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Case Report
Solitary Peutz-Jeghers type harmartomatous polyp in duodenum with gastric foveolar epithelium: a case report
Eugene Choi, Junghwan Lee, Youngsoo Park
J Pathol Transl Med. 2023;57(2):128-131.   Published online January 10, 2023
DOI: https://doi.org/10.4132/jptm.2022.11.07
  • 1,174 View
  • 146 Download
AbstractAbstract PDF
Peutz-Jeghers type hamartomatous polyp is known to be associated with Peutz-Jeghers syndrome, which shows characteristic multiple hamartomatous polyp involvement in the gastrointestinal tract, combined with mucocutaneous symptom, familial history of Peutz- Jeghers syndrome or STK11/LTB1 mutation. However, some cases showing histologic appearance of the polyps discovered in Peutz- Jeghers syndrome while lacking other diagnostic criteria of the syndrome have been reported, and these are called solitary Peutz- Jeghers type polyps. Herein, we report a case of solitary Peutz-Jeghers type polyp covered with heterotopic epithelium. The patient was 47-year-old female without any mucocutaneous symptoms nor familial history of Peutz-Jeghers syndrome. Microscopic examination revealed Peutz-Jeghers type hamartomatous polyp in duodenum covered with gastric type foveolar epithelium. Considering the definition of hamartomatous polyp, which is, the abnormal overgrowth of the indigenous epithelial component, the histological feature of current case is noteworthy in a point that it shows proliferation of heterotopic component, rather than the indigenous component.
Case Study
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
Ji Hye Moon, Kyoungbun Lee, Han-Kwang Yang, Woo Ho Kim
J Pathol Transl Med. 2018;52(3):179-182.   Published online December 27, 2017
DOI: https://doi.org/10.4132/jptm.2017.10.09
  • 6,190 View
  • 155 Download
  • 6 Web of Science
  • 6 Crossref
AbstractAbstract PDF
We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea.

Citations

Citations to this article as recorded by  
  • Relationship Between Immunophenotypes, Genetic Profiles, and Clinicopathologic Characteristics in Small Bowel Adenocarcinoma
    Aitoshi Hoshimoto, Atsushi Tatsuguchi, Takeshi Yamada, Sho Kuriyama, Ryohei Hamakubo, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Keigo Mitsui, Shu Tanaka, Shunji Fujimori, Tsutomu Hatori, Akira Shimizu, Katsuhiko Iwakiri
    American Journal of Surgical Pathology.2024; 48(2): 127.     CrossRef
  • Recurrence of Brunner Gland Adenocarcinoma After Duodenectomy and Gastrojejunostomy
    Paul Hong, Marcel Ghanim, Abdul Haseeb, Xianzhong Ding, Ayokunle T. Abegunde
    ACG Case Reports Journal.2023; 10(6): e01060.     CrossRef
  • HER2-positive adenocarcinoma arising from heterotopic pancreas tissue in the duodenum: A case report
    Yoshifumi S Hirokawa, Takashi Iwata, Yoshinaga Okugawa, Koji Tanaka, Hiroyuki Sakurai, Masatoshi Watanabe
    World Journal of Gastroenterology.2021; 27(28): 4738.     CrossRef
  • Brunner’s gland adenoma is a rare cause of upper gastrointestinal bleeding: A case report and literature review
    Nader Bakheet, Ahmed Cordie, Mohamed Nabil alkady, Ibrahim Naguib
    Arab Journal of Gastroenterology.2020; 21(2): 122.     CrossRef
  • Brunner's Gland Adenocarcinoma in an Aged Western Gorilla (Gorilla gorilla)
    Jun Sasaki, Ippei Muneuchi, Kanako Ushio, Chihiro Sochi, Youichi Irie, Kazunori Yoshizumi, Waturu Hashimoto
    Journal of Comparative Pathology.2020; 181: 47.     CrossRef
  • Adenocarcinoma of the duodenum arising from Brunner’s gland resected by partial duodenectomy: a case report
    Tetsuya Mochizuki, Nobuaki Fujikuni, Koichi Nakadoi, Masahiro Nakahara, Kazuaki Tanabe, Shuji Yonehara, Toshio Noriyuki
    Surgical Case Reports.2019;[Epub]     CrossRef
Case Report
Duodenal Somatostatinoma: A case report.
Mee Hye Oh, Yi Kyeong Chun, Hye Jae Cho, Jin Ho Lee, Hong Yong Kim, Ill Hyang Ko
Korean J Pathol. 1993;27(6):645-649.
  • 1,479 View
  • 26 Download
AbstractAbstract PDF
Somatostatinoma is rare endocrine tumor that was first described in 1977 by Ganda et al. and Larsson et al. simultaneously. It seems nonfunctioning at clinical level. But it may present with diabetes, diarrhea, cholelithiasis, steatorrhea, indigestion, hypochlorhydria, and anemia. In contrast with pancreatic somatostatinoma, duodenal somatostatinoma, in general, is clinically silent. Duodenal endocrine tumors show similar histologic pattern. Therefore, the definite diagnosis is performed by immunohistochemistry and electron microscopic examination. We have experienced a case of somatostatinoma of duodenum in a 62-year-old male. He has complained generalized pruritus for one year and jaundice for 2 weeks. Grossly, the mass was a intraluminary protruding, polypoid lesion with focal mucosal erosion at immediately distal to Ampulla of Vater. Histologically, it showed tall, cylindrical cells with distinct cell membranes, having granular cytoplasm and small innocent looking nuclei. No mitosis was seen. The tumor cells were arraged in small solid groups and trabeculae, separated by fibrovascular stroma. Immunohistochemically, the tumor cells were strongly positive with somatostatin and negative with several other hormonal and neuroendocrine markers. Ultrastructurally, the cytoplasm contains numerous, homogeneous low electron dense secretory granules, which are essentially similar to those seen in normal delta cells.
Original Articles
Gastroduodenal Adenomas and Carcinoma in Patients with Familial Polyposis Coli.
Seung Sook Lee, Woo Ho Kim, Yong Il Kim
Korean J Pathol. 1993;27(3):263-267.
  • 1,481 View
  • 19 Download
AbstractAbstract PDF
Gastric lesion in familial polyposis coli is commonly presented with fundic gland hyperplastic polyps, but duodenal and gastric adenomas together with their carcinomatous transformation have been rarely described in familial polyposis coli mostly by case reports. We present three cases of gastric adenomas in familial polyposis coli with one in synchronous development of gastric adenocarcinoma in Korea. All three cases had the family history related to familial polyosis coli and received proctocolectomy because of synchronous development of colonic adenocarcinoma. One patient developed gastric polyposis and adenocarcinoma 8 years after colectomy, and the remaining two presented with multiple polyps either in the stomach or duodenum synchronously at the time of the diagnosis of familial polyposis coli with colonic adenocarcinoma. None disclosed any evidence of Gardner's syndrome. We conclude that association of gastric adenomas in familial oplyposis coli is not uncommon and gastric adenoma-carcinoma sequence is an another important participating mechanism to understand the histogenesis of gastric carcinoma in Korea.
Gastric Metaplasia in Duodenum.
Young Lyun Oh, Mi Kyung Kim, Woo Ho Kim, Yong Il Kim
Korean J Pathol. 1992;26(3):242-246.
  • 3,463 View
  • 77 Download
AbstractAbstract PDF
The partial replacement of the human duodenal mucosa by epithelial cells containing gastric-type mucus(gastric metaplasia) is not an uncommon finding, and an emphasis on its etiological role in duodenal ulcerogenesis has been proposed. It is unclear, Furthermore, all the previous studies were done with endoscopic biopsy specimens. We reviewed a total of 118 surgically resected stomachs with attached duodenal stumps(24 cases of gastric ulcer, 15 duodenal ulcer and 79 advanced gastric cancer). The gastric-type mucous cells were homogeneously stained red with PAS in contrast to the intestinal cells which gave a strong PAS stainability only along the the brush border. The gastric metaplasia was seen near the tips or on the sides of the villi and occasionally in the crypts. It was observed in 8 cases(53%) in duodenal ulcer, 12 cases(50%) in gastric ulcer and 29 cases(37%) in gastric cancer. There were no significant statistical differences in incidence among the groups. Nevertheless, diffuse form of gastric metaplasia was more prevalent in patients with duodenal ulcer(p<0.05).

J Pathol Transl Med : Journal of Pathology and Translational Medicine