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Original Article
Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng
J Pathol Transl Med. 2017;51(1):32-39.   Published online December 25, 2016
DOI: https://doi.org/10.4132/jptm.2016.10.17
  • 7,493 View
  • 175 Download
  • 19 Citations
AbstractAbstract PDF
Background
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.
Methods
AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.
Results
AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).
Conclusions
AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients.

Citations

Citations to this article as recorded by  
  • Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer
    Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
    Cellular and Molecular Gastroenterology and Hepatology.2022; 13(2): 517.     CrossRef
  • Colorectal cancer on a dish: exploring the 3D-sphere culture of primary colorectal cancer cells from an Indonesian perspective
    Murdani Abdullah, DR Noor, Amanda Pitarini Utari, Virly Nanda Muzellina, Nur Rahadiani, Radiana Dhewayani Antarianto
    F1000Research.2022; 11: 182.     CrossRef
  • Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
    Chang-Hyeon Kim, Da-Eun Kim, Dae-Hoon Kim, Ga-Hong Min, Jung-Won Park, Yeo-Bin Kim, Chang K. Sung, Hyungshin Yim
    Experimental & Molecular Medicine.2022; 54(4): 414.     CrossRef
  • AURKA is a prognostic biomarker for good overall survival in stage II colorectal cancer patients
    Peter Jung, David Horst, Thomas Kirchner, Frederick Klauschen, Jens Neumann
    Pathology - Research and Practice.2022; 235: 153936.     CrossRef
  • Therapeutic Potential of Mitotic Kinases’ Inhibitors in Cancers of the Gastrointestinal System
    Aadil Javed, Gianluca Malagraba, Mahdieh Yarmohammadi, Catalina M. Perelló-Reus, Carles Barceló, Teresa Rubio-Tomás
    Future Pharmacology.2022; 2(3): 214.     CrossRef
  • Bioinformatics Analysis of RNA-seq Data Reveals Genes Related to Cancer Stem Cells in Colorectal Cancerogenesis
    Kristian Urh, Nina Zidar, Emanuela Boštjančič
    International Journal of Molecular Sciences.2022; 23(21): 13252.     CrossRef
  • Unweaving the mitotic spindle: A focus on Aurora kinase inhibitors in lung cancer
    Alessio Stefani, Geny Piro, Francesco Schietroma, Alessandro Strusi, Emanuele Vita, Simone Fiorani, Diletta Barone, Federico Monaca, Ileana Sparagna, Giustina Valente, Miriam Grazia Ferrara, Ettore D’Argento, Mariantonietta Di Salvatore, Carmine Carbone,
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer
    Jiyoon Jung, Hoiseon Jeong, Jung-Woo Choi, Hye-Sun Kim, Hwa Eun Oh, Eung Seok Lee, Young-Sik Kim, Ju-Han Lee
    Pathology - Research and Practice.2021; 224: 153524.     CrossRef
  • SALL Proteins; Common and Antagonistic Roles in Cancer
    Claudia Álvarez, Aracelly Quiroz, Diego Benítez-Riquelme, Elizabeth Riffo, Ariel F. Castro, Roxana Pincheira
    Cancers.2021; 13(24): 6292.     CrossRef
  • AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children
    Yong-Ping Chen, Li Yuan, Hui-Ran Lin, Xiao-Kai Huang, Ji-Chen Ruan, Zhen-Jian Zhuo
    Discover Oncology.2021;[Epub]     CrossRef
  • Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA
    Xiaojiang Liu, Yaru Zhang, Siqi Wu, Minmin Xu, Youfeng Shen, Min Yu, Jinhua Fan, Sijia Wei, Chaohang Xu, Lu Huang, Han Zhao, Xuegang Li, Xiaoli Ye
    Biochemical Pharmacology.2020; 175: 113933.     CrossRef
  • New landscapes and horizons in hepatocellular carcinoma therapy
    Melchiorre Cervello, Maria R. Emma, Giuseppa Augello, Antonella Cusimano, Lydia Giannitrapani, Maurizio Soresi, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Alessandro Gulino, Beatrice Belmonte, Giuseppe Montalto, James A. McCubrey
    Aging.2020; 12(3): 3053.     CrossRef
  • The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes
    Anna Maria Grimaldi, Federica Conte, Katia Pane, Giulia Fiscon, Peppino Mirabelli, Simona Baselice, Rosa Giannatiempo, Francesco Messina, Monica Franzese, Marco Salvatore, Paola Paci, Mariarosaria Incoronato
    International Journal of Molecular Sciences.2020; 21(18): 6690.     CrossRef
  • The GTEx Consortium atlas of genetic regulatory effects across human tissues
    François Aguet, Shankara Anand, Kristin G. Ardlie, Stacey Gabriel, Gad A. Getz, Aaron Graubert, Kane Hadley, Robert E. Handsaker, Katherine H. Huang, Seva Kashin, Xiao Li, Daniel G. MacArthur, Samuel R. Meier, Jared L. Nedzel, Duyen T. Nguyen, Ayellet V.
    Science.2020; 369(6509): 1318.     CrossRef
  • Upregulation of aurora kinase A promotes vascular smooth muscle cell proliferation and migration by activating the GSK-3β/β-catenin pathway in aortic-dissecting aneurysms
    Jia Meng, He-Liang Liu, Dong Ma, Hong-Yan Wang, Yue Peng, Hong-Li Wang
    Life Sciences.2020; 262: 118491.     CrossRef
  • Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1
    Lihong Wang-Bishop, Zheng Chen, Ahmed Gomaa, Albert Craig Lockhart, Safia Salaria, Jialiang Wang, Keeli B. Lewis, Jeffrey Ecsedy, Kay Washington, Robert Daniel Beauchamp, Wael El-Rifai
    Gastroenterology.2019; 156(3): 662.     CrossRef
  • Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer
    Kulbe, Otto, Darb-Esfahani, Lammert, Abobaker, Welsch, Chekerov, Schäfer, Dragun, Hummel, Leser, Sehouli, Braicu
    Cells.2019; 8(7): 713.     CrossRef
  • Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
    Ahmed Gomaa, Dunfa Peng, Zheng Chen, Mohammed Soutto, Khaled Abouelezz, Alejandro Corvalan, Wael El-Rifai
    Scientific Reports.2019;[Epub]     CrossRef
  • The functional diversity of Aurora kinases: a comprehensive review
    Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister
    Cell Division.2018;[Epub]     CrossRef
Brief Case Report
A Rare Case of Nodular Mucinosis of the Breast
Hyun Min Koh, Young Hee Maeng, Bo Geun Jang, Jae Hyuk Choi, Chang lim Hyun
J Pathol Transl Med. 2017;51(3):332-334.   Published online December 5, 2016
DOI: https://doi.org/10.4132/jptm.2016.07.26
  • 6,340 View
  • 119 Download
  • 6 Citations
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Citations

Citations to this article as recorded by  
  • New and emerging conditions of acquired cutaneous mucinoses in adults
    F. Rongioletti
    Journal of the European Academy of Dermatology and Venereology.2022; 36(7): 1016.     CrossRef
  • Altered presence of extra cellular matrix components in murine skin cancer: Modulation by Azadirachta indica leaf extract
    N.A. Chugh, A. Koul
    Journal of Traditional and Complementary Medicine.2021; 11(3): 197.     CrossRef
  • Mucinosis nodular de la mama
    Bernardo Weil Lara, Daniela Pérez Martínez, Beatriz Romero Madrid
    Revista Española de Patología.2020; 53(1): 42.     CrossRef
  • Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice
    Ashwani Koul, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, Neha Arora Chugh
    International Journal for Vitamin and Nutrition Research.2020; 90(5-6): 493.     CrossRef
  • A review of mucinous lesions of the breast
    Paula S. Ginter, Xiaoyu Tang, Sandra J. Shin
    The Breast Journal.2020; 26(6): 1168.     CrossRef
  • Mesenchymal Lesions of the Breast: What Radiologists Need to Know
    Debra S. Whorms, Michael D. C. Fishman, Priscilla J. Slanetz
    American Journal of Roentgenology.2018; 211(1): 224.     CrossRef
Original Article
Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis
Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon Mee Kim, Hye Seung Han, Won Ae Lee, Yoon Jung Choi, Dong Wook Kang, Sunhoo Park, Jae Hyuk Lee, Mee-Yon Cho
Korean J Pathol. 2013;47(3):245-251.   Published online June 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.245
  • 8,586 View
  • 54 Download
  • 1 Citations
AbstractAbstract PDF
Background

The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis.

Methods

We collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists.

Results

The average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma.

Conclusions

Further research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.

Citations

Citations to this article as recorded by  
  • Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
    Yun Kyung Kang
    Clinical Endoscopy.2014; 47(5): 404.     CrossRef
Case Report
Lymphadenopathy of Kimura's disease Associated with Nephrotic Syndrome: A case report.
Bohong Hee Kim, Myung Suk Kang, Young Hee Maeng, Young Koo Park, Juhie Lee, Moon Ho Yang
Korean J Pathol. 1995;29(1):113-115.
  • 1,601 View
  • 14 Download
AbstractAbstract PDF
Kimura's disease is an important category of reactive lymphadenopathy especially among Asians. It is a chronic inflammatory disorder of unknown etiology and is characterized by angiolymphoid proliferation and eosinophilia. The patient was a 17-year-old man with a 3-year-history of submandibular lymphadenopathy Who was referred to Kyung Hee University Hospital for evaluation of enlarging mass. He had a history of nephrotic syndrome for 7-8 years since 1984. Laboratory findings were not specific except for peripheral blood eosinophilia. The submandibular lymph node showed florid germinal enters, increased postcapillary venules in the paracortex, eosinophilic infiltration, and sclerosis. In this paper, a case of lymphadenopathy of Kimura's disease associated with nephrotic syndrome is reported.
Original Article
CD30 (Ber H2) Distribution in Hodgkin's Disease and non-Hodgkin's Lymphoma.
Bong Hee Kim, Young Hee Maeng, Ju Hie Lee, Moon Ho Yang
Korean J Pathol. 1994;28(4):381-388.
  • 1,516 View
  • 19 Download
AbstractAbstract PDF
Forty one cases of Hodgkin's disease and non-Hodgkin's lymphomas were immunohisto-chemi-cally studied for the presence of CD30 antigen on the paraffin embedded formaldehyde fixed tissue by using Ber H2(CD30) monoclonal antibody (Dakopatts, diluted l : 20) and avidin biotin peroxidase complex technique seventy five %(6/8) of Hodgkin's lymphoma and 27% (9/33) of non-Hodgkin's lymphomas were CD30 positive. Five of l7 diffuse large cell and immunoblastic lymphoma and one large cell anaplastic lymphoma showed large numbers of CD30 positive cells. Occasional CD30 positive cells were found in one of 2 angiommunoblastic lymphadenopathy-like T cell lymphoma, one of 4 small lymphocytic lymphoma and one unclassified lymphoma. Immunophenotypically l6% of B cell lymphoma and 42% of T cell lymphoma showed CD30 positivity. six cases of Hodgkin's disease except lymphocyte predominance showed positive tumor cells. Our results show that CD30 is more widespread in histologic subtypes of lymphomas and is not specific for the diagnosis of Hodgkin's disease.
Case Reports
Inflammatory Pseudotumor of the Liver: A case report.
Young Hee Maeng, Jae Hoon Park, Youn Wha Kim, Yong Koo Park, Ju Hie Lee, Moon Ho Yang
Korean J Pathol. 1994;28(1):90-92.
  • 1,285 View
  • 10 Download
AbstractAbstract PDF
Inflammatory pseudotumor of the Aver is a rare benign lesion that usually has been discovered at laparotomy. This lesion is inflamrhatory and reactive, but the etiology remains unknown. In-flammatory pseudotumor of the liver is of the interest not only because of its rarity also because it needs to be clinically differentiated from hepatocellular carcinoma and other malignant tu-mors. In this report, we describe a case of inflammatory pseudotumor of the liver with fever and weight loss in a 46-year-old male. Grossly, the lesion showed a rather well demarcated, gray white to pale yellowish nodular mass mesuring 7 x 5.5 x 5 cm in dimensions. M icroscqpically, the tumor was composed of diffuse infiltration of predominantly plasma cells, lymphocytes and histocytes associated with fibroblastic proliferation.
Lipoleiomyoma of the Uterus: A case report.
Myung Sook Kang, Young Hee Maeng, Jae Hoon Park, Yun Wha Kim, Ju Hee Lee, Moon Ho Yang
Korean J Pathol. 1993;27(5):535-537.
  • 1,356 View
  • 22 Download
AbstractAbstract PDF
A rare case of uterine lipoleiomyoma is reported with presentation of computed tomography, histomorphologic and immunohistochemical findings. This tumor is predominantly lipomatous with an admixture of smooth muscle fiber and hyalinized fibrous tissue. Immunohistochemical study revealed a positive reaction of S-100 protein in fat cells and desmin in smooth muscle fibers. Its histogenesis also has been discussed.

JPTM : Journal of Pathology and Translational Medicine