimicking the villous structures of the placenta were observed within the bullous airspaces. These papillary cores contained many vascular structures, lymphoid aggregates, interstitial clear cells, mature fat and dystrophic calcification. This case was solitary and not associated with other pulmonary or systemic diseases. The etiology is unknown, and further studies will be needed to understand the pathogenesis of the lesion.

JPTM : Journal of Pathology and Translational Medicine