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Case Study
Unusual Histology of Eosinophilic Myenteric Ganglionitis: A Case Report
Hyekyung Lee, Dongwook Kang, Heejin Kim, Byungsun Cho, Jeho Jang
J Pathol Transl Med. 2017;51(3):320-324.   Published online April 4, 2017
DOI: https://doi.org/10.4132/jptm.2016.09.07
  • 7,453 View
  • 130 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Eosinophilic myenteric ganglionitis is a disorder characterized by infiltration of the Auerbach myenteric plexus by eosinophils. As a cause of chronic intestinal pseudo-obstruction (CIPO), eosinophilic myenteric ganglionitis has been rarely reported and the majority of the reported cases in the literature were children. We experienced a case of eosinophilic myenteric ganglionitis associated with CIPO in a 53-year-old female patient. Histologic examination of the resected descending colon showed moderate eosinophilic infiltrates with hypogangliosis in the myenteric plexus. Immunohistochemical study revealed increased number of CD4-positive lymphocytes and stronger but scantier glial fibillary acid protein expression in the inflamed myenteric plexus.

Citations

Citations to this article as recorded by  
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    Alyson Kim, Jeffrey L. Roberson, Lillias H. Maguire, Bo Jian, Nicole M. Saur
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  • Histological characteristics of eosinophilic myenteric ganglionitis: an under-recognised cause of chronic intestinal pseudo-obstruction
    Yoichi Akazawa, Takuo Hayashi, Tsuyoshi Saito, Koichiro Niwa, Hirohiko Kamiyama, Noriko Sasahara, Kazuhiro Sakamoto, Akihito Nagahara, Takashi Yao
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Original Article
Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
Hyuck Cho, Sung-Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim, Ji Won Min, Byeong-joo Noh
J Pathol Transl Med. 2016;50(1):45-51.   Published online December 14, 2015
DOI: https://doi.org/10.4132/jptm.2015.10.16
  • 8,945 View
  • 118 Download
  • 38 Web of Science
  • 39 Crossref
AbstractAbstract PDF
Background
A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors. Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining. Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase. Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.

Citations

Citations to this article as recorded by  
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    International Journal of Molecular Sciences.2021; 22(7): 3801.     CrossRef
  • CCL24 Protects Renal Function by Controlling Inflammation in Podocytes
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    Sharon Grisaru-Tal, Michal Itan, Daniel G Grass, Javier Torres-Roca, Steven A Eschrich, Yaara Gordon, Avishay Dolitzky, Inbal Hazut, Shmuel Avlas, Elizabeth A Jacobsen, Tomer Ziv-Baran, Ariel Munitz
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