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Review & Perspective
Acinar Cell Carcinoma of the Pancreas: Clinical and Cytomorphologic Characteristics
Adam D. Toll, Ralph H. Hruban, Syed Z. Ali
Korean J Pathol. 2013;47(2):93-99.   Published online April 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.93
  • 14,191 View
  • 90 Download
  • 20 Crossref
AbstractAbstract PDF

Acinar cell carcinoma is a rare malignant epithelial neoplasm with predominantly exocrine acinar differentiation and is seen primarily in older men (mean age, 62 years). The presenting symptoms are usually non-specific, and jaundice is often not present. Symptoms relating to the overproduction and release of lipase into the circulation are present in 10-15% of patients. Characteristic cytomorphologic features include a population of cells with minimal pleomorphism, eccentrically placed nuclei with a single prominent nucleoli and moderate hyperchromasia. The cytoplasm is finely granular, and the background may contain granular debris secondary to cytolysis. A significant proportion of the cases also have a minor neuroendocrine component or scattered neuroendocrine cells. Approximately 50% of patients have metastatic disease at presentation, often restricted to the regional lymph nodes and liver. The prognosis is poor, only slightly better than that of pancreatic ductal adenocarcinoma.

Citations

Citations to this article as recorded by  
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    Shinnosuke Nakayama, Akihisa Fukuda, Tadayuki Kou, Manabu Muto, Hiroshi Seno
    Clinical Journal of Gastroenterology.2023; 16(4): 610.     CrossRef
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    Ana Veron Sanchez, Nuria Santamaria Guinea, Silvia Cayon Somacarrera, Ilias Bennouna, Martina Pezzullo, Maria Bali
    Diagnostics.2023; 13(16): 2719.     CrossRef
  • Pancreatic acinar cell carcinoma: A comprehensive review
    Luis Fernando Calimano-Ramirez, Taher Daoud, Dheeraj Reddy Gopireddy, Ajaykumar C Morani, Rebecca Waters, Kazim Gumus, Albert Russell Klekers, Priya R Bhosale, Mayur K Virarkar
    World Journal of Gastroenterology.2022; 28(40): 5827.     CrossRef
  • Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: A case report and review of literature
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    World Journal of Gastroenterology.2022; 28(45): 6420.     CrossRef
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Original Article
Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
Min Jung Jung, Joon Seon Song, Sang Yoon Kim, Soon Yuhl Nam, Jong-Lyel Roh, Seung-Ho Choi, Sung-Bae Kim, Kyung-Ja Cho
Korean J Pathol. 2013;47(1):36-43.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.36
  • 12,005 View
  • 93 Download
  • 71 Crossref
AbstractAbstract PDF
Background

A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features.

Methods

Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor.

Results

Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive.

Conclusions

MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.

Citations

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Case Report
Acinic Cell Carcinoma of the Palatine Tonsil: A Brief Case Report.
Hun Soo Kim, Keum Ha Choi
Korean J Pathol. 2010;44(4):441-443.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.441
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AbstractAbstract PDF
Acinic cell carcinoma (ACC) is a rare, low-grade malignancy of the salivary glands. Most cases occur in the major salivary glands, especially the parotid gland, with only a few cases involving the minor salivary gland previously described. A 67-year-old male patient was admitted complaining of an obstructive feeling in the throat. On examination, a lobulated mass in the tonsillar surface was noticed. Tonsillectomy was performed under general anesthesia. Histopathological examination of the mass revealed sheets of large, polygonal acinar cells with granular, slightly basophilic cytoplasm, which led to the diagnosis of ACC. Here, we present a case of low-grade ACC of the palatine tonsil, which we believe to be the first reported case of ACC in this location.

Citations

Citations to this article as recorded by  
  • A case of unusual heteratopic salivary gland tissue mimicking tonsillar neoplasm and review of literature
    Aysegul Sule Altindal, Nermin Unal
    Journal of Otolaryngology-ENT Research.2018;[Epub]     CrossRef

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